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General Information

• Evidence
• Gene
• mRNA
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Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
22155602	2011	Cell line : - Source : Department of General Surgery, Sher-I-Kashmir Institute of Medical Sciences, Kashmir. Sample Type : CRC tumor and Normal tissue No. of Sample : 86 CRC cases and 160 control Stage : TNM Stage I-III	-	Polymorhpism	-	There is a significant relationship between the CYP2E1 RsaI and 96-bp insertion polymorphisms and the risk of CRC.

Gene Details

Chromosome: 10; NC_000010.10 (135340867..135352620)
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Gene Type	protein coding
Gene Family	Cytochrome P450s
Description	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
Chromosome	10
Location	10q26.3
Start	133527363
End	133539116
Strand	+
Gene Sequence	>gi|568815588:133527363-133539116 Homo sapiens chromosome 10, GRCh38.p2 Primary Assembly CTCCCGGGCTGGCAGCAGGGCCCCAGCGGCACCATGTCTGCCCTCGGAGTCACCGTGGCCCTGCTGGTGT GGGCGGCCTTCCTCCTGCTGGTGTCCATGTGGAGGCAGGTGCACAGCAGCTGGAATCTGCCCCCAGGCCC TTTCCCGCTTCCCATCATCGGGAACCTCTTCCAGTTGGAATTGAAGAATATTCCCAAGTCCTTCACCCGG GTAAGAGAAATAGTGTTGATTTTAGGGAGAATAACTCAGCAATTGGATCTGGTATGTGTGTATTCAACTC ATTTGCAGACAAATTGTGGTTGTTCAATACCAGCCTGTTGTGAATTACCTGAATTGATAGCATCCTGGAG CGACACTCAAAATGTGTCGCCTGTGGTGCAGCTGGAGCCCGGAGCCTGCGTGCCAGGCCCCGGAGGCCCC CGCCGGTGCCTTGTCCTGGGGCTGATGATGGGGAGGCCGGCGAGGCCGGGCTGCTGCGACGCCAGGATAA CCGGGCTGGCGGCCAGATGCGCACTCGCTGGGCGTCCGCCTGTGTTTGCCAAAGCACGAGTTGAAACGTG AAGTGTTGGGCCAGCCCGTGTGGCACCAATACCTGCCGCCTACGACTGTTGTGAACACTGAATGGGCCAA CAAACCTAAACGTTAAATGAACTGATAACGCCGTCAGCACGGAGCAGGCGCTGGGTGTTTGCGCTCTTGC GCGTGCGCTCTGTGGGGCGCAGGCTGACGGCGGGCGGGGGTCGCCTGCTCCAGCTCGGGCTCCCGCGCCA GAACCGGGTCCAGAACCTTGATTCCGGAAGCGGGCAACGGGGTGGTTGGTGGGCGCGCCTGAGGGAAGGG ACGTGAGGAGCCGGAGTCCGCGGAGTTGCCGCGGAGTTGTCCGCGGAGTCCAGGCGGGTGGGGAGCAGAG CAGCTGGAACCCCCCGAGCGCCCTGCAGACGCAGCAGCCTCTTGAGGGGAGGGTCTCCCCCACCTCGGGC TGGACAAAGACAGCTTTTCCCCACGTCCCTCTGGGTTCTCTAGAGCAACAGCAATACCCGCCCGGCAGGG GTGTGGCTTAGAGCCCCGCACCTCCTCGCCGCGCGGCGGGCCTGACTTCTAGCCACGGGTCTCCGCAGTT GGCCCAGCGCTTCGGGCCGGTGTTCACGCTGTACGTGGGCTCGCAGCGCATGGTGGTGATGCACGGCTAC AAGGCGGTGAAGGAAGCGCTGCTGGACTACAAGGACGAGTTCTCGGGCAGAGGCGACCTCCCCGCGTTCC ATGCGCACAGGGACAGGGGTGAGTCCGCGTCCCTGGCACGGAGCGGGGGGTGCATAACACGCCCCGGGAC AGTTACGGGCGCTAGCCACGTCGGCGATGGCCAAATAATAAACTAACAGTAATATTATAGTAACAGCATC CGAAGGATGAGATCAGGATTAGGGCGATGGCCCCCGCGCGTTGCCTGCGGAGCGAGGCGCACTGAGTCGC CCAGGAATCCGGCCTCTCGGCGACTGTGCGGGAGAGTTTATGGGGATGGGCGGGGCTGCTTCTGAGCAGG AGTCGCCGCCCCCACCCCCACCGTTCCGCCTCTGGGCCCGCAGGCTCCTCCCGGGAGCGCTTTCCCCTCC TGTTCAACCGCCGGGGTACAGGTGGCTTCGTCCACCGAGGTCCCCTCACCCACGCTGAGGCGTCGGAAGC TGCGGACACTGCTCGCTTCAGGGCTTTGCTCAGCTGCAGCTGGTGACCTCCAGAGAGGGAGTCTCTGATG TCCCGCTGGGGTGGATGTCCTGAGACCGGGAAGGGGGAAGAGACCCACTGAAATCCTATCTCCCAGCCTC ACCTCTGCTGTCTCCTCCACGCTTCCTGTCTCCAGAGCCCCGAGTTCAGCATAAGCAGAAAGCGGCCTGT TCCCTCTCTAGGGAGAGGAGGGTTGCGGTCTGGAGGTCTGGCTCGTCTTTATCTGCGCATTCTCCCAGCC TCCTGGCTTCAGACCTCAGCGAGGCGGCGGCTGCCGGCCGGCTCTCCTCTTCCTGCCTGCAGACCTGGCC TGCTGCTTCTTTCTCCTTCCTCCCTCCCTGCCTGCCCTGCGGTTTCAAAGTAGATTAGAAATAACAGTGT CCCACATGGAAGCCTCTACTTCTTCCTGGGTCAACTTTGATGACGAGGCTCCAGAAAACCTTTGCAATGC TGTGTGGAATTTTTAAATCGGTGAGCTCGTGCTCTTGCCCTATTTATTTGTCCAGCGTACATTTCTGAAC ATTGTGAACGTCGAATGGGCCAACAAATCTAAAAATTAAATGAGCTGATAAAGAACGCCGTCAGCACAGA GCAGACGCTGGGTGTTCGCGCTCTTGAGCGTGCGCTCTGCGGGGCGCGGGCTGGTGGCGGGCGGGGGTCG CCGGCTCCAGCTCAGGTTCCCGCGCCAGGACCGCGTCCAGAACCTTGTCTCCGGAAGCGGGCAACGGGGT GGTTGTATCACAATTAGTGGCATTTGGTTTTCCTTCTTCTGCATTGTGGGTTTTACTTCTCTGGGGTTGC CAAAAACAAAATTAACCATCTCAGTCCTTGTCGTTAACGCAGGAGAAGCATTACTGGAGGAGGCTCTGGG GTTCTGTGGTTGAGGAGCTCAGTTCTGGTTCCGGGGAGCCCTTATCTGCCACCCACGGGTCCAAGGCACA GTCGGAGGCAGCAGGGAGGGGAGCGGAATTCACATCAACACAGATGGGGCTCAAGGGGACTTTGCTGCCT CTGCCTGGAGGGTCTAAAGTTTCATTTTCATATGACCCGCAGGGCGCAGACTGGCGGAAAATTAGCAGAG CCCTGGGCATGGGCTGCACCTGGCCCTTAAGGGACAATGATGGAAATATTCCTTATTAGCACAATACTGA GCACAGGCTGTGTGATAATGTGTCAAGGGAACTGCAGACATCCTTTCAGAAAAAGTTCATAAAACGGAGA AAGTTTGGTTCCCAACCTAGATTTTTAACCTGTTGAACTCTGTCTAAATGGGTCATCTCGGGATGTCCTC CACTCAACATGACCACGTCTGCCCCTCTGTCCCACCTGTCTCCTCAGTCCTTCCTCCCCACCTTTCAGGA TGAAATGAAACCCTCAGTCCAGCTGCACCCCTGCCCCACCCACCTCATCTCATGTGCCCTCCCGCCCCTC TCAGGCCGGACAGCCTTGCTTCTGGAACACACGAGCACAGCTTCACCAGGCACTTTCTGAGCACCCTGCA GGCGCCTCCCAGGAGTGGTCAGTGGTCAATCAGCTAATGAAGCTGCATAGGACATGACCCTTGTTTACCG CAGAATGCCCAGAGCTGGCAGGATGTCTTATATGCAGGAAGTACCCAAAATGTATTTATTGAGGAAGTGA TGATGGATAAGAGGAAGACGGAGAGCGAGGGAGAGAGGGGCTAGGGGCCCCTGCGGTGTAAAGGGGGTGT GGCTGGGAGTGTGCAGGGGAACAGGGATCATTTCAAGGTTCCTATCTGGGAGAAAATAAAAAGGTTTACA GTTAGTTGAGATAAGCGTGGGAATATGCGAACATTTTTAAAGAATAAAAAGTTTAGCTTTAAATTTGTTG ATTCCAAATGTGTTCATACTCTCGGGAGGATCCATCAAGCAACTCTTGGGAGGAGAGACAGGGCAGGGCC AGGCCTTGACAGCTCAGAAGGGTGCAGTAGGGACAGTTCTTGGTTTTCCCAGCTCTGATGCTTTGCACAG TCACTTGTGTGACCTGCAAGATTTTAGTGAAGAAACTTGCTGTGGAGTCGGAAAGCTGCAAGTTGAGGTG TGTGTGGTGTGAGGGTTAAAAATCTGTGAGAACAGAATGAATGGCTTTTCAAGAATGTTGTCGATAGATA GGAAAGAGGTGGGAGGTGTTCTTGGAGTGGCCATATGTGGTTTTATGTAGCATGGGGAAGACTCAGCAGA AAGGAAAAAGAAAGAAGGTAAATTGACAGCATGAAGTAGAGCACCCAGGAGAGGCTACATGTGATGAAGA AACCACAGTGCAGACTGTGAGGACCCCAGAAAGGCTCCTCCCCAAAACCTGACCAGTGGCCGGTGCTGGC AGCTCCCAGGCTGGGACACCCCTCTGTCTCTCTGTCCCTCTGCCCCCTCTGTCACTTCTTTATACACCTG TAAATCCTGCCCTGCTCTCCAAGGCCCTCTGTAGCCCATTTCTCCCCAAAATGGGTATTTAGAATAACCT TCTGCTGGCCCCTCTGCCTTAGGAATCATTTTTAATAATGGACCTACCTGGAAGGACATCCGGCGGTTTT CCCTGACCACCCTCCGGAACTATGGGATGGGGAAACAGGGCAATGAGAGCCGGATCCAGAGGGAGGCCCA CTTCCTGCTGGAAGCACTCAGGAAGACCCAAGGTGCGTATCTGCTGCCTAGCAGGGCCCAGTCCTCTTGC AGACCAGCGGTGTGGGGAGCCCTGGCTGGGACTCCTAGACTGCATCTGAACCACAGGGACCTACGGACAA GGAGAGGGTCTCGTGAGTCCCCAGATACTGCATTTTACAACTCTAGGTTCCAGCTACACAGTTCAGGGAG CAAGGGTGGCCATTAAACACGTGACTTGTATCCTAAATACTGTTGAAAAGCAAAGGAAACTCAAACAGGT TCAGACATTCACTATCTTTCGTAAACTGGCAGTTTTCAGGGCACCTTCTCACAGGCCTTGGTGAACCTCA GTGGGTGACTGAGCAGGTGGAGGAGTCTCCTCACCCCCATCTTCTGGTTGCCCTGACTGCCTGTTTTGTA GGCCAGCCTTTCGACCCCACCTTCCTCATCGGCTGCGCGCCCTGCAACGTCATAGCCGACATCCTCTTCC GCAAGCATTTTGACTACAATGATGAGAAGTTTCTAAGGCTGATGTATTTGTTTAATGAGAACTTCCACCT ACTCAGCACTCCCTGGCTCCAGGTGAAGCCACTTTCCTCTTTCATCAGTCATCAACTGTAGAGTTTACGT TAGAAAAAGAAGGAAAATTTGGGTTATATGTGATAGACAGGACTGCAAAAGCCAAACAACATAGCTTCGA GGGGTGTTTGATTAGACAGCCCAAATATTCCTCCCAGAGACATCTCTGGGGCCCCACGCACCCCCTTTCC TAACGTCAGGATGTGTATCGACCTGTGTGTGCACATTTGCCATGCAGAGTTTGCACTGCTGAGGAGAATG GTGCCCAAGAAGGACACTGTTGACCCAAAATATTCCAAATAAACAATGATTACAGCCACAAATTCAGGTT TGGAGAAAGTTGTTGGTCCAACACACACAATTATGTTGCATCCAGAAAAAAGTAGTAAAATATTTTTTTC CCTCTCTAGCTTTACAATAATTTTCCCAGCTTTCTACACTACTTGCCTGGAAGCCACAGAAAAGTCATAA AAAATGTGGCTGAAGTAAAAGAGTATGTGTCTGAAAGGGTGAAGGAGCACCATCAATCTCTGGACCCCAA CTGTCCCCGGGACCTCACCGACTGCCTGCTCGTGGAAATGGAGAAGGTAGGCTCGGCCCTCCCATGATGT GGGCTCTCCGGGGTGGGCAGAGAATGCACAATTTCAGATTTACAGAGTGAGCTGCACTTGCTGGTGTCCA GACCTCCCACCGCAGCATGCTCTGAGTTTCATACACACACTCTTGGCTTCAGCATGACCACTGGACGCAA GTCAGCCTGCCTGGCTGCCAAGCTGGCCTGGGGCTTTGGGGTCACATGGGCGGGACGCTTAGCTCTCTCC AGGCCCTGCTGCTCAACCCTTTCTAGTCTGCAGACTTTGAGAATTGCATTTTGTCTGAGGAGAAGCCCTC AGCCTTCCTTGTGGGCATGCACTCCCCAACTGTGCGCAGCTGCAGGACTTCCAGGCCTCCCCAGCTTCAT CCACCTGCAGGTGCTCAGGATCCTGATCCCCTGCCCCCTTCCCACCTTGGTGAAACTTCTTGTATCCTTG TCTTGTCCTTTCCTATGGCTTGTGGCTCAAGAACAAATGTGGAGCCCACACTGATTTCCCAGGACTGTCT GAGCATCTTCTCCACCAGTTTGGCCCCTCGTGGCAGCAGACACTAGCCCTGTAGCAGGAGGGGTTAGCAG GAGCCGTTTAGCTCCTGCCTGAGCTATGACCAAGGTCAGGGGGATCTCACCTCTCCCAGGATGGCCCTCA TGCTGTGGAGGGAGACAGAGCCCTGGCCTGCCCTCAGCAGATTTCTGGGAGCCTCAGTTTCCCTGGCTGT GAGGTGGAGATGACTCTGTCTGTCACAGCTCCAAGTCACAGTTCCACTGGGAGAGCCTCTTGGACACTGT CTCCTGTGTCCCTGTGGAGCTGGGAGGTGGCTGGTTCTGTGCTGAAAGGAGACAAGCAGCCCCTTCTCCT CCGGTCTGTCTCCGGTATCACAGGAAAAGCACAGTGCAGAGCGCTTGTACACAATGGACGGTATCACCGT GACTGTGGCCGACCTGTTCTTTGCGGGGACAGAGACCACCAGCACAACTCTGAGATATGGGCTCCTGATT CTCATGAAATACCCTGAGATCGAAGGTAGGCAAGTGACTGAAGGGACACCGTGCGTGCGGCTGCATCTCC CTGGATGGCCAGCCTTGCACATTTTAGGCTGCAGCTTTCTGTCTGAAGCTGCTTGTTAACCCTCATGGTG ATGTGGTGAGATGGCTAGATGCACTGCTGTGAGGGGAGGTGTTATGGTCTGTGCTGAACACCTGGTACTC TTGCACACTGGTTGGTCCATACCCCACTAAGACACCCCTGGTTGCAGAAAAGAACATCCCAACACCAGAG TGGAGAGAGGTGGCAGGGTCTGCATTCTGCTCCATAAATAACCTCTTTATGACAGAGAAGATAATGTCCC AGTTCCCCCCAAGTAAGACCTGGTCTTCTAGGCAGAGCAGGTGGGGAGGTTGGAGCTGGAGGGGAGGGTC CTTGCTGGGGCGTCTTCCTCAAATGCGGACGTGAGGAGGGAAGTCCAGGAAGAAGCAGCTACAGCTGCCC TGGACCCTTGTTCCTTCCACAGGGCTCCTCCCAGCGGCACCTGGGGCAGCTGGGACTCTGTGCCTGGAGG AGGTGTGAAAGGTCTGGGTCTAGGTGGGCAGAGGGTCATGCCCTGAGAAACACCCATCTGGGCCAAGTAG AGGTGATGTGAGGGCACCCGCATGCAAACAGGCCAGTCAGGGTTGGGTCCAAGTAAAGGGGAGGAAAGGG AGCTGCAGCCTGGCTGGAGAGTGCCGGGGGGCCCAGAGCCCCTGCCTCTCGCTGGGCTGGAAACAGGGCT GGGCAGCCTCTGCCCGAGGCAGTTCACAGCCTGAGTGGTGTGTGCCGCCCTCCTCCTGAAGCTGCTGCTA ATGGTCACTTGTGGTCTTAAGGCTCGTCAGTTCCTGAAAGCAGGTATTATAGGCTATGAAGTTATTTCCC CCAAGAAAGTCGACATGTGATGGATCCAGGGTCAGACCCTGGGCTTTTCTTGTTCTTTCCTTCTTCTTCT TCTTTTTATTTATTTATTTTTTTTTTTGAGGGGACAGGGTCTCACTCTGTTGCCCAGGCTGGAGTGCGGT GATGCAATCATGGCTCATTGTAGCTTCTACCTATTGGGCTCAAGCGATCCTCCCACCTCAGCCTCCCAAG TAACTGGGCCACAGGTGCACACCACCACACCCAGCTGATTAAAAATTTAAAAAAATTATTTTGGCTGGGC ACAGTGGCTCATACCTGTAATCCTGGCACTTTGGGAGGCTGAGGCAGGCGATCACGAGGTCAGGAGTTCG AGACCTTCCTGGCCAACATGATGAAACCCTGTCTCTCCTAAAATACAAAAAAGTAGCCGGGTGTGGTGGC ACGCGCCTATAGTCACAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTCAACCTCAGAGGCACAGGGT GCAGTGATCCGAGATTGCACCCCACTGCACTCTAGCCTGACAACAGAGCAAGAATCAGTCTAAAAAAAAA ATTGTAGAGACAAGTTGTTACTATGTTTTGTAGGCTGGTCTTGAACTCCTGGGCTCAAGTCATCCTCCTG CCTTGGCCTCCCAAAGTGCTGGGGTTACAGGTGTGGCCACCGTGCCCCATCCCTGGCCTTTGCTTTTTCA ATCACATGGAAATGTGAAGGGTGAAGGAGCCAAAAGTTTAGGGAAGGAATCATTGTATGGATCTGCAGTG ATTATAAGAGAACTTTCGACTACTCTGCACTAGGGGAACCATGGAATCAAAAAATGTTTTAAATTATTAT TTATGAGGAGGTTCCAATATAGACAAAAGGAAAATAAATATGATTGACATGTATATATCCATTGCCAAAT TGAACGTTTATTAACATTTTGCGATACTTCCATCAGAGCTCTTAAAAAGAAAATGTGTTACAGAGCCAGC CAAAGTCTACCTCCTCACATCTCCCCACCTCTCTCACCAGAAATGGCTTCAGAATTGCTGTGTGGCTTTG CACTTTTAACAGTTGTTAATTATCAGCACAGTATTCATATTATTGCTGTATGTGTTTAATATTTTACCTG GGTACTGTACATAACATTTTGCAGCTTGGTTTTTTCACTCAACATATGATGATGTTCCATGGGAACTCCA AACACGGGGAGGCTAGGCGACTTGCTCAAGGCAGCTGTTACCTCTGTCAGAAAGACAGAGGCTTTCAGAT TCAAGAAGTAGACCCTGCATGTCTGATTCTGTTCTGTAAACCCCCTTCATACTCAGAAGCATGCAATAAA CAAGCCTGGGGTAATTATCAATGCAAAGGTTACCCTCCCAGAAGAAATTTCCAAAACACTTTCATTATTC TCTGCTCTTGACATGAAGAGAACTGAATAAGCCATCATCAACTGAGATAATGGATGCCAAAACATCCAGT AAATAACCTCATAGAGCTTAGCTCTCACTAAGTTTTTGGAGCATTTTCCAGTAATTCAAAGGACCTGGGG AACCTTAAGCACTGCTTAGGATGCTCCATAAACATCTTCTGCGTGGGTAGGGGAGTGGATGGATGGCTGG ATGGGTGGGTGGATGGACGGACGGATGGATGGATGGATGGATGGATGGATGGTTGGATGGATGGGTGGGT GGATGGATGGATGGGTCAATGGATGTGTGGATGGATGGAAGGGTGGGTGGATGGGTGGATGGTTGGATGT ATAGATGGGTGGATGGGTGGATGCTTGGATGGATGCGTGGGTAGGTGGATGGAGGGATGGCTGGATGGAT GGGTGGGTGGGTGGGTGGGTGGATGGATGGGTGGATGGGTGGTTGGGTGGATGGATGGATAGGAGGGTGG ATAAATGGGTGGATGGATGGATGGGAGGGTGGATAAATGGGTGGATGGGTGGATGGTTGGATGGATGGGT GGGTGGGTGGATGGATGGGTGGTTGGATGGATGGGTGGGTGGGTGGATGGGAGGGTGGATGGATGGGTGG TTGGATGGATGGGTGGGTGGGTGGATGGGAGGGTGGATGGCTGGCTGGCTGGGTGGGTGGGTGGATGGAT GCATGGGTGGATGGATGGAGGATGGATGGATGGATGGAGGGGTGTATAGATGGAGGGGTGGATGGATGTG TAGGTGGGCAGATGGATAAAAGCGTGATTGAATAGATGGGTGGATGATGGGTGGATGCCCAACTGGCCAG GAACCAATCCCTGAAATTTGTCCCATTCATATCTTGGCAGAGAAGCTCCATGAAGAAATTGACAGGGTGA TTGGGCCAAGCCGAATCCCTGCCATCAAGGATAGGCAAGAGATGCCCTACATGGATGCTGTGGTGCATGA GATTCAGCGGTTCATCACCCTCGTGCCCTCCAACCTGCCCCATGAAGCAACCCGAGACACCATTTTCAGA GGATACCTCATCCCCAAGGTTAAGCAATGAGCCTGCAGCACACAGCATGAACACCATCCTATCAGCTAAT CGCCTTCCTGCCAGGGAGCAGGATGGGGGCCCCAAGACCCTTCCCTTTGGCAGGGGTCACTGAGGGGAAG GGCTGGCCCCACTCCCACCCTGTGGGATACTGCATCTCCAGGAGTGCTCACATTGGCCTGGTGACCAGAG AGGTGGAGGAAATCTGGAAAAGAGCCTCAGCAGATAGTGCCTGGGACTGTAGTGAATTCTAATGCCAGGA ACAAACTATCACAACCAGCCCTGGGGTTAATCCTGTGAGAAGATTAGGGCTTTCATCTTCATTTAGACCT GACCCCTGACTGCTTTCTATCTAATCCTTCACTAAGCAACTCCTTCAACTGGAAATATACTATCCTATAT AGCATAATATTCAAAACTACATTCTTCACTGGGGGTTTCCAGATGAAAGCCCACATTTTGTTAACATGAC TCACTGAGACAGTCTTTGTTTCTCCTAGGGCACAGTCGTAGTGCCAACTCTGGACTCTGTTTTGTATGAC AACCAAGAATTTCCTGATCCAGAAAAGTTTAAGCCAGAACACTTCCTGAATGAAAATGGAAAGTTCAAGT ACAGTGACTATTTCAAGCCATTTTCCACAGGTGAGAAAGATCAGAGGCAGTACCTTCCCTTGAGGAGCAG CCCACACTCCTCATCTCCCCTCCACATGTGCTCTGCCCTCGTCCCAGGCACCCACTGACACCCCAAACCT CACTGTGTGCCCTGTTTCTATTGACAACATGACCCAAATGTGCTCTTCCCTGTTCAGAGAAGTTACATAA CATCTTTTAGCAGCAATCCTGGGAATGAAGTGTTGTTGTAGGTGGATTTTTTTTTTCCCAAAGACTAGAC ATTTTACATCATTCATTGCTAAATTTTGTTTCTATTTTAACAAGACTTAGTGAAAAGCTCTCAAAGCCAT ATTACCCAATTCTCCCTAATTTTAAACCAGAGCTACTAAACAAAACCTAACCTTTGGTTACCTAGAATCA TCACAGGAAGCATCAAAGCCTTCCTGGGATGTGACTCAGTGATTTTCTTTGAGGCACTTGTCCTCCTTCC CAGGGCCTCATCTTAGGGATTGTTGTGGGAAGATCATACAACCAACTCCATACTTTTCACACCCAGTGCT GGAGCCCCAGCTTCTAACAGGGCACTATTTCCCTCCTGTAGGCATCACTGATGAGCACTGGGGGTGCCTT CTTTACTGGGCAGACACGGTCTTCCCAACTTAACACCGGTTTTTGCAGTTGAGCTCTGGATAATTGAGAT TGTATGAAGACTGGTCCCCGAATTAGTCAGTGTTGCTGGTATCCTTCCACTCAAGTACATTTTGTGCTTC TTTTAATAGGCAGAGAAGGGTGAGTCCTGCCTTGTGATGGCCGTTTGCCCACAGCCTCCTCCTCCCCGCT TCCCCTAGTCTCACTGTTAACAGTGTCGTGTCTCTGAAACTCCCTCAGTGTCTCATCAATACCATTGTTA CTTCTAGGAAAACGAGTGTGTGCTGGAGAAGGCCTGGCTCGCATGGAGTTGTTTCTTTTGTTGTGTGCCA TTTTGCAGCATTTTAATTTGAAGCCTCTCGTTGACCCAAAGGATATCGACCTCAGCCCTATACATATTGG GTTTGGCTGTATCCCACCACGTTACAAACTCTGTGTCATTCCCCGCTCATGAGTGTGTGGAGGACACCCT GAACCCCCCGCTTTCAAACAAGTTTTCAAATTGTTTGAGGTCAGGATTTCTCAAACTGATTCCTTTCTTT GCATATGAGTATTTGAAAATAAATATTTTCCCAGAATATAAATAAATCATCACATGATTATTTT    Download   Select all
Length	11754
OMIM ID	124040
HGNC ID	HGNC:2631
Unigene ID	Hs.12907
Ensembl ID	ENSG00000130649
PharmGKB ID	PA129

mRNA Information

mRNA ID	NM_000773.3
Exon	join(1..210,1119..1278,4223..4372,4762..4922,5330..5506, 6394..6535,9701..9888,10389..10530,11418..11754)
mRNA Sequence	>1571 CTCCCGGGCTGGCAGCAGGGCCCCAGCGGCACCATGTCTGCCCTCGGAGTCACCGTGGCCCTGC TGGTGTGGGCGGCCTTCCTCCTGCTGGTGTCCATGTGGAGGCAGGTGCACAGCAGCTGGAATCT GCCCCCAGGCCCTTTCCCGCTTCCCATCATCGGGAACCTCTTCCAGTTGGAATTGAAGAATATT CCCAAGTCCTTCACCCGGTTGGCCCAGCGCTTCGGGCCGGTGTTCACGCTGTACGTGGGCTCGC AGCGCATGGTGGTGATGCACGGCTACAAGGCGGTGAAGGAAGCGCTGCTGGACTACAAGGACGA GTTCTCGGGCAGAGGCGACCTCCCCGCGTTCCATGCGCACAGGGACAGGGGAATCATTTTTAAT AATGGACCTACCTGGAAGGACATCCGGCGGTTTTCCCTGACCACCCTCCGGAACTATGGGATGG GGAAACAGGGCAATGAGAGCCGGATCCAGAGGGAGGCCCACTTCCTGCTGGAAGCACTCAGGAA GACCCAAGGCCAGCCTTTCGACCCCACCTTCCTCATCGGCTGCGCGCCCTGCAACGTCATAGCC GACATCCTCTTCCGCAAGCATTTTGACTACAATGATGAGAAGTTTCTAAGGCTGATGTATTTGT TTAATGAGAACTTCCACCTACTCAGCACTCCCTGGCTCCAGCTTTACAATAATTTTCCCAGCTT TCTACACTACTTGCCTGGAAGCCACAGAAAAGTCATAAAAAATGTGGCTGAAGTAAAAGAGTAT GTGTCTGAAAGGGTGAAGGAGCACCATCAATCTCTGGACCCCAACTGTCCCCGGGACCTCACCG ACTGCCTGCTCGTGGAAATGGAGAAGGAAAAGCACAGTGCAGAGCGCTTGTACACAATGGACGG TATCACCGTGACTGTGGCCGACCTGTTCTTTGCGGGGACAGAGACCACCAGCACAACTCTGAGA TATGGGCTCCTGATTCTCATGAAATACCCTGAGATCGAAGAGAAGCTCCATGAAGAAATTGACA GGGTGATTGGGCCAAGCCGAATCCCTGCCATCAAGGATAGGCAAGAGATGCCCTACATGGATGC TGTGGTGCATGAGATTCAGCGGTTCATCACCCTCGTGCCCTCCAACCTGCCCCATGAAGCAACC CGAGACACCATTTTCAGAGGATACCTCATCCCCAAGGGCACAGTCGTAGTGCCAACTCTGGACT CTGTTTTGTATGACAACCAAGAATTTCCTGATCCAGAAAAGTTTAAGCCAGAACACTTCCTGAA TGAAAATGGAAAGTTCAAGTACAGTGACTATTTCAAGCCATTTTCCACAGGAAAACGAGTGTGT GCTGGAGAAGGCCTGGCTCGCATGGAGTTGTTTCTTTTGTTGTGTGCCATTTTGCAGCATTTTA ATTTGAAGCCTCTCGTTGACCCAAAGGATATCGACCTCAGCCCTATACATATTGGGTTTGGCTG TATCCCACCACGTTACAAACTCTGTGTCATTCCCCGCTCATGAGTGTGTGGAGGACACCCTGAA CCCCCCGCTTTCAAACAAGTTTTCAAATTGTTTGAGGTCAGGATTTCTCAAACTGATTCCTTTC TTTGCATATGAGTATTTGAAAATAAATATTTTCCCAGAATATAAATAAATCATCACATGATTAT TTT    Download   Select all
Length	1667

CDS Information

   

Location	join(34..210,1119..1278,4223..4372,4762..4922,5330..5506, 6394..6535,9701..9888,10389..10530,11418..11602)
CDS Sequence	>gi|75709190:34-1515 Homo sapiens cytochrome P450, family 2, subfamily E, polypeptide 1 (CYP2E1), mRNA ATGTCTGCCCTCGGAGTCACCGTGGCCCTGCTGGTGTGGGCGGCCTTCCTCCTGCTGGTGTCCATGTGGA GGCAGGTGCACAGCAGCTGGAATCTGCCCCCAGGCCCTTTCCCGCTTCCCATCATCGGGAACCTCTTCCA GTTGGAATTGAAGAATATTCCCAAGTCCTTCACCCGGTTGGCCCAGCGCTTCGGGCCGGTGTTCACGCTG TACGTGGGCTCGCAGCGCATGGTGGTGATGCACGGCTACAAGGCGGTGAAGGAAGCGCTGCTGGACTACA AGGACGAGTTCTCGGGCAGAGGCGACCTCCCCGCGTTCCATGCGCACAGGGACAGGGGAATCATTTTTAA TAATGGACCTACCTGGAAGGACATCCGGCGGTTTTCCCTGACCACCCTCCGGAACTATGGGATGGGGAAA CAGGGCAATGAGAGCCGGATCCAGAGGGAGGCCCACTTCCTGCTGGAAGCACTCAGGAAGACCCAAGGCC AGCCTTTCGACCCCACCTTCCTCATCGGCTGCGCGCCCTGCAACGTCATAGCCGACATCCTCTTCCGCAA GCATTTTGACTACAATGATGAGAAGTTTCTAAGGCTGATGTATTTGTTTAATGAGAACTTCCACCTACTC AGCACTCCCTGGCTCCAGCTTTACAATAATTTTCCCAGCTTTCTACACTACTTGCCTGGAAGCCACAGAA AAGTCATAAAAAATGTGGCTGAAGTAAAAGAGTATGTGTCTGAAAGGGTGAAGGAGCACCATCAATCTCT GGACCCCAACTGTCCCCGGGACCTCACCGACTGCCTGCTCGTGGAAATGGAGAAGGAAAAGCACAGTGCA GAGCGCTTGTACACAATGGACGGTATCACCGTGACTGTGGCCGACCTGTTCTTTGCGGGGACAGAGACCA CCAGCACAACTCTGAGATATGGGCTCCTGATTCTCATGAAATACCCTGAGATCGAAGAGAAGCTCCATGA AGAAATTGACAGGGTGATTGGGCCAAGCCGAATCCCTGCCATCAAGGATAGGCAAGAGATGCCCTACATG GATGCTGTGGTGCATGAGATTCAGCGGTTCATCACCCTCGTGCCCTCCAACCTGCCCCATGAAGCAACCC GAGACACCATTTTCAGAGGATACCTCATCCCCAAGGGCACAGTCGTAGTGCCAACTCTGGACTCTGTTTT GTATGACAACCAAGAATTTCCTGATCCAGAAAAGTTTAAGCCAGAACACTTCCTGAATGAAAATGGAAAG TTCAAGTACAGTGACTATTTCAAGCCATTTTCCACAGGAAAACGAGTGTGTGCTGGAGAAGGCCTGGCTC GCATGGAGTTGTTTCTTTTGTTGTGTGCCATTTTGCAGCATTTTAATTTGAAGCCTCTCGTTGACCCAAA GGATATCGACCTCAGCCCTATACATATTGGGTTTGGCTGTATCCCACCACGTTACAAACTCTGTGTCATT CCCCGCTCATGA    Download   Select all
CCDS ID	CCDS7686.1

Protein Information

      

Protein ID	NP_000764.1
Protein Name	Cytochrome P450, family 2, subfamily E, polypeptide 1
Molecular Wt. (Da)	53767
Protein Sequence	>1571 MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRF GPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRF SLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYN DEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQS LDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPE IEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIP KGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELF LLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRS    Download   Select all
Length	493
Uniprot ID	P61587
Ensembl Protein ID	ENSP00000263895

Post-translational Modification Information (Source : HPRD)

No matching records could be found.

Enzyme Information

   

EC	1.14.13.29
Name	4-nitrophenol 2-monooxygenase 4-nitrophenol hydroxylase 4-nitrophenol-2-hydroxylase
Class	Oxidoreductases; Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2; With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname	4-nitrophenol,NADH:oxygen oxidoreductase (2-hydroxylating)
Substrate	4-nitrophenol [CPD:C00870]; NADH [CPD:C00004]; H+ [CPD:C00080]; O2
Product	4-nitrocatechol [CPD:C02235]; NAD+ [CPD:C00003]; H2O
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING)      View   

               

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
5447	POR	485	NP_000932.3	in vitro	9398194

Pathway Information

                                                

Pathway Name	Pathway ID
Arachidonic acid metabolism	hsa00590
Chemical carcinogenesis	hsa05204
Drug metabolism - cytochrome P450	hsa00982
Linoleic acid metabolism	hsa00591
Metabolic pathways	hsa01100
Metabolism of xenobiotics by cytochrome P450	hsa00980
Non-alcoholic fatty liver disease (NAFLD)	hsa04932
Steroid hormone biosynthesis	hsa00140

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
pfam00067	33-489	p450
cl12078	33-489	p450 superfamily
PTZ00404	34-492	PTZ00404
PLN03112	7-486	PLN03112
PLN02966	6-471	PLN02966
PLN03234	1-471	PLN03234
PLN00110	9-472	PLN00110
COG2124	33-458	CypX
PLN02394	7-472	PLN02394
PLN02687	7-457	PLN02687
PLN02183	10-492	PLN02183
PLN00168	4-447	PLN00168
PLN02655	34-484	PLN02655
PLN02290	6-460	PLN02290
PLN02971	265-461	PLN02971
PLN02196	1-451	PLN02196
PLN02302	154-463	PLN02302
PLN02987	4-462	PLN02987
PLN02936	296-472	PLN02936
PLN03018	214-461	PLN03018
PLN02500	228-466	PLN02500
PLN02426	293-466	PLN02426
PLN02774	264-449	PLN02774
PLN02169	296-461	PLN02169
PLN03141	228-451	PLN03141
PLN03195	292-458	PLN03195
TIGR04538	285-455	P450_cycloAA_1
PLN02648	319-420	PLN02648
PLN02738	296-472	PLN02738

Ontology Information

   

HPRD ID	4233
Molecular Class	Enzyme: Hydroxylase
Molecular Function	GTPase activity (GO:0003924)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report   

Drug Information

Uniprot ID	DrugBank ID	Name	Type
P05181	DB00041	Aldesleukin	BiotechDrug
P05181	DB00109	Enfuvirtide	BiotechDrug
P05181	DB00118	S-Adenosylmethionine	SmallMoleculeDrug
P05181	DB00158	Folic Acid	SmallMoleculeDrug
P05181	DB00170	Menadione	SmallMoleculeDrug
P05181	DB00176	Fluvoxamine	SmallMoleculeDrug
P05181	DB00184	Nicotine	SmallMoleculeDrug
P05181	DB00201	Caffeine	SmallMoleculeDrug
P05181	DB00203	Sildenafil	SmallMoleculeDrug
P05181	DB00208	Ticlopidine	SmallMoleculeDrug
P05181	DB00215	Citalopram	SmallMoleculeDrug
P05181	DB00228	Enflurane	SmallMoleculeDrug
P05181	DB00250	Dapsone	SmallMoleculeDrug
P05181	DB00255	Diethylstilbestrol	SmallMoleculeDrug
P05181	DB00257	Clotrimazole	SmallMoleculeDrug
P05181	DB00259	Sulfanilamide	SmallMoleculeDrug
P05181	DB00277	Theophylline	SmallMoleculeDrug
P05181	DB00316	Acetaminophen	SmallMoleculeDrug
P05181	DB00321	Amitriptyline	SmallMoleculeDrug
P05181	DB00347	Trimethadione	SmallMoleculeDrug
P05181	DB00356	Chlorzoxazone	SmallMoleculeDrug
P05181	DB00359	Sulfadiazine	SmallMoleculeDrug
P05181	DB00363	Clozapine	SmallMoleculeDrug
P05181	DB00371	Meprobamate	SmallMoleculeDrug
P05181	DB00379	Mexiletine	SmallMoleculeDrug
P05181	DB00428	Streptozocin	SmallMoleculeDrug
P05181	DB00458	Imipramine	SmallMoleculeDrug
P05181	DB00468	Quinine	SmallMoleculeDrug
P05181	DB00477	Chlorpromazine	SmallMoleculeDrug
P05181	DB00501	Cimetidine	SmallMoleculeDrug
P05181	DB00503	Ritonavir	SmallMoleculeDrug
P05181	DB00514	Dextromethorphan	SmallMoleculeDrug
P05181	DB00526	Oxaliplatin	SmallMoleculeDrug
P05181	DB00540	Nortriptyline	SmallMoleculeDrug
P05181	DB00549	Zafirlukast	SmallMoleculeDrug
P05181	DB00586	Diclofenac	SmallMoleculeDrug
P05181	DB00593	Ethosuximide	SmallMoleculeDrug
P05181	DB00599	Thiopental	SmallMoleculeDrug
P05181	DB00617	Paramethadione	SmallMoleculeDrug
P05181	DB00622	Nicardipine	SmallMoleculeDrug
P05181	DB00623	Fluphenazine	SmallMoleculeDrug
P05181	DB00633	Dexmedetomidine	SmallMoleculeDrug
P05181	DB00636	Clofibrate	SmallMoleculeDrug
P05181	DB00655	Estrone	SmallMoleculeDrug
P05181	DB00675	Tamoxifen	SmallMoleculeDrug
P05181	DB00679	Thioridazine	SmallMoleculeDrug
P05181	DB00683	Midazolam	SmallMoleculeDrug
P05181	DB00690	Flurazepam	SmallMoleculeDrug
P05181	DB00703	Methazolamide	SmallMoleculeDrug
P05181	DB00748	Carbinoxamine	SmallMoleculeDrug
P05181	DB00752	Tranylcypromine	SmallMoleculeDrug
P05181	DB00753	Isoflurane	SmallMoleculeDrug
P05181	DB00763	Methimazole	SmallMoleculeDrug
P05181	DB00773	Etoposide	SmallMoleculeDrug
P05181	DB00780	Phenelzine	SmallMoleculeDrug
P05181	DB00818	Propofol	SmallMoleculeDrug
P05181	DB00822	Disulfiram	SmallMoleculeDrug
P05181	DB00829	Diazepam	SmallMoleculeDrug
P05181	DB00835	Brompheniramine	SmallMoleculeDrug
P05181	DB00851	Dacarbazine	SmallMoleculeDrug
P05181	DB00882	Clomifene	SmallMoleculeDrug
P05181	DB00883	Isosorbide Dinitrate	SmallMoleculeDrug
P05181	DB00898	Ethanol	SmallMoleculeDrug
P05181	DB00904	Ondansetron	SmallMoleculeDrug
P05181	DB00908	Quinidine	SmallMoleculeDrug
P05181	DB00918	Almotriptan	SmallMoleculeDrug
P05181	DB00949	Felbamate	SmallMoleculeDrug
P05181	DB00951	Isoniazid	SmallMoleculeDrug
P05181	DB00969	Alosetron	SmallMoleculeDrug
P05181	DB00972	Azelastine	SmallMoleculeDrug
P05181	DB01007	Tioconazole	SmallMoleculeDrug
P05181	DB01011	Metyrapone	SmallMoleculeDrug
P05181	DB01028	Methoxyflurane	SmallMoleculeDrug
P05181	DB01037	Selegiline	SmallMoleculeDrug
P05181	DB01041	Thalidomide	SmallMoleculeDrug
P05181	DB01045	Rifampicin	SmallMoleculeDrug
P05181	DB01068	Clonazepam	SmallMoleculeDrug
P05181	DB01085	Pilocarpine	SmallMoleculeDrug
P05181	DB01100	Pimozide	SmallMoleculeDrug
P05181	DB01110	Miconazole	SmallMoleculeDrug
P05181	DB01115	Nifedipine	SmallMoleculeDrug
P05181	DB01127	Econazole	SmallMoleculeDrug
P05181	DB01131	Proguanil	SmallMoleculeDrug
P05181	DB01136	Carvedilol	SmallMoleculeDrug
P05181	DB01151	Desipramine	SmallMoleculeDrug
P05181	DB01156	Bupropion	SmallMoleculeDrug
P05181	DB01159	Halothane	SmallMoleculeDrug
P05181	DB01167	Itraconazole	SmallMoleculeDrug
P05181	DB01173	Orphenadrine	SmallMoleculeDrug
P05181	DB01174	Phenobarbital	SmallMoleculeDrug
P05181	DB01191	Dexfenfluramine	SmallMoleculeDrug
P05181	DB01198	Zopiclone	SmallMoleculeDrug
P05181	DB01204	Mitoxantrone	SmallMoleculeDrug
P05181	DB01213	Fomepizole	SmallMoleculeDrug
P05181	DB01223	Aminophylline	SmallMoleculeDrug
P05181	DB01234	Dexamethasone	SmallMoleculeDrug
P05181	DB01236	Sevoflurane	SmallMoleculeDrug
P05181	DB01296	Glucosamine	SmallMoleculeDrug
P05181	DB01355	Hexobarbital	SmallMoleculeDrug
P05181	DB01394	Colchicine	SmallMoleculeDrug
P05181	DB01403	Methotrimeprazine	SmallMoleculeDrug
P05181	DB01412	Theobromine	SmallMoleculeDrug
P05181	DB01435	Antipyrine	SmallMoleculeDrug
P05181	DB01544	Flunitrazepam	SmallMoleculeDrug
P05181	DB01558	Bromazepam	SmallMoleculeDrug
P05181	DB01586	Ursodeoxycholic acid	SmallMoleculeDrug
P05181	DB01595	Nitrazepam	SmallMoleculeDrug
P05181	DB01628	Etoricoxib	SmallMoleculeDrug
P05181	DB02701	Nicotinamide	SmallMoleculeDrug
P05181	DB04794	Bifonazole	SmallMoleculeDrug
P05181	DB04920	Clevidipine	SmallMoleculeDrug
P05181	DB04946	Iloperidone	SmallMoleculeDrug
P05181	DB05109	Trabectedin	SmallMoleculeDrug
P05181	DB06201	Rufinamide	SmallMoleculeDrug
P05181	DB06637	Dalfampridine	SmallMoleculeDrug
P05181	DB06689	Ethanolamine Oleate	SmallMoleculeDrug
P05181	DB06712	Nilvadipine	SmallMoleculeDrug
P05181	DB06770	Benzyl alcohol	SmallMoleculeDrug
P05181	DB06774	Capsaicin	SmallMoleculeDrug
P05181	DB08868	Fingolimod	SmallMoleculeDrug

External Links

                                 

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO