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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20584285 | 2010 | Cell line : - Source : CHUVI hospital (Complejo Hospitalario Universitario de Vigo; Spain) Sample Type : CRC tumor and Normal tissue No. of Sample : 299 Stage : - | ELISA | Up-regulation | - | Measurement of the sCD26 is a non-invasive and reasonably sensitive assay, which could be combined with others such as the faecal occult blood test for the early diagnosis and screening of CRC and advanced adenomas. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules |
| Description | The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. |
| Chromosome | 2 |
| Location | 2q24.2 |
| Start | 161992241 |
| End | 162074542 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 82302 |
| OMIM ID | 102720 |
| HGNC ID | HGNC:3009 |
| Unigene ID | Hs.368912 |
| Ensembl ID | ENSG00000197635 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_005246371.2 |
|---|---|
| Exon | join(421..567,1057..1144,27045..27140,27537..27628, 28931..29011,35359..35411,35522..35594,36121..36241, 39219..39379,40890..41002,49604..49739,51744..51788, 53855..53962,54247..54314,55267..55320,55693..55814, 57388..57435,57677..57775,60078..60147,62556..62750, 65248..65302,65882..65981,68734..68798,79171..79243, 79509..79582,81159..82302) | mRNA Sequence | Download Select all |
| Length | 3913 |
CDS Information
| Location | join(562..567,1057..1144,27045..27140,27537..27628, 28931..29011,35359..35411,35522..35594,36121..36241, 39219..39379,40890..41002,49604..49739,51744..51788, 53855..53962,54247..54314,55267..55320,55693..55814, 57388..57435,57677..57775,60078..60147,62556..62750, 65248..65302,65882..65981,68734..68798,79171..79243, 79509..79582,81159..81260) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001926.2 |
|---|---|
| Protein Name | dipeptidyl-peptidase 4 |
| Molecular Wt. (Da) | 88148 |
| Protein Sequence | Download Select all |
| Length | 766 |
| Uniprot ID | P09210 |
| Ensembl Protein ID | ENSP00000420168 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 150 |
Enzyme Information
| EC | 3.4.14.5 |
|---|---|
| Name | dipeptidyl-peptidase 4 |
| Class | Hydrolases; Acting on peptide bonds (peptidases); Dipeptidyl-peptidases and tripeptidyl-peptidases |
| Sysname | |
| Substrate | |
| Product | |
| Reaction (IUBMB) |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 100 | ADA | 38 | NP_000013.2 | in vitro | 11772392 |
| 920 | CD4 | 1740 | NP_000607.1 | in vitro | 7539755 |
| 3627 | CXCL10 | 930 | NP_001556.2 | in vitro | 11390394 |
| 4283 | CXCL9 | 3416 | NP_002407.1 | in vitro | 11390394 |
| 5788 | PTPRC | 1050 | NP_002829.2 | in vivo | 1680916 |
| 6349 | CCL3L1 | 3234 | NP_066286.1 | in vitro;in vivo | 1 096 186 211 390 390 |
| 6352 | CCL5 | 1751 | NP_002976.2 | in vitro | 951 641 411 390 394 |
| 6356 | CCL11 | 3098 | NP_002977.1 | in vitro | 11390394 |
| 6367 | CCL22 | 4263 | NP_002981.2 | in vitro;in vivo | 993 358 911 390 394 |
| 6373 | CXCL11 | 5329 | NP_005400.1 | in vitro | 11390394 |
| 6387 | CXCL12 | 2904 | NP_001029058.1 | in vitro | 11390394 |
| 7852 | CXCR4 | 1217 | NP_001008540.1 | in vivo | 11278278 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Protein digestion and absorption | hsa04974 |
Structure Information
| PDB ID | 1J2E |
|---|---|
| Resolution | 2.6 |
| Method | X-RAY DIFFRACTION |
| Chains | A, B |
| Molecule | Dipeptidyl peptidase IV |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00326 | 559-763 | Peptidase_S9 |
| cl21494 | 559-763 | Esterase_lipase superfamily |
| pfam00930 | 108-478 | DPPIV_N |
| COG1506 | 398-764 | DAP2 |
| pfam12695 | 563-723 | Abhydrolase_5 |
| COG0412 | 579-750 | DLH |
| pfam12697 | 563-726 | Abhydrolase_6 |
| COG1073 | 528-740 | FrsA |
| COG0400 | 586-742 | YpfH |
| pfam01738 | 597-743 | DLH |
Ontology Information
| HPRD ID | 2700 |
|---|---|
| Molecular Class | Protease |
| Molecular Function | Glutathione transferase activity (GO:0004364) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P27487 | DB06655 | Liraglutide | BiotechDrug |
| P27487 | DB01076 | Atorvastatin | SmallMoleculeDrug |
| P27487 | DB01261 | Sitagliptin | SmallMoleculeDrug |
| P27487 | DB04876 | Vildagliptin | SmallMoleculeDrug |
| P27487 | DB06203 | Alogliptin | SmallMoleculeDrug |
| P27487 | DB06335 | Saxagliptin | SmallMoleculeDrug |
| P27487 | DB08882 | Linagliptin | SmallMoleculeDrug |