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General Information
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22865632 | 2013 | Cell line : - Source : Steven F. Moss and Lelia Simao (Rhode Island Hospital, Providence, RI). Sample Type : CRC tumor and adjacent normal tissues No. of Sample : 30 Stage : - | real-time RT-PCR, immunoblotting and immunohistochemistry,methylation-specific PCR, bisulfite sequencing and pyrosequencing | Hypermethylation | - | Mechanistic studies revealed hypermethylation of EDN2 and EDN3 genes in human primary colon cancers, and in a panel of human colon cancer cell lines. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] |
| Chromosome | 1 |
| Location | 1p34 |
| Start | 41944446 |
| End | 41950348 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 5903 |
| OMIM ID | 131241 |
| HGNC ID | HGNC:3177 |
| Unigene ID | Hs.1407 |
| Ensembl ID | ENSG00000127129 |
| PharmGKB ID | PA27615 |
mRNA Information
| mRNA ID | NM_001302269.1 |
|---|---|
| Exon | join(1..146,481..637,2096..2218,5182..5909) | mRNA Sequence | Download Select all |
| Length | 1168 |
Protein Information
| Protein ID | NP_001289198.1 |
|---|---|
| Protein Name | endothelin 2 |
| Molecular Wt. (Da) | 14069 |
| Protein Sequence | Download Select all |
| Length | 145 |
| Uniprot ID | P62875 |
| Ensembl Protein ID | ENSP00000324124 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| W | Proteolytic Cleavage | 69 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00322 | 48-74 | Endothelin |
| cl23108 | 48-74 | Endothelin superfamily |
| smart00272 | 48-69 | END |
| cl23350 | 48-69 | END superfamily |
| smart00272 | 96-116 | END |
| cl23350 | 96-116 | END superfamily |
| PHA02659 | 43-69 | PHA02659 |
Ontology Information
| HPRD ID | 1252 |
|---|---|
| Molecular Class | Peptide hormone |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.