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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
DNMT3B 1789 DNA (cytosine-5-)-methyltransferase 3 beta  20- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25769449   2015Cell line : -

Source : -

Sample Type : CRC tumor and adjacent normal tissues

No. of Sample : 108 CRC and 185 healthy controls

Stage : -

 PCR-RFLP,methylation specific PCRPolymorhpism-DNMT3b polymorphism is involved in the development of colon cancer.


Gene Details



NC_000020.10 (31350191..31397162)

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Gene Type protein coding
Gene Family -
Description CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011]  
Chromosome 20
Location 20q11.2
Start 31350191  
End 31397162  
Strand +  
Gene Sequence

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Length 46972  
OMIM ID 602900   
HGNC ID HGNC:2979   
Unigene ID Hs.643024   
Ensembl ID ENSG00000088305   
PharmGKB ID PA27446   

mRNA Information


mRNA ID NM_006892.3
Exon join(1..315,17934..18081,18969..19030,22374..22475, 24118..24243,24846..25067,26470..26628,29217..29324, 30242..30386,31152..31211,33025..33150,33266..33310, 34406..34485,34803..34915,36076..36259,36860..36944, 37769..37914,38451..38541,38894..39042,40001..40086, 42954..43023,43825..43943,45378..46972)  
mRNA Sequence

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Length 4353  



CDS Information


   
Location322..2883
CDS Sequence

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CCDS ID CCDS13204.1



Protein Information


      
Protein IDNP_008823.1
Protein NameDNA (cytosine-5-)-methyltransferase 3 beta
Molecular Wt. (Da)95620
Protein Sequence

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Length 853  
Uniprot IDQ03405
Ensembl Protein ID ENSP00000221264  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation387
SPhosphorylation367
SPhosphorylation367
SPhosphorylation379
SPhosphorylation136
SPhosphorylation136
SPhosphorylation136
SPhosphorylation148
SPhosphorylation209
SPhosphorylation209
SPhosphorylation209
SPhosphorylation221
SPhosphorylation82
SPhosphorylation82
SPhosphorylation82
SPhosphorylation94
TPhosphorylation383
TPhosphorylation363
TPhosphorylation363
TPhosphorylation375
SPhosphorylation202
SPhosphorylation202
SPhosphorylation202
SPhosphorylation214
TPhosphorylation353

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                       
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1786DNMT1532NP_001124295.1in vitro;in vivo12145218   
1788DNMT3A4141NP_072046.2in vitro;in vivo12145218   
2146EZH23342NP_004447.2in vitro16357870   
3065HDAC13143NP_004955.2in vitro;in vivo12202768   
3066HDAC25521NP_001518.2in vitro;in vivo15120635   
6839SUV39H12221NP_003164.1in vitro;in vivo15120635   
7341SUMO13554NP_003343.1in vivo;yeast 2-hybrid11735126   
8467SMARCA54538NP_003592.2in vitro;in vivo15120635   
8726EED9343NP_003788.2in vitro16357870   


Pathway Information


                  
Pathway Name Pathway ID
Cysteine and methionine metabolism hsa00270
Metabolic pathways hsa01100
MicroRNAs in cancer hsa05206


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd11728431-550  ADDz_Dnmt3b
cl22851431-550  PHD_SF superfamily
cd05835223-309  Dnmt3b_related
cl02554223-309  PWWP superfamily
cd11725431-536  ADDz_Dnmt3
cd11727430-550  ADDz_Dnmt3l
cd11729430-553  ADDz_Dnmt3a
cd11672432-529  ADDz
cd05162223-308  PWWP
pfam00855223-307  PWWP
smart00293223-281  PWWP
COG0270574-756  Dcm
cl21501574-756  Dcm superfamily
cd11726435-529  ADDz_ATRX
cd00315575-843  Cyt_C5_DNA_methylase
cl17173575-843  AdoMet_MTases superfamily
pfam00145575-699  DNA_methylase
TIGR00675627-840  dcm
cd05836223-265  N_Pac_NP60
cd05837222-266  MSH6_like
cd05834221-252  HDGF_related
cd05840223-280  SPBC215_ISWI_like
cd06080223-278  MUM1_like


Ontology Information


   
HPRD ID3857
Molecular ClassDNA methyltransferase
Molecular FunctionPhospholipase activity (GO:0004620)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO