Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
DRD2 1813 dopamine receptor D2  11- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
17108814   2006Cell line : -

Source : -

Sample Type : Prostate, Lung, Colorectal, Ovarian Cancer

No. of Sample : Genotyped in 2374 participants selected randomly from the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer

Stage : -

SNPUnknown--


Gene Details



NC_000011.9 (113280317..113346413, complement)

View Larger Image
   
Gene Type protein coding
Gene Family GPCR / Class A : Dopamine receptors
Description This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]  
Chromosome 11
Location 11q22-q23
Start 113280317  
End 113346413  
Strand -  
Gene Sequence

   Download   Select all

Length 66097  
OMIM ID 126450   
HGNC ID HGNC:3023   
Unigene ID Hs.73893   
Ensembl ID -   
PharmGKB ID PA27478   

mRNA Information


mRNA ID NM_016574.3
Exon join(1..204,50598..50913,57144..57253,58281..58417, 59669..59859,62397..62724,64360..65685)  
mRNA Sequence

   Download   Select all

Length 2626  



CDS Information


   
Location236..1480
CDS Sequence

   Download   Select all

CCDS ID CCDS8361.1



Protein Information


      
Protein IDNP_057658.2
Protein Namedopamine receptor D2
Molecular Wt. (Da)47216
Protein Sequence

   Download   Select all

Length 414  
Uniprot IDP00747
Ensembl Protein ID ENSP00000308938  



Post-translational Modification Information (Source : HPRD)


Residue Type site
CDisulfide Bridge107;182
CDisulfide Bridge107;182

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
135ADORA2A43NP_000666.2in vivo12804599   
2891GRIA24726NP_000817.2in vitro;in vivo15858065   
4905NSF3380NP_006169.2in vitro;in vivo15858065   
8618CADPS5236NP_003707.2in vivo15857609   
93664CADPS212996NP_060424.9yeast 2-hybrid15857609   


Pathway Information


                                                
Pathway Name Pathway ID
Alcoholism hsa05034
cAMP signaling pathway hsa04024
Cocaine addiction hsa05030
Dopaminergic synapse hsa04728
Gap junction hsa04540
Neuroactive ligand-receptor interaction hsa04080
Parkinson's disease hsa05012
Rap1 signaling pathway hsa04015


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam1032049-233  7TM_GPCR_Srsx
cl2156149-233  7tm_4 superfamily
pfam1032843-226  7TM_GPCR_Srx
pfam1032353-233  7TM_GPCR_Srv
pfam0000157-426  7tm_1
PHA0308725-228  PHA03087
PHA0263832-226  PHA02638
PHA0283435-226  PHA02834


Ontology Information


   
HPRD ID3837
Molecular ClassG protein coupled receptor
Molecular FunctionIon channel activity (GO:0005216)
Biological ProcessMuscle contraction (GO:0006936)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P14416DB00182AmphetamineSmallMoleculeDrug
P14416DB00246ZiprasidoneSmallMoleculeDrug
P14416DB00248CabergolineSmallMoleculeDrug
P14416DB00268RopiniroleSmallMoleculeDrug
P14416DB00334OlanzapineSmallMoleculeDrug
P14416DB00363ClozapineSmallMoleculeDrug
P14416DB00370MirtazapineSmallMoleculeDrug
P14416DB00391SulpirideSmallMoleculeDrug
P14416DB00408LoxapineSmallMoleculeDrug
P14416DB00409RemoxiprideSmallMoleculeDrug
P14416DB00413PramipexoleSmallMoleculeDrug
P14416DB00420PromazineSmallMoleculeDrug
P14416DB00433ProchlorperazineSmallMoleculeDrug
P14416DB00450DroperidolSmallMoleculeDrug
P14416DB00458ImipramineSmallMoleculeDrug
P14416DB00477ChlorpromazineSmallMoleculeDrug
P14416DB00490BuspironeSmallMoleculeDrug
P14416DB00502HaloperidolSmallMoleculeDrug
P14416DB00508TriflupromazineSmallMoleculeDrug
P14416DB00540NortriptylineSmallMoleculeDrug
P14416DB00543AmoxapineSmallMoleculeDrug
P14416DB00568CinnarizineSmallMoleculeDrug
P14416DB00589LisurideSmallMoleculeDrug
P14416DB00623FluphenazineSmallMoleculeDrug
P14416DB00679ThioridazineSmallMoleculeDrug
P14416DB00696ErgotamineSmallMoleculeDrug
P14416DB00714ApomorphineSmallMoleculeDrug
P14416DB00726TrimipramineSmallMoleculeDrug
P14416DB00734RisperidoneSmallMoleculeDrug
P14416DB00777PropiomazineSmallMoleculeDrug
P14416DB00805MinaprineSmallMoleculeDrug
P14416DB00831TrifluoperazineSmallMoleculeDrug
P14416DB00850PerphenazineSmallMoleculeDrug
P14416DB00875FlupentixolSmallMoleculeDrug
P14416DB00915AmantadineSmallMoleculeDrug
P14416DB00933MesoridazineSmallMoleculeDrug
P14416DB00934MaprotilineSmallMoleculeDrug
P14416DB00988DopamineSmallMoleculeDrug
P14416DB01043MemantineSmallMoleculeDrug
P14416DB01049Ergoloid mesylateSmallMoleculeDrug
P14416DB01063AcetophenazineSmallMoleculeDrug
P14416DB01069PromethazineSmallMoleculeDrug
P14416DB01100PimozideSmallMoleculeDrug
P14416DB01142DoxepinSmallMoleculeDrug
P14416DB01151DesipramineSmallMoleculeDrug
P14416DB01184DomperidoneSmallMoleculeDrug
P14416DB01186PergolideSmallMoleculeDrug
P14416DB01200BromocriptineSmallMoleculeDrug
P14416DB01221KetamineSmallMoleculeDrug
P14416DB01224QuetiapineSmallMoleculeDrug
P14416DB01233MetoclopramideSmallMoleculeDrug
P14416DB01235LevodopaSmallMoleculeDrug
P14416DB01238AripiprazoleSmallMoleculeDrug
P14416DB01239ChlorprothixeneSmallMoleculeDrug
P14416DB01267PaliperidoneSmallMoleculeDrug
P14416DB01392YohimbineSmallMoleculeDrug
P14416DB01403MethotrimeprazineSmallMoleculeDrug
P14416DB01425AlizaprideSmallMoleculeDrug
P14416DB01614AcepromazineSmallMoleculeDrug
P14416DB01618MolindoneSmallMoleculeDrug
P14416DB01621PipotiazineSmallMoleculeDrug
P14416DB01622ThioproperazineSmallMoleculeDrug
P14416DB01623ThiothixeneSmallMoleculeDrug
P14416DB01624ZuclopenthixolSmallMoleculeDrug
P14416DB04842FluspirileneSmallMoleculeDrug
P14416DB04844TetrabenazineSmallMoleculeDrug
P14416DB04946IloperidoneSmallMoleculeDrug
P14416DB05271RotigotineSmallMoleculeDrug
P14416DB06016CariprazineSmallMoleculeDrug
P14416DB06144SertindoleSmallMoleculeDrug
P14416DB06148MianserinSmallMoleculeDrug
P14416DB06216AsenapineSmallMoleculeDrug
P14416DB06288AmisulprideSmallMoleculeDrug
P14416DB08815LurasidoneSmallMoleculeDrug
P14416DB09018BromoprideSmallMoleculeDrug
P14416DB09128BrexpiprazoleSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO