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General Information
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22688350 | 2014 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry | Down-regulation | - | E2F2 was expressed in 41 cases at low levels. |
| 24793496 | 2014 | Cell line : SW620 Source : - Sample Type : - No. of Sample : - Stage : - | Western blotting,Luciferase reporter assay,Transfection, cell viability assay, real time RT-PCR | Down-regulation | - | E2F2 acts as a tumor suppressor in colorectal carcinoma. miR-155 plays an important role in colorectal carcinoma tumorigenesis by negative regulation of its targets including E2F2. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008] |
| Chromosome | 1 |
| Location | 1p36 |
| Start | 23832920 |
| End | 23857712 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 24793 |
| OMIM ID | 600426 |
| HGNC ID | HGNC:3114 |
| Unigene ID | Hs.194333 |
| Ensembl ID | ENSG00000007968 |
| PharmGKB ID | PA27572 |
mRNA Information
| mRNA ID | XM_011540870.1 |
|---|---|
| Exon | join(337..709,6763..6868,9195..9414,10180..10338, 12121..12235,14724..14916,25066..25277) | mRNA Sequence | Download Select all |
| Length | 1378 |
Protein Information
| Protein ID | XP_011539172.1 |
|---|---|
| Protein Name | E2F transcription factor 2 |
| Molecular Wt. (Da) | 38023 |
| Protein Sequence | Download Select all |
| Length | 350 |
| Uniprot ID | O15162 |
| Ensembl Protein ID | ENSP00000345494 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 130 |
| S | Phosphorylation | 133 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1018 | CDK3 | 446 | NP_001249.1 | in vivo | 117 330 018 846 921 |
| 5925 | RB1 | 1574 | NP_000312.2 | in vitro;in vivo | 773 953 788 323 941 000 000 000 000 000 |
| 6667 | SP1 | 1796 | NP_612482.2 | in vitro | 865 714 296 947 918 000 000 |
| 7027 | TFDP1 | 1792 | NP_009042.1 | in vivo | 77 395 378 755 520 |
| 7528 | YY1 | 2482 | NP_003394.1 | in vitro;in vivo;yeast 2-hybrid | 12411495 |
| 9564 | BCAR1 | 4248 | NP_055382.2 | yeast 2-hybrid | 16169070 |
| 387893 | SETD8 | 6254 | NP_065115.3 | yeast 2-hybrid | 12411495 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Bladder cancer | hsa05219 |
| Cell cycle | hsa04110 |
| Chronic myeloid leukemia | hsa05220 |
| Glioma | hsa05214 |
| Hepatitis B | hsa05161 |
| HTLV-I infection | hsa05166 |
| Melanoma | hsa05218 |
| MicroRNAs in cancer | hsa05206 |
| Non-small cell lung cancer | hsa05223 |
| Pancreatic cancer | hsa05212 |
| Pathways in cancer | hsa05200 |
| Prostate cancer | hsa05215 |
| Small cell lung cancer | hsa05222 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd14660 | 206-306 | E2F_DD |
| cl22411 | 206-306 | E2F_DD superfamily |
| pfam02319 | 129-194 | E2F_TDP |
| cl03534 | 129-194 | E2F_TDP superfamily |
Ontology Information
| HPRD ID | 2598 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | DNA repair protein (GO:0003685) |
| Biological Process | DNA repair (GO:0006281) |
Drug Information
No matching records could be found.