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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 11309363 | 2001 | Cell line : HCT116,LoVo, HCT15,SW837,SW48. Source : Los Angeles Country University of southern california norris comprihensive cancer center. Sample Type : - No. of Sample : - Stage : - | real time RT-PCR, methylation specific PCR | Hypermethylation | - | - |
| 24326135 | 2013 | Cell line : - Source : Department of Gastrointestinal Surgery in Affiliated Hospital of Ningbo University . Sample Type : CRC Tumor and adjecent normal tissue No. of Sample : 42 Stage : - | real time RT-PCR, methylation-specific PCR | Hypermethylation | - | EDNRB promoter hypermethylation might downregulate its gene expression in CRC, and thus played an important role in the development of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class A : Endothelin receptors |
| Description | The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] |
| Chromosome | 13 |
| Location | 13q22 |
| Start | 78469616 |
| End | 78549664 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 80049 |
| OMIM ID | 131244 |
| HGNC ID | HGNC:3180 |
| Unigene ID | Hs.82002 |
| Ensembl ID | ENSG00000136160 |
| PharmGKB ID | PA27618 |
mRNA Information
| mRNA ID | NM_000115.3 |
|---|---|
| Exon | join(1..183,56906..57439,71923..72035,72170..72374, 74323..74472,74876..75009,75563..75671,77196..80049) | mRNA Sequence | Download Select all |
| Length | 4296 |
Protein Information
| Protein ID | NP_000106.1 |
|---|---|
| Protein Name | endothelin receptor type B |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 442 |
| Uniprot ID | Q07869 |
| Ensembl Protein ID | ENSP00000262735 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 200 |
| S | Phosphorylation | 205 |
| S | Phosphorylation | 305 |
| C | Palmitoylation | 400 |
| C | Palmitoylation | 402 |
| C | Palmitoylation | 403 |
| C | Palmitoylation | 405 |
| S | Phosphorylation | 407 |
| S | Phosphorylation | 413 |
| S | Phosphorylation | 419 |
| Y | Phosphorylation | 430 |
| S | Phosphorylation | 435 |
| S | Phosphorylation | 436 |
| Y | Phosphorylation | 439 |
| S | Phosphorylation | 440 |
| S | Phosphorylation | 441 |
| S | Phosphorylation | 442 |
| Y | Phosphorylation | 200 |
| S | Phosphorylation | 205 |
| S | Phosphorylation | 305 |
| R | Proteolytic Cleavage | 64 |
| R | Proteolytic Cleavage | 64 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 857 | CAV1 | 3028 | NP_001744.2 | in vitro;in vivo | 12694195 |
| 1906 | EDN1 | 7030 | NP_001946.3 | in vitro;in vivo | 12972292 |
| 1908 | EDN3 | 570 | NP_996917.1 | in vivo | 800 116 011 982 704 |
| 2767 | GNA11 | 759 | NP_002058.2 | in vivo | 10789830 |
| 2870 | GRK6 | 2925 | NP_002073.2 | in vitro | 9211925 |
| 4846 | NOS3 | 1224 | NP_000594.2 | in vitro | 10510297 |
| 10672 | GNA13 | 5100 | NP_006563.2 | in vivo | 12135322 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Calcium signaling pathway | hsa04020 |
| cGMP-PKG signaling pathway | hsa04022 |
| Melanogenesis | hsa04916 |
| Neuroactive ligand-receptor interaction | hsa04080 |
| Pathways in cancer | hsa05200 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam10320 | 112-399 | 7TM_GPCR_Srsx |
| cl21561 | 112-399 | 7tm_4 superfamily |
| pfam00001 | 125-384 | 7tm_1 |
| PHA03087 | 96-399 | PHA03087 |
| PHA02834 | 102-402 | PHA02834 |
| PHA02638 | 110-394 | PHA02638 |
Ontology Information
| HPRD ID | 3288 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P24530 | DB00559 | Bosentan | SmallMoleculeDrug |
| P24530 | DB06268 | Sitaxentan | SmallMoleculeDrug |
| P24530 | DB06403 | Ambrisentan | SmallMoleculeDrug |
| P24530 | DB08932 | MACITENTAN | SmallMoleculeDrug |