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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 10755408 | 2000 | Cell line : - Source : Mallory Institute of Pathology or through the Cooperative Human Tissue Network (CHTN), with cancer samples and normal mucosa obtained from each patient. Sample Type : CRC tumor and normal tissue No. of Sample : 77 Stage : Duke Stage A-D | Western blotting,Laser densitometry,Immunohistochemistry | Up-regulation | - | Cathepsin H-specific activity was significantly increased in colorectal cancers compared to control mucosa . |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Cathepsins |
| Description | The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] |
| Chromosome | 15 |
| Location | 15q25.1 |
| Start | 79214092 |
| End | 79237436 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 23345 |
| OMIM ID | 116820 |
| HGNC ID | HGNC:2535 |
| Unigene ID | Hs.148641 |
| Ensembl ID | ENSG00000103811 |
| PharmGKB ID | PA27033 |
mRNA Information
| mRNA ID | NM_004390.3 |
|---|---|
| Exon | join(12..199,5919..5950,7667..7772,9340..9410, 10008..10112,12632..12718,13584..13639,15597..15678, 17309..17377,19650..19756,21972..22097,22885..23340) | mRNA Sequence | Download Select all |
| Length | 1494 |
Protein Information
| Protein ID | NP_004381.2 |
|---|---|
| Protein Name | cathepsin H |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 335 |
| Uniprot ID | P01009 |
| Ensembl Protein ID | ENSP00000348068 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 89;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 632 | BGLAP | 205 | NP_954642.1 | in vivo | 9076588 |
| 6439 | SFTPB | 1523 | NP_942140.1 | in vitro | 14766755 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Lysosome | hsa04142 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd02248 | 117-331 | Peptidase_C1A |
| cl00296 | 117-331 | Peptidase_C39_like superfamily |
| pfam00112 | 117-332 | Peptidase_C1 |
| smart00645 | 116-331 | Pept_C1 |
| cd02621 | 117-332 | Peptidase_C1A_CathepsinC |
| cd02620 | 117-324 | Peptidase_C1A_CathepsinB |
| cd02619 | 119-330 | Peptidase_C1 |
| cd02698 | 117-319 | Peptidase_C1A_CathepsinX |
| pfam08246 | 35-90 | Inhibitor_I29 |
| cl22448 | 35-90 | Inhibitor_I29 superfamily |
| smart00848 | 35-89 | Inhibitor_I29 |
| PTZ00021 | 28-335 | PTZ00021 |
| PTZ00200 | 35-324 | PTZ00200 |
| PTZ00203 | 35-332 | PTZ00203 |
| PTZ00049 | 100-333 | PTZ00049 |
| COG4870 | 103-316 | COG4870 |
| PTZ00364 | 115-334 | PTZ00364 |
| PTZ00462 | 87-327 | PTZ00462 |
Ontology Information
| HPRD ID | 1436 |
|---|---|
| Molecular Class | Cysteine protease |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.