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General Information
- Evidence
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24175772 | 2013 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 21 Stage : TNM Stage I-IV. | - | Polymorhpism | - | EFNA1 is involved in colorectal tumorigenesis, and rs12904 A>G polymorphism in the 3' UTR of EFNA1 is associated with CRC susceptibility. |
| 14965363 | 2004 | Cell line : - Source : Xiaoshan County and Oncomine expression profiling database. Sample Type : Case-control study No. of Sample : 306 subjects (102 cases and 204 well-matched controls) Stage : - | real time RT-PCR,double-immunostained | Up-regulation | - | Trends of overexpression of both EPHA2 and EFNA1 was found in tumor tissue compared to the corresponding normal tissue in the same specimen. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Ephrins |
| Description | This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008] |
| Chromosome | 1 |
| Location | 1q21-q22 |
| Start | 155100349 |
| End | 155107386 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 7038 |
| OMIM ID | 191164 |
| HGNC ID | HGNC:3221 |
| Unigene ID | Hs.516664 |
| Ensembl ID | ENSG00000169242 |
| PharmGKB ID | PA27656 |
mRNA Information
| mRNA ID | NM_004428.2 |
|---|---|
| Exon | join(1..197,3467..3762,5631..5696,5858..5908,6083..7038) | mRNA Sequence | Download Select all |
| Length | 1590 |
Protein Information
| Protein ID | NP_004419.2 |
|---|---|
| Protein Name | ephrin-A1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 205 |
| Uniprot ID | O60437 |
| Ensembl Protein ID | ENSP00000340510 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| R | Glycosyl phosphatidyl inositol GPI | 186 |
| R | Glycosyl phosphatidyl inositol GPI | 164 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1969 | EPHA2 | 1494 | NP_004422.2 | in vitro;in vivo | 1 469 287 787 554 740 000 000 |
| 2041 | EPHA1 | 1554 | NP_005223.4 | in vitro;in vivo | 875 547 411 519 828 |
| 2042 | EPHA3 | 1555 | NP_005224.2 | in vivo | 8070404 |
| 2045 | EPHA7 | 3721 | NP_004431.1 | in vitro | 8755474 |
| 2047 | EPHB1 | 2790 | NP_004432.1 | in vitro;in vivo | 875 547 479 736 388 000 000 |
| 5473 | PPBP | 7171 | NP_002695.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Axon guidance | hsa04360 |
| PI3K-Akt signaling pathway | hsa04151 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd10425 | 19-148 | Ephrin-A_Ectodomain |
| cl19115 | 19-148 | Cupredoxin superfamily |
| pfam00812 | 18-152 | Ephrin |
| cd02675 | 20-130 | Ephrin_ectodomain |
| cd10426 | 23-130 | Ephrin-B_Ectodomain |
Ontology Information
| HPRD ID | 4384 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Enzyme regulator activity (GO:0030234) |
| Biological Process | Regulation of cell proliferation (GO:0042127) |
Drug Information
No matching records could be found.