Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ADAMTS15 | 170689 | ADAM metallopeptidase with thrombospondin type 1 motif, 15 | 11 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19458070 | 2009 | Cell line : HCT-116, SW 620 Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 50 Stage : - | Cell culture and transfection, real time RT-PCR, DNA methylation analysis,RNA interference,Colony formation assays,Western blotting,Invasion assays,Immunostaining | Mutation | - | ADAMTS15 is genetically inactivated in colon?cancer |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | ADAM metallopeptidases with thrombospondin type 1 motif |
| Description | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the proteins encoded by ADAMTS1 and ADAMTS8. [provided by RefSeq, Jul 2008] |
| Chromosome | 11 |
| Location | 11q25 |
| Start | 130318869 |
| End | 130346539 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 27671 |
| OMIM ID | 607509 |
| HGNC ID | HGNC:16305 |
| Unigene ID | Hs.534221 |
| Ensembl ID | ENSG00000166106 |
| PharmGKB ID | PA24541 |
Protein Information
| Protein ID | NP_620686.1 |
|---|---|
| Protein Name | ADAM metallopeptidase with thrombospondin type 1 motif, 15 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 950 |
| Uniprot ID | Q5VWI1 |
| Ensembl Protein ID | ENSP00000357631 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04273 | 218-424 | ZnMc_ADAMTS_like |
| cl00064 | 218-424 | ZnMc superfamily |
| pfam05986 | 683-801 | ADAM_spacer1 |
| cl20316 | 683-801 | ADAM_spacer1 superfamily |
| cd04267 | 218-416 | ZnMc_ADAM_like |
| cd04269 | 218-425 | ZnMc_adamalysin_II_like |
| pfam01562 | 24-143 | Pep_M12B_propep |
| cl03265 | 24-143 | Pep_M12B_propep superfamily |
| cd00203 | 218-415 | ZnMc |
| cd04272 | 219-423 | ZnMc_salivary_gland_MPs |
| smart00209 | 519-571 | TSP1 |
| cl15278 | 519-571 | TSP_1 superfamily |
| pfam13688 | 217-372 | Reprolysin_5 |
| pfam13582 | 262-372 | Reprolysin_3 |
| smart00209 | 897-950 | TSP1 |
| cl15278 | 897-950 | TSP_1 superfamily |
| pfam00090 | 522-570 | TSP_1 |
| smart00209 | 846-895 | TSP1 |
| cl15278 | 846-895 | TSP_1 superfamily |
| smart00608 | 437-506 | ACR |
| cl15456 | 437-506 | ADAM_CR superfamily |
| pfam00090 | 900-950 | TSP_1 |
| cd04270 | 313-422 | ZnMc_TACE_like |
| pfam01421 | 218-427 | Reprolysin |
Ontology Information
| HPRD ID | 18170 |
|---|---|
| Molecular Class | Metallo protease |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.