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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ECHS1 1892 enoyl CoA hydratase, short chain, 1, mitochondrial  10SCEH 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25279201   2014Cell line : -

Source : Chenggong Hospital Affiliated to Xiamen University.

Sample Type : CRC tumor and normal tissue

No. of Sample : 148

Stage : TNM Stage I-IV

Immunohistochemistry,Western blottingUp-regulation- ECHS1 protein expression may contribute to the occurrence, progression and metastasis of CRC, is closely associated with prognosis and may provide useful information for CRC molecular-targeted therapy.


Gene Details



NC_000010.10 (135175987..135186908, complement)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene functions in the second step of the mitochondrial fatty acid beta-oxidation pathway. It catalyzes the hydration of 2-trans-enoyl-coenzyme A (CoA) intermediates to L-3-hydroxyacyl-CoAs. The gene product is a member of the hydratase/isomerase superfamily. It localizes to the mitochondrial matrix. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. [provided by RefSeq, Jul 2008]  
Chromosome 10
Location 10q26.2-q2
Start 135175987  
End 135186908  
Strand -  
Gene Sequence

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Length 10922  
OMIM ID 602292   
HGNC ID HGNC:3151   
Unigene ID Hs.76394   
Ensembl ID ENSG00000127884   
PharmGKB ID PA27597   

mRNA Information


mRNA ID NM_004092.3
Exon join(1..159,2648..2845,3374..3501,4383..4482,6412..6516, 7310..7429,8680..8747,10472..10922)  
mRNA Sequence

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Length 1350  



CDS Information


   
Location72..944
CDS Sequence

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CCDS ID CCDS7681.1



Protein Information


      
Protein IDNP_004083.3
Protein Nameenoyl CoA hydratase, short chain, 1, mitochondrial
Molecular Wt. (Da)31256
Protein Sequence

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Length 290  
Uniprot IDP06746
Ensembl Protein ID ENSP00000265421  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KAcetylation118
TPhosphorylation251
SPhosphorylation186

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
150472CBWD216687NP_742000.1yeast 2-hybrid16169070   


Pathway Information


                                                                  
Pathway Name Pathway ID
beta-Alanine metabolism hsa00410
Butanoate metabolism hsa00650
Carbon metabolism hsa01200
Fatty acid degradation hsa00071
Fatty acid elongation hsa00062
Fatty acid metabolism hsa01212
Lysine degradation hsa00310
Metabolic pathways hsa01100
Propanoate metabolism hsa00640
Tryptophan metabolism hsa00380
Valine, leucine and isoleucine degradation hsa00280


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0655836-229  crotonase-like
cl2146636-229  crotonase-like superfamily
PRK0614356-284  PRK06143
PRK0832123-289  PRK08321
PRK0586933-250  PRK05869
PRK0711247-209  PRK07112
PRK08788131-214  PRK08788
PLN0321469-248  PLN03214
PRK0621344-254  PRK06213
PLN0226765-231  PLN02267
cd0702367-170  S49_Sppa_N_C
PRK0586232-288  PRK05862
pfam0037840-282  ECH
PRK0967447-288  PRK09674
PRK0813847-290  PRK08138
COG102432-287  CaiD
PRK0580933-290  PRK05809
PRK0765744-288  PRK07657
PRK0765847-290  PRK07658
PRK0668847-289  PRK06688
PRK0598036-287  PRK05980
PRK0649431-288  PRK06494
PRK0924534-289  PRK09245
PRK0619036-259  PRK06190
PRK0907634-290  PRK09076
PRK0825239-284  PRK08252
PRK0358050-288  PRK03580
PRK0649547-289  PRK06495
PRK0813952-290  PRK08139
PRK0779934-288  PRK07799
PRK0621047-288  PRK06210
PLN0260050-284  PLN02600
PRK0751152-288  PRK07511
PRK0598144-288  PRK05981
COG044723-287  MenB
PRK0599532-290  PRK05995
PRK0612736-288  PRK06127
PLN0288845-286  PLN02888
PRK0814047-288  PRK08140
PLN0292122-287  PLN02921
TIGR0192950-287  menB
PRK0656339-288  PRK06563
PRK0912050-283  PRK09120
TIGR0228047-288  PaaB1
PRK0826047-289  PRK08260
TIGR0321033-288  badI
PRK0829033-250  PRK08290
PRK0614447-288  PRK06144
PRK0750943-289  PRK07509
PRK0739650-289  PRK07396
PLN0266440-287  PLN02664
PRK1142345-288  PRK11423
PRK0785447-288  PRK07854
PRK0614247-289  PRK06142
PRK0765933-290  PRK07659
PRK0586447-289  PRK05864
PRK0746847-290  PRK07468
PRK0726033-284  PRK07260
PRK0561736-208  PRK05617
PRK0793868-285  PRK07938
PRK0815047-232  PRK08150
PRK0587045-247  PRK05870
PRK0607236-288  PRK06072
PRK1115459-228  fadJ
PRK0827232-289  PRK08272
PRK0825943-231  PRK08259
TIGR0244142-252  fa_ox_alpha_mit
PRK1173050-224  fadB
PRK0782747-283  PRK07827
PRK0602334-282  PRK06023
TIGR0244045-234  FadJ
TIGR0243750-224  FadB
PRK0711047-274  PRK07110
PRK0567452-290  PRK05674
PRK0825847-288  PRK08258
PLN0287434-220  PLN02874
PRK0732747-287  PRK07327
PRK1247847-289  PRK12478
TIGR0318950-290  dienoyl_CoA_hyt
PLN028515-213  PLN02851
PLN0215752-210  PLN02157
PLN0298843-232  PLN02988
TIGR0320050-215  dearomat_oah
PRK0818468-233  PRK08184
TIGR0322258-233  benzo_boxC


Ontology Information


   
HPRD ID5105
Molecular ClassEnzyme: Hydratase
Molecular FunctionDNA-directed RNA polymerase activity (GO:0003899)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO