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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
DAB2IP 153090 DAB2 interacting protein  9AF9Q34, DIP1/2, KIAA1743, AIP1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26336990   2015Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Co-immunoprecipitation analysesDown-regulation-DAB2IP may be a potential, novel therapeutic and prognostic target for clinical CRC patients.DAB2IP was down-regulated in CRC tissues and a valuable prognostic marker for survival of CRC patients.


Gene Details



NC_000009.11 (124329162..124547809)

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Gene Type protein coding
Gene Family -
Description DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]  
Chromosome 9
Location 9q33.1-q33
Start 124329162  
End 124547809  
Strand +  
Gene Sequence

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Length 218648  
OMIM ID 609205   
HGNC ID HGNC:17294   
Unigene ID Hs.522378   
Ensembl ID ENSG00000136848   
PharmGKB ID PA27133   

mRNA Information


mRNA ID ?NM_032552.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS6832.1



Protein Information


      
Protein IDNP_115941.2
Protein NameDAB2 interacting protein
Molecular Wt. (Da)0
Protein Sequence

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Length 1189  
Uniprot IDQ7RTV2
Ensembl Protein ID ENSP00000284562  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation698
SPhosphorylation602
YPhosphorylation701
YPhosphorylation605
SPhosphorylation719
SPhosphorylation623
SPhosphorylation735
TPhosphorylation762
SPhosphorylation639
TPhosphorylation666
TPhosphorylation907
SPhosphorylation921
TPhosphorylation811
SPhosphorylation825
TPhosphorylation914
YPhosphorylation917
SPhosphorylation929
TPhosphorylation818
YPhosphorylation821
SPhosphorylation833
SPhosphorylation927
SPhosphorylation831
SPhosphorylation964
SPhosphorylation967
SPhosphorylation868
SPhosphorylation871
SPhosphorylation1044
SPhosphorylation950
SPhosphorylation854
SPhosphorylation674
SPhosphorylation578

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1600DAB14582NP_066566.3in vitro;in vivo11812785   
4217MAP3K53904NP_005914.1in vivo;yeast 2-hybrid12813029   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd05136333-656  RasGAP_DAB2IP
cl02569333-656  RasGAP superfamily
cd04013203-342  C2_SynGAP_like
cl14603203-342  C2 superfamily
cd1337675-261  PH_DAB2IP
cl1717175-261  PH-like superfamily
cd1337570-261  PH_SynGAP
cd04519345-597  RasGAP
cd1337372-217  PH_nGAP
cd1326275-211  PH_RasSynGAP-like
pfam00616392-563  RasGAP
cd05137331-582  RasGAP_CLA2_BUD2
cd05128358-598  RasGAP_GAP1_like
cd05392341-637  RasGAP_Neurofibromin_like
cd05391339-646  RasGAP_p120GAP
cd05134370-597  RasGAP_RASA3
cd05130374-626  RasGAP_Neurofibromin
cd13374124-226  PH_RASAL3
cd05135361-592  RasGAP_RASAL
cd05394379-599  RasGAP_RASA2
cd05132413-643  RasGAP_GAPA
cd05395359-599  RasGAP_RASA4
cd08383215-334  C2A_RasGAP
cd08400215-334  C2_Ras_p21A1
cd00030215-312  C2
smart00239214-310  C2
cd05131419-667  RasGAP_IQGAP2
cd05127521-645  RasGAP_IQGAP_like
smart00233149-202  PH
cd05133510-613  RasGAP_IQGAP1
cd04022219-312  C2A_MCTP_PRT_plant
cd12207521-668  RasGAP_IQGAP3
cd08391213-312  C2A_C2C_Synaptotagmin_like
pfam00169149-202  PH
pfam00168215-276  C2
cd04054219-310  C2A_Rasal1_RasA4
cd04015291-334  C2_plant_PLD
cd05129425-580  RasGAP_RAP6
cd08401217-313  C2A_RasA2_RasA3
cd00821149-197  PH
cd13260147-199  PH_RASA1
cd08382250-301  C2_Smurf-like
pfam12004646-1159  DUF3498
smart00323328-649  RasGAP
pfam007691026-1182  ERM
COG11961032-1168  Smc
COG04191024-1159  SbcC
COG11961026-1158  Smc
PRK039181032-1157  PRK03918
TIGR021681020-1159  SMC_prok_B
TIGR021681030-1158  SMC_prok_B
COG11961032-1157  Smc
COG11961013-1157  Smc
TIGR021691031-1158  SMC_prok_A
COG11961026-1159  Smc
TIGR021691026-1160  SMC_prok_A
COG04191030-1158  SbcC
TIGR0060541-222  rad4
COG11961027-1159  Smc
COG49421026-1173  EnvC
COG11961030-1158  Smc
COG04191025-1189  SbcC
pfam150701021-1121  GOLGA2L5
TIGR021681032-1180  SMC_prok_B
COG11961026-1158  Smc
TIGR006061028-1158  rad50
TIGR021691029-1162  SMC_prok_A
COG04191033-1159  SbcC
TIGR021681032-1158  SMC_prok_B
COG11961030-1158  Smc
TIGR021681010-1159  SMC_prok_B
pfam059111031-1140  DUF869
TIGR021691030-1179  SMC_prok_A
pfam078881025-1164  CALCOCO1
pfam04094869-1165  DUF390
PRK039181032-1158  PRK03918


Ontology Information


   
HPRD ID9620
Molecular ClassUnclassified
Molecular FunctionGlutathione transferase activity (GO:0004364)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO