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General Information
- Evidence
- Gene
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21304002 | 2011 | Cell line : - Source : Publicly available data from GenBank and Oncomine and Samsung Medical Center in Seoul, Korea Sample Type : - No. of Sample : - Stage : - | RT-PCR, Meta analysis | Up-regulation | - | 9 (ECT2, ETV4, DDX21, RAN, S100A11, RPS4X, HSPD1, CKS2, and C9orf140) of the 34 candidate genes are expressed at significantly elevated levels in CRC tissues compared to normal tissues. |
| 26211594 | 2015 | Cell line : - Source : Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University Sample Type : CRC tumor No. of Sample : 345 Stage : TNM Stage I-IV | Immunohistochemistry,real-time PCR | Up-regulation | - | ECT2 is an unfavorable biomarker of prognosis in CRC and that ECT2 may be a potential therapeutic candidate for CRC treatment. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Rho guanine nucleotide exchange factors |
| Description | The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
| Chromosome | 3 |
| Location | 3q26.1-q26 |
| Start | 172468425 |
| End | 172539264 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 70840 |
| OMIM ID | 600586 |
| HGNC ID | HGNC:3155 |
| Unigene ID | Hs.518299 |
| Ensembl ID | ENSG00000114346 |
| PharmGKB ID | PA27600 |
mRNA Information
| mRNA ID | XM_005247176.1 |
|---|---|
| Exon | join(1..176,3828..3979,4614..4693,6302..6484,8299..8388, 9475..9582,10929..11002,11735..11865,12010..12125, 12229..12291,13597..13819,18326..18462,23222..23341, 31482..31550,33118..33228,34026..34122,35812..35893, 51935..52013,52180..52299,55050..55188,57089..57243, 64923..65030,66010..66156,67867..68133,69467..70793) | mRNA Sequence | Download Select all |
| Length | 4354 |
Protein Information
| Protein ID | XP_005247233.1 |
|---|---|
| Protein Name | epithelial cell transforming 2 |
| Molecular Wt. (Da) | 104945 |
| Protein Sequence | Download Select all |
| Length | 927 |
| Uniprot ID | Q07864 |
| Ensembl Protein ID | ENSP00000322570 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 815 |
| T | Phosphorylation | 815 |
| S | Phosphorylation | 40 |
| Y | Phosphorylation | 41 |
| S | Phosphorylation | 334 |
| T | Phosphorylation | 342 |
| S | Phosphorylation | 345 |
| S | Phosphorylation | 336 |
| S | Phosphorylation | 339 |
| S | Phosphorylation | 811 |
| T | Phosphorylation | 328 |
| S | Phosphorylation | 685 |
| S | Phosphorylation | 852 |
| S | Phosphorylation | 858 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 391 | RHOG | 1537 | NP_001656.2 | in vitro | 12376551 |
| 2151 | F2RL2 | 3561 | NP_004092.1 | in vitro;yeast 2-hybrid | 15254234 |
| 50855 | PARD6A | 6316 | NP_058644.1 | in vitro;yeast 2-hybrid | 15254234 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01229 | 631-804 | PH_Ect2 |
| cl17171 | 631-804 | PH-like superfamily |
| cd00160 | 453-639 | RhoGEF |
| cl02571 | 453-639 | RhoGEF superfamily |
| cd00027 | 178-248 | BRCT |
| cl00038 | 178-248 | BRCT superfamily |
| cd00027 | 273-342 | BRCT |
| cl00038 | 273-342 | BRCT superfamily |
| pfam00621 | 456-640 | RhoGEF |
| smart00325 | 456-640 | RhoGEF |
| pfam12738 | 179-242 | PTCB-BRCT |
| pfam00533 | 266-341 | BRCT |
| smart00292 | 178-247 | BRCT |
| smart00292 | 268-341 | BRCT |
| pfam00533 | 178-245 | BRCT |
| COG5422 | 446-652 | ROM1 |
Ontology Information
| HPRD ID | 1155 |
|---|---|
| Molecular Class | Guanine nucleotide exchange factor |
| Molecular Function | DNA-directed RNA polymerase activity (GO:0003899) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.