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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23674142 | 2013 | Cell line : SW1116 Source : - Sample Type : - No. of Sample : - Stage : - | Microarray,Real time RT-PCR,Dual-luciferase report assay,Western blotting ,Cell viability assay | Down-regulation | - | miR-449b downregulates CCND1 and E2F3 expression. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013] |
| Chromosome | 6 |
| Location | 6p22 |
| Start | 20402137 |
| End | 20493945 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 91809 |
| OMIM ID | 600427 |
| HGNC ID | HGNC:3115 |
| Unigene ID | Hs.269408 |
| Ensembl ID | ENSG00000112242 |
| PharmGKB ID | PA27573 |
mRNA Information
| mRNA ID | XM_011515046.1 |
|---|---|
| Exon | complement(join(<1..257,364..475,520..867)) | mRNA Sequence | Download Select all |
| Length | 1875 |
Protein Information
| Protein ID | XP_011513348.1 |
|---|---|
| Protein Name | E2F transcription factor 3 |
| Molecular Wt. (Da) | 37982 |
| Protein Sequence | Download Select all |
| Length | 355 |
| Uniprot ID | P29590 |
| Ensembl Protein ID | ENSP00000268058 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 890 | CCNA2 | 453 | NP_001228.1 | in vitro;in vivo | 11980909 |
| 1018 | CDK3 | 446 | NP_001249.1 | in vivo | 117 330 018 846 921 |
| 5925 | RB1 | 1574 | NP_000312.2 | in vivo | 88 323 947 739 537 |
| 6667 | SP1 | 1796 | NP_612482.2 | in vitro | 8657141 |
| 7027 | TFDP1 | 1792 | NP_009042.1 | in vivo | 77 395 378 755 520 |
| 7030 | TFE3 | 2439 | NP_006512.2 | in vitro;in vivo;yeast 2-hybrid | 12748276 |
| 7528 | YY1 | 2482 | NP_003394.1 | in vitro;in vivo;yeast 2-hybrid | 12411495 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Bladder cancer | hsa05219 |
| Cell cycle | hsa04110 |
| Chronic myeloid leukemia | hsa05220 |
| Glioma | hsa05214 |
| Hepatitis B | hsa05161 |
| HTLV-I infection | hsa05166 |
| Melanoma | hsa05218 |
| MicroRNAs in cancer | hsa05206 |
| Non-small cell lung cancer | hsa05223 |
| Pancreatic cancer | hsa05212 |
| Pathways in cancer | hsa05200 |
| Prostate cancer | hsa05215 |
| Small cell lung cancer | hsa05222 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd14660 | 254-354 | E2F_DD |
| cl22411 | 254-354 | E2F_DD superfamily |
| pfam02319 | 178-243 | E2F_TDP |
| cl03534 | 178-243 | E2F_TDP superfamily |
Ontology Information
| HPRD ID | 1337 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.