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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SLC26A3 1811 Solute carrier family 26, member 3  7CLD; DRA 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19678923   2009Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

RT-PCRDown-regulation12.43-

19940027   2010Cell line : CACO 2

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

Cell lysates and Western blotting, Site-directed mutagenesis, Transient transfection and luciferase Down-regulation-This studies showed that the inhibitory effects of IFN- on SLC26A3 promoter were mediated through both the JAK and STAT1 pathway.

GAS element may be important for IFN mediated downregulation of SLC26A3 promoter activity in Caco-2 cells.

22968445   2012Cell line : -

Source : Department of Pathology of Wrocaw Medical University.

Sample Type : CRC tumor and Normal tissue

No. of Sample : 87

Stage : Duke Stage A-D

Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-freequantitation.Down-regulation0.12-

23098991   2012Cell line : -

Source : Helsinki University Central Hospital and at Turku University Central Hospital.

Sample Type : CRC tumor and Normal tissue

No. of Sample : 99

Stage : TNM Stage I-IV

real time RT-PCRDown-regulation11-

22081019   2011Cell line : -

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

Single-cell PCR gene-expression analysis(SINCE-PCR),Immunohistochemistry and immunofluorescence.Unknown-SLC26A3 and CD177 proteins preferentialy expressed at the top of the human colonic crypts.


Gene Details



Chromosome: 7; NC_000007.13 (107405912..107443678, complement)

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Gene Type protein coding
Gene Family Solute carriers
Description The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008]  
Chromosome 7
Location 7q31.1
Start 107765467  
End 107803233  
Strand -  
Gene Sequence

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Length 37767  
OMIM ID 126650   
HGNC ID HGNC:3018   
Unigene ID Hs.1650    
Ensembl ID ENSG00000091138   
PharmGKB ID -   

mRNA Information


mRNA ID NM_000111.2
Exon join(1..123,8637..8855,9353..9492,11294..11404, 11999..12186,13546..13710,15725..15877,16325..16407, 19882..20029,20141..20254,20360..20437,23471..23566, 24953..25059,26528..26597,26690..26782,28362..28457, 29081..29314,31126..31180,35326..35468,35590..35655, 37356..37767)  
mRNA Sequence

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Length 2894  



CDS Information


   
Location join(8725..8855,9353..9492,11294..11404,11999..12186, 13546..13710,15725..15877,16325..16407,19882..20029, 20141..20254,20360..20437,23471..23566,24953..25059, 26528..26597,26690..26782,28362..28457,29081..29314, 31126..31180,35326..35468,35590..35655,37356..37379)
CDS Sequence

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CCDS ID CCDS5748.1



Protein Information


      
Protein IDNP_000102.1
Protein NameSolute carrier family 26, member 3
Molecular Wt. (Da)84374
Protein Sequence

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Length 764  
Uniprot IDP30530
Ensembl Protein ID ENSP00000301178  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation520;-
SPhosphorylation509;-
TPhosphorylation503;-

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


            
Pathway Name Pathway ID
Mineral absorption hsa04978
Pancreatic secretion hsa04972


Structure Information


PDB ID2DNT
Resolution-
MethodSOLUTION NMR
Chains A  
Molecule Chromodomain protein, Y chromosome-like, isoform b  
Model View



Domain Information




ID Location Description
cd07042526-712  STAS_SulP_like_sulfate_transporter
cl00604526-712  STAS superfamily
pfam00916193-471  Sulfate_transp
cl19250193-471  Sulfate_transp superfamily
pfam1379258-141  Sulfate_tra_GLY
cl1828558-141  Sulfate_tra_GLY superfamily
pfam01740645-716  STAS
pfam1022551-205  DUF2215
cl1091251-205  DUF2215 superfamily
COG0636376-432  AtpE
cl00466376-432  ATP-synt_C superfamily
TIGR0081559-716  sulP
COG065956-572  SUL1
PRK1166061-547  PRK11660


Ontology Information


   
HPRD ID171
Molecular ClassTransport/cargo protein
Molecular FunctionTransmembrane receptor protein tyrosine kinase activity (GO:0004714)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO