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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23536776 | 2013 | Cell line : - Source : Medical University of South Carolina (MUSC), Charleston, SC, USA.Gene Expression Omnibus (GEO) Datasets, an NCBI public database. Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry | Down-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class A : Endothelin receptors |
| Description | This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] |
| Chromosome | 4 |
| Location | 4q31.22 |
| Start | 148402069 |
| End | 148466106 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 64038 |
| OMIM ID | 131243 |
| HGNC ID | HGNC:3179 |
| Unigene ID | Hs.183713 |
| Ensembl ID | ENSG00000151617 |
| PharmGKB ID | PA27617 |
mRNA Information
| mRNA ID | NM_001957.3 |
|---|---|
| Exon | join(1..460,4696..5185,38935..39062,51590..51788, 54961..55113,58901..59034,59461..59569,61562..64038) | mRNA Sequence | Download Select all |
| Length | 4168 |
Protein Information
| Protein ID | NP_001948.1 |
|---|---|
| Protein Name | endothelin receptor type A |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 427 |
| Uniprot ID | Q01860 |
| Ensembl Protein ID | ENSP00000259915 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1908 | EDN3 | 570 | NP_996917.1 | in vitro;in vivo | 11982704 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Calcium signaling pathway | hsa04020 |
| cAMP signaling pathway | hsa04024 |
| cGMP-PKG signaling pathway | hsa04022 |
| Neuroactive ligand-receptor interaction | hsa04080 |
| Pathways in cancer | hsa05200 |
| Renin secretion | hsa04924 |
| Vascular smooth muscle contraction | hsa04270 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00001 | 104-367 | 7tm_1 |
| PHA03087 | 80-376 | PHA03087 |
| PHA02638 | 90-377 | PHA02638 |
| PHA02834 | 75-382 | PHA02834 |
Ontology Information
| HPRD ID | 2679 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Transcription (GO:0006350) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P25101 | DB00559 | Bosentan | SmallMoleculeDrug |
| P25101 | DB00945 | Acetylsalicylic acid | SmallMoleculeDrug |
| P25101 | DB06268 | Sitaxentan | SmallMoleculeDrug |
| P25101 | DB06403 | Ambrisentan | SmallMoleculeDrug |
| P25101 | DB08932 | MACITENTAN | SmallMoleculeDrug |