Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PPM1L | 151742 | protein phosphatase, Mg2+/Mn2+ dependent, 1L | 3 | PP2CE |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19847890 | 2010 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Real-time PCR analyses | Down-regulation | >2 Fold | PPM1L transcript was down-regulated more than two-folds in all six polyps and tumors compared to matched mucosa of the affected member. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Serine/threonine phosphatases / Protein phosphatases, Mg2+/Mn2+ dependent |
| Description | The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015] |
| Chromosome | 3 |
| Location | 3q26.1 |
| Start | 160473996 |
| End | 160788817 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 314822 |
| OMIM ID | 611931 |
| HGNC ID | HGNC:16381 |
| Unigene ID | Hs.389027 |
| Ensembl ID | ENSG00000163590 |
| PharmGKB ID | PA134871016 |
Protein Information
| Protein ID | NP_640338.2 |
|---|---|
| Protein Name | protein phosphatase, Mg2+/Mn2+ dependent, 1L |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 360 |
| Uniprot ID | Q68CP9 |
| Ensembl Protein ID | ENSP00000335044 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 6885 | MAP3K7 | 4011 | NP_663304.1 | in vitro;in vivo | 12556533 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00143 | 93-351 | PP2Cc |
| cl00120 | 93-351 | PP2Cc superfamily |
| smart00332 | 93-349 | PP2Cc |
| pfam00481 | 93-344 | PP2C |
| COG0631 | 97-360 | PTC1 |
| pfam13672 | 128-324 | PP2C_2 |
| smart00331 | 102-325 | PP2C_SIG |
| PTZ00224 | 92-353 | PTZ00224 |
| PLN03145 | 100-352 | PLN03145 |
| PRK14559 | 100-360 | PRK14559 |
Ontology Information
| HPRD ID | 17141 |
|---|---|
| Molecular Class | Serine/threonine phosphatase |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.