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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
DOCK2 1794 dedicator of cytokinesis 2  5KIAA0209 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24951259   2015Cell line : -

Source : -

Sample Type : CRC tumor and normal tissues

No. of Sample : -

Stage : -

Illumina based whole-exome sequencing and reads alignment,Detection of somatic mutations and indels,Identification of significantly mutated pathways .Mutation--


Gene Details



NC_000005.9 (169064251..169510386)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection. [provided by RefSeq, Oct 2011]  
Chromosome 5
Location 5q35.1
Start 169064251  
End 169510386  
Strand +  
Gene Sequence

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Length 446136  
OMIM ID 603122   
HGNC ID HGNC:2988   
Unigene ID Hs.586174   
Ensembl ID ENSG00000134516   
PharmGKB ID PA27454   

mRNA Information


mRNA ID NM_004946.2
Exon join(1..123,17157..17240,32042..32082,33296..33351, 33832..33928,37051..37199,44498..44633,46950..47104, 52006..52087,58557..58692,61128..61203,62136..62212, 62768..62893,65057..65181,70923..71021,74689..74761, 74874..74977,76782..76965,77114..77211,78967..79056, 80138..80238,81411..81545,110150..110258,122459..122529, 124273..124379,165812..165960,203511..203606, 345822..345920,348582..348676,358840..358918, 371251..371351,371442..371500,381714..381862, 390617..390702,397153..397309,399269..399309, 403809..403899,404767..404886,408570..408659, 410264..410368,413010..413151,418059..418140, 419438..419522,420334..420420,430264..430440, 431891..431974,438701..438838,440464..440591, 441729..441900,44  
mRNA Sequence

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Length 6117  



CDS Information


   
Location81..5573
CDS Sequence

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CCDS ID CCDS4371.1



Protein Information


      
Protein IDNP_004937.1
Protein Namededicator of cytokinesis 2
Molecular Wt. (Da)211818
Protein Sequence

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Length 1830  
Uniprot IDQ13393
Ensembl Protein ID ENSP00000342793  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation1688
TPhosphorylation1689
SPhosphorylation1706
YPhosphorylation209;-
YPhosphorylation212;-
YPhosphorylation481
KAcetylation738
KAcetylation304
KAcetylation1058
KAcetylation67
YPhosphorylation1220
SPhosphorylation1685
SPhosphorylation1780

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
919CD2471729NP_932170.1in vivo12176041   
1399CRKL3596NP_005198.1in vitro;in vivo12393632   
5879RAC13627NP_061485.1in vitro10559471   
5880RAC23628NP_002863.1in vitro10559471   
7409VAV11284NP_005419.2in vitro12393632   


Pathway Information


            
Pathway Name Pathway ID
Chemokine signaling pathway hsa04062
Fc gamma R-mediated phagocytosis hsa04666


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd117061200-1620  DHR2_DOCK2
cl061231200-1620  DHR2_DOCK superfamily
cd12050Dec-67  SH3_DOCK2_A
cl17036Dec-67  SH3 superfamily
cd116971218-1617  DHR2_DOCK_A
cd117071218-1617  DHR2_DOCK1
cd117081218-1617  DHR2_DOCK5
cd116961218-1613  DHR2_DOCK_B
cd116841218-1613  DHR2_DOCK
cd117051218-1610  DHR2_DOCK4
cd117041218-1610  DHR2_DOCK3
cd08694422-617  C2_Dock-A
cl14603422-617  C2 superfamily
cd08695422-617  C2_Dock-B
pfam14429418-617  DOCK-C2
cd08679423-615  C2_DOCK180_related
pfam069201433-1615  Ded_cyto
cd11872Dec-67  SH3_DOCK_AB
cd12051Dec-67  SH3_DOCK1_5_A
cd116981255-1609  DHR2_DOCK9
cd116991267-1609  DHR2_DOCK10
cd116941303-1610  DHR2_DOCK_D
cd117011342-1553  DHR2_DOCK8
cd12049Dec-67  SH3_DOCK4_B
cd12048Dec-67  SH3_DOCK3_B
cd116951280-1539  DHR2_DOCK_C
cd117001314-1609  DHR2_DOCK11
cd117021280-1568  DHR2_DOCK6
smart00326Sep-64  SH3
cd117031342-1553  DHR2_DOCK7
cd0017414-63  SH3
cd1178115-66  SH3_Sorbs_1
cd1183714-64  SH3_Intersectin_2
cd1184213-66  SH3_Ysc84p_like
cd1183814-64  SH3_Intersectin_3
pfam1460415-65  SH3_9
cd1181813-63  SH3_Eve1_5
cd1192314-66  SH3_Sorbs2_2
cd11815Dec-64  SH3_Eve1_2
cd1192117-66  SH3_Vinexin_1
cd1181714-63  SH3_Eve1_4
pfam0001814-60  SH3_1
pfam07653Dec-64  SH3_2
cd1184714-64  SH3_Brk
cd1192414-66  SH3_Vinexin_2
cd1194814-66  SH3_GRAP_N
cd11919Nov-66  SH3_Sorbs1_1
cd1194714-66  SH3_GRAP2_N


Ontology Information


   
HPRD ID1417
Molecular ClassUnclassified
Molecular FunctionPeptidase activity (GO:0008233)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO