CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
JAG1	182	jagged 1	20	AHD, AWS, HJ1, CD339

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
22539391	2012	Cell line : - Source : Third Affiliated Hospital of Nanjing University of TCM Sample Type : - No. of Sample : 146 Stage : -	Immunohistochemistry	Up-regulation	-	The expressions of JAG1 and DLL1 are related to tumor differentiation and tumor location. The expression of JAG1 gene is associated with long-term survival.

Gene Details

NC_000020.10 (10618332..10654694, complement)
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Gene Type	protein coding
Gene Family	CD molecules
Description	The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]
Chromosome	20
Location	20p12.1-p1
Start	10618332
End	10654694
Strand	-
Gene Sequence	>gi\|568815578:c10674046-10637684 Homo sapiens chromosome 20, GRCh38.p2 Primary Assembly CTGCCCGGCGTGCTGGGTAGAGGTGGCCAGCCCCGGCCGCTGCTGCCAGACGGGCTCTCCGGGTCCTTCT CCGAGAGCCGGGCGGGCACGCGTCATTGTGTTACCTGCGGCCGGCCCGCGAGCTAGGCTGGTTTTTTTTT TTCTCCCCTCCCTCCCCCCTTTTTCCATGCAGCTGATCTAAAAGGGAATAAAAGGCTGCGCATAATCATA ATAATAAAAGAAGGGGAGCGCGAGAGAAGGAAAGAAAGCCGGGAGGTGGAAGAGGAGGGGGAGCGTCTCA AAGAAGCGATCAGAATAATAAAAGGAGGCCGGGCTCTTTGCCTTCTGGAACGGGCCGCTCTTGAAAGGGC TTTTGAAAAGTGGTGTTGTTTTCCAGTCGTGCATGCTCCAATCGGCGGAGTATATTAGAGCCGGGACGCG GCGGCCGCAGGGGCAGCGGCGACGGCAGCACCGGCGGCAGCACCAGCGCGAACAGCAGCGGCGGCGTCCC GAGTGCCCGCGGCGCGCGGCGCAGCGATGCGTTCCCCACGGACGCGCGGCCGGTCCGGGCGCCCCCTAAG CCTCCTGCTCGCCCTGCTCTGTGCCCTGCGAGCCAAGGTAGGAGCCCTTCTCCGGGCCTCCCTCCCAGCC GTCCTCTCCCTCCCCTCGCGGCGCCCTGGGCGGTTGAGCCCCGCGAGCAGGCTCGGCAGCCCTCGAGCGC CCGACTCCTCGCCCCTGCGCCCGAGCGGCTGCACCTGGGCTGAGCGCGCCAACTCCCCCACGGGAGCCCC TGCCTCCTGAGGGTGACCCCTCCAGGCCGGACAGGGGCGCGTTCGCTCCGCTGTTGCCCCCCGGGAAGTC GTCGGATTTCTTCCGCACTCGTGCATTTTTTTTTTTTTTTGCCCCGGAATCATGTTGAGTCCTTGAACGT AGTTTCGCAAAATTATTTTCACTCGGCGAGGAGGGCTCGTCGGGGCGGGGAGTGGGAGGGAGTCGCCACC TCTATACTCGAAGAAAACAGCTTTCTCCCGCGCTGACCTACCTCCTTCCCTCGCCGGCAGGTGTGTGGGG CCTCGGGTCAGTTCGAGTTGGAGATCCTGTCCATGCAGAACGTGAACGGGGAGCTGCAGAACGGGAACTG CTGCGGCGGCGCCCGGAACCCGGGAGACCGCAAGTGCACCCGCGACGAGTGTGACACATACTTCAAAGTG TGCCTCAAGGAGTATCAGTCCCGCGTCACGGCCGGGGGGCCCTGCAGCTTCGGCTCAGGGTCCACGCCTG TCATCGGGGGCAACACCTTCAACCTCAAGGCCAGCCGCGGCAACGACCGCAACCGCATCGTGCTGCCTTT CAGTTTCGCCTGGCCGGTGAGTGACTACTCGGGAAGGAGGCCGGGCGGAGCCTCACACCCGCGCCTGGCC GAGCCCTGTTATCCCTTGCGAGAGGGATTTAAAGGGCTTTGGCTTGAAACTAGGCGCTAACTGGGGAAAT CTCTAGGGGTGGCGGGTGAGGGAGCCGGGACACTATAGTTAGATCTCGGCTGGGGTAGTCGAGGTGGGTC CCATTCCTGCTGCTATTTGCTTAGTGCACAAAAGTGGGGATCCCAGAGGGTTTATGGGACCAGGCTCCTA GGAAGGCCGGTGTAAACTTGCAACTTGAAGTTCCCAGAGTAACTCTCCCGGCCCCAAGCCAAGAGATCGT TGTAGCTGATCTCTTTGCTTAACTAATTAAACCTGGTGCGCCGTGGAAGGCGACTCGGCGCAGTTCTGGC CTGCGAACGCCGTCCAAATTGGCAACCTCCCCTTTCCCGTGAACGGCCGGGAGGGCGGGTGTGTCCTTCC TGGAGGGTGTGGGGGAGTCCGTTTCCCGCTGCTCCCCGGGAGATTTTAGTGTGTGCGGGGGCGCTCTCCA GGTTCGGCTTAAGGGCCGGGGGCGGCCGCCGCAGGAGGAGGTTCTTGGGGCCCTCACAGGAGCTGTAGAC CTGGGAACCCCCGCCCGCTGCTGGCCCCTTCCTGCCCCCGCCCCCGAGTGGTGTAGCTCTTGTGGCCTCA CTTCCAGCGGTTCCCGGGCTCTGGAACAGCTGTGTTTGCAGACTTCCCCGGGAAGGGCGGGTGCACGGCC CCCGCAAGCCTTCGGGGGCCGTGCCAAGGCTTGGAAGGGGTGGTCTTCTGGAGGTAGTGCCTGAGGGTGT AAGTGATAGGCCCTCATCCCCCCGCCCCATTCCGCCCCCAAAGGAGCTCGAGGCCCGGGCCCAGCTGGCA GATCCTGCAGCGAGGCCCTTGCAACATCCCAAAATGGGTGGAAGGAAGATGGGTGCGATTGCAGAAGGGG AGGAAAGGGAAATGTTGGGGGTGTGCCCTCTGCCTGGCTCCTGCTGTCCAGGAGGCATGACTCATTGCCA AGACTGGGGCTTGGCCTAGCCTGTGCTGGGAGGGTGGGTGGTGAGAGGGGGAGCTCGGTGCCCCAGAGCA TTGCTTTCCACCACGTGCTCTAATGGGGTGCACTCTGCTGCCTCCTGTCCGCCGGCTTAGGTTGTGATTC TGGGAGGAGACAGAGGGGAGACTATCTGGCTGTGTCTGTGTATGAAGCTTGGGGTGGCTCTTAAAATCCA CGATTACAGGAGCTGGCATTATAAAGTGCCCTCTGCTGTGGGTGAGATAAGACAGTTATCAAAAACTGCC ATGAAAAGGGGTTTATAAAAAGAAAAATTAAAACCAACGCTGTCTGTGAAGCTCTCTTGAGGTCCAAGGG CTGTTTCTGTTGTGGGATTTCATTTTTACCAAGAGTATTTATCTTGTTTGTTAATCCCCTATTAGGGAGA ACTTTAAGCTAAAGAGTCTGGCTGCGTTTAAATCTGGCTGGCCCAAGCTGACTGTGAATACTCAAACTGC CCTTGAACGTGTGTTTGGAGTTTAGGGGGAAGGGGCCTGCAGGTGGTTCCACCCTCCTGCCGGAGGATCT GTCTGGAGCCCCTCGCTTTTCACAAGACCATAAAAGGAATCTTATTAGTGATGTGGAAAAGCAGCAGCCT GGCTGAGGCTCATTTTGGAGAGTAGGGTCAGAGGGATGGCTAACATGAAAACAAGGAGGCTTGCTCCCTC GCTGGCCAAGGAAAAGTGACCTAGAAAAGTGCGTCTGTCCGCTTTTGACACTTGGTCAGAGTCCTCAATG GAAAACGAGCGGAAATAGTGTGGGAGGGTAGGAGAGGCGATTGATTTGCATTTGCTGGTGCTCTTCTGTG GTTTCAGGCCCCACGGGTCACCAACCATGAAATAGACTCTCGGCTTTTCTCGAATGGGGGAAGACCGATG GGGCACCACTGAAAATGTGGTTCTTTTGAAGTTGGGACAAACGCATGTATCACTCATAAACAAGTCTCCA CCCTGATGCCCCAGAAAGGCCTGCTGTGAAACATAAGATTTAATTCTCAAGAGAAATTGGAGTTTAGGTG TATTTGTTTTTCTGTATGTGGTTGGAGAAACGGCACAGTCCGTAACTTTCAAGAATGATTCCAGGCTGAG TAGAAACGTAACTGAAACACTTAAGTAGCTGAGCGAGTATTTAACTAGAGGGCACAGCTTCATTTAGTTT GGCAATTAACTATGTCTTTTAAAACTGATTTCCTTGAATGGGAAATAAATGAACTTAGTACAGAATTCAA GAGATAGCAAGAAAAGGATATATGGTTAAAAACAAAACAAAACTCCAAACCACCTTGGGCTCCCAACCCC TAGCAGGCACAATTACCATTTGCATGAGTCCTCCCAAATTTGCTGACGCTGGGTATCAGCAAAGGGTGCA GGGGTAGGTCAGTGTAGAAGGTCATGTAGTTCATGCTTTTTGTTTGGAATTATGACCCCTATCCAAGCAA CTGTTCATGTTCTAGAGAGGACGAGGAGGAAACGATTTGGTCAGATATGAAATACAGTCCATGTTCTGGT GTGCATGTGAAAGGCTTTGTAGAGGTGGCCCTTCCTGTCATATATCATATCTGAGTATGTCCCACGTGGT GTCCCCTGCCCCGGCTCTGGTCTTGGGGTAGTTTTTCACCACTGGCTTCTAATTCTCATACTGTTGCTGC TCTAAGGGGCTTAACTTGCAGCAACTATCTGGATTAATGATTCTCAAATTGGGGGACCAAGTGATAAGAA CCATTATTGTGGGAAGTAATTGGGCTTAACAGGAAATAATTTAGGAATTACCACTTATAAATCACTGAAA CGGTTAATCTGTACCTCCCAAAATTAGTGCTAAATCCCAGTAGTGCCTGCTTATTAAAAATACATTAGTG TAATTACCACTACTCATCTCCAAAAGCTTTTTGGGAACTTCAGAACCCCAGTTAGCTGTATTGCTGCATC GGTGGCCCCAGAGTGAAATGAATCTAGAGAAACGTTAGGGGAAGAAATTGGGGTATCTGGCTTATTAGCC TCATATTTAAATTCCATTGATCCTATTAAAAGACTTGCTGAGATCAACTTTTTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTTTTTTTGGAAAATCCAATGAAACGTGATTCTTCTGTGTGAGGGATGCCAGCTTTGGC CCCCTTCATGCTTCAGGCCTGAATGACCAATTGCCACGATGCTAATCACAGAATGTAATTGACAGGCCCT TACTTTTATGCCTTTTGCTGTCTTTTCCAGTCCCTGAGCTTCTGTAGATATGGTGTGGGCACATGGAGGG CTTAAGGATGGGGTTCTGATTTGACCTGCCTCCTTTCTGCAGCCAGGATTTGCATCCTGCCCGTGTAGTC AGCATGTATACAAAGAAAGAGCATGTGTGTACGTATGTGCTCAGAGCAAGGGACTTTCTGCATGTGGAGA AAACGCCTTTTGCCCTAAGAAGTCTACCTCAAACCAAAGGGATGAAGTGATGTATCTGTGTTGCAACACT GGGCTTGGGGGAAAGTGAAGCTGTGCTTGCTTTGAAAGAGCTGTGCTAAGTATCTGCAGAATAGCTGCTC CAAAAATGGAATCTTTATTCCAGGTACTTGGTTTCTAATTTTTTTTTCTCTTGCAGGTGTAACCTTCTGT GTTTTCTTTCTCCTTGTTGTCTTGTTTCTTAGCAACTTATTCAAACCTCCAGTACTTATAGGAATTTGCA ACCCACCAGTTCCACACCCGTAATTCTACAGGGACTTAAGATGTTTTTAGAAAACGGTGAAACTTTGGCG TGGAGGCTCTTGGGGGAGTTCAGTGGGTTAAAAGGAGAGTCAGCAGCAACTTACAGGCATGCAACCTCCC AGAAAATCAGCAATCTAAGTGCTGCTCAAAATCTTCACACCAAATAGTGGTGCCTTTGGGGACCTTTTAG ATAGAAGACGTGGAAAGTTTAGCATGGAGAAAAAAGTTACTTAAAAAAAAAAAAACAGTGTCAAGGTAAC AAGGAGCCTTCACAGTTCCTGATCTGAAAACAGGAATGTGAACCAGAGGCCTTGGCTGGATTCATATCAC CCACTGGCCCCATTGTAGAAGGGCCAGAAGTTGGTCCCAATGTCCGGCTTTCAAGGTTAGTGACAATGTA AGAATGCATGATCTCTGGATGTGCATACAATTAGCGTTGTAATCCATAAATGCAAATACTCCTGCAAATT CTTCCATGGTAAACTTCTGTAAGGCATGTTGCTCTTCCACCTACCCCCATCCTTCAAGCCTAGGATCTAG GCTGCTGAGAGAAGTGACTCTTGGCTTCAGCTTTTAAATATATATATATCTCTCAAAACTTAATCTTTTC TTCCAACTGTTGGAAGATACATTGGGATGAATGGAAAGTGGTGATTCTAAAATGGTGGTGGAAATGGAGG AGGGTCCTGGGTTCAGAAAAATCCCACCTTTACTTTGGTGCATGGCACTGGGTGGCTGTGTTGTGACTTC TTTGCTGATTTCTGATTACCGCATGGACCACAGCAGCCCTGTGACTGCTGTTTTTTTTTTTTTTTTTTTT TTTTATGGTGCCAGTGACATCTACCATTGGTGCAGTGCGTGTGCTGGGAAGAAATTCCGCAAGGTGGCTC CCAGTAGTTAAAGGAGTACATAAATAGTCAAACATGCAGAGTCCTCTACCAGCTCAACCCAGTTTTTATG CACTTTTGGTAAATAAACAGAAAGGCTTCTTGTTCAGGCTTGCTCTGTGTGAACCAGACCGTTGTGCTTG GCTGGCTTCTTGGTATTCTATCTATTAACCTCGCCACCCTTTTGTAACTGGTGCATTTAATTATCAGTGG GATGCTTTTCAAACAGGTAAGGGTAATGATGGGAAAGGGGGTGGGGATGTCTCATTGAGAGTCACAAATC TGGATATGAGCTTTGGGGCCCCTTGGTGAGCCTTTGAGTGGGCTTTGATGAGAAAATCACCCTTTGTAAC CAGATCGGACTCTATTGACATGTCAAGCCCTACAGACTTGATTGCTTTCTGTGCCTGAAGTCTTAGCCTA GATGCTATAGGATAGTTGTCCTTTCTTATCTCACTTTCCCAAAACCCACTCGCATTGTGTGCATGAGTAC GTGTGCATGCGCCACACATGGACTCCCTGCAACCTTTTCTGCTTAATATGTTTTGTGACTGGAATATTTT ATACTCTGGCCACCCAGACACAGGCAGGACAATAGAGTTGGCCGAATTGACTGAAATGAGGATTATGGAG AATAATAGGGCCTCTCCAAAAATAATGCTAACACAGGACAAGCGACAGGAAGCAACAGTTGAGTCAGCAG AGCTCAGGGCCCCTGACGAACCCTGGGAGCCGACTGACTGTGCACAATGGCCGCGTTGGCACGTCGGGCA TTCCCAGGATGTGCGTGCCGCCGGCGGGCCTGCCTGTCGCAGCAGCCTGGGGTTTTGGACGCCGCACGCG TGCCGTTTGGATGGCGGTTTATTTGTGTCCGTCAGCTTGGCAGGAGGGGAGGCAGCCGCTTCTCAGGGCT TGGTTTGGCTGTCACTGTTGCCAGGAAAAGGAAGCTCCCGGCTGCCAACACAATTACCTTTGTTTCTTAC ATCCCCCCTTCTTAATGTGGCAATTAAGTGCTTACCGCTCTGCCCAGTGCCAAGGTAACCGCCATGGAGT GGGACAGGGCAGAGAACACAACCTTGGCACAGCAGCCTAAGTGTGGAGGGCGGGAGGAGGTGCAGGGGCC CCAGCCTTGCTGGGAACCTGGTGGCCCTTGGATGCCTTGGGGCTTTGATGCCAGGACTCTCCTCTAGGTA GAATTCCACAGAAATCTTCCAAAAAGCAATTCCGAAGGCTGACCATTCCTCTTTGATGCCACACCAGAAT GGGAACCAGCTGCCAGGTTTCCAGATTTCCTTGGGCTTGGAGCTGGGAAGGGGCTGAAGTGACTCACTTT GCAAATCCAGACTAAAGATCTGTTTGCTACCCCTCCTTCCTGTGTGGCCTTCACAGTACTGTTCTGGAAA ACATAAGGAAAGATGAAAGCCAGGTGACTCTTCGGCAGAGTCTTAGTTCTGTAGTCTGAAATCAAGAAAA ACCCAGGTATTTGCTTTTGTTGTTGTTGTTTTGCTGTATAAACTTAAGTTTGAACACTTGCCTTTCCAAG CCCTCCTGGGATGGAGGACTCCGCCTCTACTGGGGGTCAGAGTTGCAGTGGCTGCTTGTATGTGACTTCG GCATAGTGGATTTGCTGCTCTGTGGCCTGGTCCCTGCTTTGATGTGGGGTGCATGATCTGGGATCTCAGT GCCTGGGTGTATGTTCAGGGATGTACAGAGGTCAAGTGTGGGCCTGGGAAAAATTAAAGTTCTCTAGCAA CTAATAATCATTGTTAAATTATCTTGATTGCTGATCTATAGTGTGGGGATGGAGTGGGAGGTTGAGTGCC TCCTAATAGGAACCTTGGAGGGAATCCTTTTTCTCTGTAGGGCTGGGCAGGAGGAATCCTCCTGCCCCAG GAGACCCTAATCCCCTCCCTGAAACAGACAGGAAAAAAAGTCCAGGCTTTGTTGCCGTCACTGTAGCTCC CTGCCCTCACCCTGTCTCTGCCTCTGAGAAAGAAGGGCAGTTCATGGAAAATCACAGAGCCAGGCACGTA GGGCTGTGTGCAATTCTTTTCTCTCCAGGTGGGGTGATGTCGGTCAGCAACTTCTGAGGTTTTCCCAGTT CTGGCGAGGATGAGCCTGGTAGACTGCTTGGTCGTCCAAGTTCTTGTGCAAGACCTAAGGATGCTTTCCT CTTTGAGTATTAAACTGAGTTAGTACTGCCATGCCAGCTCAGTCCCGGCACCTTCCCTTGCAGTGGGGTT TGTGGGTATTATGTGTTTAGCGCTTGTGCAAGTCTGTCAAAACTCCTGGTATCAATGCATTTAATCAGAG GATTAATTACAACAATACTGTTGAAGTGGAGGACGTGGGCCTCAACGTGACCAGCAAATGAAGGGCTTAA TTATACAGAATCAGCCACACATCTGGCCTCATTTTGACTGTGCTCTTACCTCAAATCAGTAGAGAAATAT AATTTCTTGCTGCTCTTAGGGAAGAGTCCTGTAATTTGCAGGAAGTCCTAAGAAACTTAAAGAGGCAGTA AATAAGGTATAACTTTCGCTAATAAAATAGTAACAACAGCAATGAATTTGGACCTGTGGCCACTAACAGG AGAGGGCTGGGTATGTGCCCTGGCTTGCCCGGTTTTGCTTGCTTTTCTGAGCATTTTCCCACAGTTATCA GTGAACGAAATGGAATCCTACTCTGCTTTGAGTATGAAACATATTTCGGCTGAATTCCAAGGCAGGGTCT ATCACAAGATATTTTTATATTCAGAGATGACCTGCTGTGTCACTCTGAGAGCGCTAAGCTGGCCTTGAGT TATGAATGAAACTCCCTTTTACCCTCCCTTTTTCTCTTTTTCCTTTATCTTATAGGTGCTTTCTCTTCTC TTGGCAGCAGTGTGCTTCTGGTGGCACAGCACGGTATTATTTAATCTATACACGCTTCTATTTCCTATGG CTTGGTTTCTGACACAGCAAAGCAGGGATTCATAACCTAGTTCATGTTCCTTGTCTACCCCACCTGCCTT GAGTACATTTCTTCAGTGCCAAGATAGCAGAAGCTTCATTTAAACGCTGGTGTTTTGTGAGACTGACCTT ACTGTAAATTACGAAGGAAAATTTTAGAAAAGGAGGGAATTTGCTAATAGCTTAGGTTTGGCTGGGGGTG GGGAGGTGGAATTCTGAGATAAGCTTGGAAGATAAAAGGTGCCTTCAGTTTAACAGCTGGCATCTTGCCA GTATCCAGGGAATTTGTTTAGTTAGTAGACTCTGATTATTCTTGGAATGTTAGATCTTATTAACAGATAA GTTCATCAATAAATATAACCCATGGGTGTGCGGTTGTTTCTCCCTTTGTACTTTCTTCCCTGGGATCTGC CCCCAACTCCACCGCCCAAGTGAGGTTGACTTCTTTGTCTTGCAGAGTCACTTTGCATCTACCCCCTCCT GTTTCCTAGAGTTACCCGATACTTGTGGGAGCCAGGATGGTCTCACATAGACAGAGTTTTCAAAGGGGTT CTAAAAAGGAAAAGGGGGCCTCCCTAGAGACTGCCTCACCAGGGCCCAAAGTGTAACCTTAGCAATACCC CCTCGGTACAAATACCTGGTTAGGTTAGCTTAGAATAAATTCTTTGTGTGTGTGTGTGTGTGTGTGTGTG TGTGTGTGTGTGTTTCCTCATGCACTAGGGTCAGGGTCTGGAAAGTTTTGGGAAACTATATGCTAAATAC TCTCATATCATATAGTGAGGTGGCATTTCCTGATCTCAACTTTGAGCTGCCTGCATGCATGTTGACTCCA GTGCGTCCCTGCCAGGTGAAAGGAGTCATTTGTCAACCTGGGAAGAGTGCTGACAAAGGAAGGGGAGTTG GTTTGGATTTAAACATCCAGGAACTCAATGCAACAACCAACAGAATTTTTATTTTGGCATTATGGTTTTG TTTGGTGGGGTATTCTGGGAGGCCAAGAATGTACGAGATTTTGGAAAGTCGACCCTGTTTCTGAATTGCT AAATTGTTTGTTTGTCTTGCAGAGGTCCTATACGTTGCTTGTGGAGGCGTGGGATTCCAGTAATGACACC GTTCGTAAGTATCGCTTCTGTGGACTTTTCTCTAAACACACGTGGAAGTGTGGGGCTTGGCCAACCAGTT GGAGCTGGATCTGTCTCCTTAGTACTTAGCATTTCTGCCACCTCTTGCCTTCTGTTCTCCCCTGTACCCC AGGGTGAACCTTCAGTGGAATGTATTCCTTAACTTTTCTAGGATTTTTGCTTGGAATATTAAGTGGCCAG AACAGAATCCCAGTTAACTCATTCCCTGATTATGAAACCTAGATTATCTTCGGGATAGAGATCTTAATGG TTTTACAACTTTAAAACCTTGTAGTCTGCTAAAGGATCAAAGTAGTGACTTTTTAAAAGTCCATTTAAAC TTTAAGTGAGTGTTTAATCTCTCATCAGAAAGATAAAGCCATAAAGGTGGTGCTGGGCTCTAGAGACCGA CCTTGAATTTCACTTGGTGGGCAGGTGAGCTTCTAGTCTCTCCGGGTTTCCCACACTGCTCCACAAACCT TTCATTGAAGCGCAATTCCAGAGCTTCACAGCCATTACCTGCCTTGTCCCTTTCTGAAAGATGGCTCTGT TTTCAGTGCAGGTTGCCTTTCAGGACTGAGGGGTTGGTTTTGGTGGATAAGCCATGGAGGATGTGATTGA AATGACATAGTCTGGCTTACAAAGTAGTCTTGCTCTTTAATTGTAACTTTACAGTGTTTTCGCTCACGAG CCGAAACTTCAAGTTCCCTTTTTGCCAGCAGAGTTTGGGTTGCGGTCGCTGGAAAACTTGATGCTCACTG AAATCTCTTGGTCTGTGCATGAGGAAGAGTGGATCCAGCTTCTTGTCTTGGCTCTCTGTTCTCTGAATGC CTTGTACTTTTTGCTTTTCTATCTTACCATTTTTTTTTGTTTGCTTTCACTGTGAATAATATATTTTCAT CTTTCCTTGCCTTGCTTTTTTTTGCTGACAGAAAATGGTGAATGCACACCGTGGGTGCAGTGAGGGCTTG GTGCCTGCTACGTGGGCAGCTTCCACCTGTGGCTGGCTTATTGGGCTACTTGGAGCCACAGAATCATTGC TGAGCTCCGATGTGCCAGAGAGTCCCAGGCCATTTGGGTCACTCTTCTAGCTTGGGAATCTTAAGTCCAG CTTTTTGGATGTCATCCTCCCTGGAGGGGGAGCTCATGAAAGTCCAAGGTTCGAGTCTTCCTCCCCAGAG GGCTACCCTGTAATGCCGTGGGGGGGTGTGTGTGGGGGTGGCAGGGAAGCTCTGTCAGCCTTGGCTATGG CTGATGCCAGTCAGGGTCATAGACACCTGTTTGTTCTCCCCTCCCTGCCACAAACGTTGAGGACTGTGAA CATTATGTCACTGTGACCTGCTTACAATGGTAACTAAGCGTTAGGCAGAAGGGGTTGAGGAGGGGGGAGA CATAGGCTCTTCTGTAATAGTATGGTGTCGACATGGTGTTCTTTCCCCTCCCTTTTAGCTATTGAAACAA TCCACCCGGTAGAGTGAACAGCTTGAGGTTGATCCTGGCCTGTGATAAGAGCCAGGTCAGTATACTTGTT AGGGACATGTGAGAGACCTCCCCGCCACACTGCAGCATTCACAGCACCTTTCCTGGACCTCCTGTCACCT CGCAGGTCAGGGAGTTATGTCCCCTGGGAACCCAGGGCTTGTCCAGAGCTACCCACAGTTGTCTGCATTT CCAGGTAGCCCGATTTTGGGGTTCTAGGATGTTTCATCTCCTGGGGGGGTAATCAAATCCCTGGAAGAGG ACAAGAAAGACTGAGGTAGGAATAAAGTTCTTTTAAACCTCAAGGGTGCCCATTGCAGGTTATCAAAACT CACTTGGTGAACCCTGAAGAGGGAGATGGGTTTGGTGGAAATGGTTTCTCCACTTGCCTATTTGGCCTCT TTTATGATGCTTCCAAGGAATCTTGAATTCAGCACAGTCAAAACCAAACTCAGGATCTTCTCTTGCCAAA AGCAGTCCCTTCCCAGGGCCCCTTCTGGGTGTCTGGCACCGATATTTGAACACTCATTGCCATAAGCCAG AAATATAGAAGGCGATCTGTGTACCCCCTCTCTGTTAGCATCCATACCTAGTCCACCTCCAAGTTCTGAA AAATCTCTCCAGCTCTTCACTTGAATCTGCCTGCCTTCTGCCACTGCCCTGGTCCAAGTCACCATCTGCT CATGACTGAACTTAGAGTAGCCTTCGTCTGGTCCACCTTTATCTGCTCTGACTCACCTCTAGTGCTTTCT CCATTCTTCTGCCATCCTGGTCTTTTCAGAGCCATAACATTTGCTTGTCACCCTTATTATGAAAAACCAA CCACTTGGTGGCCTTCTGTTGCTCTTGGGACAGATCTTCATGTGGCCCACAAGGCTCTGTGCAGCCCAGC TTTGTCTCCCTGCCAGCCTTGTCTTACACACCGTGTTGTCCATCGTATCTGTAGCCTGGCCATACCCTAG CAGTTGCCTTCCTATCCTCAACTACATCACATGCTTTCTGGCCTCAGGACCTTTGCACATGCTGTTTATG CTACTTGGAGTGTTTTGTTCCTTTCTTCACCCTCAGCCACTCCCTCTGGACTGCACTCCACAGGGCAGAA GCTGAGGATGTTCAGAAGCCCAAACGGAGTTGGCTGCCCTGTGGGACCCAAGCGAGTTGTAAACATTCTG GCTTCAGATGTAAATCAAAGGCAGAGCCCTGAGTTTTAGGGCAGAGAATTCCTTCTATCAGCTCTGCAGT GAGCCCTCACAGGCAGACTCGGGCCCAAATATAGCCTAGGTGCTGTTTATGTATTTGAAAGTATTTAAGG CTGGTCCTTCTGTCATCGGTCCTCCAAAGTCTTTTATTACATTTTGGGACTGTGGTATATAGAGTTCCAA ATTTCTTTCTCCCCTAGAGCAAATGGTTTCAGTTTACTGTAATGCATAATAAACATGTAAACATAAATAG GCACACTTCAGACCAGGTTTTCCCTGTAGCTTAGCTTTCTCGGCTAAGGCCCCCTTCCAGGTTTTTGGGT CGGTGTGGTCCCAGGTTATGCTCAGACTCGCCCTTCATCACCTCCTCCTTGGCCTGCGAGGCGGTCATGG CTTCTTCGTGACTCATCTTCGTGGCACTGGGGATTGCAGGGAGGCATGGTGATGTCCTTTTCCAGTCACA AGGCTGGACTGCCAAACGAACTGCCACAGATTCCTTTCCAGTGCCCCAAGCTGAAGGAAAGCGTGATCAG GAAGCAGGCAGCAGACGTATTTGAACCCAGACATGCTCGACCCCCTCCCTGAGCAGGTGTGAAATTATGT ATGCAGCTCCATAGCTCCACTGAGGATTCTGAAGTGATCCTCTGCACGACACTTCCCGGAAATAAGTGGA AAGCTTACTGCATGACTGAAAAGTACATATCAGTCCTGCACCCCTAGGATTGCCCTGGACTCTTGTCTAA ACTGTTTGTTGTTGATACCAGCCTCAGAAGCTGGATGCCTTTAAGCCATGGCTAGTGTGTTTAACCGATC CCTTTTATGAAGATCTTGTAAGCGCGTGGTAATAGCCCACTATGCTTTTTAACTGAACCAGCAGAGCAAA CATAGTTAATGGAGAGACATTTTTGTCATTCCTTGGCCTCTGTTTATTTGCAAAAACGAGTAAAGTGTTA CCTGCCTGCAAGTGGTTCAGTGCGTGCCGGGGTGTCAGGCTGCAGGTATGTGAGCTTGTTCAAGGCTTGT CTTGCCCACGCAGCAGTTTGAGAGCCCTAGAGGGCGAACGCTGGGGCCCTGTTGGAAGCGGTGTGTGGAT GAAGCCACCCAGGAGTCCCTTCTCTCCTGGTCACTTATAGGGCTTGCATCACTTTTTAAAGGAGCACTGG CCCGAGGCCTAGAAAAACAGCCATGTGGGTGGGTAAGAATCACAAAGACATTGCAAGTCAGTCCTAACTG TCTCTCCAAGATGGTCTTGAATTTGACAAGGTGATGAAGAGTTGGTGCTGGCAGGTTTAAGAAAACAAAC ACAAAACCAGGTTGGGGTGCTGATTTAGTGCCTTGCTGCCTTTTCAGATCCCTCCCCTGAACTGCTGGCA CCTGATGTTTGAGCTATTTTTGTACCTGTCTCTTCTCAAACTAGATGATAAGTGGCCTCAGGGCAGGGAC TACATACTCCTGAGAGCTGCTTGAGCTCGAGGTGTTTATTATCCTCAGTAAGCATTTTTTTTCAGGAGCA TGACTTGGCTCAAAAAAACAAAAAGAAAAAAGAAACCCTCCCCTCAATTTACCTGTGTCTAAACTTTGGT GAATTATTCTCCCATCTGCCTTCTGGGCAGAGGAGAAAGGTGGAATGCATCAAGTTCAAGGTCTTGGTAT TTAAGAGCTGGCTTTAAAGGTTGCCATGTTAACAATTGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAGTA ACTTAATCGTCTCCTTGGCTTCCAGTTAAGAGTTTTGAAATGGACAAAAAGCTTTTCTGAGCAAGACATA AAACCCTAAAACCAGAAATGATTGCTGACCTTTATCTGGAATAATGAAATTTCTTCAAGAGCAACATTCC ATAGGGAGCTACTGTCTCTCATATGTAAAGAGCACTTGCAAGTCAGTATGGCAATGTAATAGAAAAGTTG GCAGAGAAGAGAAGCTGTTGCTGTTCACAGGAACAAATATAAATGGTTTTGTAACTACCAGAAAGGGCTC TTGCCATCACTTAGTTAAATGCTAATTAAATGAGATACCTCTTTACCTATCAGGCATAGATTAGAAGGTT TGATAATGTACAACGTTGGCAGTGTTATTGGGAAACACAGCTTCCTGGGTGGTGGGAGGACAGACTGGTA GTTTGAGACTGTGGACAGAGGTTGATTTGTTGTGCACGGACTCTGATTCAGCACTTCCATTTCTAGAGTA TCTCATTGTGGGAACCATACACAGGCAGATACGTTCAAGGAATGCTCACTGTGGCTTTGTTTAATAGTAA GAAGCCCAAACGACTCACATGCACACATGTCAGGGACTAGGTAAATTATTTATTGGTGTTTCCAGACAAT GAAATACTGTGTACCCATTAAAGAAGGTAAACAAGTGGTAACAGGTTGTCTCTGGGTAGGGGCATAAACT TTTCATTTCTTTGCCTTTTTTACAACAGATAGAATTTTGTAGCAGGTGCATATGTTTTTATTTTAAAAAG CCAAAATGGTCAGGGAAGAAGGCTGCAATGTGAATATTAACATGATTCATCACTTTGTCTCTAGAACCTG ACAGTATTATTGAAAAGGCTTCTCACTCGGGCATGATCAACCCCAGCCGGCAGTGGCAGACGCTGAAGCA GAACACGGGCGTTGCCCACTTTGAGTATCAGATCCGCGTGACCTGTGATGACTACTACTATGGCTTTGGC TGCAATAAGTTCTGCCGCCCCAGAGATGACTTCTTTGGACACTATGCCTGTGACCAGAATGGCAACAAAA CTTGCATGGAAGGCTGGATGGGCCCCGAATGTAACAGAGGTATGTGTGTGTGTGTGCATGTGCACGTGTG CCTGTTGCTTTTAGTGTCCATTTATCACCCCACCAGCAGGCAGGTGGCATGCGGCTATCTCAGGTGGGGT GGGATTTTGGCTGTTATTCTGGGCCTGCAGTATGAAGATGCGGAGTGTAGAAGATGCTGTTGGTGCCCCA TCCAGATCCCCTTTACTGGCATCCCCATCCCCCAGGTGCTGTGTTGGCTGCCAACAGCTCACAGCTGCTC CTTCTCAGGAGACTCGTCCTTGGCCAAACCAGTGCATGCCCCATTCCTCCAGCTCACAGTCAGTGATTGA CAGACATAGGGCTACAAAGCCCAGCTTCCTTTGCCTTAAAACAGTAGTACAATTTGCACTCTAGAGCTTA CCCTGGGATTAGGCTGAAATCAGACTCCAGTTGAGACCATGTTCTTGCTCAGCTCTTTCCCCTACCCCAT CTGCTTCCCTCAATTCCTTCTACCTATGTCCAGATCCCCTTCTCAGACTCTGCTTCTAAGGAACTTGACC CAAAATAGATCCAGACAGGACTAGGTCAGCCCAGTTGTTGTCTGAACAGGCTATCCTATAGGAAATGATA GCCCCTGCATTCAGGGTAGCCTTGCAGCAAGTTTTCACTAGGTGTCTTTGGGGGCATGGCTTTGATGGGG AGAGGTATGTGGTTAGCTCAAGCTTTCCTATTGGTGTAGGAGTGGGCCCACTTTTAGTCTCTGTGCTGTC TACTGTCCCAGTCCCTTTATAGAATTCAGTGATTCCAATTCATAGCAACTTGATGGGTAATTCTGTTAAC TGTATAATATCCCCTCATGAGCAATAATGTACTCTGCTTATTTTACATGATAATTAGGTAAATTGTTTTG ATAGACTCAATTTCAAAGTGAGTTTTTCAACCATGAGAGAGGGGTGGGTCATGGGGGAAGGAATTTACAG CTCTCCCGGGTAGTACTACTGCTTTCTTAAATAATTGGAGAGAAGAGTTTAAAAAGGATGGCATTTCTGG AATTCAAATGAAAAGGGGAATTCATTAACATATTTTAGTGTGTTTTAAAAATTAAACGACCTAACACTTA GTGTGGGTTTTTTGTTTGGTGTTTTTTTTTTTTTTTAAGATAAGGTGCTCACTTTGTCACCCATGATGGC ACAATCATGGCTCACTGGAGCCTTGAACTCCTGGGTTCAAGTGATCCTCCTGCCTCAGCCTCCCAAGTAG CTGGGACTATAGGCACATGCCACCACACCCAGCTTTTTTATTTTGTGTAGACATAGTCTTGCTATGTTGT TGAGGCTGGTCTCGAACTCCTGGCCTCAAGCTATCCTTCTGCCTCAATCTCCCAAAGTGTTGGGATTATA GGCATGGGCCACTGTTGCCTGGTCTTAGAAACTGACATTTTTTAGAAGTTACTTTTTTCTTTTTTTTAAA CGAAGTAGAGAATTGCTCTGCAAGGATACTTTATAAAAGTCTCACCAGATCTGGCCACCAGATTAGCCTG CCCAATGAGTCCAGCCTGGCTGGCTCTGTTAGTCCCATGGAATTTTCAAACCAGGCATTTGGTATGGGTT GTTTTTTTTTTTTTTTTTTTTTTTAAAGGCTGAGGCTCATCTGAATGTGTCCTGGTGGGATGGGGAAGGA TTATCTATACCTTTTTTTCTTCTAATGAAAAGGGTGTGGGCAGAATGGAAACTGACCAAGCTCTGCTCAA GGAGCCAGGGTAGCTGTGGTTTAGAGAGGCTGGACGAAGGTCCCCCTTCCCTCGTCAACTTGTCTGCATT TTGTCCCCAAACAATATCATGTTTTCAGAATCTGCTAACAAGGCCTTGAAGTTTAAAGCTGGTTTTGTTA TTTGGGCCCCTCCCATCTTCCTCTCCTTACAAGGGACTTGATATGAGACCTGTTAAAATCGTGGAATTTG CAGACTTTAATGCAATGGGCCATTCTCATGACCGGGGCGATGCAAGGAACAGGCAGTGTGCTGACACGCC CTTCTCTGTTTTTTACAGCTATTTGCCGACAAGGCTGCAGTCCTAAGCATGGGTCTTGCAAACTCCCAGG TGACTGCAGGTAAATCAACTGGTCTTTTGTGAGATTTCTTTTAATTTTCCTTTATGTAAGAGAGGAACTG ACTTTATTGTGACTATGCCTCTTTTTTCCTTGGAGAACAAGAAAGCTTTTTTAAAAAAAAAATTCAGATA GACACATCCGAAGCTTATTAAATTATACCAGCTGTCTGGTGGAATGCACACACCACTTCTCTCTTGGAAT AAAAAGAAACTCTTTGGGCATAGCCAGTGACTTCATGTATTAACTGTTCTGTAAATTGATAACACATTTT TATAATCTTCCCTTATAGTGCTGATGGGCTAGATGGAGGGATGTGGGCTTGTTTCTTTGCGTCTCTCTCC TCTTCCACCAAGGCTTTCTTCTCCCAGCCCCCTCCCCGACTTTTCCCATCAATAGGCGAAAGTCCAGCAT TCTTTAGAATGGGATTAGTCCAATCTCCTGGCCCCTTTGCAGGCGGGAGCTGGGTTGGTGCTGAGAGGTT AATGGCTGCCCTGGAATCTTGTCAGTTGAGCCTGATGAATGTAGACTTTTGCTGCAGTCCTTTGAAGTCT GTTCCTTTATGGTCCAGGAACAATGCGGAAGCCAAAGGGAGGCCTGCCCTGACCACTTCACGATGGCGGG TTTTGGAACTTCTTGAAATTTATATTACGCCCGTTTGGAAAAGGCTTATTTTGGGAAATATTGTTGGTGT CTGTGGTGTTTTTGGCAGTCTTAATGCTTTGCTCTCCCTCCTCCCAAATTTTAAGGAGTAACGCTAAATG GATCCTTTGAGCCTGTCACTTTTGCCCCCAAAGCTACTCTGACATGAGTAAAGGGAATCTTATGAAACAT AGTCTAAACCAGTATGTCCCAAACTAATGTTATTTGGGGCTCTTATTAAAACGCAGGTCCTGATTCTATA GGTCTGGGCTGAGCCCAGGTTTCTGCATTTCTAACAAGCTCCCAAGCGATGCTGCTGATGGAACCATCAG CAATCACTGCCCCCAGACCTCAGTACTCAAAGTGTAACTTCCAGAATTAACAAGGGAGCTGTTAAAATGC AGGTTCGTGGGCTCCGTCCCACATCCATAGAATCCTAGTCCTTGGTTTGGCCCAGGAGTCTGCATTTGAC AAGCTGGCCACATGACTTTGCTGCTTAGTAAATTTTGAGGCTACTCCTTTAAAGAGAACTATCTGTGGCC TTTACCTTTATGATTCCACCGCTCCGTCTGTTCCCCTCCCATGCAAGGGGGAACATGGAACTAAATTAAG AACTGGTTGTCCCGAATTGTCTCTTCCTACACTTCAGAAAGATAGTTTATTTCCTGGAAGGCTGAGGGGC TTCTCCTGCTGTCTCCCATTGGTGGCGATGGACTGTAGTATTTAACAGCATTGCTGTCCAATGCGGAGCA GGAATCCACCTACCTTAACTCTTCCTAATTAAGGGTGTTCTGGAGAAAGTCCCAATGGCAGTGCTATTAG TGATTCCAAGCCTGCTGCCTGCTCAGATGGATATCAGCGGAGGCCGACTGTGATTTGTGCTGCTGTCATC AGAACACACATACAGCTATACAGGGGAGGGCCCTCCCAGCCAGAACAACAGGCTTTGTTTCCAGAATTTA GCCCTTTCTCTTTCGAAGTCCCACCTCCCTCTCCCTGCCCAGACACGCACTGATGGCCTTATTTACTTAA GGTGCGACTTTCCCACACATCATTTGCATAGTCTCCCAGCCCAGTTTTCCCTCCCTACCTTGAAAGAAAG TCAAAACAGAACCTTCACGCTGAGGAAGTTCAGGTTGTGTCCTGCTGCAGAAATAGTTGAATGGCAAGTT ACCTGCAAGTTGTCTTTTGGATTATGTATTACACAGGTTATTTTTTTTTTCACCCCCACATGAGAAAATT TACTGGTTTTTGTTGTTCCCAAGTAGACTGAGTCCCTTTCCCTGGGTATACATGCTTGCTTATTGCAAGC CTGCCAATAATATCAAACTTAATTATGAATCATCATCTGAGGAAAGTCACTTCAATTTCTCATGAGAATC TTAATCATATATTATTAAACTGGGATAACTTGGTTGGTGCCTCTTTTAGGGTCAGTATTTTTATTTGTTT TCTTTTGAAGTCATCCATGGCCTCTTGTGGTTGCTTTTTTATGCTTGGGGATTGAGGTCTCTTTAATTAG GTGAGGTTGGGTCCTCAGCTGCCTCTCCTTGCCTTTATGAGGCAACTTGAAGAGGGCTAGTGATCCTGAA TTTGGAAGAGAATAAGGGAAGACGGTGAGAATATTGCCATTTCGTAATCAGTTCCCTCTTACTATCTTTC AGGCTAAGAATATCAGCCTTGACAGAATGGCTACACCCTTACCTCCCACTAACGTGGGTGTCCGCTTTTG AGAAATTATTTAGATTGTAATTTTGTTCTTATCTTACTCCTTTAGTCACTTGTCACGTTGACATTCCATT TTACATAAACCAGAATCCAGTGTCTAACTTTAAACCACACATTCTAGTGATTTCTTTGCATGTGGGTGTG CATAGCTTGGTTTCAGAAGTTAGGAAGTGGTTAGTCAGTATTCTCAGGGGTTAAGTTGACTCTCAGCCGT GGGTGATTAGCTATTAGCTAGATCCCTATAATTTTCCCATGACAAGGATTTGCTAGCCTGCCTCCCGCTC TTGGGAAACCGAAAGCCTTTCCTTCTGGGGAGCTAGAGGGGGCGGGGGTTGTTTTCCAGAGTTACAGCTG AGCAGCTTAGGGGGTTGGCGCTGATCGTGGCTTTTCCCAGGTCCCGTTCTGGAAACATGTTGCCCATCCC ACCCGCACCCCACCCTCCACCCTCCACCCTCCACGCTCCACCGGGAGGCTAGTTGATGTTTCTCCCTGCC TTCCCCCACCCTTGTTAAAGCTTGGCTCTTGAGAAGGCAATTAAAGTTTCAGAGGGCTTGAAAATTCAAG GGAGAGTGGTTTGAGACGCTGCCCCCTCTCCCACCCCAGATGAAAGTTGTTGTATTTGTTTTTGTTTTTG CTTGGGGATCAGAGGCACTATTTGGCCCCAAAAGAGTATGATTAATCAAGGTGCTTATATAAAAGAACCT CAACTCCGCCAATACTAGATAAATTAAGCAGACTGCTTTCTTTTTTTTTTCTTTTCTTGGCAAAGCAAGA AATCACTATAAATTAGCACACAGTAATGGGACACAAATTATGGAGTTGGTTCCAAGTGTTGTCATTTCCT TCTCCTTCCCTATAGAAGTGGGTTTAGAGAGCCTACTCTGGCTTTGGCCAAGGGAGGGTGCCCCTTTCTC TCCTTGTTTTTTTAAATAAAGCGTCATCGTGAGGCAGTTTCCTGCTGCACTTGGTGGCTTGTTGCATTTC TGTGCACTGGGGTCATGACTTTCTGTGCAGACAAAGAGCAGAGTGGCAAGTGCAGCGTCTGCAGAGACTT TGGCATAGCTCTCTTGTCACCGAGAGAGTCCTTTCCTCTATAGTCTGTCGCAACTAGGTGCACGGGTTGA TTTATTCCATGCCTTCACCTTTGGCTCACTCGTGTGAGCCTGAGAAGAGAGTGGCTTTGTGAAGGGCATC CCCATGCTGGCCTCTTCCCAAACAGCCCTCCTTTTGTCAGGAGTCGGCTGGGAGGGGACCTCAGCTCAAC TGTGAAAATGTTTGTTTATACGGAGCCCCTGATGAGCCTTGGGAGTCTACCTTCCTGTCCCCAGAAACAA AACAGAAAAAGCCTGGACTTTGCAGTCTTCCATTTGAATTGTACAGGTGTCTCTTAACGTTCAAAAGGCT AACCTGGAGGTGTGCTGTGTGTCTCCAGGTGCCAGTACGGCTGGCAAGGCCTGTACTGTGATAAGTGCAT CCCACACCCGGGATGCGTCCACGGCATCTGTAATGAGCCCTGGCAGTGCCTCTGTGAGACCAACTGGGGC GGCCAGCTCTGTGACAAAGGTATGGCCCTTAGGGATGAGACCCAGGGTGGGATCTGGGGGTGGGATGGCA CTAATTTGGTTTCTAATTTTATTGGCAGGGGCTTTTATTCTGAATTCTCCTTGAATGCTGTGTGGGTTTT CTGGTTTTTCTTTTTAAAAGACGACTGGGGCTAGAAACATGGTGGGTTCGCCATCTTCACAGGCGTCTCT TAGTGACTCCAGGATCTTTTTGGCAGATCTCAATTACTGTGGGACTCATCAGCCGTGTCTCAACGGGGGA ACTTGTAGCAACACAGGCCCTGACAAATATCAGTGTTCCTGCCCTGAGGGGTATTCAGGACCCAACTGTG AAATTGGTAAGTGGTCCAAGATGAATGAGAGCCCTTTGTCTAATTTTTCTGTACTCAGCTTTTAAAAAAT ATACTTAAGGACTTGTTTAAGGAAAAAAAAGTGAAAATAGCTTCCAAAGATAGGCCTTATCCCAACCATT CTATAAGCCTTTGTAACTTTCAAGTCTCTAAAGTTTTTTGGGTGATGCTGATTCGTATAGGAGGCAGCGG GAGATGAAATGACCCCAGCTCTGAGATGTCTTGGAATGTGGTTAGAGACAGCTCAGCGAGAAAGATGACT TCCTTTCTTTCCTAGACACAGCAGGGTTCTATCACACGCTTGCTTTTGGTTTTTGAAATATGCTTGCACT AGTGGCTGTGGTGTGGGATTCGGTTGGAGGGGGGTGTGGGGAGGTAACGGTGTGCAGGCATCCCTCTCTG ACTGCCATCCTGGTTTTTGCAGCTGAGCACGCCTGCCTCTCTGATCCCTGTCACAACAGAGGCAGCTGTA AGGAGACCTCCCTGGGCTTTGAGTGTGAGTGTTCCCCAGGCTGGACCGGCCCCACATGCTCTACAAGTAA GTCCAATTTTCAGCCTGTGTCCATTCTAAGGATCCTTGTGCCAAGATACCACGCTGGGGAGAGGTACCTA GGCTTGTCCAGTGTGAATGTCTCGGTGAGAGAGGGGCGGGTGCAGGCCTAAGTCTGGTAAGCAGTCTGGT GGCTTGTGTGTTTGGAAGTCTCCCAGCACCCCCATCCTGTCCCACTAAGGTAGCGCATGTATCTGTTCTT GGAAGGAACGTCCTCGTGGAATCGCTTGTTCCTTTGCATCTGCTTCCTGGAGCTGGCCACCTTCCAATTG TGGTTATTCTTCTTGCAGCCATGGAGAGGCTGCCTTCAGGGGAGGTTGTCACTTACTACTGGATTCTGTC ATAGGGCCAGGGGGCCCCAGAGAAGAACCTGGCCTGCAGAGTTCCTTTGGCTGTGAGACAGGGCTGTATA TCAGAATCACCTGGGCTGCTTTACAGTGTAAATCTCTGGGTCCCCCAGATTCCCTCCAGAATCGGGGAGT CCATGGTCTTTGATAAACTTCTGGAATTCTGCAGTGCAGCCAGGTCTGAGAACCGCTGTCATCAGCACCC CAGGTGTGGTTATGGATGTGGATTTCTGGGGTCAGATTGCCTGTGCTGGTCCTAGGCCCCCACCTGTCAC TTGCGGAACTCCAGCAGGCCACAGAAGCTCCCCGGGCCCTCTTTAAATGGCACAGTAGCAATTCCCATCT CCGAGGTTGTCATAAAGACACAAAAGTGAATACTTCATAAATTGTTAGGAGTTGTCTCTGGTCAGAGCAG AAGTGGAGAATGCAGCCTCTAGGTGTGCTATTTTGGGCAAACTCTGTAAGCAAATGAGAGGAATAAGGTT TTCCACCTGTAAAGAACTATTTTTCCTGACTTCTTAGCTACTTCTGAGCCATGATGAAACTTTTCTTTAA AAATAAAGATTAGGCAGATAGAGATGTCCTGTGTTCCTCCTGGGCGGATGCTCCGTCAGTATCCAGCTGT CTTTCTCCCCCACTGCTTAGGTTGGGGATTACATGAACTGGGGCAGTGGGGGATTTAAAGCTAAAATCAA GGCTTCGGCCTTATCGTCACCGTCCCACTTGTCCTGCTGTAGCTTTCCTTGTAGCAGGTGTCTGGCTCTT CAATGACAGCCCCTCATGTAAGAGGTGATGTTAAAGGATCTAATTGTCAGATGGATTGAATTAAATTGTC AACCCCCTCCTTTTCTTGTTGACCAGACATTGATGACTGTTCTCCTAATAACTGTTCCCACGGGGGCACC TGCCAGGACCTGGTTAACGGATTTAAGTGTGTGTGCCCCCCACAGTGGACTGGGAAAACGTGCCAGTTAG GTAAGAACATCCCTGTGACTGTAATTTTTATACCAAGGTTGGCTTTGATTGTCAAAGCCATTACAGAAGA CGAGCGTGTGGCCGGCAGTGTGAGTTCACACTCCATCATGCTAAGAAGTAATTTATTATCAAGAGTCTAG CAGGCCTGGGAGAAATAACTTGAATGCAAATGGACTAGCTCTTTTAGGCCCTGTGGGAAAGTCGTGGGAT TCCTTGAACCATGTCAATCGTCTGTCCGAGGAGTGTTCAGCTGGGTTCCAAAAGGGGATGATCTCATGAG GAATGAGCTGTCTGCATTCTTTTTGCCACATTTAAATCCCAGCAACTAGGCTGCCTGGGTTTTGCACAGA AATGCCTGGTGGCTTTCTGCTGTTTTGTTGGGGGCTGGTTAACTAGCAGCTGGAAAGTTATCAATTAGGG TTCTTATTGGATAATAGCTAGGGAGAGGGATCAGATGCTTAAAATAGAGGGAACCTCTAGTATCTTTTAT TTAGCTAGCTTATTAAAATGTCTCATGTCTCAGACAAACTCTGGCCTGTTCTTTTTTTTTCCAAGGTGGG GGAGATGGGGGTTGAACTTCATTTCTCATGCTCATCCCCATCTCCTTTCAGATGCAAATGAATGTGAGGC CAAACCTTGTGTAAACGCCAAATCCTGTAAGAATCTCATTGCCAGCTACTACTGCGACTGTCTTCCCGGC TGGATGGGTCAGAATTGTGACATAAGTGAGTGACTTTGTTTCCATTTTGATTTTCATGAAACTTGGGTAG CCGACTTGCTGGTCCGTACTGGGGCTCCAGTCCTAGGACTTGAGCAGTAGAAGGAAAACCTTAGAGTGGG AATGGTTTTTTGAGAGGGAGTGGTCAGGGCAGCAGTGAAAACATACACTTTATCAGGCTCATTAGCTGCG AAAACCAGCCATATTCTGATAATGTGGCTGAAACAATGATGTGAAGTTTCACTCCCTCATTCTGGAAGAA TTAGGGAGGGTCCCCACCCAGCGTAATAACCTTATCTCACGGAAAGCACACAGGAAATCTGATTTGAAAC TTATCTATCCTGAGCTGAGAAGGCTTTTCAATTAAGCCCAATTTCACTGTAAATTACCTCTTTAAAATGA TGACTTATTTATTTTTTAGATATTAATGACTGCCTTGGCCAGTGTCAGAATGACGCCTCCTGTCGGGTAT GTAAATCTTTGCTTAAATCAAAACTTTGACAATTGACAACAAATCTTTAGATTTGTGCGACACTAGGAGA GCTCTGTCCCTGTGAGATTTAAAAATTTGGGTGAAAAAAGAGTCTCTTGGAAGTTTCGCTAGGGCTTATG TTACCCCAGCCTCGTGGGAGTCATTTTGAAGGCATGCACATAGAAATTCCTCTAACCACTTTCAGAGGTT TAGCATTTGGCTATTTCAGTGAACCAGCTAAACCGCAACAGTCATGCTAAACCGCTGAAGCCCTGTGTTT GTGGAATACATAGAAAAAAAGCATGTGTCTCTCTCTCCCCTTCTCCTCTTCTAGGATTTGGTTAATGGTT ATCGCTGTATCTGTCCACCTGGCTATGCAGGCGATCACTGTGAGAGAGACATCGATGAATGTGCCAGCAA CCCCTGTTTGAATGGGGGTCACTGTCAGAATGAAATCAACAGATTCCAGTGTCTGTGTCCCACTGGTTTC TCTGGAAACCTCTGTCAGGTGAGTGGTGGCAAAACCTCAGATGGCCAAGTTTTTAGAGCAGAGCCGCTGC CTCCTCCGCTTCCCTTTACTTTTCCCTCAGCTCTTGTGTCTGGAATTTCCTAACATCTATTAACATCCTA TTGATGAGAGAGTCTCTGCTAGACAAATGCTGGTGGAAGGAGATACTGACGAATTATTTTCTTCTTAGTG TCTTCGTCTTTGTGTTCTTTTTGGTTCCCTCCACCCCCTCTTGTGCTCCCTCTCCCACTCTGCCCCGTTG TTTCAAATACTGGACATTGGCAGTCCCTACAGCATAGAGATGTATCTTACAGGGTGTCTCCTAATAGAAA CCGAAGGAACTGTCAGATTCCAGTGCCTGCTGCCCCAGAGAAGTTATCGTGACACCTTTGTTTTACTCTG ATCCCTCCCCCTTTTCGCTGTTCCTGATATTTGCAGCTGGACATCGATTATTGTGAGCCTAATCCCTGCC AGAACGGTGCCCAGTGCTACAACCGTGCCAGTGACTATTTCTGCAAGTGCCCCGAGGACTATGAGGGCAA GAACTGCTCACACCTGAAAGACCACTGCCGCACGACCCCCTGTGAAGGTACCTCCCTTCTCCCGGGACCT GGCTGTCTCCAGACTTGCTCCTTTTGTCCCCACTTACTACCACTGCCCCTTGTTACACTTGAGAAGTAAT GTATTGGTGAGGAGGACCTCTATAGTGAAATGATCCTGCCTGTGTAGCGGGCCGCAACACGTGGAAACAA TCTATTCCGGCCTGCCAGTGGGAGAGCCGTGTCTACAAGTAGCCCAGGGGAGAGAATGTGAAATCCATTT AGCATTCCTGTTCTGGGGTGGGCTGATGTGCAACGCTGAGGCAAATGCCTGAGAACAACACTGTCAACAG AACTTCCTGCAACGGCAGACAGAGGGGGATGTTCTGTATCTGCACGGTCAGGTATGGGAGCCCCAGGCCA TGTGGACTGTGACTAGTGTAACTAGAAACTGATTTTATTTCATTTTAGTTCATTTAAATGTAAATAGCCA CATGTGGCCGGTGGCTGCTGTATTAGGCAGCACAACATTTAAAGCTTCTATAAGATTGTCCTTGAGCCTT GCTTAAGATCAAAAAGGAAGTAAATAAAGCAGGTCCTTTTGCCTTAGCAAGTGTTTACCAAATTGGGTAG ATGTCAAAGGTAGGATGAAGGGGATCCACAAGCATGTGGGTTTTCCTGGTTGTGTGGAGGGAGAAAATGC TTTAAAACTCTTTGCCTGGAGTCTCAACTTTGCCTGTCATAATGTGATGTGGCACGTTGCCAGTATCTTG GCTTCCCTGGGGTGTGTCTCATTAGCCAGAGGGTCCCTGTCTCCAGGAAAGTGGGCTTGGCCCAGGCCCT TGGCTTAGGAATGCCGCATCTGTGGGTGCATGGCTGTGATCTGATCCCAAGCCTATCTTCTAGTGATTGA CAGCTGCACAGTGGCCATGGCTTCCAACGACACACCTGAAGGGGTGCGGTATATTTCCTCCAACGTCTGT GGTCCTCACGGGAAGTGCAAGAGTCAGTCGGGAGGCAAATTCACCTGTGACTGTAACAAAGGCTTCACGG GAACATACTGCCATGAAAGTAAGACTCCCTCATCCGGGAATGGACCAGTGCTCCCCAGCCTGCCCCTGCC CCTGCCTCTGCCCCTGGCCCACCCTGGGATCATTGGTGTTGAAAGTTTTTTTTTTTTTTTTGAGACCGAA TTTCGCTGTTGTTGCCCAGGCTAGAGTGCAGTGGCACGATCTCGGCTCACCACAACCTCGGCCTCCCAGG TTCAAGCGATTCTCCTGCCTGCCTCAGCCTTCCTGAGTAGCTGGGATTACAGGCATGCGCACCACGCCCA CCACGCCCAGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCCCCATGTTGGTCAGGCTGGTCTCGAAC TCCCAGCCTCAGATGATCCACCCCCCGACCCCCAACTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGA GCCACCATGCCCAGCAGTGTTGAAATTGTTTTAATCAGAAACAGTAAGGCTGGGGAGACTGGTTGAGACT TATCCTTACATCTGGGATCTAAGACTGAGGTCGTGTTCAATTTACCAGATCACTCTGCCTCGGAGCCTCC ATATCTATGTTGGAACATTCTGGAATGTTGCTAGGTTGGGTGATTCCTCTTTTCTGTAGGAGTTTCTTCC CCACTTTCACCTAGTACCGGTGACTAAATGCCCATGTGAGGGCATTAAGTGGGTAAGGCACTCTCTGGAA GCTTCTGCTTGATAAGCCGCCTGTCTAATTTGAGAAACAGCCCTGATGGAGGGTAGCAGGTGGAGGTGCC AGGTGCATTGTGTCAGGAGGGAGCCATGAAAACTGCTGAACAGTGCTTGTCTATGGCTTCACAAGTCCTT CAGTTCTTTTTTTGCTTTACTTTGTTTCATAGATATTAATGACTGTGAGAGCAACCCTTGTAGAAACGGT GGCACTTGCATCGATGGTGTCAACTCCTACAAGTGCATCTGTAGTGACGGCTGGGAGGGGGCCTACTGTG AAACCAGTGAGTCTGCCACTCTTTGGGGAGCTCTGGGATGTATGGGTCATGTTGGAGGGATCCCACTTCA ACGTGGGAAAACTTTCTTTGTACTGGAAATCTCTGGAAGCAAGACCGCAGTGATTTCTGCACTGGGACAG TATCACTTGTGTCTCATTTGCATTTATGAGTCCTGATGATAGCTTATGGGGAGGAGCTTCTGCTGAGGAC CTATAGAATTAGACTGTGTAATAAATATTCCTGCTTGCAAGGAAAGTCATATTTCTACTTTCATTTCCAT GGGACTTCCAGAGGCCCACCCCACATCTTGCCTAACTTGTGGCATTCAAAGTAACCCAGTTGGGAGCTCC TTTATTCCTGGAAAAGCCTGATTGTGTTAAAGTACTACGACTGTGGCTGTTCTCAGAATAGGATGTTGGA TGTAAGCAGTAGGAAAGGCTTGGCTCTCGCCTGTCGTGAATGGTCCTGGATCTCGTCTTCAGCCGATTGT CTCCCCTTTGATTCTAGATATTAATGACTGCAGCCAGAACCCCTGCCACAATGGGGGCACGTGTCGCGAC CTGGTCAATGACTTCTACTGTGACTGTAAAAATGGGTGGAAAGGAAAGACCTGCCACTCACGTAAGTGGT AGTTGGCCTTGGATGCTATCTCTGGGACCCTTCCCTCTGTCTTCTGTGGGAGGGGGCCACTGGGACTCAC ACTGAAATATTTTCCTCCAGGTGACAGTCAGTGTGATGAGGCCACGTGCAACAACGGTGGCACCTGCTAT GATGAGGGGGATGCTTTTAAGTGCATGTGTCCTGGCGGCTGGGAAGGAACAACCTGTAACATAGGTAACT TTATGCCCCACGTGGGATCTGCAGTGGGCATGGCCACCTGGGCGTGTCTGCTGGTTGGCCCCTGGAGCTT ATGATATTTCTCTGGGCCTGGTTCTTGCCCCTCCAGACTGTTTCTGGATACTCAGGGAGGGTGGTCGTGT CTGCTCTTCTTTTATAGCCCGAAACAGTAGCTGCCTGCCCAACCCCTGCCATAATGGGGGCACATGTGTG GTCAACGGCGAGTCCTTTACGTGCGTCTGCAAGGAAGGCTGGGAGGGGCCCATCTGTGCTCAGAGTGAGT GTCCTCCCCCCTTGAACTCTCCCAGGGCTGTCGGAGCAGATCCTGACACCCTTGGGGACTTGCAATGGAA ACCAGAAGCAGAGCTGTTTGATGTCTGCTTTTGTATCACCTGGGTCTGCATTAATGACTTGATGGGATAC AGCCCTGACCTGGGCATGAGAAAGTCGCCAATAAGATAAGTGGAGACAGATGGCGTCTCAGTTCCCAGCT CTGGGTCTGACCAGCAGCCTGTCTCCTTCCATTCTCACCCCCACCCCTATCCCCTACCAGGGCCTCTTCC TGTGTACATGTGTCCCACAGCAAATGAAACTAAGTGTGGTGCGGGCCTGGTTCCAATTTAGCAAAGGTAT TTTGCTGGTGTTAACTACGACTTTATCATTTGGGTATTAGGAAAATAAGTGGTGGTTTTACTTAGGGCTA AGACCGCTTTCCCTGTTGAAGTCCTCACTATTAAGTTGTCTTTTCTTTGCAGATACCAATGACTGCAGCC CTCATCCCTGGTAAGTGTGACATCCTTTTAAGCCAGCACTCATCCACTATCGTGTGTGTGTGTGTGTGTG TGTGTGTGTGTGTGTGTGTGAGAATCACCCAGGGATTGTGTTTAAAATGCAAGTTCTGAGTCAGGAGGTC TGGGGTGGGGCCTCAGACTGCTTTTCTAACAAGCTCCCAGGTGAAGCGATCCTGCTGCCCCATGGACCAC ACTTTAATTAGCCAGGTTGTGTCCTCATTTAGAGCAGTGATTTTTCAACCTTGGCTGCACACCAGAATCA CCTGGGAGCTTTTAAAAATCCCGCTGCCTGGGCTGCAACCAAGACCTGTGAAATTAGACTTTCTGGGGGT GGGACCCAGGCATCAGTATTCTTTTAAAATTCCCCAGGCAACGGCCATGGGGTGAGAGCCACTGACTGTA ACTGGTGTGGTGACATGTGAGTGATTGGCAGCCAGAGTAATGGACTGGGAGGTTGGTAACCAAGGTGGTC TTTGCTTTCTTAGTTACAACAGCGGCACCTGTGTGGATGGAGACAACTGGTACCGGTGCGAATGTGCCCC GGGTTTTGCTGGGCCCGACTGCAGAATAAGTAAGGACTGTCTCCGTCTGGTTTTCCCAATGGCTTTACCG CTTCATTCCATGCCTCACCCCAAGACTTTCATCTTTAAAAACAAAGCCACCATTCCCTTTAAGTAGCTCT CATAGAGCAAAGGATCTCTCTCCTCCAGCTGGGATTAAGATATGCCAGGCTGGATCCTCCCAGGTACCTG CTGGTAGTTCCCTGGGTGGTGTAGCCCTCCTTGTTCTTGGGGAGAGAGTGCCAGTCACAGAATCTGATGA TTAATCTACAGTGGGGTCCTGAAGAAAGTATGTGCATTTCCCCATGACTAACATGAAATTATGGGCAAGC AGATGTTAACCACAGCTACACTGGTATAGGATAAAGCTAATACAAACGGAAGGGAGGACGACTGTGGCTT CCAGAGGCTTGTCTGTGCTGGGTCTGATCAGGCCCTGGAGAAATGACTAAAACAGGAAAATAGGGGCAGG CAACGCAGTTTTTCAAGAGGCTTAAAGCATATTATTTTGAGCCTTTTCTCTACTTTTTTACAAGCCCTTT CTCTTACAGAACAAAAAAGGTGCTAGAGTAGTTATGGTTTGATTCTTGTACCCAAATTGTCTGAAATTTT ACTGGTGCTTGAAATCCAAGTCTGGGATTAACTAGTCTTCAGCACTAGATGGGGGCAGGTTGTATCTGTT TCATGTTTCTAAATAAACAGTTGGCAAACTGTGGCCCAGGGGCCGTATCCAGCCCACTGTCTGTTTTTAT AAATACAGTTTTCTTGGCACACAGCCACACATTCATTTATGTATTGTCTATGGCTACTTTCATGATACCA CAAGAGTTGGATAGTTGTGACAGAGACTATATACCCCACAAAGCCTAAGATGTTTACTGTCTGACCCCTT CCAGGAAACTTTGCCAGGCTTGCTGTAAATTGCACTGTCAAAGGAATCAAATTAAAAATTGCTGCCTCCC AAAATGGTTCTCCACTGTTAGAACTCAGGATGGTGGTGGTCTTTGGGAGCCAGTGATTGGAGGTTTTTGC AATAGATCTGTTTCTTCTTTTGGATGCTGCTTACCTGAGTGAAAATTCATCAAGCTTATGATGATATGCT TTTCTTGTATGTTATGTCAATAAAAACAATCTCAAAACATTGCCACACACCATCAGTCCCTAAACTTGAA CTCCATTTCTCCTAGACATCAATGAATGCCAGTCTTCACCTTGTGCCTTTGGAGCGACCTGTGTGGATGA GATCAATGGCTACCGGTGTGTCTGCCCTCCAGGGCACAGTGGTGCCAAGTGCCAGGAAGGTATGTGTGCC AGGCTTCAGCTGCCCATGGGTCTTCTGGGGTGAGCGAGCTTTGCAGTCACCATTTGACTTTTCACAAATA AGCCACTGTGCTCAGGGAAGGGAACACACAGTGGGACTACAAGGGAAAGGGAACGTGAAGAGTCTTCCCC AAAACAGGTAGCTGTTGTTTTTGGTCAGCTGTTGCCACAAAACTGTGTACCAAACCATCCCAAACTGCTG TGGCTTGCAGCAAGCATTATTTTTATTGCTCATGATATGCAGCATGGGCAGAGAGATTGCGCTGTGGGTT GGGTTCAGTTCGACCAGTGGCTGTGTCTGGGGCATATTCCTTTCATCGCCAGTGGGTAGGTGTGCAAGAG GCTAGTCAAAGGCTCTGCTCACATCACATCTGCCAATGTTACATTGGCCAGAGCAAGTCTTGTGGCCAAG CGCAGAGCCAGCAAAGGCAGGAAGTACACATGCTGTTACTGTGGGAAGAATGATCTTAACATGGCAAAGG GCACAGGCATAACCATTTCATAACAGGGACCAAAGAATTGAACCCCGATCCGGTTCACAGAAAAATAAAC TGCTCACCCGTCTCCACCTGTCAGTTTCAGGGAGACCTTGCATCACCATGGGGAGTGTGATACCAGATGG GGCCAAATGGGATGATGACTGTAATACCTGCCAGTGCCTGAATGGACGGATCGCCTGCTCAAAGGTAGGA CATGATGGCTGCCGCAGTTCACCTGTGTTCTGGAATCAGGGATGAGCATGCCTGCTAAGCTGCCAGCTTC TGTTTTTCTCCAGGTCTGGTGTGGCCCTCGACCTTGCCTGCTCCACAAAGGGCACAGCGAGTGCCCCAGC GGGCAGAGCTGCATCCCCATCCTGGACGACCAGTGCTTCGTCCACCCCTGCACTGGTGTGGGCGAGTGTC GGTCTTCCAGTCTCCAGCCGGTGAAGACAAAGTGCACCTCTGACTCCTATTACCAGGATAACTGTGCGAA CATCACATTTACCTTTAACAAGGAGATGATGTCACCAGTATGTAACAACCTTTGTTTTTTTTTTGAATGG TGGATGTCTGCTTGCTTGCTTTAAAGGAGGAATGCCATGAGCTAGGATCTACTTCTCCCTAGCTTACATT CCTGTTTTATAATAAAGTAAGCTTGAACTTAGCCAGCCTCAAAGAGAACATCTCAGCCTTTTGTTCTTCC TCTCAATCTTACACGTGTGTGGGTTTTTAAAAATCGTTTTAGGGTCTTACTACGGAGCACATTTGCAGTG AATTGAGGAATTTGAATATTTTGAAGAATGTTTCCGCTGAATATTCAATCTACATCGCTTGCGAGCCTTC CCCTTCAGCGAACAATGAAATACATGTGGCCATTGTAAGTATAAGACCCATTCACACCTCATTATTCGAT GGCAAGGCAGTTCGGTTAACCAGTGTCTGAATGGAGCAAATTCACTGACAAAAAGCTTTGCAGACACAGA TTGTCGAGTAATTTTGAAGAAAGGCTGCTTTGAGTATTCCTCTGACTCTCAAGTCTGACAATTGTTTTTC CAGTCTGCTGAAGATATACGGGATGATGGGAACCCGATCAAGGAAATCACTGACAAAATAATCGATCTTG TTAGTAAACGTGATGGAAACAGCTCGCTGATTGCTGCCGTTGCAGAAGTAAGAGTTCAGAGGCGGCCTCT GAAGAACAGAACAGGTAGGTGTCAAGTGGGACTAGTTTGTGTGATGATAGTAGATGATCTCATTATACTA TTCAATAAAGCCATCAGGTCGAGGGATTATCTGGCAGTGCCCTACCCTCGCAGGAGCTCCCAATTTAACT GAGAACTGAGGGCAGCCTACTTTACTAAGGTCACATGGCCCATGGGAACAGAGGTCTGCCTCATATTTTC CTTCCCAACACACTATGCAACGTTCCCTGCAGAACAGGTATTGTGCTAGATCCGTGACAAAGCCCTAGGA CACTGCTTGTCCTTTGTCCTTGAGTTTGAAGCTGTACAAAGCCTGACTTGGCATTTTGGTGTCCTGGGAC AGCCTAGCCACTGCTGAGCTCTGTGAGGCTCGATGGCCCCGCAGGGGTGTCCAGGCTTCCCTCCTGAGGA TCTCGAGCACCGTTTCAGCCAAGGGAGAGATTGGGCATGGAGCCATGGCACGTTTGAGCTGTCTGTGCTA ATTTGAATCGGATTTCTAGTTCTGAAAACCAACTCCTGTACTGAGCTGCCTCAGTAGCCAGACTTAACAA GACACTGCTCTCCCCATGCGAAGTCAAAGAGCCTGTAGGAGCTGCCGCTCCACCCAGTCTCTCCAGGGAT AAGAGTATCAAGGTCTACAGGGGCCTGATCCCAGCATTTGCTTATCAAGTTGTGAAGTGACCATATGCAA TGATGAAAAGGGACTTGTCCCTGTGGCCCCCCTCTTAGGGATAAAGGGCAGGAGAACCACTGTTGGTATT CTTTTGTTCCTGCGATGATGCTTTTTTCTTTCTTTCTTGGAGAGTTAATTGGTTTTGTGCCTGCCTTACA GATTTCCTTGTTCCCTTGCTGAGCTCTGTCTTAACTGTGGCTTGGATCTGTTGCTTGGTGACGGCCTTCT ACTGGTGCCTGCGGAAGCGGCGGAAGCCGGGCAGCCACACACACTCAGCCTCTGAGGACAACACCACCAA CAACGTGCGGGAGCAGCTGAACCAGATCAAAAACCCCATTGAGAAACATGGGGCCAACACGGTCCCCATC AAGGATTATGAGAACAAGAACTCCAAAATGTCTAAAATAAGGACACACAATTCTGAAGTAGAAGAGGACG ACATGGACAAACACCAGCAGAAAGCCCGGTTTGCCAAGCAGCCGGCGTACACGCTGGTAGACAGAGAAGA GAAGCCCCCCAACGGCACGCCGACAAAACACCCAAACTGGACAAACAAACAGGACAACAGAGACTTGGAA AGTGCCCAGAGCTTAAACCGAATGGAGTACATCGTATAGCAGACCGCGGGCACTGCCGCCGCTAGGTAGA GTCTGAGGGCTTGTAGTTCTTTAAACTGTCGTGTCATACTCGAGTCTGAGGCCGTTGCTGACTTAGAATC CCTGTGTTAATTTAAGTTTTGACAAGCTGGCTTACACTGGCAATGGTAGTTTCTGTGGTTGGCTGGGAAA TCGAGTGCCGCATCTCACAGCTATGCAAAAAGCTAGTCAACAGTACCCTGGTTGTGTGTCCCCTTGCAGC CGACACGGTCTCGGATCAGGCTCCCAGGAGCCTGCCCAGCCCCCTGGTCTTTGAGCTCCCACTTCTGCCA GATGTCCTAATGGTGATGCAGTCTTAGATCATAGTTTTATTTATATTTATTGACTCTTGAGTTGTTTTTG TATATTGGTTTTATGATGACGTACAAGTAGTTCTGTATTTGAAAGTGCCTTTGCAGCTCAGAACCACAGC AACGATCACAAATGACTTTATTATTTATTTTTTTTAATTGTATTTTTGTTGTTGGGGGAGGGGAGACTTT GATGTCAGCAGTTGCTGGTAAAATGAAGAATTTAAAGAAAAAAATGTCAAAAGTAGAACTTTGTATAGTT ATGTAAATAATTCTTTTTTATTAATCACTGTGTATATTTGATTTATTAACTTAATAATCAAGAGCCTTAA AACATCATTCCTTTTTATTTATATGTATGTGTTTAGAATTGAAGGTTTTTGATAGCATTGTAAGCGTATG GCTTTATTTTTTTGAACTCTTCTCATTACTTGTTGCCTATAAGCCAAAATTAAGGTGTTTGAAAATAGTT TATTTTAAAACAATAGGATGGGCTTCTGTGCCCAGAATACTGATGGAATTTTTTTGTACGACGTCAGATG TTTAAAACACCTTCTATAGCATCACTTAAAACACGTTTTAAGGACTGACTGAGGCAGTTTGAGGATTAGT TTAGAACAGGTTTTTTTGTTTGTTTGTTTTTTGTTTTTCTGCTTTAGACTTGAAAAGAGACAGGCAGGTG ATCTGCTGCAGAGCAGTAAGGGAACAAGTTGAGCTATGACTTAACATAGCCAAAATGTGAGTGGTTGAAT ATGATTAAAAATATCAAATTAATTGTGTGAACTTGGAAGCACACCAATCTTACTTTGTAAATTCTGATTT CTTTTCACCATTCGTACATAATACTGAACCACTTGTAGATTTGATTTTTTTTTTTAATCTACTGCATTTA GGGAGTATTCTAATAAGCTAGTTGAATACTTGAACCATAAAATGTCCAGTAAGATCACTGTTTAGATTTG CCATAGAGTACACTGCCTGCCTTAAGTGAGGAAATCAAAGTGCTATTACGAAGTTCAAGATCAAAAAGGC TTATAAAACAGAGTAATCTTGTTGGTTCACCATTGAGACCGTGAAGATACTTTGTATTGTCCTATTAGTG TTATATGAACATACAAATGCATCTTTGATGTGTTGTTCTTGGCAATAAATTTTGAAAAGTAATATTTATT AAATTTTTTTGTATGAAAACATGGAACAGTGTGGCCTCTTCTGAGCTTACGTAGTTCTACCGGCTTTGCC ATGTGCTTCTGCCACCCTGCTGAGTCTGTTCTGGTAATCGGGGTATAATAGGCTCTGCCTGACAGAGGGA TGGAGGAAGAACTGAAAGGCTTTTCAACCACAAAACTCATCTGGAGTTCTCAAAGACCTGGGGCTGCTGT GAAGCTGGAACTGCGGGAGCCCCATCTAGGGGAGCCTTGATTCCCTTGTTATTCAACAGCAAGTGTGAAT ACTGCTTGAATAAACACCACTGGATTAATGGCC Download Select all
Length	36363
OMIM ID	601920
HGNC ID	HGNC:6188
Unigene ID	Hs.224012
Ensembl ID	ENSG00000101384
PharmGKB ID	PA29986

mRNA Information

mRNA ID	XM_011529163.1
Exon	complement(<35501..>36363)
mRNA Sequence	Download Select all
Length	3345

CDS Information

Location	937..1425
CDS Sequence	Download Select all
CCDS ID	CCDS13112.1

Protein Information

Protein ID	XP_011527465.1
Protein Name	jagged 1
Molecular Wt. (Da)	18186
Protein Sequence	>lcl\|XM_011529163.1_prot_XP_011527465.1_1 [gene=SLX4IP] [protein=protein SLX4IP isoform X5] [protein_id=XP_011527465.1] [location=937..1425] MASKKFAVKCGNFAVLVDLHILPQGSNKDTSWFSEQKKEEVCLLLKETIDSRVQEYLEVRKQHRPSNAEF TRSNPLSLKGYGFQITAYFLKRGIRLRCIRSTQNAELCVFPDRFVVCVSQLAFSRDLLASQNEDLHLAAT QGILGSCRIQVYKPPEQGFASG Download Select all
Length	162
Uniprot ID	P43357
Ensembl Protein ID	ENSP00000359301

Post-translational Modification Information (Source : HPRD)

No matching records could be found.

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
4301	MLLT4	1164	NP_001035090.1	yeast 2-hybrid	9707552
4851	NOTCH1	1827	NP_060087.3	in vitro;in vivo	11006133
4853	NOTCH2	2606	NP_077719.2	in vitro;in vivo	1 055 186 310 958 680
4854	NOTCH3	2607	NP_000426.2	in vitro;in vivo	1 471 427 412 482 950
7057	THBS1	1765	NP_003237.2	yeast 2-hybrid	15258909
23509	POFUT1	6319	NP_056167.1	in vivo	12036964

Pathway Information

Pathway Name	Pathway ID
Notch signaling pathway	hsa04330
TNF signaling pathway	hsa04668

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd00054	629-665	EGF_CA
cl21504	629-665	EGF_CA superfamily
cd00054	487-523	EGF_CA
cl21504	487-523	EGF_CA superfamily
cd00054	820-856	EGF_CA
cl21504	820-856	EGF_CA superfamily
cd00054	374-410	EGF_CA
cl21504	374-410	EGF_CA superfamily
cd00054	667-702	EGF_CA
cl21504	667-702	EGF_CA superfamily
cd00054	296-334	EGF_CA
cl21504	296-334	EGF_CA superfamily
cd00054	450-485	EGF_CA
cl21504	450-485	EGF_CA superfamily
cd00054	782-817	EGF_CA
cl21504	782-817	EGF_CA superfamily
cd00054	525-560	EGF_CA
cl21504	525-560	EGF_CA superfamily
cd00054	412-447	EGF_CA
cl21504	412-447	EGF_CA superfamily
cd00054	750-779	EGF_CA
cl21504	750-779	EGF_CA superfamily
pfam07657	31-110	MNNL
cl06622	31-110	MNNL superfamily
pfam01414	167-229	DSL
cl19567	167-229	DSL superfamily
smart00051	167-229	DSL
smart00215	863-930	VWC_out
cl17735	863-930	VWC superfamily
smart00179	629-665	EGF_CA
smart00179	487-523	EGF_CA
smart00179	820-856	EGF_CA
smart00179	374-410	EGF_CA
smart00179	450-485	EGF_CA
smart00179	667-702	EGF_CA
smart00179	296-334	EGF_CA
smart00179	525-560	EGF_CA
smart00214	863-925	VWC
smart00179	782-817	EGF_CA
smart00179	412-448	EGF_CA
pfam00008	672-701	EGF
cd00053	634-661	EGF
cd00053	749-777	EGF

Ontology Information

HPRD ID	4005
Molecular Class	Cell surface receptor
Molecular Function	Protein binding (GO:0005515)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO

CoReCG

Search results:

General Information

Evidence Information

Gene Details

mRNA Information

CDS Information

Protein Information

Post-translational Modification Information (Source : HPRD)

Enzyme Information

PPi Information

Pathway Information

Structure Information

Domain Information

Ontology Information

SNP Information

Drug Information

External Links

Important Information