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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| DHX9 | 1660 | DEAH (Asp-Glu-Ala-His) box polypeptide 9 | 1 | LKP; RHA; DDX9; NDH2; NDHII |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and Normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis. | Down-regulation | - | This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. CRC tissue was collected at the VU University Medical Center, Amsterdam, The Netherlands. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | DEAH-boxes |
| Description | This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.[provided by RefSeq, Feb 2010] |
| Chromosome | 1 |
| Location | 1q25 |
| Start | 182839304 |
| End | 182887982 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 48679 |
| OMIM ID | 603115 |
| HGNC ID | HGNC:2750 |
| Unigene ID | Hs.191518 |
| Ensembl ID | ENSG00000135829 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001357.4 |
|---|---|
| Exon | join(1..153,3242..3374,3991..4131,12930..13041, 14003..14115,14727..14875,17229..17275,18801..18937, 19248..19337,19430..19591,19737..19814,20690..20881, 27141..27282,27658..27740,33034..33190,35551..35651, 36747..36960,37144..37238,37527..37600,38718..38870, 39947..40107,41194..41305,41961..42122,42217..42344, 43836..44065,44217..44332,45310..45510,47780..48679) | mRNA Sequence | Download Select all |
| Length | 4543 |
CDS Information
| Location | join(3264..3374,3991..4131,12930..13041,14003..14115, 14727..14875,17229..17275,18801..18937,19248..19337, 19430..19591,19737..19814,20690..20881,27141..27282, 27658..27740,33034..33190,35551..35651,36747..36960, 37144..37238,37527..37600,38718..38870,39947..40107, 41194..41305,41961..42122,42217..42344,43836..44065, 44217..44332,45310..45510,47780..48131) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS41444.1 |
Protein Information
| Protein ID | NP_001348.2 |
|---|---|
| Protein Name | DEAH (Asp-Glu-Ala-His) box polypeptide 9 |
| Molecular Wt. (Da) | 140828 |
| Protein Sequence | Download Select all |
| Length | 1270 |
| Uniprot ID | P16615 |
| Ensembl Protein ID | ENSP00000311186 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 87 |
| S | Phosphorylation | 321;- |
| Y | Phosphorylation | 1241;- |
| Y | Phosphorylation | 1234;- |
| Y | Phosphorylation | 206;- |
| Y | Phosphorylation | 199;- |
| T | Phosphorylation | 92 |
| T | Phosphorylation | 108 |
| K | Acetylation | 199 |
| K | Acetylation | 191 |
| K | Acetylation | 1024 |
| Y | Phosphorylation | 148 |
| S | Phosphorylation | 163 |
| T | Phosphorylation | 177 |
| S | Phosphorylation | 449 |
| S | Phosphorylation | 452 |
| S | Phosphorylation | 1142 |
| S | Phosphorylation | 1152 |
| S | Phosphorylation | 107 |
| S | Phosphorylation | 117 |
| T | Phosphorylation | 1153 |
| T | Phosphorylation | 118 |
| S | Phosphorylation | 1139 |
| Y | Phosphorylation | 1155 |
| S | Phosphorylation | 104 |
| Y | Phosphorylation | 120 |
| S | Phosphorylation | 20 |
| Y | Phosphorylation | 251 |
| T | Phosphorylation | 790 |
Enzyme Information
| EC | 3.6.4.13 |
|---|---|
| Name | RNA helicase CSFV NS3 helicase DBP2 DbpA DDX17 DDX25 DDX3 DDX3X DDX3Y DDX4 DDX5 DEAD-box protein DED1 DEAD-box RNA helicase DEAH-box protein 2 DEAH-box RNA helicase DED1 Dex(H/D) RNA helicase EhDEAD1 EhDEAD1 RNA helicase eIF4A helicase KOKV helicase Mtr4p nonstructural protein 3 helicase NPH-II RHA RNA helicase A RNA helicase DDX3 RNA helicase Hera RNA-dependent ATPase TGBp1 NTPase/helicase domain VRH1 GRTH/DDX25 |
| Class | Hydrolases; Acting on acid anhydrides; Acting on acid anhydrides to facilitate cellular and subcellular movement |
| Sysname | ATP phosphohydrolase (RNA helix unwinding) |
| Substrate | ATP [CPD:C00002]; H2O |
| Product | ADP [CPD:C00008]; phosphate |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 672 | BRCA1 | 218 | NP_009231.2 | in vitro;in vivo;yeast 2-hybrid | 125 923 859 662 397 |
| 2959 | GTF2B | 8928 | NP_001505.1 | in vitro;in vivo | 11149922 |
| 3183 | HNRNPC | 1243 | P07910 | in vivo | 15034300 |
| 3276 | PRMT1 | 4257 | NP_001527.3 | in vitro | 1 185 040 215 084 600 |
| 3725 | JUN | 1302 | NP_002219.1 | in vitro | 11823437 |
| 5111 | PCNA | 1456 | NP_002583.1 | in vitro | 12171929 |
| 6606 | SMN1 | 2646 | NP_000335.1 | in vitro | 11149922 |
| 6607 | SMN2 | 9036 | NP_059107.1 | in vitro;in vivo | 11149922 |
| 6628 | SNRPB | 1655 | NP_937859.1 | in vivo | 11149922 |
| 6732 | SRPK1 | 15992 | NP_003128.3 | in vivo | 15034300 |
| 6749 | SSRP1 | 5061 | NP_003137.1 | in vivo | 15034300 |
| 6780 | STAU1 | 3422 | NP_059347.2 | in vitro | 15121898 |
| 6908 | TBP | 2511 | NP_003185.1 | in vivo | 11149922 |
| 7153 | TOP2A | 536 | NP_001058.2 | in vivo | 1 271 166 915 034 300 |
| 8487 | SIP1 | 3999 | NP_003607.1 | in vivo | 11149922 |
| 10482 | NXF1 | 4035 | NP_006353.2 | in vitro;in vivo | 10924507 |
| 10594 | PRPF8 | 6295 | NP_006436.3 | in vivo | 15034300 |
| 10657 | KHDRBS1 | 3926 | NP_006550.1 | in vitro;in vivo | 10951562 |
| 10724 | MGEA5 | 4949 | NP_036347.1 | yeast 2-hybrid | 16169070 |
| 50628 | GEMIN4 | 7370 | NP_056536.2 | in vitro;in vivo | 11149922 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00046 | 405-546 | DEXDc |
| cl21455 | 405-546 | P-loop_NTPase superfamily |
| cd00079 | 631-776 | HELICc |
| cl21455 | 631-776 | P-loop_NTPase superfamily |
| cd00048 | Mar-69 | DSRM |
| cl00054 | Mar-69 | DSRM superfamily |
| cd00048 | 180-250 | DSRM |
| cl00054 | 180-250 | DSRM superfamily |
| pfam04408 | 831-919 | HA2 |
| cl04503 | 831-919 | HA2 superfamily |
| smart00847 | 838-919 | HA2 |
| pfam07717 | 959-1073 | OB_NTP_bind |
| cl06657 | 959-1073 | OB_NTP_bind superfamily |
| smart00358 | May-69 | DSRM |
| smart00358 | 181-251 | DSRM |
| smart00490 | 671-767 | HELICc |
| pfam00271 | 681-768 | Helicase_C |
| pfam00035 | 181-250 | dsrm |
| pfam00035 | May-69 | dsrm |
| pfam00270 | 395-546 | DEAD |
| COG1643 | 381-1095 | HrpA |
| TIGR01967 | 388-1026 | DEAH_box_HrpA |
| TIGR01970 | 388-871 | DEAH_box_HrpB |
| PRK11664 | 387-869 | PRK11664 |
| PRK11131 | 355-892 | PRK11131 |
| smart00487 | 396-569 | DEXDc |
| PHA02653 | 396-771 | PHA02653 |
| COG0571 | 178-253 | Rnc |
| TIGR00376 | 374-458 | TIGR00376 |
| COG1111 | 693-784 | MPH1 |
| PRK00102 | 180-243 | rnc |
Ontology Information
| HPRD ID | 161 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Auxiliary transport protein activity (GO:0015457) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.