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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
DMBT1 1755 deleted in malignant brain tumors 1  10GP340, muclin 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
9888459   1999Cell line : -

Source : -

Sample Type : CRC tumor

No. of Sample : ?24

Stage : -

RT-PCRDown-regulation-4 (16.7%) of 24 colorectal cancer cases showed an apparent reduction in DMBT1 mRNA in tumour tissues compared with paired normal tissues.


Gene Details



NC_000010.10 (124320181..124403252)

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Gene Type protein coding
Gene Family -
Description Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Nov 2014]  
Chromosome 10
Location 10q25.3-q2
Start 124320181  
End 124403252  
Strand +  
Gene Sequence

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Length 83072  
OMIM ID 601969   
HGNC ID HGNC:2926   
Unigene ID Hs.279611   
Ensembl ID ENSG00000187908   
PharmGKB ID PA27376   

mRNA Information


mRNA ID NM_007329.2
Exon join(1..167,5303..5332,9498..9545,10226..10273, 11650..11697,13051..13098,15735..16058,17147..17176, 18054..18095,18914..19237,20202..20231,21129..21161, 21936..22259,23658..23687,24607..24645,25396..25719, 28280..28603,30001..30030,30815..30853,31608..31931, 32905..32934,33832..33864,34639..34962,36361..36390, 37310..37348,38110..38433,39400..39429,40327..40359, 41133..41456,42436..42465,44386..44418,45192..45515, 46495..46524,48445..48477,49251..49574,50554..50583, 56564..56596,57353..57676,58644..58673,59589..59627, 60393..60716,64613..64639,65269..65301,69176..69329, 69624..69826,70297..70617,71191..71211,72197..72226, 72527..72677,75327..75535,76464..76648,79376..79785, 82458..83072)  
mRNA Sequence

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Length 7686  



CDS Information


   
Location107..7348
CDS Sequence

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CCDS ID CCDS44490.1



Protein Information


      
Protein IDNP_015568.2
Protein Namedeleted in malignant brain tumors 1
Molecular Wt. (Da)0
Protein Sequence

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Length 2413  
Uniprot IDP47712
Ensembl Protein ID ENSP00000356436  



Post-translational Modification Information (Source : HPRD)


Residue Type site
NGlycosylation1832
NGlycosylation1204
NGlycosylation1822
NGlycosylation1889
NGlycosylation1261
NGlycosylation1879
NGlycosylation2120
NGlycosylation1492
NGlycosylation2110

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
6435SFTPA11521NP_005402.3in vitro10101009   
6441SFTPD1522NP_003010.4in vitro9153228   


Pathway Information


      
Pathway Name Pathway ID
Salivary secretion hsa04970


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd000411766-1876  CUB
cl000491766-1876  CUB superfamily
cd000412008-2116  CUB
cl000492008-2116  CUB superfamily
smart002412127-2379  ZP
cl025232127-2379  Zona_pellucida superfamily
smart00202993-1093  SR
cl02509993-1093  SRCR superfamily
smart00202733-833  SR
cl02509733-833  SRCR superfamily
smart002021251-1351  SR
cl025091251-1351  SRCR superfamily
smart002021380-1480  SR
cl025091380-1480  SRCR superfamily
smart00202494-594  SR
cl02509494-594  SRCR superfamily
smart00202363-463  SR
cl02509363-463  SRCR superfamily
smart00202862-962  SR
cl02509862-962  SRCR superfamily
smart002021122-1222  SR
cl025091122-1222  SRCR superfamily
smart00202102-202  SR
cl02509102-202  SRCR superfamily
smart00202602-702  SR
cl02509602-702  SRCR superfamily
smart002021509-1609  SR
cl025091509-1609  SRCR superfamily
smart002021640-1740  SR
cl025091640-1740  SRCR superfamily
smart00202234-334  SR
cl02509234-334  SRCR superfamily
smart002021883-1986  SR
cl025091883-1986  SRCR superfamily
pfam001002127-2379  Zona_pellucida
pfam00530736-833  SRCR
pfam00530996-1093  SRCR
pfam00530497-594  SRCR
pfam005301643-1740  SRCR
pfam005301125-1222  SRCR
pfam005301254-1351  SRCR
pfam005301383-1480  SRCR
pfam00530366-463  SRCR
pfam00530865-962  SRCR
pfam005301512-1609  SRCR
pfam00530605-702  SRCR
pfam00530237-334  SRCR
pfam00530105-202  SRCR
pfam005301895-1986  SRCR
smart000421775-1874  CUB
pfam004312008-2114  CUB
pfam004311766-1874  CUB
smart000422017-2114  CUB


Ontology Information


   
HPRD ID1421
Molecular ClassUnclassified
Molecular FunctionReceptor activity (GO:0004872)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO