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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| DUSP1 | 1843 | Dual specificity phosphatase 1 | 5 | HVH1; MKP1; CL100; MKP-1; PTPN10 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22930170 | 2012 | Cell line : KM 12C, KM 12SM, HT 31 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Microarray analysis,Real time RT-PCR and Flow cytometry | Up-regulation | - | Gene differentially expressed and analysed bye by Microarray. KM12C, KM12SM (SM), HT-29 cell line were used for this study. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Protein tyrosine phosphatases / Class I Cys-based PTPs : MAP kinase phosphatases |
| Description | The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008] |
| Chromosome | 5 |
| Location | 5q34 |
| Start | 172768090 |
| End | 172771200 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 3111 |
| OMIM ID | 600714 |
| HGNC ID | HGNC:3064 |
| Unigene ID | Hs.171695 |
| Ensembl ID | ENSG00000120129 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_004417.3 |
|---|---|
| Exon | join(1..615,895..1040,1407..1626,2069..3111) | mRNA Sequence | Download Select all |
| Length | 2040 |
CDS Information
| Location | join(249..615,895..1040,1407..1626,2069..2439) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS4380.1 |
Protein Information
| Protein ID | NP_004408.1 |
|---|---|
| Protein Name | Dual specificity phosphatase 1 |
| Molecular Wt. (Da) | 39167 |
| Protein Sequence | Download Select all |
| Length | 367 |
| Uniprot ID | O60241 |
| Ensembl Protein ID | ENSP00000362759 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 359 |
| S | Phosphorylation | 364 |
| S | Phosphorylation | 296 |
| S | Phosphorylation | 323 |
Enzyme Information
| EC | 3.1.3.16 |
|---|---|
| Name | phosphoprotein phosphatase protein phosphatase-1 protein phosphatase-2A protein phosphatase-2B protein phosphatase-2C protein D phosphatase phosphospectrin phosphatase casein phosphatase Aspergillus awamori acid protein phosphatase calcineurin phosphatase 2A phosphatase 2B phosphatase II phosphatase IB phosphatase C-II polycation modulated (PCM-) phosphatase phosphopyruvate dehydrogenase phosphatase phosphatase SP branched-chain alpha-keto acid dehydrogenase phosphatase BCKDH phosphatase 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase HMG-CoA reductase phosphatase phosphatase H-II phosphatase III phosphatase I protein phosphatase phosphatase IV |
| Class | Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases |
| Sysname | phosphoprotein phosphohydrolase |
| Substrate | phosphoprotein [CPD:C00562]; H2O |
| Product | protein [CPD:C00017]; phosphate |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1163 | CKS1B | 299 | NP_001817.1 | in vitro | 18519678 |
| 1432 | MAPK14 | 2619 | NP_001306.1 | in vivo | 7535770 |
| 3308 | HSPA4 | 9025 | NP_002145.3 | in vivo | 15677475 |
| 6502 | SKP2 | 3256 | NP_005974.2 | in vitro | 18519678 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MAPK signaling pathway | hsa04010 |
| Serotonergic synapse | hsa04726 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00127 | 173-309 | DSPc |
| cl21483 | 173-309 | PTPc superfamily |
| cd01446 | 7-136 | DSP_MapKP |
| cl00125 | 7-136 | RHOD superfamily |
| smart00195 | 174-309 | DSPc |
| pfam00782 | 181-311 | DSPc |
| smart00450 | 21-134 | RHOD |
| pfam00581 | 13-130 | Rhodanese |
| smart00404 | 217-293 | PTPc_motif |
| smart00012 | 217-293 | PTPc_DSPc |
| cd00158 | 13-128 | RHOD |
| cd00047 | 217-293 | PTPc |
| cd01525 | 16-51 | RHOD_Kc |
| pfam14566 | 218-275 | PTPlike_phytase |
| cd01530 | 13-46 | Cdc25 |
| COG2453 | 188-313 | CDC14 |
| PRK12361 | 176-319 | PRK12361 |
| pfam00102 | 217-293 | Y_phosphatase |
| PHA02747 | 217-314 | PHA02747 |
| smart00194 | 217-293 | PTPc |
Ontology Information
| HPRD ID | 4063 |
|---|---|
| Molecular Class | Dual specificity phosphatase |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.