Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GADD45A | 1647 | growth arrest and DNA-damage-inducible, alpha | 1 | GADD45 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24062075 | 2013 | Cell line : - Source : First Surgery Department University Hospital Comenius University Bratislava. Sample Type : CRC tumor and adjacent normal tissues No. of Sample : 25 Stage : - | real time RT- PCR | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010] |
| Chromosome | 1 |
| Location | 1p31.2 |
| Start | 68150860 |
| End | 68154021 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 3162 |
| OMIM ID | 126335 |
| HGNC ID | HGNC:4095 |
| Unigene ID | Hs.80409 |
| Ensembl ID | ENSG00000116717 |
| PharmGKB ID | PA28510 |
mRNA Information
| mRNA ID | NM_001924.3 |
|---|---|
| Exon | join(1..362,849..950,1174..1411,2485..3162) | mRNA Sequence | Download Select all |
| Length | 1398 |
Protein Information
| Protein ID | NP_001915.1 |
|---|---|
| Protein Name | growth arrest and DNA-damage-inducible, alpha |
| Molecular Wt. (Da) | 18205 |
| Protein Sequence | Download Select all |
| Length | 165 |
| Uniprot ID | P08F94 |
| Ensembl Protein ID | ENSP00000341097 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 983 | CDK1 | 302 | NP_001777.1 | in vivo | 1 097 396 310 362 260 |
| 1026 | CDKN1A | 298 | NP_510867.1 | in vitro;in vivo;yeast 2-hybrid | 7478594 |
| 1432 | MAPK14 | 2619 | NP_001306.1 | in vitro;in vivo | 12748288 |
| 2512 | FTL | 616 | NP_000137.2 | yeast 2-hybrid | 16169070 |
| 4216 | MAP3K4 | 3886 | NP_005913.2 | in vitro;in vivo;yeast 2-hybrid | 9827804 |
| 10540 | DCTN2 | 9568 | NP_006391.1 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle | hsa04110 |
| FoxO signaling pathway | hsa04068 |
| MAPK signaling pathway | hsa04010 |
| p53 signaling pathway | hsa04115 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01248 | 21-123 | Ribosomal_L7Ae |
| cl00600 | 21-123 | Ribosomal_L7Ae superfamily |
Ontology Information
| HPRD ID | 4177 |
|---|---|
| Molecular Class | DNA repair protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell adhesion (GO:0007155) |
Drug Information
No matching records could be found.