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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
EGR1 1958 early growth response 1  5TIS8, G0S30, NGFI-A, KROX-24, ZIF-268, AT225, ZNF225 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21436631   2011Cell line : -

Source : -

Sample Type : CRC tumor

No. of Sample : 5

Stage : TNM Stage I-IV

ImmunohistochemistryUp-regulation-The study suggests a connection between CD133 and EGR1 and emphasises the importance of the EGR1/TCF4/CD133/LGR5 network in CRC.


Gene Details



NC_000005.9 (137801181..137805004)

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Gene Type protein coding
Gene Family Zinc fingers, C2H2-type
Description The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]  
Chromosome 5
Location 5q23-q31
Start 137801181  
End 137805004  
Strand +  
Gene Sequence

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Length 3824  
OMIM ID 128990   
HGNC ID HGNC:3238   
Unigene ID Hs.326035   
Ensembl ID ENSG00000120738   
PharmGKB ID PA27673   

mRNA Information


mRNA ID NM_001964.2
Exon join(1..577,1266..3824)  
mRNA Sequence

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Length 3136  



CDS Information


   
Location271..1902
CDS Sequence

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CCDS ID CCDS4206.1



Protein Information


      
Protein ID NP_001955.1
Protein Nameearly growth response 1
Molecular Wt. (Da)57376
Protein Sequence

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Length 543  
Uniprot IDP30154
Ensembl Protein ID ENSP00000311344  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation378
TPhosphorylation391
TPhosphorylation526

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1029CDKN2A2542NP_478102.1in vitro19057511   
6667SP11796NP_612482.2in vivo12569082   


Pathway Information


                  
Pathway Name Pathway ID
AGE-RAGE signaling pathway in diabetic complications hsa04933
HTLV-I infection hsa05166
Prion diseases hsa05020


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam11928135-219  DUF3446
cl13380135-219  DUF3446 superfamily
pfam13465382-407  zf-H2C2_2
cl22375382-407  zf-H2C2_2 superfamily
pfam13465354-373  zf-H2C2_2
cl22375354-373  zf-H2C2_2 superfamily
pfam00096338-362  zf-C2H2
cl23491338-362  zf-C2H2 superfamily
pfam05687451-514  DUF822
cl05316451-514  DUF822 superfamily
pfam00096368-390  zf-C2H2
cl23491368-390  zf-C2H2 superfamily
pfam13894368-390  zf-C2H2_4
cl20498368-390  zf-C2H2_4 superfamily
pfam00096396-418  zf-C2H2
cl23491396-418  zf-C2H2 superfamily
smart00355338-362  ZnF_C2H2
cl18194338-362  ZnF_C2H2 superfamily
smart00355368-390  ZnF_C2H2
cl18194368-390  ZnF_C2H2 superfamily
pfam11914442-530  DUF3432
COG5048306-543  COG5048
COG5189323-416  SFP1
PHA00733337-387  PHA00733
PHA00733367-414  PHA00733
COG5048297-380  COG5048


Ontology Information


   
HPRD ID9345
Molecular ClassTranscription factor
Molecular FunctionProtein serine/threonine phosphatase activity (GO:0004722)
Biological ProcessSignal transduction (GO:0007165); Cell growth and/or maintenance (GO:0008151)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO