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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and Normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis. | Up-regulation | - | This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. CRC tissue was collected at the VU University Medical Center, Amsterdam, The Netherlands. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] |
| Chromosome | 16 |
| Location | 16p13.3 |
| Start | 3611745 |
| End | 3662875 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 51131 |
| OMIM ID | 125505 |
| HGNC ID | HGNC:2956 |
| Unigene ID | Hs.629638 |
| Ensembl ID | ENSG00000213918 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011522398.1 |
|---|---|
| Exon | join(1..262,28971..29493,31148..31292,43217..43300, 43629..43776,44358..44441,44894..45009,45443..45597, 45976..46072,46162..46351) | mRNA Sequence | Download Select all |
| Length | 3108 |
CDS Information
| Location | join(43010..43051,43217..43300,43629..43776,44358..44441, 44894..45009,45443..45597,45976..46072,46162..46209) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_005214.2 |
|---|---|
| Protein Name | Deoxyribonuclease I |
| Molecular Wt. (Da) | 29254 |
| Protein Sequence | Download Select all |
| Length | 282 |
| Uniprot ID | Q04656 |
| Ensembl Protein ID | ENSP00000345728 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
| EC | 3.1.21.1 |
|---|---|
| Name | deoxyribonuclease I pancreatic DNase DNase thymonuclease, dornase dornava dornavac pancreatic deoxyribonuclease pancreatic dornase deoxyribonuclease (pancreatic) pancreatic DNase DNAase deoxyribonucleic phosphatase DNase I alkaline deoxyribonuclease alkaline DNase endodeoxyribonuclease I DNA depolymerase Escherichia coli endonuclease I deoxyribonuclease A DNA endonuclease DNA nuclease |
| Class | Hydrolases; Acting on ester bonds; Endodeoxyribonucleases producing 5'-phosphomonoesters |
| Sysname | |
| Substrate | |
| Product | |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 58 | ACTA1 | 30 | NP_001091.1 | in vitro;in vivo | 117 072 832 395 459 |
| 59 | ACTA2 | 31 | NP_001604.1 | in vitro | 11707283 |
| 71 | ACTG1 | 17 | NP_001605.1 | in vitro | 11474115 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd10282 | 24-281 | DNase1 |
| cl00490 | 24-281 | EEP superfamily |
| smart00476 | 21-282 | DNaseIc |
| cd09075 | 24-281 | DNase1-like |
| cd08372 | 25-281 | EEP |
| cd10283 | 23-281 | MnuA_DNase1-like |
| pfam03372 | 26-274 | Exo_endo_phos |
Ontology Information
| HPRD ID | 2054 |
|---|---|
| Molecular Class | Deoxyribonuclease |
| Molecular Function | ATPase activity (GO:0016887) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.