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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CYP2A6 1548 cytochrome P450, family 2, subfamily A, polypeptide 6  19CPA6, CYP2A 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
17683511   2007Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : Colon specimens (n = 53) were diagnosed as adenoma (n = 16), adenocarcinoma (n = 30) or carcinoma in or with adenoma (n = 7)

Stage : TNM Stage I-IV

Immunohistochemistry, in situ hybridization Up-regulation--


Gene Details



NC_000019.9 (41349441..41356360, complement)

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Gene Type protein coding
Gene Family Cytochrome P450s
Description This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008]  
Chromosome 19
Location 19q13.2
Start 41349441  
End 41356360  
Strand -  
Gene Sequence

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Length 6920  
OMIM ID 122720   
HGNC ID HGNC:2610   
Unigene ID Hs.250615   
Ensembl ID ENSG00000255974   
PharmGKB ID PA121   

mRNA Information


mRNA ID NM_000762.5
Exon join(1..201,468..630,1685..1834,2069..2229,3397..3573, 4351..4492,4967..5154,5676..5817,6471..6910)  
mRNA Sequence

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Length 1775  



CDS Information


   
Location22..1506
CDS Sequence

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CCDS ID CCDS12568.1



Protein Information


      
Protein IDNP_000753.3
Protein Namecytochrome P450, family 2, subfamily A, polypeptide 6
Molecular Wt. (Da)54314
Protein Sequence

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Length 494  
Uniprot IDP42336
Ensembl Protein ID ENSP00000263967  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation131

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                                          
Pathway Name Pathway ID
Caffeine metabolism hsa00232
Chemical carcinogenesis hsa05204
Drug metabolism - cytochrome P450 hsa00982
Drug metabolism - other enzymes hsa00983
Metabolic pathways hsa01100
Metabolism of xenobiotics by cytochrome P450 hsa00980
Retinol metabolism hsa00830


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam0006734-491  p450
cl1207834-491  p450 superfamily
PTZ004046-464  PTZ00404
COG212434-462  CypX
PLN023946-494  PLN02394
PLN0011027-474  PLN00110
PLN026871-473  PLN02687
PLN0296612-473  PLN02966
PLN032346-471  PLN03234
PLN031127-472  PLN03112
PLN0218311-474  PLN02183
PLN001681-463  PLN00168
PLN0265535-441  PLN02655
PLN029711-473  PLN02971
PLN0293658-462  PLN02936
PLN021966-462  PLN02196
PLN02302315-463  PLN02302
PLN02987296-482  PLN02987
PLN0229036-467  PLN02290
TIGR04538242-463  P450_cycloAA_1
PLN02500216-461  PLN02500
PLN02426246-469  PLN02426
PLN030187-466  PLN03018
PLN03141230-461  PLN03141
PLN02169282-463  PLN02169
PLN02774277-455  PLN02774
PLN03195244-454  PLN03195
PLN02648321-422  PLN02648
PLN0273865-448  PLN02738


Ontology Information


   
HPRD ID4161
Molecular ClassEnzyme: Oxidase
Molecular FunctionLipid kinase activity (GO:0001727)
Biological ProcessSignal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P11509DB00170MenadioneSmallMoleculeDrug
P11509DB00182AmphetamineSmallMoleculeDrug
P11509DB00184NicotineSmallMoleculeDrug
P11509DB00207AzithromycinSmallMoleculeDrug
P11509DB00216EletriptanSmallMoleculeDrug
P11509DB00238NevirapineSmallMoleculeDrug
P11509DB00255DiethylstilbestrolSmallMoleculeDrug
P11509DB00257ClotrimazoleSmallMoleculeDrug
P11509DB00281LidocaineSmallMoleculeDrug
P11509DB00312PentobarbitalSmallMoleculeDrug
P11509DB00313Valproic AcidSmallMoleculeDrug
P11509DB00316AcetaminophenSmallMoleculeDrug
P11509DB00356ChlorzoxazoneSmallMoleculeDrug
P11509DB00363ClozapineSmallMoleculeDrug
P11509DB00381AmlodipineSmallMoleculeDrug
P11509DB00396ProgesteroneSmallMoleculeDrug
P11509DB00412RosiglitazoneSmallMoleculeDrug
P11509DB00470DronabinolSmallMoleculeDrug
P11509DB00471MontelukastSmallMoleculeDrug
P11509DB00495ZidovudineSmallMoleculeDrug
P11509DB00531CyclophosphamideSmallMoleculeDrug
P11509DB00544FluorouracilSmallMoleculeDrug
P11509DB00553MethoxsalenSmallMoleculeDrug
P11509DB00568CinnarizineSmallMoleculeDrug
P11509DB00604CisaprideSmallMoleculeDrug
P11509DB00636ClofibrateSmallMoleculeDrug
P11509DB00675TamoxifenSmallMoleculeDrug
P11509DB00690FlurazepamSmallMoleculeDrug
P11509DB00752TranylcypromineSmallMoleculeDrug
P11509DB00755TretinoinSmallMoleculeDrug
P11509DB00763MethimazoleSmallMoleculeDrug
P11509DB00818PropofolSmallMoleculeDrug
P11509DB00860PrednisoloneSmallMoleculeDrug
P11509DB00882ClomifeneSmallMoleculeDrug
P11509DB00921BuprenorphineSmallMoleculeDrug
P11509DB00951IsoniazidSmallMoleculeDrug
P11509DB00972AzelastineSmallMoleculeDrug
P11509DB00983FormoterolSmallMoleculeDrug
P11509DB01006LetrozoleSmallMoleculeDrug
P11509DB01011MetyraponeSmallMoleculeDrug
P11509DB01026KetoconazoleSmallMoleculeDrug
P11509DB01028MethoxyfluraneSmallMoleculeDrug
P11509DB01037SelegilineSmallMoleculeDrug
P11509DB01043MemantineSmallMoleculeDrug
P11509DB01045RifampicinSmallMoleculeDrug
P11509DB01059NorfloxacinSmallMoleculeDrug
P11509DB01085PilocarpineSmallMoleculeDrug
P11509DB01110MiconazoleSmallMoleculeDrug
P11509DB01115NifedipineSmallMoleculeDrug
P11509DB01118AmiodaroneSmallMoleculeDrug
P11509DB01151DesipramineSmallMoleculeDrug
P11509DB01156BupropionSmallMoleculeDrug
P11509DB01159HalothaneSmallMoleculeDrug
P11509DB01174PhenobarbitalSmallMoleculeDrug
P11509DB01181IfosfamideSmallMoleculeDrug
P11509DB01191DexfenfluramineSmallMoleculeDrug
P11509DB01213FomepizoleSmallMoleculeDrug
P11509DB01234DexamethasoneSmallMoleculeDrug
P11509DB01236SevofluraneSmallMoleculeDrug
P11509DB01274ArformoterolSmallMoleculeDrug
P11509DB01351AmobarbitalSmallMoleculeDrug
P11509DB01361TroleandomycinSmallMoleculeDrug
P11509DB01435AntipyrineSmallMoleculeDrug
P11509DB01544FlunitrazepamSmallMoleculeDrug
P11509DB04841FlunarizineSmallMoleculeDrug
P11509DB04871LorcaserinSmallMoleculeDrug
P11509DB04953EzogabineSmallMoleculeDrug
P11509DB06292DapagliflozinSmallMoleculeDrug
P11509DB06712NilvadipineSmallMoleculeDrug
P11509DB06729SulfaphenazoleSmallMoleculeDrug
P11509DB09068VortioxetineSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO