Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| DSG2 | 1829 | Desmoglein 2 | 18 | HDGC; CDHF5; ARVC10; ARVD10; CMD1BB |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and Normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis. | Up-regulation | - | This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. CRC tissue was collected at the VU University Medical Center, Amsterdam, The Netherlands. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Cadherins / Major cadherins |
| Description | Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. This gene product is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jul 2008] |
| Chromosome | 18 |
| Location | 18q12.1 |
| Start | 31498064 |
| End | 31548851 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 50788 |
| OMIM ID | 125671 |
| HGNC ID | HGNC:3049 |
| Unigene ID | Hs.412597 |
| Ensembl ID | ENSG00000046604 |
| PharmGKB ID | PA27502 |
mRNA Information
| mRNA ID | NM_001943.3 |
|---|---|
| Exon | join(1..233,20176..20211,21740..21874,22740..22901, 23036..23180,24020..24186,26385..26522,26640..26825, 32924..33189,37207..37349,38139..38366,40688..40915, 43130..43251,44457..44789,47658..50788) | mRNA Sequence | Download Select all |
| Length | 5677 |
CDS Information
| Location | join(189..233,20176..20211,21740..21874,22740..22901, 23036..23180,24020..24186,26385..26522,26640..26825, 32924..33189,37207..37349,38139..38366,40688..40915, 43130..43251,44457..44789,47658..48680) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS42423.1 |
Protein Information
| Protein ID | NP_001934.2 |
|---|---|
| Protein Name | Desmoglein 2 |
| Molecular Wt. (Da) | 119890 |
| Protein Sequence | Download Select all |
| Length | 1118 |
| Uniprot ID | P61769 |
| Ensembl Protein ID | ENSP00000452780 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 968 |
| S | Phosphorylation | 680;- |
| Y | Phosphorylation | 1013;- |
| S | Phosphorylation | 703 |
| N | Glycosylation | 462 |
| N | Glycosylation | 182 |
| N | Glycosylation | 193 |
| N | Glycosylation | 190 |
| T | Phosphorylation | 922 |
| S | Phosphorylation | 782 |
| T | Phosphorylation | 733 |
| T | Phosphorylation | 903 |
| Y | Phosphorylation | 1012 |
| Y | Phosphorylation | 978 |
| T | Phosphorylation | 552 |
| S | Phosphorylation | 559 |
| T | Phosphorylation | 645 |
| S | Phosphorylation | 1021 |
| S | Phosphorylation | 1118 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1823 | DSC1 | 511 | NP_077739.1 | in vitro;in vivo | 9214392 |
| 1824 | DSC2 | 512 | NP_077740.1 | in vitro | 11853539 |
| 11187 | PKP3 | 5711 | NP_009114.1 | in vivo;yeast 2-hybrid | 12707304 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | hsa05412 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd11304 | 163-268 | Cadherin_repeat |
| cl15786 | 163-268 | CA_like superfamily |
| cd11304 | 392-495 | Cadherin_repeat |
| cl15786 | 392-495 | CA_like superfamily |
| cd11304 | 62-155 | Cadherin_repeat |
| cl15786 | 62-155 | CA_like superfamily |
| cd11304 | 276-382 | Cadherin_repeat |
| cl15786 | 276-382 | CA_like superfamily |
| smart00112 | 182-270 | CA |
| pfam00028 | 164-262 | Cadherin |
| smart00112 | 414-497 | CA |
| smart00112 | 75-157 | CA |
| pfam00028 | 396-490 | Cadherin |
| pfam00028 | 281-377 | Cadherin |
| cd00031 | 53-155 | CA_like |
| pfam00028 | 97-150 | Cadherin |
| smart00112 | 294-382 | CA |
| pfam01049 | 785-842 | Cadherin_C |
| cl03079 | 785-842 | Cadherin_C superfamily |
Ontology Information
| HPRD ID | 189 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | MHC class I receptor activity (GO:0030106); MHC class II receptor activity (GO:0045012) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.