Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SLC26A3 | 1811 | Solute carrier family 26, member 3  | 7 | CLD; DRA  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19678923    | 2009 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | RT-PCR | Down-regulation | 12.43 | - |
| 19940027    | 2010 | Cell line : CACO 2 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Cell lysates and Western blotting, Site-directed mutagenesis, Transient transfection and luciferase | Down-regulation | - | This studies showed that the inhibitory effects of IFN- on SLC26A3 promoter were mediated through both the JAK and STAT1 pathway. GAS element may be important for IFN mediated downregulation of SLC26A3 promoter activity in Caco-2 cells. |
| 22968445    | 2012 | Cell line : - Source : Department of Pathology of Wrocaw Medical University. Sample Type : CRC tumor and Normal tissue No. of Sample : 87 Stage : Duke Stage A-D | Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-freequantitation. | Down-regulation | 0.12 | - |
| 23098991    | 2012 | Cell line : - Source : Helsinki University Central Hospital and at Turku University Central Hospital. Sample Type : CRC tumor and Normal tissue No. of Sample : 99 Stage : TNM Stage I-IV | real time RT-PCR | Down-regulation | 11 | - |
| 22081019    | 2011 | Cell line : - Source : ATCC Sample Type : - No. of Sample : - Stage : - | Single-cell PCR gene-expression analysis(SINCE-PCR),Immunohistochemistry and immunofluorescence. | Unknown | - | SLC26A3 and CD177 proteins preferentialy expressed at the top of the human colonic crypts. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Solute carriers |
| Description | The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008]   |
| Chromosome | 7 |
| Location | 7q31.1 |
| Start | 107765467   |
| End | 107803233   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 37767   |
| OMIM ID | 126650    |
| HGNC ID | HGNC:3018    |
| Unigene ID | Hs.1650     |
| Ensembl ID | ENSG00000091138    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_000111.2 |
|---|---|
| Exon | join(1..123,8637..8855,9353..9492,11294..11404, 11999..12186,13546..13710,15725..15877,16325..16407, 19882..20029,20141..20254,20360..20437,23471..23566, 24953..25059,26528..26597,26690..26782,28362..28457, 29081..29314,31126..31180,35326..35468,35590..35655, 37356..37767)   | mRNA Sequence |    Download   Select all |
| Length | 2894   |
CDS Information
| Location | join(8725..8855,9353..9492,11294..11404,11999..12186, 13546..13710,15725..15877,16325..16407,19882..20029, 20141..20254,20360..20437,23471..23566,24953..25059, 26528..26597,26690..26782,28362..28457,29081..29314, 31126..31180,35326..35468,35590..35655,37356..37379) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS5748.1 |    
Protein Information
| Protein ID | NP_000102.1 |
|---|---|
| Protein Name | Solute carrier family 26, member 3 |
| Molecular Wt. (Da) | 84374 |
| Protein Sequence |    Download   Select all |
| Length | 764   |
| Uniprot ID | P30530 |    
| Ensembl Protein ID | ENSP00000301178   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 520;- |
| S | Phosphorylation | 509;- |
| T | Phosphorylation | 503;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Mineral absorption |    hsa04978 |    
| Pancreatic secretion |    hsa04972 |    
Structure Information
| PDB ID | 2DNT |
|---|---|
| Resolution | - |
| Method | SOLUTION NMR |
| Chains | A   |
| Molecule | Chromodomain protein, Y chromosome-like, isoform b   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07042 | 526-712  | STAS_SulP_like_sulfate_transporter |
| cl00604 | 526-712  | STAS superfamily |
| pfam00916 | 193-471  | Sulfate_transp |
| cl19250 | 193-471  | Sulfate_transp superfamily |
| pfam13792 | 58-141  | Sulfate_tra_GLY |
| cl18285 | 58-141  | Sulfate_tra_GLY superfamily |
| pfam01740 | 645-716  | STAS |
| pfam10225 | 51-205  | DUF2215 |
| cl10912 | 51-205  | DUF2215 superfamily |
| COG0636 | 376-432  | AtpE |
| cl00466 | 376-432  | ATP-synt_C superfamily |
| TIGR00815 | 59-716  | sulP |
| COG0659 | 56-572  | SUL1 |
| PRK11660 | 61-547  | PRK11660 |
Ontology Information
| HPRD ID | 171 |    
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | Transmembrane receptor protein tyrosine kinase activity (GO:0004714) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
