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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
DNMT1 1786 DNA (cytosine-5-)-methyltransferase 1  19MCMT, CXXC9 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25107489   2014Cell line : -

Source : Golestan Research Center of Gastroenterology and Hepatology-GRCGH, Golestan University of Medical Sciences, Gorgan, Iran.

Sample Type : Formalin-fixed paraffin-embedded CRC and healthy tissues

No. of Sample : 125

Stage : TNM Stage I-IV.

 Methylation specific PCR,real time RT-PCRUp-regulation-The rate of gene promoter methylation of WNT pathway regulators is high in colorectal cancer cells. Hyper-methylation is associated with increased expression of the DNMT1 enzyme.


Gene Details



NC_000019.9 (10244021..10305783, complement)

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Gene Type protein coding
Gene Family -
Description This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]  
Chromosome 19
Location 19p13.2
Start 10244021  
End 10305783  
Strand -  
Gene Sequence

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Length 61763  
OMIM ID 126375   
HGNC ID HGNC:2976   
Unigene ID Hs.202672   
Ensembl ID -   
PharmGKB ID PA27443   

mRNA Information


mRNA ID XM_011527772.1
Exon join(58..260,13003..13039,14195..14302,14511..14730, 14846..14893,17713..17788,19462..19540,21175..21209, 21906..21990,26716..26750,28395..28482,31720..31754, 32332..32413,34662..34696,35017..35062,35158..35238, 35313..35422,38571..38689,39135..39227,40024..40175, 40307..40494,40601..40787,43233..43330,43535..43682, 45112..45227,45423..45627,46063..46196,48556..48729, 51093..51314,52860..53052,53891..53975,54171..54299, 54752..55034,55263..55404,56475..56641,57071..57248, 57800..58004,58793..58959,59228..59344,60773..60863, 61379..61735)  
mRNA Sequence

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Length 5353  



CDS Information


   
Location124..5031
CDS Sequence

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CCDS ID CCDS12228.1



Protein Information


      
Protein IDXP_011526074.1
Protein NameDNA (cytosine-5-)-methyltransferase 1
Molecular Wt. (Da)184906
Protein Sequence

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Length 1635  
Uniprot IDP00749
Ensembl Protein ID ENSP00000361850  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation714
SPhosphorylation954
SPhosphorylation714;-
YPhosphorylation969;-
SPhosphorylation127
TPhosphorylation137
SPhosphorylation141
SPhosphorylation152
SPhosphorylation154
SPhosphorylation143
SPhosphorylation394
KAcetylation1111
KAcetylation1113
KAcetylation1115
KAcetylation173
SPhosphorylation133
SPhosphorylation1105
TPhosphorylation208
SPhosphorylation209
SPhosphorylation312
SPhosphorylation398
SPhosphorylation346

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2146EZH23342NP_004447.2in vitro16357870   
5987TRIM2715996NP_006501.1yeast 2-hybrid16169070   
8726EED9343NP_003788.2in vitro16357870   


Pathway Information


                  
Pathway Name Pathway ID
Cysteine and methionine metabolism hsa00270
Metabolic pathways hsa01100
MicroRNAs in cancer hsa05206


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd04711965-1101  BAH_Dnmt1_II
cl02608965-1101  BAH superfamily
cd04760754-877  BAH_Dnmt1_I
cl02608754-877  BAH superfamily
pfam12047399-534  DNMT1-RFD
cl13480399-534  DNMT1-RFD superfamily
COG02701138-1592  Dcm
cl215011138-1592  Dcm superfamily
pfam001451139-1593  DNA_methylase
cl171731139-1593  AdoMet_MTases superfamily
smart00439978-1100  BAH
cd003151139-1593  Cyt_C5_DNA_methylase
TIGR006751143-1592  dcm
pfam01426755-880  BAH
pfam01426978-1100  BAH
smart00439756-880  BAH
pfam0646416-105  DMAP_binding
cl0579116-105  DMAP_binding superfamily
cd04370754-878  BAH
cd04708927-1151  BAH_plantDCM_II
cd04370969-1096  BAH
pfam02008645-691  zf-CXXC
cl03401645-691  zf-CXXC superfamily
cd04712752-881  BAH_DCM_I
cd04710970-1098  BAH_fungalPHD
cd04714755-797  BAH_BAHCC1
cd04717757-797  BAH_polybromo
cd04716756-878  BAH_plantDCM_I
cd04721751-828  BAH_plant_1
pfam10243108-310  MIP-T3
pfam05764134-225  YL1
pfam0975520-221  DUF2046


Ontology Information


   
HPRD ID3855
Molecular ClassDNA methyltransferase
Molecular FunctionPhosphoric diester hydrolase activity (GO:0008081)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P26358DB00928AzacitidineSmallMoleculeDrug
P26358DB01035ProcainamideSmallMoleculeDrug
P26358DB01099FlucytosineSmallMoleculeDrug
P26358DB01262DecitabineSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO