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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
EGF 1950 epidermal growth factor  4- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22925500   2012Cell line : HCT116

Source : -

Sample Type : -

No. of Sample : -

Stage : -

real time PCR,fluorescence activated cell sorting, western blotting.Up-regulation- EGF signalling was essential for formation and maintenance of colon CSCs.


Gene Details



NC_000004.11 (110834040..110934118)

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Gene Type protein coding
Gene Family -
Description This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]  
Chromosome 4
Location 4q25
Start 110834040  
End 110934118  
Strand +  
Gene Sequence

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Length 100079  
OMIM ID 131530   
HGNC ID HGNC:3229   
Unigene ID Hs.419815   
Ensembl ID ENSG00000138798   
PharmGKB ID PA27664   

mRNA Information


mRNA ID XM_005262796.2
Exon join(1..580,28064..28263,30372..30553,30960..31187, 32191..32393,46430..46555,47985..48107,48981..49103, 50291..50416,51519..51655,56089..56237,61821..61925, 63130..63353,67090..67257,67944..68093,70540..70659, 74862..74978,75702..75827,80365..80487,81851..81998, 86797..86964,91623..91740,95270..95372,98320..100080)  
mRNA Sequence

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Length 5608  



CDS Information


   
Location 454..4101
CDS Sequence

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CCDS ID CCDS3689.1



Protein Information


      
Protein ID XP_005262853.1
Protein Nameepidermal growth factor
Molecular Wt. (Da)134678
Protein Sequence

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Length 1215  
Uniprot IDQ9UQK1
Ensembl Protein ID ENSP00000238994  



Post-translational Modification Information (Source : HPRD)


Residue Type site
LProteolytic Cleavage1022

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2885GRB2150NP_002077.1in vivo10973965   


Pathway Information


                                                                                                                                          
Pathway Name Pathway ID
Bladder cancer hsa05219
Choline metabolism in cancer hsa05231
Cytokine-cytokine receptor interaction hsa04060
Endocytosis hsa04144
Endometrial cancer hsa05213
ErbB signaling pathway hsa04012
Focal adhesion hsa04510
FoxO signaling pathway hsa04068
Gap junction hsa04540
Glioma hsa05214
Hepatitis C hsa05160
HIF-1 signaling pathway hsa04066
MAPK signaling pathway hsa04010
Melanoma hsa05218
Non-small cell lung cancer hsa05223
Pancreatic cancer hsa05212
Pathways in cancer hsa05200
Phospholipase D signaling pathway hsa04072
PI3K-Akt signaling pathway hsa04151
Prostate cancer hsa05215
Rap1 signaling pathway hsa04015
Ras signaling pathway hsa04014
Regulation of actin cytoskeleton hsa04810


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00054870-910  EGF_CA
cl21504870-910  EGF_CA superfamily
cd00054912-940  EGF_CA
cl21504912-940  EGF_CA superfamily
smart00135635-676  LY
cl22866635-676  LY superfamily
smart00135547-587  LY
cl22866547-587  LY superfamily
smart00135590-633  LY
cl22866590-633  LY superfamily
pfam14670745-780  FXa_inhibition
cl21504745-780  EGF_CA superfamily
pfam00058654-693  Ldl_recept_b
cl22870654-693  Ldl_recept_b superfamily
smart00135505-546  LY
cl22866505-546  LY superfamily
smart00179870-910  EGF_CA
pfam14670360-395  FXa_inhibition
cl21504360-395  EGF_CA superfamily
cd01475352-393  vWA_Matrilin
cl00057352-393  vWFA superfamily
pfam07645870-910  EGF_CA
smart00179356-395  EGF_CA
pfam14670439-476  FXa_inhibition
cl21504439-476  EGF_CA superfamily
pfam07645356-395  EGF_CA
pfam07645912-940  EGF_CA
pfam12947887-910  EGF_3
cd00054356-395  EGF_CA
pfam00058611-650  Ldl_recept_b
cl22870611-650  Ldl_recept_b superfamily
smart00179912-940  EGF_CA
pfam00058567-606  Ldl_recept_b
cl22870567-606  Ldl_recept_b superfamily
smart00135152-189  LY
cl22866152-189  LY superfamily
pfam12947916-940  EGF_3
PHA03099976-1014  PHA03099
cl20104976-1014  PHA03099 superfamily
cd14963523-650  NHL_like_5
cl18310523-650  NHL superfamily
pfam14670408-436  FXa_inhibition
cl21504408-436  EGF_CA superfamily
PHA02887975-1013  PHA02887
cl20100975-1013  PHA02887 superfamily
cd14962557-692  NHL_like_6
pfam12947360-395  EGF_3
cd05819557-666  NHL
smart00135677-718  LY
cl22866677-718  LY superfamily
pfam12662377-395  cEGF
cd01475865-903  vWA_Matrilin
cl00057865-903  vWFA superfamily
pfam06247840-940  Plasmod_Pvs28


Ontology Information


   
HPRD ID9223
Molecular ClassGrowth factor
Molecular FunctionProtein serine/threonine phosphatase activity (GO:0004722)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P01133DB00364SucralfateSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO