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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
DPYD 1806 dihydropyrimidine dehydrogenase  1DPD 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26281864   2015Cell line : -

Source : -

Sample Type : CRC tumor

No. of Sample : 115

Stage : TNM Stage I,II,III,IV

-Polymorhpism-The polymorphism c.496A>G was the�DPYD�gene variant with the highest detection rate (12.9%), occurred predominantly in females (86.7%, p=0.0044) and was exclusively seen in KRAS wild type primary CRC�


Gene Details



NC_000001.10 (97543299..98386615, complement)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]  
Chromosome 1
Location 1p22
Start 97543299  
End 98386615  
Strand -  
Gene Sequence

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Length 843317  
OMIM ID 612779   
HGNC ID HGNC:3012   
Unigene ID Hs.335034   
Ensembl ID ENSG00000188641   
PharmGKB ID PA145   

mRNA Information


mRNA ID XM_005270562.3
Exon join(1..176,37686..37796,92864..92946,180581..180668, 199389..199550,221513..221709,229262..229343, 241878..241965,325894..326001,327673..327842, 347090..347300,371316..371500,470837..471001, 538599..538667,547416..547499,614763..614883, 615682..615801,686066..686208,727812..727991, 822428..822571,838590..838730,841914..843317)  
mRNA Sequence

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Length 4232  



CDS Information


   
Location 138..2999
CDS Sequence

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CCDS ID CCDS30777.1



Protein Information


      
Protein IDXP_005270619.2
Protein Namedihydropyrimidine dehydrogenase
Molecular Wt. (Da)103557
Protein Sequence

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Length 953  
Uniprot IDO14939
Ensembl Protein ID ENSP00000263088  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KAcetylation384

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                              
Pathway Name Pathway ID
beta-Alanine metabolism hsa00410
Drug metabolism - other enzymes hsa00983
Metabolic pathways hsa01100
Pantothenate and CoA biosynthesis hsa00770
Pyrimidine metabolism hsa00240


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd02940532-834  DHPD_FMN
cl21457532-834  TIM_phosphate_binding superfamily
cd02810535-833  DHOD_DHPD_FMN
COG0167532-848  PyrD
cd04740534-846  DHOD_1B_like
PRK07259532-846  PRK07259
pfam1469158-166  Fer4_20
cl1910258-166  HCP_like superfamily
pfam01180534-838  DHO_dh
cd04738521-819  DHOD_2_like
cd04739532-852  DHOD_like
PRK07565532-852  PRK07565
cd04722559-817  TIM_phosphate_binding
cd04741535-838  DHOD_1A_like
PRK02506620-852  PRK02506
cd02801654-810  DUS_like_FMN
pfam13450194-238  NAD_binding_8
cl21454194-238  NADB_Rossmann superfamily
pfam13183951-997  Fer4_8
cl19102951-997  HCP_like superfamily
TIGR02936934-997  fdxN_nitrog
COG1635190-225  THI4
PRK04176190-225  PRK04176
PRK08318532-1007  PRK08318
PRK1174953-513  PRK11749
PRK1283158-511  PRK12831
PLN02495532-853  PLN02495
PRK1277857-510  PRK12778
COG049357-506  GltD
TIGR0131661-507  gltA
PRK1281058-506  gltD
TIGR0331563-500  Se_ygfK
PRK1277572-508  PRK12775
PRK1281482-519  PRK12814
PRK0985382-500  PRK09853
TIGR0131842-500  gltD_gamma_fam
PRK1277186-506  PRK12771
PRK1398472-510  PRK13984
TIGR01037533-846  pyrD_sub1_fam
PRK1280953-500  PRK12809
PRK1276930-500  PRK12769
PRK1277975-500  PRK12779
PRK12770189-510  PRK12770
pfam14697946-1004  Fer4_21
TIGR0131764-507  GOGAT_sm_gam
pfam07992189-484  Pyr_redox_2
PRK05286662-838  PRK05286
TIGR01036515-818  pyrD_sub2
TIGR00737600-833  nifR3_yhdG
TIGR01944945-1005  rnfB
COG1146948-1008  PreA
PRK05113945-1005  PRK05113
PRK06991945-1008  PRK06991
pfam13237948-997  Fer4_10
COG0492194-509  TrxB
COG1144941-1005  PorD
COG2878945-1005  RnfB
COG0042652-810  DusA
COG1149936-1009  COG1149
COG1249194-484  Lpd
pfam01207651-821  Dus
TIGR01292189-507  TRX_reduct
PLN02826533-818  PLN02826
TIGR02179948-1005  PorD_KorD
PRK08764945-1005  PRK08764
COG4231946-997  IorA
pfam12838953-997  Fer4_7
pfam13187953-1002  Fer4_9
COG1245945-1005  Rli1
COG1145946-1005  NapF
PRK10415648-852  PRK10415
TIGR03336948-1002  IOR_alpha
PRK06292190-484  PRK06292
COG1233194-252  COG1233
TIGR03224947-1011  benzo_boxA
COG0446194-483  FadH2
PRK09624949-1008  porD
COG1232189-252  HemY
PRK07233189-252  PRK07233
TIGR02494947-997  PFLE_PFLC
PRK09625951-997  porD
TIGR01971977-1022  NuoI
TIGR02053245-484  MerA
PRK12771896-1005  PRK12771
PRK13409945-1005  PRK13409
COG0437948-997  HybA
PRK07208189-227  PRK07208
PRK09623945-1005  vorD
COG1148927-997  HdrA
COG3349189-229  COG3349
COG2907189-225  COG2907
PRK06292189-231  PRK06292
PRK08348910-1004  PRK08348
TIGR02512947-997  FeFe_hydrog_A


Ontology Information


   
HPRD ID3652
Molecular ClassEnzyme: Dehydrogenase
Molecular FunctionProtein serine/threonine kinase activity (GO:0004674)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q12882DB00544FluorouracilSmallMoleculeDrug
Q12882DB01101CapecitabineSmallMoleculeDrug
Q12882DB03147Flavin adenine dinucleotideSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO