Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| DACH1 | 1602 | dachshund family transcription factor 1 | 13 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25778865 | 2015 | Cell line : SW480 Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR and western blotting | Loss of function/Mutation | - | results suggest that DACH1 loss of function results in increased cell growth, motility and invasiveness through TGF-?-mediated EMT, and DACH1 loss of function has important therapeutic implications for targeted therapies of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] |
| Chromosome | 13 |
| Location | 13q22 |
| Start | 72012098 |
| End | 72441330 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 429233 |
| OMIM ID | 603803 |
| HGNC ID | HGNC:2663 |
| Unigene ID | Hs.129452 |
| Ensembl ID | ENSG00000165659 |
| PharmGKB ID | PA27134 |
mRNA Information
| mRNA ID | XM_011534939.1 |
|---|---|
| Exon | join(1698..3192,187204..187319,238397..238558, 295541..295696,296102..296274,309159..309294, 311956..312090,379966..380117,389798..389945, 393265..393408,393905..393973,428422..431148) | mRNA Sequence | Download Select all |
| Length | 5613 |
Protein Information
| Protein ID | XP_011533241.1 |
|---|---|
| Protein Name | dachshund family transcription factor 1 |
| Molecular Wt. (Da) | 78431 |
| Protein Sequence | Download Select all |
| Length | 758 |
| Uniprot ID | Q13526 |
| Ensembl Protein ID | ENSP00000247970 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 531 |
| T | Phosphorylation | 534 |
| T | Phosphorylation | 528 |
| S | Phosphorylation | 441 |
| S | Phosphorylation | 443 |
| S | Phosphorylation | 447 |
| S | Phosphorylation | 675 |
| T | Phosphorylation | 677 |
| S | Phosphorylation | 527 |
| T | Phosphorylation | 529 |
| S | Phosphorylation | 473 |
| T | Phosphorylation | 475 |
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2138 | EYA1 | 3388 | NP_000494.2 | in vitro;yeast 2-hybrid | 11950062 |
| 2140 | EYA3 | 9042 | NP_001981.2 | in vitro | 14628042 |
| 4088 | SMAD3 | 4380 | NP_005893.1 | in vivo | 14525983 |
| 4089 | SMAD4 | 2995 | NP_005350.1 | in vitro;in vivo | 14525983 |
| 6495 | SIX1 | 3125 | NP_005973.1 | in vitro | 14628042 |
| 7329 | UBE2I | 9045 | NP_003336.1 | in vitro;yeast 2-hybrid | 11025202 |
| 9611 | NCOR1 | 2911 | NP_006302.2 | in vivo | 14525983 |
| 25942 | SIN3A | 9690 | NP_056292.1 | in vivo | 14525983 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02437 | 185-284 | Ski_Sno |
| cl03592 | 185-284 | Ski_Sno superfamily |
| CHL00019 | 617-732 | atpF |
| cl21478 | 617-732 | Mt_ATP-synt_B superfamily |
Ontology Information
| HPRD ID | 3688 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.