CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
EPHA2	1969	EPH receptor A2	1	ECK; CTPA; ARCC2; CTPP1; CTRCT6

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
14564515	2003	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	Western blotting and RT-PCR	Up-regulation	-	DCA induced up-regulation of EphA2 in colon cancer cells is due to activation of erk1/2 cascade, and is p53-independent.
14767510	2004	Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 194 Stage : TNM Stage I-III	Immunohistochemistry	Up-regulation	-	Overexpression of EphA2 protein in colorectal carcinoma tissue correlates closely with cancer progression and hematogenous and lymphogenous metastasis.
14965363	2004	Cell line : - Source : Hamamatsu University Schoolof Medicine. Sample Type : CRC tumor and Normal tissue No. of Sample : 37 Stage : TNM Stage I,II	real time RT-PCR and double immunostaining	Up-regulation	-	EPHA2 involved in colon carcinogenesis, mainly in stages I and II. Overexpression of EPHA2 and EFNA1 was noted more frequently in the early stage than in the late stage. EPHA2 is activated by VEGF through induction of EFNA1 ligand. EPHA2 might be a candidate target for clinical treatment of colorectal cancer and angiogenesis.
19089910	2009	Cell line : - Source : The Jackson Laboratory (Bar Harbor, Maine). Sample Type : Mouse model No. of Sample : - Stage : -	real time RT-PCR and Immunohistochemistry	Up-regulation	-	EphA2 plays an oncogenic role in the mammalian intestine suggesting that strategies to target EphA2 activity may offer new therapeutic modalities for colorectal cancer. EphA2 was significantly up-regulated in tumors from both regions when compared with normal control tissues.
19934926	2009	Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 117 Stage : TNM Stage I-IV	real time RT-PCR and Immunohistochemistry	Up-regulation	-	Found vasculogenic mimicry in 23 (19.7%) of 117 colorectal tumor samples.
21852108	2012	Cell line : - Source : Princess Alexandra Hospital tissue bank and the Royal Brisbane Hospital (Brisbane, Australia). Sample Type : CRC tumor and Normal tissue No. of Sample : 153 Stage : TNM Stage I-IV	real time RT- PCR, Flow cytometry, Western blotting and immunocytochemistry	Up-regulation	-	Analysed expression of all Eph and ephrin genes in colorectal cancer (CRC)
24050852	2013	Cell line : - Source : - Sample Type : Formalin-fixed paraffin-embedded tumor No. of Sample : 226 Stage : TNM Stage I-IV	TaqMan RT-PCR	Up-regulation	-	High EphA2 receptor expression in CRC was associated with a worse outcome in patients treated with cetuximab-based therapy..

Gene Details

Chromosome: 1; NC_000001.10 (16450832..16482582, complement)
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Gene Type	protein coding
Gene Family	EPH receptors, Sterile alpha motif (SAM) domain containing, Fibronectin type III domain containing
Description	This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]
Chromosome	1
Location	1p36
Start	16124337
End	16156087
Strand	-
Gene Sequence	>gi\|568815597:c16156087-16124337 Homo sapiens chromosome 1, GRCh38.p2 Primary Assembly GGTTCTCACCCAACTTCCATTAAGGACTCGGGGCAGGAGGGGCAGAAGTTGCGCGCAGGCCGGCGGGCGG GAGCGGACACCGAGGCCGGCGTGCAGGCGTGCGGGTGTGCGGGAGCCGGGCTCGGGGGGATCGGACCGAG AGCGAGAAGCGCGGCATGGAGCTCCAGGCAGCCCGCGCCTGCTTCGCCCTGCTGTGGGGCTGTGCGCTGG CCGCGGCCGCGGCGGCGCAGGGCAAGGAAGGTGAGTGCGCGCGGCGTCTGGACCCCTGGCCCCCGGGCCC CAGTGCCCCCTAGAGCCCGGCGCTCCTTGACGCGCGCAACTTTGGAACCTACCTGGTGTCGCCCAGTCCC GGCGAACTGGAGTCCGGAGGGCGCACGGGCTGCGATCGAGGCGAGCCCTGGCCCCCACCCGGGGTCATAG GGGCTCCGGAGAATAAGCGGTTTCAGCTTGGTCGCACGGGCCTCGGAGGCTGCGGAGAAGAGGACGCGGC GCAGGCCACGCGGTTGCAGTCCAGGCGGCGACTTCGGGAACGCGTCCCGGCGGGGGGCGTGGGGAGTCCC CTAGAGAAGGGGGTGTTTGGGCAGCTTTCCGCGGGCTCAGCTTCTTAGTGACCTGAATTCACTAACCCGC TTGCCGAGGTTTTGCGGAGAAGGCATACTGTGCAGGCCTCGCATTTTGGGGAGGGGGCTCGGGCGGGCGG GAGCCCCCTGTCGAAGCCCCTGTTCCCTGAGATTTTCTCCACGCCCCCCTTCACCTCCAGTCCCGGGGGA GAGCGTGGAGATAGGTTCGGGCCAATCCCTGCTCACACACTCCTTTCCCTCCTTCCCAAGCCGCACTCCC GGGCTCCCGGGGCAGGTTAGGGGCCGCGAGTGCGGACAGGAAGTCCCAAAGTCAAGCGTTCTGAGCAAGG GTGACTCAGAACGAGGAAATGCGGCAGGTGGGGGTGCGGCCTCCCAAGGTGTGGAGCTGTCAGCCCAGGG CCACCAGGGAGTCAGGACACCCGGGGGTGGGGGACTGAATCACCCACCCCCGCCCCAGTGTTCCCGGAGC CGCGCCGAGTGAGGGGCCGCAGACTTTGCTCATGGCGCAGCGGGTGCGTGGTGGGGGTGTTGTCCCTCCG CTAGGGTCAGGGCGAGGATGGGGGCTCCTGCCCTGGCCGAAGACCTTCCTGTCCACCCAGCCCAGGCCAG CTTCAATTTCCAACAGTGAGGGCAAGGCTTCCCCTCCTGCCTGGGCAGAGCGAGGTTTCCGCAGGCTCCA CAAGGGGGAAGCCGGGAGGAAACTTGGGCCGGTGAGAAGTTTCCTTCTTTTTTTTTTTTTTTTTTTTTTT TGAGACGGAGTTTCGCACTTGTTGCCCAGACTGGAGTGCAATGGCGCAATCTCGGCTCACTGCAACCTCT GCCTCCCGGGTTCAAGCTATTCTCCTGTCTCAAGCCTCCCTAGTAGCTGGGATTACAGGTGCCCGCCACC AGGCGCGTCTAATTTTTGCATCTTTTAGTGGAGACGAGGTTTCACCATGTTGGCCAGGCTGATTCTGAAC TCCTGACCTCAGGTGATCCACCCGCCGCGGCCTCCCAAAGTGCTGCGATTACAGGCATGAGCCACCACCC CCGGCCTGTTTCCTTCTTTTTCTGCCTCCCAAACTGGGTTTGGAGGTTTTGCTGTTCTGTGTTGGGAGGA AAAGAGGCCGGATCTGGAGCCGTTGGGCAGTGGCAGGTGTTGGGGGTGGCATCCTGTCTCAGTCTCTGGA GTGACAGGGCCCGGGTTGGGGTCTCAACCGGGACTTCTGGTTGCAGGAGCTCATGGCAAGGATTTCTGCC ACCCTCAATATCCGCCCCACCAACGTTTGGTCCTCCCCCTTCCTGGGGGACTGTGGTTGGAGAGAAGGGG AGAGACAGCTGGAATCACTATAGGCCTTTCTCCTCGGCTGCCCATGGGGGGGTGGGGGATTAGGCGGGTG CTTTGCTGCTGCAGTCCCCAAGCTGGCCTGGAAGCCTGGAGCTGCCTTGTCCTTGTCCCCTGTGTCCACC TCTCCCCAGCCTGTGTGATTAAACCCCACCCCCACACCCCATGGGATGCAGGGGGAAAGGCTTGTGTATT GCACTGGGGTGGGGGTACATTTTTGCTTCGACTCTGAGTCCCCGTGAAAGAGTCCCTAGAGAAGTGTGCC TAGGTGGGGGTGGGCATGATGGCCTAGCTGGCAGCTGCTGGTTTCAGTTCCTGGGAATCAGGCTGTATGT GGTGGGTCTGCCTGGGGGTGGCTTAGGGGGCAGGCAGGAGGACACAGGTGCCTTTTTCACCTACCCCCAG GCTGCTTCAGACTTCTTTCTTGCCCCCTCACCCCTAGGCTATACTTGGTTGCCCACGTGGCTCCTGTTAG GTCATCAACAGCCACTGAATCTGCCCTCATTTTTACAAATGGGGAAACTGAGGGAGGCCCGAGCCCTTGC CAACCAGGGCCTTCTGGACAGAGGACCAGACCTGAGCATCCCGCTTCTTGGCTGCCAGAGCCAAGGCCCT GCCTGCTTTGTGGTTGGTGTCATGGTAGATTTTCCTGGGAAGCAGGCATAGCTGGGCAGGGGCCTGGGCG GGTGGCAGGGGGTGCTGAGCTGGGGTGCTGCTGATGGGAAGAGGGCTGGAGAGTGCCAGGAAGTCCTTGG TTTCTGGTTCTACCGGGGCCAAGTCTGCCCTCTGTCCCCTTTCCCTTTTCTTTCATGTTTTCCCCAGAGT CCCCACCTCCCTGCTTCCTTTAGGGATTAGCTAGTCTTGGTTAGAGAGGAATGGGGGAAGCGGGGAGGGA ACCACAGCCTCGGAGGCTGCGGAGAAGGACCGGAGACCGGGAGTGGGTGGCAGTCCTGCATTTGTGGAAG AAGCTGTGGAGCAATGTGGACCCACAAAGATGGCACTTACGGTGGAACTCATGGCAAAGAAGGAGGTGTT TTTTGCTTTTTTTTTTTCCCCCCAGAAATGGGAAGGTAAGGGGATAGAGAGCTCATGGATAAGCCCTGCT TAGCCTAAGCCTCTCCAGGAAGCCGTCTGGGTCAGCCGAGGGGCTCCCAGGCTCCCACCCTTTCCAGAGA AGCGGGAGCCTCTGTCCCTGGAAGAACCTGGGGAAAGAGCCGCGCCCGCGTCAGGGCGGAGGGACCCAGC GCTGGGCGCCTCCTGTTCCTGGTGGTTGGTTCGAGGGAATTTCCCTGGGAGGGGGCCGGGGTTGGAAACC CCTGCAGGGGGGGCTCCTTCCTGTGTGAGGGCTTCTTTTCTTCTCCGATTGAGCCCTGTGCTACTTCTAG AGCCAGGCCTAGGCTGGAAAGGGAGGGCCCTCCATGCCAGGTTAACCCTTCAGAAGCCTGGTAGCGGTGA GCCCTCTCACTTGGGCACAGACCTCAGCCTCCTGTCAATCTAAGGGGGGGCTGCAGGACTGTGAGGAACC TTTGTCCTTCTACCCACCCAGCTGAAATCAGGAGCCTCCAGATTCCTTCCTGTGTAGCTGGAACATTCCA TTTGCTAGTGGGGTTAGTGAGTTTCAAAGCCCCGGCCCTGGGCATGTCTGAACAAATCCCTGCCCCTGCC CACCCCGCTGCCCCCAGCCACCCTCCCCTATCCCCACAGCCTCTGTCATGGGGCCGGTGTCACATTGGAT TTCCTCTTGCCTGTCTGGGCTGCCTGACCCTTCCTAGAGAGGTTTGGCCCCGGTCAGTAGTGGGGGTGGC AGCATTTCACGCCCCAGCCTGGGGGCCTTCAGCCCAGGTAGGAGGGCCATGTCACTTCAGGAGGCGGTCT TCAAGACCACCCTCAGAGCCCAGCTCCCATCTCCACAAACCAGGCCATCCCTGCTCCCAGCCTGCCTGGA GCTCTGTCCACCCTTTGAGTCCTTCTCCGGTCCTGGCCTTGAGGAATGGGGCTTCTGAGGCAGATCCCTC ATGCTCCAGGGCCCAAAGGAAGCATTGACTTGGTTTCTTTACCCCCACCTTAGGGCTTTACCCTCTGAAT CCATCTTGCATAGGTTCTATGCCCCGGTTTCTCCTATCTCCTTACCCTCTAGGGAGGGTAGCACTTATTG GCAGCTACCTGGACTTTACTTGGAAATAGAGTGGGGACAGTACCTAGGGTCTTAGGTTTTGTCTATGGCC TCTGAGCCTGGCAGAGAACCTGGGGTGGATCAGTGGGAGGTGCCCAATGGCAGGACTAGGTCTAGGGAAG ACCCCGGGAGTGTATCCCTCCGCCAGGCTCCAGTTGCCTCTCTGGGAACAGGATGGTCCTGACACCTGGT CTCTGGGCCTAGAATGTCCCCTACAAGGGCTTTTATTCCTGATCCCCCAGGAACCTCTGGCACCCCTGGC AGGGCAGTGGTCAGGATGTGAGGGGCAGGGGTGGTGGGAGTGACTTTCCCAGGGAGGGGACCTCACCAGC TGTGTGTATCTTTGGGCCCCTCTTAGGGGCCCTATGGGTCCAGGGCTTTATCCTGCCTGCTCTGTGGCTT TTGTGGTGAGAAGATCGGTTTCCAGATACCCTCTTCCCTCCTCCACCCTGGAGCTGTTCCCACCTGTTCA CAGCACTCTCTTCTTGGAGTACCGCAAGATGCACGTGTACATATAGGTGCATATGTGTGTGCTACATGAC CTGAGTGGGGTTGGTGTGTTTCCTGCTGGGGGGAATGTGGCAGAAGCAGACACCAGTGTCCCTAAGGCCC ACATGCACGTGAAGTGCTGCCAAAGGGCCTTGTTCAAGGAAGCAGAGGGGGCGGTGTGGTGTCACTTAAT ACCCTGCTCAGCCCAGCTCTCTGCCCAGCTGCTGTTCTCCTGCCGGGCTGAGCTCCCTGGCCTGCTCTGC CCAGCTGGGGACTAACGGAGGGGGACAGGATGGCTGGAATCCTGGCCTGGGAGACTGGAGGCCCAGTCCT GACCCCAGCCTGCTGTGTGCCTTCAGCTGGGTTCCATCCTTTTTCTGGGCCTGTTTCCCTCATGAGTCGA GGGATGATTTTCTTGGATATGGTGACCCTGTGTGGTGGGGTCCCTCTCGCTCTGTCTGAGAGTTGGGGTT CCTGGAGGGATCCTCACCTTTCCTGCCATGGTCTGACTCCTGAAGACACCCCCAGGCTCACCCCCTCTCC CTTCTCCCTTTCAGTGGTACTGCTGGACTTTGCTGCAGCTGGAGGGGAGCTCGGCTGGCTCACACACCCG TATGGCAAAGGGGTATGTAAGCCTTCGGGGTGGGGAGAGGTGTGAGAATGGGGCTGCTGGTCCCCTGTAG AGATGGAGAAACTGAGGCCCAGGGAGCGTGGGGCCTGGCTTCAATTCAGCAGCTCAGCCAGGTCTCAGGC TCAGGGTCCAGCTTCTCACACCAGGCTCAGAGTCAGCCGGCCCAGGCCAGGGCTGGATGGGCGTGGGAAG GTACGAGGGTGTGGGTGTAAGCCTGAGAGGTGGGGGGAACTGGGGAGACAGAGAAGGCCCTAGCGGAGCT GGGCCTTCCATGTTCCAGAAGGGCTGACAGTCAGAGGGATCTCTGGCACCACCCATCCACCTCTTGGGAG GGAAGGGGTTAAAGATGCCCCCTGTCTTGAGGTCTCAGCCCAGGAGGTGAGGGGTGAAGAAGAGACAGGG AACAGGAAAACCTGATCAAGTTCCTTCCTGCCCGCCCCTTTCCCACCTCTAGCTGTTGCTTCCCCTTCCT GTGGGGGGCTGCATTTCTCTGCCTCATTCTCACCCAGGTCTTCCCCTCTATGCCGTCCTGATGTGACCAG GAATGGGGGCAGGGGCTGGGGGTTCTTCCCCTGGCTGTGTGTGTCTGCTGTGTGATCTTGGGGAAGATGT GGCTCTCGGGGCCTCAGTTTCCCTCTCTATACAATGGGCCCTTGCTGAGTTTGTCCTGGGACCCTGAGCT GAGAAAGGGGGCTGTCTCCCAGGGGCTACTTGGAATAGTTCCCAGAGCTGGCCAGATCTGCATGAGTCGA GTTCTTGTCCCCGGTCACCCTAGCTCTGGGCAGGCTTGGCTGGGGTGTAGCCCTGAGCAGGTTTCTAGGA TCCTGGAAGTCTAGCTGGGAGGGAACACGGGTCACCTAATACAACCCAGTCTTTATACAGAGTGGGAAAC TGAGGCCCAAGGGCATGTAGGGCCTTGGCCAACGCCACACAGTATAGCCCGGGCCTCTGTCCTCCTCCCC TGTGCTTTCATTCATTCTTTTGTTTATTCATTCAACAAACGCTTCCCTGAGCACCTACTCTGTCTCAGGC CGGCTCTCGGGACACAGGACACAGGTGAATTAGATGCAGACTCTGGCTGAGGAGCTCAGAATCTCATGTG GGAGCCCAGATGTGGGTGTCCCCATGTGCCGTGCCAAGTGCACTTTGGTAAATGGCAAGGGGTACAGGGT AAAGGGAACATGGCAACTTTGGGAGTTGGGTGGCGGGGGGCACCTGGCCCAACTGTAGCCTAACCTGGGA ATTCTTTCTGGAGAAGGCTGAGTTATGATCCAGGGAGGGAGGAACATGTTCATCTGCTGCAAAGCCAAAT TCTAAATGACGGAGAGCATCATCCGTTGTTTTTGACTTAATGCCACTCCTGCGTTTGCCAACACACATGG GTGCATGGTGAATAATACCAAGAGTAACAATAATCATACTGGCTGCCCGTATGCCTGTTACCTTGTGCCA AGCACTGTGTTCAGCCAGTGTAGACATTCTGTCCTTTATCCTCACAGCAATTCTGTGAGGTAGGGGGTCT TGCTCCCATTGTACAGATGAGGAAATTGCGGCTTAGAGAGCATAACCCACCTGAGGTCACATGGAGTCCC GGACTCCACCTGCAGGCTCACAACCTAATAGAGAGGTTTGGCTTCCAGACATGTGCCAGAAAGACCAGGG GCCAGATTCCAGCTCAGCCACTTATGGATGCAGCCCCCACCCGCCTCAGGCCTCAGTTTCCTTCACCGTA GAACCCGGAGAGCACGAACTGGAAAGCATCTTCCTAGTGCCCTACTCTGCCACCTGGGCCTCAGTTTCCC CAGGCACCTGCCCACACTAACCTGTATCTTCCCCCCACAGTGGGACCTGATGCAGAACATCATGAATGAC ATGCCGATCTACATGTACTCCGTGTGCAACGTGATGTCTGGCGACCAGGACAACTGGCTCCGCACCAACT GGGTGTACCGAGGAGAGGCTGAGCGTATCTTCATTGAGCTCAAGTTTACTGTACGTGACTGCAACAGCTT CCCTGGTGGCGCCAGCTCCTGCAAGGAGACTTTCAACCTCTACTATGCCGAGTCGGACCTGGACTACGGC ACCAACTTCCAGAAGCGCCTGTTCACCAAGATTGACACCATTGCGCCCGATGAGATCACCGTCAGCAGCG ACTTCGAGGCACGCCACGTGAAGCTGAACGTGGAGGAGCGCTCCGTGGGGCCGCTCACCCGCAAAGGCTT CTACCTGGCCTTCCAGGATATCGGTGCCTGTGTGGCGCTGCTCTCCGTCCGTGTCTACTACAAGAAGTGC CCCGAGCTGCTGCAGGGCCTGGCCCACTTCCCTGAGACCATCGCCGGCTCTGATGCACCTTCCCTGGCCA CTGTGGCCGGCACCTGTGTGGACCATGCCGTGGTGCCACCGGGGGGTGAAGAGCCCCGTATGCACTGTGC AGTGGATGGCGAGTGGCTGGTGCCCATTGGGCAGTGCCTGTGCCAGGCAGGCTACGAGAAGGTGGAGGAT GCCTGCCAGGGTGAGTGACGGTTCTGGGTTGCAGGGAAGGGGGTTCTGCATTCCCAGGTTCTGGTCTTTA GCTTTGGAATCATGGAATCTTGGTAAGCTCATCCCTGCTTTGACACACATTAGTTCTGTTAGTGGAAATT ATAGATCCTTCCCAGACATCAGTTTCCTTATTAAGGCTGGACTAACTCATTCATTAAGAATGAATGAATT GTGGCTGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACTTGA GCCCAGGAGTTTGAGACCAGCCTGGGCAACATAATGAAACGCCGTCTCTACCAAAAACACAAAAATTAGC TGGGTGTGGTGGCATGCACCTGTAATCCCAGCTACTTGGGAGGCTGAAGCACGAGAATCAATTGCTTGAA CCCGGGAGGTGGAGGATGCAGTAAGCTGAGATCGCACCACTGTACTCCAGCCTGGGGTGACAGAGGAGAT GCTTGTCTGAAAAAAAAAAAAAGAATGAATGAATTGAGAAACAGCAGAATGTGGAGTTTATGATTGATGA CTCTGAAACAAGAATGCCTGTGTTCAAATCCCAGGTCTACATTTTTAGCTGTGTGGCTTTAGGCCATTTC CTTGACCTCTCTGTGCCTGGGTTTCCTCATCTGTAAAATGGAGAGGATCATAGCGTCTATCTCGTAGGGT GGCTGTGATAATCAAATGACTTAATAGTAAAGTGCTTAGGTCAGTGCCTGCCACATGAGTACTTTTAAAT GTGGCTGTTATTTTTGATTCATCCCACGAATGTATACTGAGTAGCTCTGGTACAGCGGCACTGTGGTCCC ACGGTGGAGTACCAGGAGCAAGTTCCATGTCTGTTATCAGCTCACTATGTGGCCTTAGGCAAGATACTTA AACTCCCTGGGCCTCAAACTCCTCTTTCGTACATAGAAGTGACTGAGTTGGACCCGGGGTGCACATCCCC TGGCTGCATATCAGGATCACCCGCGGAGCTTTTGGGAAATGCTTCTGTTGAGGGAGAGGTTGGAGGGGGG CCAAGGGTCTGCCTTTCTTGTCTGAATGTCCCCAGGGCCACAAATTTCCCATTGGGACCTCTATTGATTT TCCACTGGGGCCTCTATAGATGACACACTGGGCCCAGAAAAGGGCCAATTCATTCAGACTCTCCTTGGGG AATGAGGCTTGGGCATTAGTGAGTTCACATGGAGGAAGCCGTGGCGTGGTGTGGCCAGGGCCTGTGACAG CGGAAATCTCCACAGCAATGTGGATTTTCAATGGGTGACTTTTTCTGGAAATGGCCATGAGGCAGAGCAT TTGTGGAATGCAGGCCAACCTTTGGAGGGCTGGCTCATTCCCTCTCTCTGGCAGCTTCTTTGCTGAGATA AGCGGGACGTTAAGGAATTGGAGGTTTAGTGGCTGCGTTGCACACACCTTGGCTAACTCCCCCCTCATCT CTGGTCTTGGGTTTCCTTTGAGTAAAATGAGAAAGTTCAACAGCACCAGCAGACTTTATGCTTGTTTTCT AGCCATGGATCCTGCAGCCCCTGGAGGGGGTTGAAGGGTTGGAGGACACTGAAGCCCTTTGTGATGGGCC CTACTTGCCTCCTAAAGCAAGTCCTCAGAACCTTACTTAACACGGTCTGTAAACCCCCCGATGAGAAGTT CCCTACGAGCTTTCTGGCCATAAGCCTGTGGTGTAGGCTCTGCTCCGGCCCATGCCATCGCCCCCTTGTC TTCCCAGCTCCCCTCTGCTGAGCGAGCCCCCCTTCCCCAGGCGGCCCCTGCTTTAGGTGACCTCGAATGC ATACTCTCAGTTTCAGACAATGAGTGCGGTTGAGGGGGCCGGGACGAGGCAGCCCAGTGGGGCGAGCAGG CTCCTCCCACATGACATCCTCGCACAAGAATGCGGGGGTGGGGGTGAGGGGCAGCTGAAAACTTTCCACA GGCTGGTGAGGCAGGCCCCGCAGAGATAAGTGGACGGTTGGGGTGGGGGTGTCTCTCCAGGAAGCGGGGC AGCCTTCCCTCCTCTAGAGGTGGGGGGTCAGGGTTCTGGCAGATTTTGTTTGCAGAGAGCCGAGCAGCCC CCTGTTGGGAAGATCAGCCCAGCAGGAGGACAAGTTTCCAAGAGCGAAATTTCCGACTTAGTTCGTGGAA CCCTGTCAATCGCTAGTCACCTACTGCCGGATTGTTCCTCCTCGGGATCCTCCCACCAAAATTCCTTTCA GTGTGGCTGGGTGCCGGTGCGCGAGATGCCAGGAACGCCCGGCTGGCTCCTCTTTATACCTCTAGACTTC TCTCAGCAGCCCCTGGCCATGCTGCTGCTGGAAGTGATGACAGTCGCTACCGTAGACGGGTGTCGTCCGA GGGGCAGGCGCTGAGCCAAGCAAGCGCTTTATCAGACATGCGAGCGGAATCCACACCGCCTTTCTGCGTG GCAGGGACTGTGATCAATCCCATTTGATAGACCAGGAAACTGAGGTTCAGAGAGCTAAAGAGGCTTGCCT GAAGTCACACAGCTAGGATGTGGCTGCATCAGGATCTGAATCCAGGCGGTGCAGCGGCGCCCAGGCTGCA GGATGGGTCAGGAAATGGGGCGGGAAGTGACCAGTTCCTTTGGAATCCCTGACTCAGCTCCTGGCCCTGG GGTAGGCTCTCTGGCCAGCCCTGGGGATGGCAGGGTCTGTTGCAGGGGCTTGGGGGCTCTGTTGGAGGCA GGGGTCCTGGAGAGGGCACTGCTGGGTACATTGAGGGAGAACCAGAGGGAGGCACAGGGTCTGCCCTCCC TGCCGGACCCTCCCCAGGCCTGGAGACCCAGATTCTTTCACTGGGGCTCCTGCTGGTGACAAACCAGACC CAGAGCGAGGCGGGGCACCCTGAGGTCACCTGGCACCTTGTCTAGGTTATTCCCAGTTTGTCCGTTTCTC CTCAGGGTTCTTTCCCCAGGAAGCCCAGAGCTCAGGAAAGAGTTAAGTGGGCAGAGGAAGGGAGGCACCT CCCAGGTGCTGTGTGCGGCAGGTGGGCACGCTGCCCGGAGCGCTCCCATGAACTATGTCAGGAATGAGCC AGCTTCCCTTGGTTCCCCCGCCCTGCCCCCGGCCCTGCCTGCGGGGACAGTGGAGTCGCTCGGGCTGACC GCTGTCCCCCGGGGGCTGCTTTGTCTCCATGTCTCCGCTTCCTGTGCTGGCCTCAGCAGCTGGCGGGGCC CCTGCTGGCGCCTCAGCCCTGGGGACCGCTGGTCAGGTGAGCAGGTGGCCAGCAGCCTTGGCCAGTGGCT CAGCTGAACAGCTGGGAGGCCAGAGCTGGGGTTGTGGGGAGTTGGAGATTCCCTCCTGAGAGGCTCCTGC TCCCTCAAGGGGCCCAGCCCCTTGGGGAGGTCCCCTCCCTACTGTAGTTTCATGATCCCCTAGTTCATAG GGACACCGCATTCCAGGCACCATGCTGGACATCTCATAAGCAGGGCTTTCTTCCATCTTCACACACAACC CAGAGAGGATGAGGACTTGATCCCCATTTTACAGATGAGGAAACTGAGGTCCGGAGAGGAAGCAGTGAAC AGTGACCAAAAGAACGGGGGCCTGGCACAGGAAGGCAGTTGCCCCTGGTGTGTGTCCTTCCACCCACAGG CTGTATGACCTTAGCAGGTCCCCTTGGGGTCCCACCCCCATCTGTAAAATGAGTGGGCTGGACCTGTGGC CCTGAAGGACGCTGTCAACCTGGTGATCCGAGCTTCCCTCCTGTGGTTTCCCACTGGGGCTCAGTCTGAA CACCGGGGAAGCTGTTGACTGTGTGACACAAGTGTGGTGAGGAGGGGTCCCACTGCTTACAGCCCCAGTG GCCTAAAGTCCATAGCTGACAGGGAGGAGTCCCCTGGCCAGGGTATGTCTGTGGTTAAGGTGGTCTTTAG ACAGGGTGGTCTCGGGCCATGGCAGGGGCTGCTGGCAGGATTCCTGTTTCATCAGATCACAGTTGGTCCC CCAGGTGGAAGACTCTGGGAGCTGCTGGCTGTGGCTCGCAGGCTTTGTCCCCTGCTGGGAAGTCCCACCA GGCCTTATTTCTGTGATGTTTCTTCTGGCCTACAGAGGTGGGACCACGGTGGCAGCACCCCCAGCCCCCC ATGGTGGCTCTCACCTCTGTGCCCTGTCTGCCCCACCCTCAGCTCACACTGGGGGCAAAGCTAGGCGCTG GCATCTCCGCTGGGCGGGCACCGGCTTCTCCCTCCCTCCCTCTCTCCCTCCTGGAGGTAAGTGGGTCCCC AGAACGGAAGGAAGGAGGCGAGGGAAAGCAAACAGAAGATGAAAGGCTGGAGGCAGGACAGGAGCGGTAG GCGGGGGCTGAGGTGGGGAGTGGTGCTTATCAATGGTGGAGGAATGTGCCTGCAGATAGCTCCCTAGGGT GTGTGTGAAAGGGACAGGGTGCTGGCAGCCGTCAGGCCCTGGGGGCAGCCCCCCTTCTGCAGAGACGACA GGGCCTGCTGGGAGCAAGAAGCCACCAGGGCCTGAGGTTGTCAGCTCCCTCATTTGCTGGGTCAGTAACC CATAGGTCGCCATTTGCCGTCTGTCAGGGCCCAGAGACAAAGTCCAAGCTCCACATCCCTGGGCCAAGGT GGTTCCTGCGGTCACCTGCTGGGCCTGGCTTGGGCGGTGACTGGCCCTAGGTGAATTGCCACCATGACCT CTTGACCTCACAACCTTGCCATTGCCAGCCTGGGAGGTGGCTGTGCCTTGGGAGGAGGGGCTCCACTGGG GGCTGGACTTGCGTCACGATAAGGGCGTCTGTCCCTGAGTCACCTCATGCTGCCACCTGAGGGGCGGGCA TCAGGAACTGGAAAAACCAGGGTATAGCCGGAGGTGCAGCCACTGTGCCCCAGTTCCCCTGCTCGGAGTA GCCCAGGCCTGCCAGACAACCGGGGCCAGAACAGCTCTCCACAGGTGTGCCACAGGTGTGCCAAAGTTAG GCTCTTGTGTAAGGCAGGTAGGCATCCTGGTGGACCTTCTCCACAGTGTCTCTCTGGGCGCTGAAACACT GCTCATTTCTCTGGCCCTGGAGTGCATATTTCACATGCACATGGTAGGTTTGCCACCCATTCTCTCTCCC ACTCACTCTTCCATCCACCTGTCCACCCATCCACTCATCCATCCATCCACCCCTCCACCCATCCACCCCT ACATCCATCCATCCATTCATCCATCCATCCATCCATCCATCCATCCATCATCCATCCATTCACTCGTCTA CCCGCCAACCCACCAAACCACCCATCCACTTGTCCATTCATCTATCCATCCATCCATCCACTCATACCCC CCTCCACCCATCCATCTGCCCACCCCTCCACCCAACCACCCACCTATCCACCCATCCATCCATCCATCCA TCCATCCATCCATTCATCCCTCCACCCACCCACCCTCCTGCCTATCCATCCCTCATCCATCCATCTACTC ATCCATCCGTCCACCCACCAACCCACCCATCCACTTGTCCATTCATCTGTCCATCCTCCGCCCCATCCAT CCATCTATCCACCCCTCCACCCAGCCATCCACCTATCCATCCCGCATCCATCCATCCACTCATCCACCTG TCCACCCACCAACCCACCCATCCACTTGTCCATTCATCTGTCCATCCTCCCCACCCATCCATACATCCAT CCATCCAACCACCACTCCACCCACCCACCCATCCATCCCTCATCCATCCATCCACTCATCCACCTGTCCA CCCACCAACCCACCCATCCATTTGTCCATTCATCTGTCCATTCATCCACCCACTCATACCCCCCTCCACC CATCCATCCATTCATCCACCCACCCATCCATCCACACACTCATCTACCCATCCACCCACCAACTCACCCA TCTATCCATCCATCCATCTGTCTGTCCATCCATTCAGCAAACATTAACTGAGCACCGCTGGGCCATGGGA CACAGATAAATTGGTCTCCATTCCTGCTCCTCAGGAGCTGCTGGTCTCACGGAAGCTCCTGATACATGCA GGAATAATTTCAAATGGAGCATAAAAGCCAAGTTTTGAATTCCCCTGGAGCTGAAACAGTGTTTATCTGT CTCACCATCGCATCCTAGCACCCAGCATTGTGCCAGACACGTATGAAGTGCCCATTTCTATTTGGTAAAC ATAAGATTAATAGATGCCCTAATGGGGGCCGGGGGGCCAGGAATTGGGCAGTCTGGGAGGGCTGTGTAGA GGAGCTTAAGCTGGGTATTAAAGGATGCATAGGAGTTTGCTGGTTGGCTAAGGAACAGTAGGTATCTGGT GTATGTGGGTGTGTTTGAGTGTGTGTGACCCCTGTCCCCACTTGCCCGCCTAGAATGCCAGGAAATCCAA CTAGATAAAGTCAGGAAGAACACAGGGGCTTGCTGGTGTCCTACTCATGAACTCTGGGACCCCTGAGCAC TTGGAAACTCTGGCGGGGCCCTGGAGACAGCCCCTGGTAGCTTTGTGGTTGGAGGAGGGGAAGCACATCT CGTCAGGCAGGCACATGCCCTGTTGACGCTGCCTCTCTGCTGTATTATCTGGCACATCCGCAGCGGAAAT CTCTCCAAATTCCCTCTTTCCTGGCGGCAGCAGGCAGGCAGGCCACCCCCGGGCGCTGGGGCCAAAGAGC CCATCTCTTCCCCCACTTCCTCCTCTTGGCATAGAAGCAGCCACACGGTGGGGAGTCGGGGCATTGTGAG GGTTTGCAGGTGGCTAAAGCCTCCAGTGGGTCCGAGCCTGGGCTGTGGGGGTTTATGGCCCCTGCCTGGC CTGAGAGCCTGGGCTGGGAACGCCCCCGAGCTTCCCAAGTCAGCTGGCCCTGGACCACCTGAACCAGCAC TGAGCCAGGTGAAGTCTCCTCCACAGACAAGTCAGGGCATTTGGGGGAACTGACCCCAGGATAAACATGG CCCAGCTTTCTGGAGTCTCAGTTTTACTCACAGATCTGGTGGAGGAGAGAGCTATTTTTGTATCATGCAG ATATGTTATGGGGAGGGATGCAATATACTCATGGGTTTCCAAATACAATAGGAGACTTGAAGACATTCGG GGCTTGAAGGAGACCACTTCAGCCACCCCAACCAACCCCCCTGGGCTGGAGTCTACACTTTTCTGCTCAC AGACACAAAAGTGCCCAGTTTGAGAAGATCTGTGGTGGGGAATACCCTCCCCTCCTCCACAACACATAGA CCCACAGCTGCTCTGAAATTCGTCAGGAGTTTCTGGCTTTTGAAGTGGGTCAGGCCTTATCTCCTCTCTC TTCAGGCTTGTTTCAGAATGTTGATTTATCTTTGCTCCAAATTGAAGTGTTCCTAAGAACAGAAGTGGGA AAGGAGGCCCGGTGAGGTGGCTCACGCCTGTAATCCCAGCATTGTGGGAAGTCGAGGTGGGAGGATCACT TGAGGCCAGGAGGTCAAGAGACCAGCCTGGGCAACAAAGACACACCCCGTCTCTAAAAAATAAAATAGGC CGGACGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGACGGGTGGATCACTTGAGGCCA GGAGTTCGAGACCAGGCTGCATCTCTACTAAAAATACAAAAGTTAGCCAGGCTTGATGGCCGGTGCCTGT AGTTCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCT GAGATCCCACCACTTCACTCCAGCCTGGGCAACAGAGCGAGACTCCATCTCAAAAACAAAATAAATAAAT AATGAAAAAGGAGTGGGAGAGGAGAGAGGCTGAAAATCAGGCATCCTAAGTTTGAGTTCTGGTTTCCTTC TTGGGAGCTTGGTGACCTTGGACAAGCTTTTTTGTCTCTCCTCACCTCCAAAGTGGAACCAGCGCTAATA GTGCCTGTATATAGCAGGTCTATTGCGAGGACTAAATGAGGGTACAGTGCTTAGCCCGAGCCCTGCGCAT AGTAGGTACTGTCATTGGGACTCCAGGCTCTGTGCAGAGCAGGAGTCGGGTCCCGGGCCTCCTCTGTCCT GCTGCATGACCTGGGACAAGCCCCCTTCCCTGCCCTATGTGCCTGAGCTCTTGCAGGGCCAATGCTGAGG GTCTGCAGAAGCAGGATGGACCAAGGGGGTGAGAGCGGCTGTTTGTGTGGTCCCTGGGCCAGGGTTGGGA GGGGACAGGGATGCAGCCTGGCTCTGAGAGCAGAGTCATCAGCAGGAGGTCACTATCTGGCACCTTACAG AGCTGGGTGTCCTTTGAGTCCTGTTCCCCTGACTCCTGGTCCCCCTCTGCACCTCTGCTCACACAGGGGA CTGGATGACGAGAGTCTTCGCTCCAGATTCTGTCCCTGAGAGTTAGCAGGTTTGCTTGGGTCAGGGCACT TGAAATTGCTTCCCTGGAGGGGGTTGTCCTTAGGCCATTAGGGGCCAGGTTGTCCCCAGGGTCTTGGACA AAAGCTGCCTCCAGGCACAGATTTTTCCTGACGGCAGGGGTCTGACTTCTCCACATCAGACCTCCAGCGG CTTTCCATTGCCTCCAGGATAAAGTCCCAGCTTCTTGGCCTGGCATTGAAGGCCTTTCTCAACTGTTTTA TTGCTTGCTGCTCCCCACATTTGTGCCCACAAACCCACTCATACCTTCCGTATTAGTCATGCACTTTCTC ACTCCTAACTCCCTCTCCCAACATCTATCATTCCCCTGCTGAACTCCTATGCAGCCTCTGAACCCCAGCC AAAATGTCCCCTCTGTGACTTCTCAGACTCCTGGCCAAGGTTGTTTCCCCTTCTCCACCCCCTTAGCTGT TAGCTTGTTTCCTCCCTCTGTCTTGCAGACCTTGTCAGGTGCTTCTGCTCCCTGAGATCAGGAGTTTGTT TTCATCTTGGTGCATACCCAGCACTGGGGGTGGGCCAGGCACAGAGCAGAGGATCATTGTGTGTGTGGTG AACACGGTGCTGAGGTTGGAGGTGTCTCAGGACCCTCTCATCAGAACAATCTGAAGGATTATAATTGTAG GGTTGTTGGAGGAGCTCCCTAGGGTGACCTCTACCCACCCTGGCCACTTCAGCAGCTGCCCAAGCCCTGG ACAGCCCTGCACCGTGAGCCCTGTGTCTGGGCAGCTTCCTGCCTGTAGGGCCAGGAAGGGGCTTAGGGCA GGGGCGGGATGAGACAGGATAGGGCGGTGGGAGGAAGAAGCCCCCGGAGTCAGGTGCCTGAGCCCCCAGC CTGCTGGGCCAGGACAGGACTGGCCACTGGGGGAGGAAGAGTCACTTCCTGGCTGTCCTTGTGAGTGGCG GATATGACTCGGTCCTGGAAGCAGAGCCAGAGAAAATGCCAGGGGGCTTGGCCTTTCCTGCTTCCTGGTC AGCCCCGGATGGAAAGGAGGGCAGGTCCTGGGCTGGAGGTAACACCTGCAGGGATGGCATCCTGAACTGA TGAGGCTGGCCAGTGAGTCAGGGTGGTGGTGACAGTCAACAAACACACATGGTCAAGAAGAGGCAGTCAT TGCCCTGGGCAGCTCTCAGCTACCCAGGTGGGGACCGGACAGGCTAGTCTGCATGGAGGAAAGGGGATGA GGCCGGTGGGCAGCGTGCTTGGTCAAGTGCTGAGCTAGGCTGTGATGGGATTCTTGGTTGGCTGAAAGGC GAGGTATGGCCTTGAATGCCAGGCTCAGGGGCGTGGTGCTTCTTGCAGGAGCCAGTGGGGAGTGAAGCAA AGGTTTGCAGCATGTGTGTGAAGCACTTCCTGGGTGCCCGGTACATGCTAGGCCCTTGCCATGCATTTTT CCATCACAAGACATTTTGCCGATGAGAAAACAGGTCCATAGAGATTTACTGACCTGCTTGCAGGGCAGGG GTCCCTGGTGAGGGAATGAGACAGTCACGTGGGGTGGAAGCAGATTGAACTGATGTCCTTGTGCTCTGTC TGTCCTGTGTCCACCAGCCTGCTCGCCTGGATTTTTTAAGTTTGAGGCATCTGAGAGCCCCTGCTTGGAG TGCCCTGAGCACACGCTGCCATCCCCTGAGGGTGCCACCTCCTGCGAGTGTGAGGAAGGCTTCTTCCGGG CACCTCAGGACCCAGCGTCGATGCCTTGCACACGTGAGTCTTGCAGTGGGTCAGGGTGGCGTGACTGAGG GTGACGTGTCCGCCTGGGTCCAGCACAGCACTGACTCCTCCTGTCTGTGCAGGACCCCCCTCCGCCCCAC ACTACCTCACAGCCGTGGGCATGGGTGCCAAGGTGGAGCTGCGCTGGACGCCCCCTCAGGACAGCGGGGG CCGCGAGGACATTGTCTACAGCGTCACCTGCGAACAGTGCTGGCCCGAGTCTGGGGAATGCGGGCCGTGT GAGGCCAGTGTGCGCTACTCGGAGCCTCCTCACGGACTGACCCGCACCAGTGTGACAGTGAGCGACCTGG AGCCCCACATGAACTACACCTTCACCGTGGAGGCCCGCAATGGCGTCTCAGGCCTGGTAACCAGCCGCAG CTTCCGTACTGCCAGTGTCAGCATCAACCAGACAGGTGAGGTCCAGGGGTGGCAGCTGTGCCCTATGGGG CCTGCCCAGGTGGGGCTTAAGGAGGACGGCCATCTGGGGCTCGGGTGTGTTTAGAGAGAGGCAGCAGAGC AAGTGGTTAAAGGCACAGTGTCTAGAGCAAGCTTGTCCAACCCGTGGGCCACATGTGGCCCCAGCCGACA TTGAATGCGGCCCAACACAAATTCGTAAATTATCTTAAAACATTATGATATTATTTTTGCAATATTTTTC CCTTTTTTTTGAGACAGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCTTGATCTCGGCTCACTG CAACCTCTGCCTTCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCTGGAGTAGCTGGGATTACAGGCACG TGCCACCACACACAGCTAATTTTTTGTATTTTTAGGAGAGACAGGGTTTCACTATGTCGGCCAGGCTGGT CTCGATCTCCTGACCTTGCGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGAGATCACAGGCGTGAGCCAC TGCGCCCAGCCTGCAATTTTTTTTTTTTTTAGCTCATCACCTGTTGTTAGTGTTGCTGTATTTTATTTGT GGCCCAAGACCATTCTTCCATTATGGCCCACAGAAGCTGAAAGATTGGACACTCCTGCTCCAGAGCCGCT TCTGAGCTCTGTGACTGTGGGCAGGTTACTTAACCTCTCTGGGCCTCAATGTTCTCCCCTGTAAAGTGGG ATAATAATTGAGAATTGAGACTGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGG TGGGCAGATCACCTGAGGTCGAGAGTTCCAGACCAGCCTGACCAACATGGAGAAACCCCATCTCTACTAA AAATACAAAAAATTAGCTGGGTGTGGTGGCGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGG AGAATCGCTTGAACCCAGGAGGTGGAGGTTGCGGTGAGCCGAGATCGCACCATTGCACTCCAGCCTGGGC AACAAGAGCGAAACTCCGTCTCAAAAGAAAAAAAAAAAAAGAAAGCATTCAGCAAAAGTTAGTTCTTCTT CTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTTTCTTCTTCTTCTTCT TCTTCCTCTTCTTCTTTCTTCTTCTTTTCTTCTTTTCTTCTTCTTTCTTCTTCTGTCTTCTTCTTCTTCT TTTTTTTTGAGACGGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGCAATGGCACAATCTTGGCTCACCGC AACCTCTGCATCCCGGATTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCATGC GCCACCATGCCCAGCTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCATGTTGGTCAGGCTGGTCTC GAACTCCCAACCTCAGGCAATCCTCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGGGTGAACCACC ACACCTGGCCTTTTATTATTATTATTATTATTATTATTATTATTTATGCACTCGTAAATATGGGGCACCT CTGATGTGCCAGCCCCTGTGATGGGGCCAGGGTGGAGGCCTGGGGCTCTGGCCCTGTGCTCTGGAGCTGA AAGTTTAGGATCCTAGGTTGGGATCTAAAGAGCCTGGGAGCTGGGCGTGGTGACCACGCCCATAATCCCA GCATTTTGGGAGGTTGAGGCAGGAGGATTGCTTGAGCTCAGGCATTTGAGACCAGCATGGGCAACATAGG GAGACCCCATCTCTACAAAAAATACAAAAATTAGCCAGGTACAGTAGCATGTGTCTGTAGCCCCAGCTAT TCAGGAAGCTGAGGCAGGAGGATCACTTGAGCACAGGAGTTCAAAGCTGTAGTGGGCCGAGATCATGCCA CTGCACTCGAGCCTGGGTGAGAGAGCGAGATCCTGTCTCAAAAAAATGAAAGAATCTGGGCTGTGGAGGA TGTGGCTCCACGTCCACTTGTCCCCCCAAACCCTGCCTGCTCGTAGGCAGCTTCTTACCCACTTCCCCCA CTGCCTGTCCTGCCCAGAGCCCCCCAAGGTGAGGCTGGAGGGCCGCAGCACCACCTCGCTTAGCGTCTCC TGGAGCATCCCCCCGCCGCAGCAGAGCCGAGTGTGGAAGTACGAGGTCACTTACCGCAAGAAGGTAACTC CCAGAGGGGCGGGGCTGGCTCTAGCTGGGCCGACAGCAGGGGACAGGCTGGTCACATAGATGATCACCAA ACCACCCAGCCATCTGAAGAAGCACCCTTCTGCAGATGGGGAAACTGAGGCCTGGGGTCTGCCAGGGGGT TACATCTCCCAAGGCAGCACAGCAGAGATTTGTACGAGAGAAGACATGGCGTCCTTGGAAGAGGCAGTCA GGGTGAGGACAGGGGCAGAATTTTGGGACCCCACACACTCAGTTTGAGTCCTGGCTCATGCATTTAGTGG TTCTGACCTTGAGTGAGTCACTTAATTCCGAGCCTCAGTTTCCTCCTCTGTAAGAAGAGCCTCAAGTTTG CTAACAAAGGCAAGCCACCTTGCTAGCTTGGGGTGGTCTCCAGCGGGCTGAGCCGAGGCCCCTGCCCTGC CCTCACTGCCTGCTCCTCCGCCGGCCACCCACCCACAGGGAGACTCCAACAGCTACAATGTGCGCCGCAC CGAGGGTTTCTCCGTGACCCTGGACGACCTGGCCCCAGACACCACCTACCTGGTCCAGGTGCAGGCACTG ACGCAGGAGGGCCAGGGGGCCGGCAGCAAGGTGCACGAATTCCAGACGCTGTGTGAGTTGGGGGACCCTG GGCATGGACCAGGCCAGGGCCCAGAACCAAGCAATTGAGACATCTTGGGAAAGGAAGTGAATCAAATAAC TTAGAAATGCCCCTTTCTCGGTCACCGGCGGCCTGGGACAGCCCTTCGGGGACTGCCCCCAAGCCTGGGG AGGGGGAAGCATGGAAGGCTGAGGGGTGGAGGAGCCGGGATGTGGATTCACGACAGTGGTGTGAGGAAGT TCAAATCCGCATCTCAGAAAAAGCCAGAGCTTTGAGCCCCACATACCTGCAATACCTCCCGTGAGACCTT CGGGAAGGCCTCCGCTTGACCGTCTATGAAATGGGACTAAGTACCCTCTGGAGCCTTCCCAAGTGCAAGC ACCCAGCACACAGTAGGGGCCCAGGTGTCTTGGGTGCAGCGCGGGTGTTGCTGTAATTTGTGGGGGAACT CCCTTGTCATCAGCTGATTTCTTCCACCAGCCCCGGAGGGATCTGGCAACTTGGCGGTGATTGGCGGCGT GGCTGTCGGTGTGGTCCTGCTTCTGGTGCTGGCAGGAGTTGGCTTCTTTATCCACCGCAGGTTCGTCAGA GCCCATACCCTGGCTCCACATGGGCTTGGGTGGGAAAATGGGGCAGGAACCTCCATTTCCTCATCTGAAC GATGGGGCCCACAGGATGCTAGTCGAGTCTAATCCCTGCCTCCGGATGGTGCGAGGATATACGAGTTAGA GTGTGTAGCGAAGTGCCTGGCACGCGGCGGGGCCGGGACACGGGGGTCATTACCTCTGCTCTTGTTGTTA TTAATGATGTGTCCACACTTCCTCTGGACACGCAGGCAGGAATCCCCGAGTAGCTCTAATGGGAATGCCT TCGTCACGACTGCTTAAGGGGCCATTCTGGGGCCTAGATCCTGGAGAGGGAGTCCTGGCTCGCTCACTTC CTCCCTGTTCCTCCACCCGCCTTCTCCGCACCCTCGGCCCTGAGAGTGGAGCTTGGGCAGCAAAAGCGGG GACTGGGCCGCATTCTGAGCACCCCAGGTCCTCCTAGGACCAAAGTAGGGCCAGGAGGCTTCCCTGGCCG GAGCAGACCTCACTGACCTCCCTGCATTTGGTTCCCCGTGGGGCTCTTTCAGGAGGAAGAACCAGCGTGC CCGCCAGTCCCCGGAGGACGTTTACTTCTCCAAGTCAGGTGAGACGCAGCCCCCGCTCCAGGCCCAGCCC TGCCCGCACCGTCCCCAGCTCTGTGGGGGAGGTGGGGGCAGCCAGGGTGTTCCCAGGGCACTGGGGTGGG GCCACAGGCTTCCGTGGGCAGCTCTGAGGGGTCCGTCCCCCACAGCCTGGTCCAAGTCTCTGAAGATCAC GTGACCTTCTCCTCTGACTCCAGAGCACCCCCCATGGGGCCCCTCCTGAGCTGCCTGTGACCCCACCCCT TCTCCTTCCAGAACAACTGAAGCCCCTGAAGACATACGTGGACCCCCACACATATGAGGACCCCAACCAG GCTGTGTTGAAGTTCACTACCGAGATCCATCCATCCTGTGTCACTCGGCAGAAGGTGATCGGAGCAGGTG AGGTTGGCCCCCTGCCAAGGGGCCCTGAGGAGGCAGCGGTGGTGACACAGTGTGGGAGCCCTCATGCCGG GGCTGACCAGGGCACTCCCCTGACCCTGTCTGCCCACAGGAGAGTTTGGGGAGGTGTACAAGGGCATGCT GAAGACATCCTCGGGGAAGAAGGAGGTGCCGGTGGCCATCAAGACGCTGAAAGCCGGCTACACAGAGAAG CAGCGAGTGGACTTCCTCGGCGAGGCCGGCATCATGGGCCAGTTCAGCCACCACAACATCATCCGCCTAG AGGGCGTCATCTCCAAATGTGAGGCTTGGGGCCTGCCCACACTGGGTGGAGAGGGGCCACTTAGCAGGGG CTCTGTCTGTGACTGTGCCCACCTCCCCTATACCTGTGCCCACCTTCCCCCCACACCTGCACCCACCTCC TCTACAACTGTGCCCACTTCTCCCCAATACCTGTACCCACCTCCTAACACCTGTGCCCACCTTCCCCCCA TACCTGCACCCACCTCCTTACACCCGTGCCCACCTCTCCCCATACTTGTACCCACCTCCTCTACACCTGT GCCCACCTCTCCCCGATACCTGTACCCACCTCCTTACACCTGTGCCCACCTTCCCCCCATACCTGCACCC ACCTCCTTACACCCGTGCCCACCTCTCCCCATACTTGTACCCACCTCCTCTACACCTGTGCCCACCTCTC CCCGATACCTGTACCCACCTCCTTACACCCGTGCCCACCTCTCCCCATACTTGTACCCACCTCCTCTACA CCTGTGCCCACCTGTCCTCAATACCTGTGCCCTCCTCCCCAATACCTGAACCCACCTCTCCCCATACCTC TGCCCACTCCTCCGCCTGTGCCCAGCTTTCCCCACACCTCTCCCCATACCTGTACCCACCCTCCCCACAC CTGTTCCACCTCTCCCCACACCTGTGCCCACCTCTCCTACACCTGTGCCCACCTTCCCCCATATCTGTGC CCACCTCTCCCACATGCCTGGGCCCACTTACCTCTCACCTGTGCCCACCCCCCTACAGACAAGCCCATGA TGATCATCACTGAGTACATGGAGAATGGGGCCCTGGACAAGTTCCTTCGGGTAAGGATGTGGGTTGTAGG GGGCGGGGATGCCTGGCCATTGAGCCCGGGGCTGGCCTGGCGGGTTCAGGGCTGGCCTGCAGCTGAGCGC CTGTGCTCCGGCAGGAGAAGGATGGCGAGTTCAGCGTGCTGCAGCTGGTGGGCATGCTGCGGGGCATCGC AGCTGGCATGAAGTACCTGGCCAACATGAACTATGTGCACCGTGACCTGGCTGCCCGCAACATCCTCGTC AACAGCAACCTGGTCTGCAAGGTGTCTGACTTTGGCCTGTCCCGCGTGCTGGAGGACGACCCCGAGGCCA CCTACACCACCAGTGTAAGTTGGGGAAGGGGACCTCAAGGGAGAAGCGGCCTTCGCCCTGCATGGTGTCC TCTCACCTGCACACCTGGGCAGTGCTTCAGGAGGCAGAACACCTGTAGGAGTCCAGGGAGGGGTCGTGGG GCTTGGCTGCAATGGTCCTGGGGCCAGCCAGAGGGCACAGTGGTGACTGGGCCTGGGTTCCCTGCAGGGC GGCAAGATCCCCATCCGCTGGACCGCCCCGGAGGCCATTTCCTACCGGAAGTTCACCTCTGCCAGCGACG TGTGGAGCTTTGGCATTGTCATGTGGGAGGTGATGACCTATGGCGAGCGGCCCTACTGGGAGTTGTCCAA CCACGAGGTGGGTGCCCTTGCCCTCCCCAGGCCTGTCCGGACCTGAACTCAAGCCCTTTACTCATCTCAA ACTGCAGGGGCTGGGCAGAGGACAGTTTAGATGAACCTTCTTAGGCTTGCTCCATAAATGTTTATTTTTT TTTTTTGGAGACGGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTTCACTGGCATGATCTCAGTTCACTGCA ACCTCCACCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCATGCG CCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACTATGTTGGCCAGGCTGGTCTC TAGCTCCTCGCTTCAGGTGATCCACATGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACC GCACCCAGCCCCGTAAATATTTCTTGAGGATCTACTGCGTGCCAGGCCTTGTGCTGGGTTCCAGGAGCTG ATTCAGAGAGTGCAGAGATGAAAAAAGGAGTGGGGTGTACGTGTGTATCCGTGTGTCCATGCATGTGTGT GCATCCGTATGTGTGCACATGTGCATGCATGCATGTGTGTGTGTGTCTGTGTGCTTGGTGCCTCTCTCAG CCTGGTGGCCTGGGAGGCTTCTCAGAAGAGGTCACATCTCTGCCAAGACCAAGGGCACTGTAAGGCAGCC AGATGAGAGGGAGGGGAAGAGAGATGGGAGGGAGGCTGGGCTGAGGGTACACAGTGTGGCTGCTGCCTGG TGCCCTGTGAGGGAGCAGGGTCCCTTCTAGCTGGGAGCAATGGCGCATGCCTGTAATCCTAGCACTTTGG GAGGCTGAGGCAGGAGTATCGCTTGAGCTCAGGAGTTCGAGACCAGCCTGGACAACATGACGAAACCCCA TCTCTACAAAAAATTAAAAAATTAGCCAAGTGTGTTGGCACGTGCCTGTAGTCTCAGCTACTCAGGAGGC GGAGGTGGGAGGATCACCTGAGCACAGGAGGTTGAGGCTGCCGTGAGGTGTGATAGCGCCACTGCACTCT AGCCTGGGTGACAGACTGAGACCCTGTCTCAGTCAAAAAAAAAAAAGTCCCTTCCAGTGAACTCTGGACA CAGACCCTTAGGCATTTGCCCTTTGGGCAGCTCTGAAGGTTGGGTGGCAGCTCAAGAAAGGCCCTTCCTG TCTGTTTCTGGGATGTTCCTGTTCCCCTCCCCTCCCCTGCCCACCTCCATAGGCTGGAGGCTGCAGAGGG TTTCAGTGGCTTTCTGCAACAGCGCCCCTGACCTTCGTGCCCCGCCAGGTGATGAAAGCCATCAATGATG GCTTCCGGCTCCCCACACCCATGGACTGCCCCTCCGCCATCTACCAGCTCATGATGCAGTGCTGGCAGCA GGAGCGTGCCCGCCGCCCCAAGTTCGCTGACATCGTCAGCATCCTGGACAAGCTCATTCGTGCCCCTGAC TCCCTCAAGACCCTGGCTGACTTTGACCCCCGGTGAGTTCTATGCCCTCTGCCCATGATGACCTCAATTT TCCTTCTGCAGACTCTTGAACCACTTCGGTAGAGTGGCCACCCAGGTGAAGCTGGTAGGGGGGGTGCTGG GGGCTAAGAGGTTATGTGTGGACTTGACTTAGACTGGACACGATGGCCCAGGAAATCCTAATAGAAGCAA CCAGCTTATGTGTCTGTGTGCAGGGCACTGCGTGAGCACTTAATATGTTTTCATTCATTTAAACAACCTA CGAGATGAGTCCTCCAGTGATCCTCATTTTGTAGAAGAAGAAACTGAGACACAGGGCGATTGAATATCTT ACATGGCTGGAAGTGGTCAGGCTGGGATTGTGACCTCAGGATCTGGAATCTCTGCTCGTAGCATTTTATG ATGTGGTAGTTATTGGTGGTGGTCCTGTTAGTAGGAGTGGAGGGGCAGCAGTAGTTACAGATGCTGAGCG CTCCCAACGTGCCAGGAGGTCTCATTGAACCCTACTTGACTGGGCTTCCCTGTTGCCCAGATAAGGAGAC GGAGGCACGGGGCAGCCGAGTCAATCATCCAGGTTAGGGAGCAGCAGGTGCAGGGCCCAGGGTGGACTGG GTGCTGCAGCCCCTCACCTGCAGTGCTTCCTGTTGCAGCGTGTCTATCCGGCTCCCCAGCACGAGCGGCT CGGAGGGGGTGCCCTTCCGCACGGTGTCCGAGTGGCTGGAGTCCATCAAGATGCAGCAGTATACGGAGCA CTTCATGGCGGCCGGCTACACTGCCATCGAGAAGGTGGTGCAGATGACCAACGAGTAAGTCAGGCCCCTT TCCGTCCCCCCTCGCCTCCCGCCTCCCACTCCAGAGGCTGCCTCCATGCCCCCCCCAGCCCTCTTCCCTG CCCCTCAATGCTCCTCTCTTTGTTCTTTCTCTTCTGGGAAGAGGCTCCTTGGAAGAGAAGGGCAGAACTC CGCCAGCAGCTGGCAGCTCTGGGTGCCCACTCTCAGCTCTCTCCTCTTCCTACATCCTTTACCAGAGTGG GGAAATAATAGTAACCGTAATCATAACAGTAGCTACTGTTTACTGAGGGCTATGTGCCGTCTCTGCTTGA GCACTTTGAATGAGAACCCAGCGGGGTGAGTCCTGTTAACAGGTGAGAAACAGGTGCAGGTGAGAAACAG ATGCAGAGAAGTGCAGTGACCTGCCCAGGGTCCCACAGCCATGAGGGGGAGAGCAGGATTCCAGGCCCAG TCAGTCGGGATCCCAGAGCGCAGGGATCGGAGAGGTCATTGGTAGAGAAACAGGCTGAGATGTTACCGGC TTGCCTGAGGTCACACAGCCAGTTTGGGGCAGTCTTCTCCAAGATGCCCTGACTGCTGCCCAGGAGAGAG AACCCCTGGCCTACCCCGGGCACCTCTCTCCACTTGGTTGGCTCTCAGCCTGCAGTCCCACCTGGTGAGA AGTGCCACTTACTCTCTGCTGGCCCTGGGTTTGCCCCTTTGTCAAGCTGCCCCTTGGCAGCTCTTCTCCC CTTCCCAACTCCAGCATTGAGACTTTTCCCGGCATGGCCTTGGCACAGACACCTCCTCCTGTCCCAGGAA GGGGGAGACCCTATCCTCTTAGCCTTTTGTGCCTCTAAAAATAGTGGCCAGTTTCAACAACCCAGCTTGT GCATGGTCAAAGATCATGGCGGGAACAGACCGGGAGGCTGGGAGGTTTTGGGAACCGTATGGAGGGGATG ACCTGGGCCTCCCATGGTTCTAGGTCACAGAAGTTCTGGGATTTGAGCCTGTTCATGAACATTCTCTAGG GCCTTTGGAAATTGCTCAGCTGGGCTCCCAACCTGCTGGCCAAGGCCATAGCCTCCCTCAGGGGACAGTC GGTGATGGGAAGCAGGCAGGAACAGAGCCGACCAGAGGGGAGGCGGGGACACGTAGGGAGGGGAGATGGA TCACAGGATGTCTTTTGCTGCCCGCCAGCCCAGCAGGGCCACAGGCTTGGGCTCTGCACACATACCTGGG TTCAAGTCCCGCATCTGCCACTTCCTAGCGGGTGACCTTGATCAAGTTTGATGGGATTGCATGGGTGCAG CGCAGATGACACGACTGGTATACAGTGGGTGCTAAATCCTCATTGCTCTCCTCTTTTCCTCCACTCCCTT GCTTTCCTCCCCTAGCACTGTGCAAATGCCCCCTCCTTTTCTCCTTTTTCCTGGGAACATCCACCAGACC CTTTGCTCCTCCAGGGGCTCCCACCAAGGACAACACAGCCTCTCTTCTGGGGACCAGAGCTGAGGGCACG GAGAAGTGCTTATGGGAAACACATGTTCTTAGAAGCTTCCCTAAATAGCCCAGGGTGCTCCTCGCCAATT CCTTTCCCACGAGCAGGGACGGGGCAGTCTTGGATGGATGGAGGCTGTGTGTGTGTGCGCTGCAGTGCGC GTTGTTGTGAAAGGGCCTGGATAAAGGCAGGAAGTCATTCGGCGCCCCCCACCACCCACCACCCGCTCCT CCCACCAGCCACTGGTGCTCAGAGCTGGGGCCTGCATGCCTCCTCCTTCCCCTCTGCCTCTTTCCAAATA AATGGGGATCTCAAAGGACTTTTTAAAACCTGAAGCCTGGGTCTACACACGCCATGGGTCCCAACGGGAG ACTTGGAGCTGGTAGCAGGGGAATGCGTGCCTTTCCCAATGGGATCAGGATTTAGGCTTCAGTGTCCCAC CTCCTCCCCTTCTCAGCCTCCTGCCTTCTTGACTCCCTCCCAGGGGACCAGCTGCCTGGTCCCCTGGGGT CCCACAGCCACTGTCTCTTCTCCATTTGTGCTATTTTGGAGTCAGTTGGGTTTCTAGCTAGACTAGTGGT CCCAGATGTTTTGTGAGCAGCTGACGAAAGGCGTGGATGTTGCACCCCAGAAAAATAGCCCAACCCCAGG CTCTGTCTAGAGCTGGGACTACAGCATTTGCATCCTGTGTGGGGGTCGAGGGCACAGGCTGTAGATCTTA GGGTCTCCAGTGCCCTTGGCATAGGCTTGGCACTGAAGGAATGCTTGCTGAATGAATGAATGATCTGACA CGTGAGGCTCCAGGAGCCATTTCTTACTCCCGTCTCCCTGCACCCAGGGCCAGAACACAGTAGGAGCTCA CCGAGTATATGGCCTTGGAGTTTTCTACGCAGGGCCTCCAAAGCAAACTGTGCTCCCATCCTGTGAGATT AACCACTACCATTTGCAAGAGGGACCAGAGGTGGCCCAGCAACGGCCCAACCTCCGCTAAAGCATTCATT CGCTCATGCATTCATGCAGCAGACACTTCCTAGGGACCTACTATGTGCCAGGCCTATCCTGGACCCTGGG CAGGGGTGGGGGCGGGAGCAGGTGCTGTGGGGGTGATGGGCCCAGATGACAAGGTCTCAGCACTTGTCCT CCTGGAGCTTACAACCCACTGGTTTTTAAACCGGATGTCAGGTTTCTTCTGGGATTCAACCAAATGCAGA CTCCTTGCCCCACCTGCGGAACTGCAAATCGAGTGAATCTGGGGTCAGGCCGGGGGTCCTGTCTCCTTCA CCGTGGTCTGAGCGCTTTTCCAGGGACCACAATTTGAGACCTTCAAGTGTGTGGGAAACTGCTGCTTTTT CAGCACCTCCAACTGTATAGGTTAGAAACGTCCTGTGCAGGTAGCGTAGGAAGTTCTCCCAAATGTCCCA AATGTCTCGGCCTTCCTGCTGCTGTGGGAGCACCAGCCTCTGCGGGAGGTCCTGGAGTCCCCCCAACTCA CCTGGGTCTGCCCTTCCCTGCTCTGCGCCTGTGCCGGGGCTCCCGGAGCCTGTGGGAAAGTCATGTCTGC AGAACTGCAACTAGGATCTTGCATCATATAATTAGCTCCCTTTACAGCCAAAAGTCGGCCCATAAAAACT TGGGTGTTTTCATGGGTTTGGGCTAGTGGGTGAGGACGGTGGAGGAGAAAACTCCCAAAGTGAGTAATAA ATGCCCTCCTCACAGGTTCCTGGGAGCATAAGTGATTTCATGAGGGGACGGAGGGGCATGGAAGGGGGCC CCAGGAGAGCGTGTACCCTGTGGGGGTGGGAAAGCAGGGCTGTGGGCTCCTGGGCACATCTGTCCATCTG GTACTGATGCTGCCTTCCCCCTCGGCTGCTGGTTTTGAGGTCTCTCGCCCTCCAGATGGACAGTAGCTCC CATTTTACACGGGAGGAAACTGAGGTTTCCCCAAGGGAAGACATCTTCCTAGTCACTGGATCTGGTGACC CGCAAGCCTCACCCATGAAGACTCGCAAAGTTTAACCCTTCAAGTATTTCCCAAGTCCTTCCTTCATGAT CAGCAGTGGGAACTTGGAAGGAGTGAGGGAGAAATGAGGCAGCAGGTGGGAAGAGACCTTGGGCAGAGAG GCTTTGAGCGACATCCCTAGAGAGTTCCTGGGAAGGAGGCCTGAGCTGGGGGCACTGGGAACAGACTAGG GGTGAGGGGAGGGAAGGCATTTGTTCATAGCTGGTTTGATTCCCAGCTCTTCCACCTCCTAGCTGTGTGA CTTCAGGCAAGTCACTTTACCTCTCTGACCTCAGTTCTCTAATCTGCAAAATGGGGATGAAAAAGAGCAC CTGCCTCACAGATAATTCAGAAGATTTGATTTATTTTTATTTTTTTAAAGCATCGTACAGAGTTGAGGCT TCTGTCGTTTTCCTAACTTTGTTGATGGTGGGCCACCTTGGCAAGCTTCTAGGCTGTGGCTCCTTCTCCC AGGCCTACCTAACCAGAGCTCTCTTGCCCTACAGGTCCCCAAGGCACCCTCTCCACCCTCCTCCTCTGCC TCCCTCCACTCCCCTCCCCAGCCGCCCACCGAGTCCTGTCCCCACCCAGCCCGGCCCCCTCCCCTGCTCC AGCCCCTAACTCTCCCTCTCTCCCTCCCGGCCCACAGCGACATCAAGAGGATTGGGGTGCGGCTGCCCGG CCACCAGAAGCGCATCGCCTACAGCCTGCTGGGACTCAAGGACCAGGTGAACACTGTGGGGATCCCCATC TGAGCCTCGACAGGGCCTGGAGCCCCATCGGCCAAGAATACTTGAAGAAACAGAGTGGCCTCCCTGCTGT GCCATGCTGGGCCACTGGGGACTTTATTTATTTCTAGTTCTTTCCTCCCCCTGCAACTTCCGCTGAGGGG TCTCGGATGACACCCTGGCCTGAACTGAGGAGATGACCAGGGATGCTGGGCTGGGCCCTCTTTCCCTGCG AGACGCACACAGCTGAGCACTTAGCAGGCACCGCCACGTCCCAGCATCCCTGGAGCAGGAGCCCCGCCAC AGCCTTCGGACAGACATATGGGATATTCCCAAGCCGACCTTCCCTCCGCCTTCTCCCACATGAGGCCATC TCAGGAGATGGAGGGCTTGGCCCAGCGCCAAGTAAACAGGGTACCTCAAGCCCCATTTCCTCACACTAAG AGGGCAGACTGTGAACTTGACTGGGTGAGACCCAAAGCGGTCCCTGTCCCTCTAGTGCCTTCTTTAGACC CTCGGGCCCCATCCTCATCCCTGACTGGCCAAACCCTTGCTTTCCTGGGCCTTTGCAAGATGCTTGGTTG TGTTGAGGTTTTTAAATATATATTTTGTACTTTGTGGAGAGAATGTGTGTGTGTGGCAGGGGGCCCCGCC AGGGCTGGGGACAGAGGGTGTCAAACATTCGTGAGCTGGGGACTCAGGGACCGGTGCTGCAGGAGTGTCC TGCCCATGCCCCAGTCGGCCCCATCTCTCATCCTTTTGGATAAGTTTCTATTCTGTCAGTGTTAAAGATT TTGTTTTGTTGGACATTTTTTTCGAATCTTAATTTATTATTTTTTTTATATTTATTGTTAGAAAATGACT TATTTCTGCTCTGGAATAAAGTTGCAGATGATTCAAACCGA Download Select all
Length	31751
OMIM ID	176946
HGNC ID	HGNC:3386
Unigene ID	Hs.171596
Ensembl ID	ENSG00000142627
PharmGKB ID	-

mRNA Information

mRNA ID	NM_004431.3
Exon	join(1..240,5125..5192,7041..7710,17658..17813, 17903..18235,20318..20433,20899..21052,21521..21620, 22173..22228,22482..22607,22720..22908,23649..23710, 23815..24024,24218..24367,25669..25862,26499..26654, 30768..31751)
mRNA Sequence	>1969 GGTTCTCACCCAACTTCCATTAAGGACTCGGGGCAGGAGGGGCAGAAGTTGCGCGCAGGCCGGC GGGCGGGAGCGGACACCGAGGCCGGCGTGCAGGCGTGCGGGTGTGCGGGAGCCGGGCTCGGGGG GATCGGACCGAGAGCGAGAAGCGCGGCATGGAGCTCCAGGCAGCCCGCGCCTGCTTCGCCCTGC TGTGGGGCTGTGCGCTGGCCGCGGCCGCGGCGGCGCAGGGCAAGGAAGTGGTACTGCTGGACTT TGCTGCAGCTGGAGGGGAGCTCGGCTGGCTCACACACCCGTATGGCAAAGGGTGGGACCTGATG CAGAACATCATGAATGACATGCCGATCTACATGTACTCCGTGTGCAACGTGATGTCTGGCGACC AGGACAACTGGCTCCGCACCAACTGGGTGTACCGAGGAGAGGCTGAGCGTATCTTCATTGAGCT CAAGTTTACTGTACGTGACTGCAACAGCTTCCCTGGTGGCGCCAGCTCCTGCAAGGAGACTTTC AACCTCTACTATGCCGAGTCGGACCTGGACTACGGCACCAACTTCCAGAAGCGCCTGTTCACCA AGATTGACACCATTGCGCCCGATGAGATCACCGTCAGCAGCGACTTCGAGGCACGCCACGTGAA GCTGAACGTGGAGGAGCGCTCCGTGGGGCCGCTCACCCGCAAAGGCTTCTACCTGGCCTTCCAG GATATCGGTGCCTGTGTGGCGCTGCTCTCCGTCCGTGTCTACTACAAGAAGTGCCCCGAGCTGC TGCAGGGCCTGGCCCACTTCCCTGAGACCATCGCCGGCTCTGATGCACCTTCCCTGGCCACTGT GGCCGGCACCTGTGTGGACCATGCCGTGGTGCCACCGGGGGGTGAAGAGCCCCGTATGCACTGT GCAGTGGATGGCGAGTGGCTGGTGCCCATTGGGCAGTGCCTGTGCCAGGCAGGCTACGAGAAGG TGGAGGATGCCTGCCAGGCCTGCTCGCCTGGATTTTTTAAGTTTGAGGCATCTGAGAGCCCCTG CTTGGAGTGCCCTGAGCACACGCTGCCATCCCCTGAGGGTGCCACCTCCTGCGAGTGTGAGGAA GGCTTCTTCCGGGCACCTCAGGACCCAGCGTCGATGCCTTGCACACGACCCCCCTCCGCCCCAC ACTACCTCACAGCCGTGGGCATGGGTGCCAAGGTGGAGCTGCGCTGGACGCCCCCTCAGGACAG CGGGGGCCGCGAGGACATTGTCTACAGCGTCACCTGCGAACAGTGCTGGCCCGAGTCTGGGGAA TGCGGGCCGTGTGAGGCCAGTGTGCGCTACTCGGAGCCTCCTCACGGACTGACCCGCACCAGTG TGACAGTGAGCGACCTGGAGCCCCACATGAACTACACCTTCACCGTGGAGGCCCGCAATGGCGT CTCAGGCCTGGTAACCAGCCGCAGCTTCCGTACTGCCAGTGTCAGCATCAACCAGACAGAGCCC CCCAAGGTGAGGCTGGAGGGCCGCAGCACCACCTCGCTTAGCGTCTCCTGGAGCATCCCCCCGC CGCAGCAGAGCCGAGTGTGGAAGTACGAGGTCACTTACCGCAAGAAGGGAGACTCCAACAGCTA CAATGTGCGCCGCACCGAGGGTTTCTCCGTGACCCTGGACGACCTGGCCCCAGACACCACCTAC CTGGTCCAGGTGCAGGCACTGACGCAGGAGGGCCAGGGGGCCGGCAGCAAGGTGCACGAATTCC AGACGCTGTCCCCGGAGGGATCTGGCAACTTGGCGGTGATTGGCGGCGTGGCTGTCGGTGTGGT CCTGCTTCTGGTGCTGGCAGGAGTTGGCTTCTTTATCCACCGCAGGAGGAAGAACCAGCGTGCC CGCCAGTCCCCGGAGGACGTTTACTTCTCCAAGTCAGAACAACTGAAGCCCCTGAAGACATACG TGGACCCCCACACATATGAGGACCCCAACCAGGCTGTGTTGAAGTTCACTACCGAGATCCATCC ATCCTGTGTCACTCGGCAGAAGGTGATCGGAGCAGGAGAGTTTGGGGAGGTGTACAAGGGCATG CTGAAGACATCCTCGGGGAAGAAGGAGGTGCCGGTGGCCATCAAGACGCTGAAAGCCGGCTACA CAGAGAAGCAGCGAGTGGACTTCCTCGGCGAGGCCGGCATCATGGGCCAGTTCAGCCACCACAA CATCATCCGCCTAGAGGGCGTCATCTCCAAATACAAGCCCATGATGATCATCACTGAGTACATG GAGAATGGGGCCCTGGACAAGTTCCTTCGGGAGAAGGATGGCGAGTTCAGCGTGCTGCAGCTGG TGGGCATGCTGCGGGGCATCGCAGCTGGCATGAAGTACCTGGCCAACATGAACTATGTGCACCG TGACCTGGCTGCCCGCAACATCCTCGTCAACAGCAACCTGGTCTGCAAGGTGTCTGACTTTGGC CTGTCCCGCGTGCTGGAGGACGACCCCGAGGCCACCTACACCACCAGTGGCGGCAAGATCCCCA TCCGCTGGACCGCCCCGGAGGCCATTTCCTACCGGAAGTTCACCTCTGCCAGCGACGTGTGGAG CTTTGGCATTGTCATGTGGGAGGTGATGACCTATGGCGAGCGGCCCTACTGGGAGTTGTCCAAC CACGAGGTGATGAAAGCCATCAATGATGGCTTCCGGCTCCCCACACCCATGGACTGCCCCTCCG CCATCTACCAGCTCATGATGCAGTGCTGGCAGCAGGAGCGTGCCCGCCGCCCCAAGTTCGCTGA CATCGTCAGCATCCTGGACAAGCTCATTCGTGCCCCTGACTCCCTCAAGACCCTGGCTGACTTT GACCCCCGCGTGTCTATCCGGCTCCCCAGCACGAGCGGCTCGGAGGGGGTGCCCTTCCGCACGG TGTCCGAGTGGCTGGAGTCCATCAAGATGCAGCAGTATACGGAGCACTTCATGGCGGCCGGCTA CACTGCCATCGAGAAGGTGGTGCAGATGACCAACGACGACATCAAGAGGATTGGGGTGCGGCTG CCCGGCCACCAGAAGCGCATCGCCTACAGCCTGCTGGGACTCAAGGACCAGGTGAACACTGTGG GGATCCCCATCTGAGCCTCGACAGGGCCTGGAGCCCCATCGGCCAAGAATACTTGAAGAAACAG AGTGGCCTCCCTGCTGTGCCATGCTGGGCCACTGGGGACTTTATTTATTTCTAGTTCTTTCCTC CCCCTGCAACTTCCGCTGAGGGGTCTCGGATGACACCCTGGCCTGAACTGAGGAGATGACCAGG GATGCTGGGCTGGGCCCTCTTTCCCTGCGAGACGCACACAGCTGAGCACTTAGCAGGCACCGCC ACGTCCCAGCATCCCTGGAGCAGGAGCCCCGCCACAGCCTTCGGACAGACATATGGGATATTCC CAAGCCGACCTTCCCTCCGCCTTCTCCCACATGAGGCCATCTCAGGAGATGGAGGGCTTGGCCC AGCGCCAAGTAAACAGGGTACCTCAAGCCCCATTTCCTCACACTAAGAGGGCAGACTGTGAACT TGACTGGGTGAGACCCAAAGCGGTCCCTGTCCCTCTAGTGCCTTCTTTAGACCCTCGGGCCCCA TCCTCATCCCTGACTGGCCAAACCCTTGCTTTCCTGGGCCTTTGCAAGATGCTTGGTTGTGTTG AGGTTTTTAAATATATATTTTGTACTTTGTGGAGAGAATGTGTGTGTGTGGCAGGGGGCCCCGC CAGGGCTGGGGACAGAGGGTGTCAAACATTCGTGAGCTGGGGACTCAGGGACCGGTGCTGCAGG AGTGTCCTGCCCATGCCCCAGTCGGCCCCATCTCTCATCCTTTTGGATAAGTTTCTATTCTGTC AGTGTTAAAGATTTTGTTTTGTTGGACATTTTTTTCGAATCTTAATTTATTATTTTTTTTATAT TTATTGTTAGAAAATGACTTATTTCTGCTCTGGAATAAAGTTGCAGATGATTCAAACCGAAAAA AA Download Select all
Length	3970

CDS Information

Location	join(156..240,5125..5192,7041..7710,17658..17813, 17903..18235,20318..20433,20899..21052,21521..21620, 22173..22228,22482..22607,22720..22908,23649..23710, 23815..24024,24218..24367,25669..25862,26499..26654, 30768..30873)
CDS Sequence	>gi\|296010835:156-3086 Homo sapiens EPH receptor A2 (EPHA2), mRNA ATGGAGCTCCAGGCAGCCCGCGCCTGCTTCGCCCTGCTGTGGGGCTGTGCGCTGGCCGCGGCCGCGGCGG CGCAGGGCAAGGAAGTGGTACTGCTGGACTTTGCTGCAGCTGGAGGGGAGCTCGGCTGGCTCACACACCC GTATGGCAAAGGGTGGGACCTGATGCAGAACATCATGAATGACATGCCGATCTACATGTACTCCGTGTGC AACGTGATGTCTGGCGACCAGGACAACTGGCTCCGCACCAACTGGGTGTACCGAGGAGAGGCTGAGCGTA TCTTCATTGAGCTCAAGTTTACTGTACGTGACTGCAACAGCTTCCCTGGTGGCGCCAGCTCCTGCAAGGA GACTTTCAACCTCTACTATGCCGAGTCGGACCTGGACTACGGCACCAACTTCCAGAAGCGCCTGTTCACC AAGATTGACACCATTGCGCCCGATGAGATCACCGTCAGCAGCGACTTCGAGGCACGCCACGTGAAGCTGA ACGTGGAGGAGCGCTCCGTGGGGCCGCTCACCCGCAAAGGCTTCTACCTGGCCTTCCAGGATATCGGTGC CTGTGTGGCGCTGCTCTCCGTCCGTGTCTACTACAAGAAGTGCCCCGAGCTGCTGCAGGGCCTGGCCCAC TTCCCTGAGACCATCGCCGGCTCTGATGCACCTTCCCTGGCCACTGTGGCCGGCACCTGTGTGGACCATG CCGTGGTGCCACCGGGGGGTGAAGAGCCCCGTATGCACTGTGCAGTGGATGGCGAGTGGCTGGTGCCCAT TGGGCAGTGCCTGTGCCAGGCAGGCTACGAGAAGGTGGAGGATGCCTGCCAGGCCTGCTCGCCTGGATTT TTTAAGTTTGAGGCATCTGAGAGCCCCTGCTTGGAGTGCCCTGAGCACACGCTGCCATCCCCTGAGGGTG CCACCTCCTGCGAGTGTGAGGAAGGCTTCTTCCGGGCACCTCAGGACCCAGCGTCGATGCCTTGCACACG ACCCCCCTCCGCCCCACACTACCTCACAGCCGTGGGCATGGGTGCCAAGGTGGAGCTGCGCTGGACGCCC CCTCAGGACAGCGGGGGCCGCGAGGACATTGTCTACAGCGTCACCTGCGAACAGTGCTGGCCCGAGTCTG GGGAATGCGGGCCGTGTGAGGCCAGTGTGCGCTACTCGGAGCCTCCTCACGGACTGACCCGCACCAGTGT GACAGTGAGCGACCTGGAGCCCCACATGAACTACACCTTCACCGTGGAGGCCCGCAATGGCGTCTCAGGC CTGGTAACCAGCCGCAGCTTCCGTACTGCCAGTGTCAGCATCAACCAGACAGAGCCCCCCAAGGTGAGGC TGGAGGGCCGCAGCACCACCTCGCTTAGCGTCTCCTGGAGCATCCCCCCGCCGCAGCAGAGCCGAGTGTG GAAGTACGAGGTCACTTACCGCAAGAAGGGAGACTCCAACAGCTACAATGTGCGCCGCACCGAGGGTTTC TCCGTGACCCTGGACGACCTGGCCCCAGACACCACCTACCTGGTCCAGGTGCAGGCACTGACGCAGGAGG GCCAGGGGGCCGGCAGCAAGGTGCACGAATTCCAGACGCTGTCCCCGGAGGGATCTGGCAACTTGGCGGT GATTGGCGGCGTGGCTGTCGGTGTGGTCCTGCTTCTGGTGCTGGCAGGAGTTGGCTTCTTTATCCACCGC AGGAGGAAGAACCAGCGTGCCCGCCAGTCCCCGGAGGACGTTTACTTCTCCAAGTCAGAACAACTGAAGC CCCTGAAGACATACGTGGACCCCCACACATATGAGGACCCCAACCAGGCTGTGTTGAAGTTCACTACCGA GATCCATCCATCCTGTGTCACTCGGCAGAAGGTGATCGGAGCAGGAGAGTTTGGGGAGGTGTACAAGGGC ATGCTGAAGACATCCTCGGGGAAGAAGGAGGTGCCGGTGGCCATCAAGACGCTGAAAGCCGGCTACACAG AGAAGCAGCGAGTGGACTTCCTCGGCGAGGCCGGCATCATGGGCCAGTTCAGCCACCACAACATCATCCG CCTAGAGGGCGTCATCTCCAAATACAAGCCCATGATGATCATCACTGAGTACATGGAGAATGGGGCCCTG GACAAGTTCCTTCGGGAGAAGGATGGCGAGTTCAGCGTGCTGCAGCTGGTGGGCATGCTGCGGGGCATCG CAGCTGGCATGAAGTACCTGGCCAACATGAACTATGTGCACCGTGACCTGGCTGCCCGCAACATCCTCGT CAACAGCAACCTGGTCTGCAAGGTGTCTGACTTTGGCCTGTCCCGCGTGCTGGAGGACGACCCCGAGGCC ACCTACACCACCAGTGGCGGCAAGATCCCCATCCGCTGGACCGCCCCGGAGGCCATTTCCTACCGGAAGT TCACCTCTGCCAGCGACGTGTGGAGCTTTGGCATTGTCATGTGGGAGGTGATGACCTATGGCGAGCGGCC CTACTGGGAGTTGTCCAACCACGAGGTGATGAAAGCCATCAATGATGGCTTCCGGCTCCCCACACCCATG GACTGCCCCTCCGCCATCTACCAGCTCATGATGCAGTGCTGGCAGCAGGAGCGTGCCCGCCGCCCCAAGT TCGCTGACATCGTCAGCATCCTGGACAAGCTCATTCGTGCCCCTGACTCCCTCAAGACCCTGGCTGACTT TGACCCCCGCGTGTCTATCCGGCTCCCCAGCACGAGCGGCTCGGAGGGGGTGCCCTTCCGCACGGTGTCC GAGTGGCTGGAGTCCATCAAGATGCAGCAGTATACGGAGCACTTCATGGCGGCCGGCTACACTGCCATCG AGAAGGTGGTGCAGATGACCAACGACGACATCAAGAGGATTGGGGTGCGGCTGCCCGGCCACCAGAAGCG CATCGCCTACAGCCTGCTGGGACTCAAGGACCAGGTGAACACTGTGGGGATCCCCATCTGA Download Select all
CCDS ID	CCDS169.1

Protein Information

Protein ID	NP_004422.2
Protein Name	EPH receptor A2
Molecular Wt. (Da)	105706
Protein Sequence	>1969 MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPI YMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDL DYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGACVALL SVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVP IGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTLPSPEGATSCECEEGFFRAPQDP ASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDIVYSVTCEQCWPESGECGPCEASVR YSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSGLVTSRSFRTASVSINQTEPPKVRLEGRS TTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQ EGQGAGSKVHEFQTLSPEGSGNLAVIGGVAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYF SKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKE VPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFL REKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDP EATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAIND GFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLP STSGSEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAY SLLGLKDQVNTVGIPI Download Select all
Length	976
Uniprot ID	P10415
Ensembl Protein ID	ENSP00000329623

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
Y	Phosphorylation	588
Y	Phosphorylation	594
Y	Phosphorylation	772
Y	Phosphorylation	921;-
Y	Phosphorylation	930;-
S	Phosphorylation	901;-
T	Phosphorylation	898;-
S	Phosphorylation	899;-
S	Phosphorylation	897;-
S	Phosphorylation	570;-
Y	Phosphorylation	575;-
S	Phosphorylation	892
T	Phosphorylation	647
S	Phosphorylation	579
T	Phosphorylation	593
Y	Phosphorylation	628
T	Phosphorylation	771
S	Phosphorylation	790
T	Phosphorylation	587
Y	Phosphorylation	960
T	Phosphorylation	773
T	Phosphorylation	774

Enzyme Information

EC	2.7.10.1
Name	receptor protein-tyrosine kinase AATK AATYK AATYK2 AATYK3 ACH ALK anaplastic lymphoma kinase ARK ATP:protein-tyrosine O-phosphotransferase (ambiguous) AXL Bek Bfgfr BRT Bsk C-FMS CAK CCK4 CD115 CD135 CDw135 Cek1 Cek10 Cek11 Cek2 Cek3 Cek5 Cek6 Cek7 CFD1 CKIT CSF1R DAlk DDR1 DDR2 Dek DKFZp434C1418 Drosophila Eph kinase DRT DTK Ebk ECK EDDR1 Eek EGFR Ehk2 Ehk3 Elk EPH EPHA1 EPHA2 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EphB5 ephrin-B3 receptor tyrosine kinase EPHT EPHT2 EPHT3 EPHX ERBB ERBB1 ERBB2 ERBB3 ERBB4 ERK Eyk FGFR1 FGFR2 FGFR3 FGFR4 FLG FLK1 FLK2 FLT1 FLT2 FLT3 FLT4 FMS Fv2 HBGFR HEK11 HEK2 HEK3 HEK5 HEK6 HEP HER2 HER3 HER4 HGFR HSCR1 HTK IGF1R INSR INSRR insulin receptor protein-tyrosine kinase IR IRR JTK12 JTK13 JTK14 JWS K-SAM KDR KGFR KIA0641 KIAA1079 KIAA1459 Kil Kin15 Kin16 KIT KLG LTK MCF3 Mdk1 Mdk2 Mdk5 MEhk1 MEN2A/B Mep MER MERTK MET Mlk1 Mlk2 Mrk MST1R MTC1 MUSK Myk1 N-SAM NEP NET Neu neurite outgrowth regulating kinase NGL NOK nork novel oncogene with kinase-domain Nsk2 NTRK1 NTRK2 NTRK3 NTRK4 NTRKR1 NTRKR2 NTRKR3 Nuk NYK PCL PDGFR PDGFRA PDGFRB PHB6 protein-tyrosine kinase (ambiguous) protein tyrosine kinase (ambiguous) PTK PTK3 PTK7 receptor protein tyrosine kinase RET RON ROR1 ROR2 ROS1 RSE RTK RYK SEA Sek2 Sek3 Sek4 Sfr SKY STK STK1 TEK TIE TIE1 TIE2 TIF TKT TRK TRKA TRKB TRKC TRKE TYK1 TYRO10 Tyro11 TYRO3 Tyro5 Tyro6 TYRO7 UFO VEGFR1 VEGFR2 VEGFR3 Vik YK1 Yrk
Class	Transferases; Transferring phosphorus-containing groups; Protein-tyrosine kinases
Sysname	ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
Substrate	ATP [CPD:C00002]; [protein]-L-tyrosine
Product	ADP [CPD:C00008]; [protein]-L-tyrosine phosphate
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
867	CBL	1320	NP_005179.2	in vivo	12496371
1003	CDH5	3075	NP_001786.2	in vivo	16481735
1364	CLDN4	4218	NP_001296.1	in vivo	16236711
2885	GRB2	150	NP_002077.1	in vitro;in vivo	12400011
5296	PIK3R2	4404	NP_005018.1	in vitro;in vivo;yeast 2-hybrid	7982920
5781	PTPN11	1470	NP_002825.3	in vitro;in vivo	10655584

Pathway Information

Pathway Name	Pathway ID
Axon guidance	hsa04360
PI3K-Akt signaling pathway	hsa04151
Rap1 signaling pathway	hsa04015
Ras signaling pathway	hsa04014

Structure Information

PDB ID	1MQB
Resolution	2.3
Method	X-RAY DIFFRACTION
Chains	A,B
Molecule	Ephrin type-A receptor 2
Model	View

Domain Information

ID	Location	Description
cd05063	607-875	PTKc_EphR_A2
cl21453	607-875	PKc_like superfamily
cd10480	28-201	EphR_LBD_A2
cl02704	28-201	EphR_LBD superfamily
cd09543	902-971	SAM_EPH-A2
cl15755	902-971	SAM_superfamily superfamily
cd00063	439-526	FN3
cl21522	439-526	FN3 superfamily
cd00063	329-429	FN3
cl21522	329-429	FN3 superfamily
cd05033	608-875	PTKc_EphR
cd05066	608-875	PTKc_EphR_A
cd05065	608-875	PTKc_EphR_B
cd00192	617-872	PTKc
cd05064	607-875	PTKc_EphR_A10
cd10473	28-200	EphR_LBD_A
cd05034	617-872	PTKc_Src_like
pfam01404	28-201	Ephrin_lbd
cd05068	607-864	PTKc_Frk_like
smart00615	28-200	EPH_lbd
cd05041	619-872	PTKc_Fes_like
cd05060	619-871	PTKc_Syk_like
cd05059	608-871	PTKc_Tec_like
cd10319	29-200	EphR_LBD
cd05148	619-872	PTKc_Srm_Brk
cd05039	619-871	PTKc_Csk_like
cd05032	607-872	PTKc_InsR_like
cd05056	607-871	PTKc_FAK
cd05072	607-880	PTKc_Lyn
cd05112	608-865	PTKc_Itk
cd05048	607-867	PTKc_Ror
cd13999	619-871	STKc_MAP3K-like
cd05040	617-871	PTKc_Ack_like
cd05049	607-873	PTKc_Trk
cd05067	617-877	PTKc_Lck_Blk
cd14203	617-872	PTKc_Src_Fyn_like
cd05057	617-878	PTKc_EGFR_like
cd05044	617-871	PTKc_c-ros
cd05052	607-875	PTKc_Abl
cd05036	606-873	PTKc_ALK_LTK
cd05051	616-867	PTKc_DDR
cd05085	617-867	PTKc_Fer
cd05114	608-875	PTKc_Tec_Rlk
cd05084	619-871	PTKc_Fes
cd10486	28-200	EphR_LBD_A8
cd05038	614-874	PTKc_Jak_rpt2
cd05115	619-867	PTKc_Zap-70
cd10487	28-200	EphR_LBD_A10
cd10479	28-200	EphR_LBD_A1
cd05073	607-872	PTKc_Hck
cd05113	608-869	PTKc_Btk_Bmx
cd05050	619-873	PTKc_Musk
cd10485	27-201	EphR_LBD_A7
cd05092	619-871	PTKc_TrkA
cd10484	28-200	EphR_LBD_A6
cd05069	619-879	PTKc_Yes
cd10481	28-200	EphR_LBD_A3
cd05070	607-879	PTKc_Fyn
cd05061	613-871	PTKc_InsR
cd05071	619-872	PTKc_Src
cd05053	607-875	PTKc_FGFR
cd05083	613-873	PTKc_Chk
cd05058	617-869	PTKc_Met_Ron
cd10483	28-200	EphR_LBD_A5
cd05082	613-867	PTKc_Csk
cd05046	617-873	PTK_CCK4
cd05109	615-878	PTKc_HER2
cd05090	607-867	PTKc_Ror1
cd05116	619-865	PTKc_Syk
cd05045	617-875	PTKc_RET
cd05095	613-871	PTKc_DDR2
cd10482	28-200	EphR_LBD_A4
cd05097	619-867	PTKc_DDR_like
cd05035	617-875	PTKc_TAM
cd05110	613-902	PTKc_HER4
cd05091	607-867	PTKc_Ror2
cd05093	616-877	PTKc_TrkB
cd05108	615-916	PTKc_EGFR
cd05096	611-871	PTKc_DDR1
cd05094	616-877	PTKc_TrkC
cd10472	31-200	EphR_LBD_B
cd05099	617-877	PTKc_FGFR4
cd05062	607-869	PTKc_IGF-1R
cd14204	617-875	PTKc_Mer
cd05075	613-877	PTKc_Axl
cd05047	618-874	PTKc_Tie
cd05074	614-874	PTKc_Tyro3
cd05089	613-888	PTKc_Tie1
cd05101	594-875	PTKc_FGFR2
cd05055	592-875	PTKc_PDGFR
cd10478	28-200	EphR_LBD_B3
cd05043	613-871	PTK_Ryk
cd05054	617-874	PTKc_VEGFR
cd05098	617-875	PTKc_FGFR1
cd05111	610-878	PTK_HER3
cd10477	28-200	EphR_LBD_B2
cd10476	31-200	EphR_LBD_B1
cd00180	619-871	PKc
cd14205	617-874	PTKc_Jak2_rpt2
cd05100	607-905	PTKc_FGFR3
cd05088	616-875	PTKc_Tie2
cd05103	617-877	PTKc_VEGFR2
cd05102	617-876	PTKc_VEGFR3
cd05079	615-875	PTKc_Jak1_rpt2
cd10474	28-200	EphR_LBD_B4
cd05080	609-871	PTKc_Tyk2_rpt2
cd10475	28-200	EphR_LBD_B6
cd05081	618-874	PTKc_Jak3_rpt2
cd14061	618-874	STKc_MLK
cd05106	617-876	PTKc_CSF-1R
cd14014	616-866	STKc_PknB_like
cd14058	619-876	STKc_TAK1
cd14207	617-874	PTKc_VEGFR1
cd05107	592-875	PTKc_PDGFR_beta
cd14059	619-872	STKc_MAP3K12_13
cd05104	592-875	PTKc_Kit
cd13978	619-866	STKc_RIP
cd14066	619-874	STKc_IRAK
cd14148	618-874	STKc_MLK2
cd14060	620-874	STKc_MLTK
cd06606	614-862	STKc_MAPKKK
cd14062	619-872	STKc_Raf
cd05122	612-840	PKc_STE
cd05105	592-875	PTKc_PDGFR_alpha
cd14154	619-874	STKc_LIMK
cd14147	616-874	STKc_MLK3
cd06627	616-862	STKc_Cdc7_like
cd14146	618-871	STKc_MLK4
cd14150	617-877	STKc_A-Raf
cd14065	619-871	PKc_LIMK_like
cd14149	607-874	STKc_C-Raf
cd14151	607-877	STKc_B-Raf
cd14145	607-874	STKc_MLK1
cd05087	617-860	PTKc_Aatyk1
cd14064	619-872	PKc_TNNI3K
cd05042	617-867	PTKc_Aatyk
cd08215	614-872	STKc_Nek
cd05037	620-871	PTK_Jak_rpt1
cd14221	619-876	STKc_LIMK1
cd05117	616-833	STKc_CAMK
cd14003	616-867	STKc_AMPK-like
cd14206	619-867	PTKc_Aatyk3
cd05086	619-854	PTKc_Aatyk2
cd13979	616-862	STKc_Mos
cd14222	619-874	STKc_LIMK2
cd14025	619-878	STKc_RIP4_like
cd13992	667-874	PK_GC
cd14664	619-872	STK_BAK1_like
cd14008	619-842	STKc_LKB1_CaMKK
cd14026	641-884	STKc_RIP2
cd14158	619-874	STKc_IRAK4
cd14009	619-867	STKc_ATG1_ULK_like
cd06628	615-869	STKc_Byr2_like
cd14063	616-876	PK_KSR
cd09488	905-965	SAM_EPH-R
cd06614	617-830	STKc_PAK
cd06623	617-862	PKc_MAPKK_plant_like
cd14155	619-876	PKc_TESK
cd06632	617-863	STKc_MEKK1_plant
cd07834	616-812	STKc_MAPK
cd06609	614-837	STKc_MST3_like
cd14027	621-867	STKc_RIP1
cd07840	615-812	STKc_CDK9_like
cd06612	618-830	STKc_MST1_2
pfam14575	556-610	EphA2_TM
cl22928	556-610	EphA2_TM superfamily
cd14156	619-874	PKc_LIMK_like_unk
cd14097	619-833	STKc_STK33
cd08225	617-873	STKc_Nek5
cd14007	617-869	STKc_Aurora
cd08222	616-870	STKc_Nek11
cd07841	614-818	STKc_CDK7
cd14208	613-868	PTK_Jak3_rpt1
cd06629	614-869	STKc_Bck1_like
cd07830	616-812	STKc_MAK_like
cd08530	616-867	STKc_CNK2-like
cd07829	614-812	STKc_CDK_like
cd14043	667-867	PK_GC-2D
cd05076	613-871	PTK_Tyk2_rpt1
cd14080	617-869	STKc_TSSK-like
cd14121	619-866	STKc_ULK3
cd14057	625-874	PK_ILK
cd06605	617-865	PKc_MAPKK
cd06640	614-862	STKc_MST4
pfam00536	902-966	SAM_1
cd14103	619-818	STKc_MLCK
cd14002	618-841	STKc_STK36
cd14162	616-860	STKc_TSSK4-like
cd05077	619-868	PTK_Jak1_rpt1
cd14054	618-812	STKc_BMPR2_AMHR2
cd14055	617-812	STKc_TGFbR2_like
cd08220	614-869	STKc_Nek8
cd06626	615-862	STKc_MEKK4
cd14052	614-810	PTKc_Wee1_fungi
cd08529	616-867	STKc_FA2-like
cd14056	617-854	STKc_TGFbR_I
cd14120	619-869	STKc_ULK1_2-like
cd14202	614-866	STKc_ULK1
cd06610	616-862	STKc_OSR1_SPAK
cd14000	618-871	STKc_LRRK
cd13998	618-810	STKc_TGFbR-like
cd06642	614-827	STKc_STK25
cd14137	614-812	STKc_GSK3
cd05078	619-872	PTK_Jak2_rpt1
cd06611	619-830	STKc_SLK_like
cd14044	642-874	PK_GC-C
cd06620	619-877	PKc_Byr1_like
cd05123	619-861	STKc_AGC
cd05581	617-833	STKc_PDK1
cd14099	614-869	STKc_PLK
cd06641	619-868	STKc_MST3
cd14053	617-812	STKc_ACVR2
cd14073	616-869	STKc_NUAK
cd13997	619-868	PKc_Wee1_like
cd14663	617-818	STKc_SnRK3
cd14161	617-869	STKc_NUAK2
cd06917	614-830	STKc_NAK1_like
cd13996	616-809	STKc_EIF2AK
cd14201	614-818	STKc_ULK2
cd09542	903-965	SAM_EPH-A1
cd07866	619-812	STKc_BUR1
cd06608	618-837	STKc_myosinIII_N_like
cd06624	618-823	STKc_ASK
cd14190	616-818	STKc_MLCK2
cd14192	613-830	STKc_MLCK3
cd06648	610-832	STKc_PAK_II
cd06625	615-869	STKc_MEKK3_like
cd08217	617-867	STKc_Nek2
cd13983	618-823	STKc_WNK
cd09547	906-966	SAM_EPH-A6
cd14084	617-828	STKc_Chk2
cd14042	628-874	PK_GC-A_B
cd08218	615-873	STKc_Nek1
cd05582	617-830	STKc_RSK_N
cd14001	617-873	PKc_TOPK
cd14159	619-874	STKc_IRAK1
cd07833	618-815	STKc_CDKL
cd09546	906-969	SAM_EPH-A5
cd05118	617-812	STKc_CMGC
cd08224	616-873	STKc_Nek6_7
cd06630	614-869	STKc_MEKK1
cd14071	616-846	STKc_SIK
cd14050	612-869	PKc_Myt1
cd07864	618-875	STKc_CDK12
cd07843	619-812	STKc_CDC2L1
cd06644	619-844	STKc_STK10
cd05580	617-841	STKc_PKA_like
cd06613	619-830	STKc_MAP4K3_like
cd07849	616-812	STKc_ERK1_2_like
cd14186	616-818	STKc_PLK4
cd14069	617-821	STKc_Chk1
cd14079	617-838	STKc_AMPK_alpha
cd14144	617-861	STKc_BMPR1
cd14193	613-830	STKc_MLCK4
cd14167	616-830	STKc_CaMKI_alpha
cd14081	617-818	STKc_BRSK1_2
cd07859	616-812	STKc_TDY_MAPK
cd07832	619-811	STKc_CCRK
cd09552	906-970	SAM_EPH-B2
cd05578	616-818	STKc_Yank1
cd14096	619-833	STKc_RCK1-like
cd14006	619-813	STKc_MLCK-like
cd08528	619-869	STKc_Nek10
cd14072	617-851	STKc_MARK
cd14045	643-874	PK_GC_unk
cd14098	618-833	STKc_Rad53_Cds1
cd06643	619-830	STKc_SLK
cd14076	619-818	STKc_Kin4
cd06607	619-869	STKc_TAO
cd13990	619-818	STKc_TLK
cd06619	616-862	PKc_MKK5
cd14010	619-839	STKc_ULK4
cd14105	619-818	STKc_DAPK
pfam00041	438-519	fn3
cd14038	619-818	STKc_IKK_beta
cd13994	619-870	STKc_HAL4_like
cd13982	616-818	STKc_IRE1
cd08223	617-812	STKc_Nek4
cd09545	908-969	SAM_EPH-A4
cd06653	617-868	STKc_MEKK3_like_u1
cd07836	619-812	STKc_Pho85
cd06631	614-862	STKc_YSK4
cd09551	906-968	SAM_EPH-B1
cd14142	613-874	STKc_ACVR1_ALK1
cd14152	619-874	STKc_KSR1
cd09553	906-969	SAM_EPH-B3
cd08221	617-812	STKc_Nek9
cd07860	616-812	STKc_CDK2_3
cd14191	619-830	STKc_MLCK1
cd07845	619-812	STKc_CDK10
cd06621	619-863	PKc_Pek1_like
cd07853	619-811	STKc_NLK
cd06647	614-861	STKc_PAK_I
cd14188	612-868	STKc_PLK2
cd14189	614-868	STKc_PLK3
cd14166	617-834	STKc_CaMKI_gamma
cd09554	906-968	SAM_EPH-B4
cd07855	617-817	STKc_ERK5
cd09548	906-969	SAM_EPH-A7
cd13989	619-828	STKc_IKK
cd06633	619-890	STKc_TAO3
cd07856	619-893	STKc_Sty1_Hog1
cd14160	619-824	PK_IRAK3
cd14091	619-833	STKc_RSK_C
cd14033	619-849	STKc_WNK4
cd14075	619-818	STKc_NIM1
cd14220	617-874	STKc_BMPR1a
cd06659	619-839	STKc_PAK6
cd14164	619-818	STKc_TSSK6-like
cd14197	617-818	STKc_DRAK1
cd13985	617-873	STKc_GAK_like
cd14116	617-831	STKc_Aurora-A
cd08219	617-869	STKc_Nek3
cd14165	619-850	STKc_TSSK1_2-like
cd07880	617-828	STKc_p38gamma
cd14077	617-818	STKc_Kin1_2
cd06622	619-867	PKc_PBS2_like
cd14179	615-833	STKc_MSK1_C
cd14143	618-861	STKc_TGFbR1_ACVR1b_ACVR1c
cd05572	619-833	STKc_cGK
cd06652	617-838	STKc_MEKK2
cd14082	617-820	STKc_PKD
cd14086	619-839	STKc_CaMKII
cd14067	645-869	STKc_LRRK1
cd07842	619-813	STKc_CDK8_like
cd07857	723-820	STKc_MPK1
cd05612	615-861	STKc_PRKX_like
cd09550	907-969	SAM_EPH-A8
cd07873	619-812	STKc_PCTAIRE1
cd14095	617-808	STKc_DCKL
cd06658	619-832	STKc_PAK5
cd14068	618-872	STKc_LRRK2
cd14196	619-830	STKc_DAPK2
cd06636	617-839	STKc_MAP4K4_6_N
cd14175	616-818	STKc_RSK1_C
cd07858	617-812	STKc_TEY_MAPK
cd07831	619-812	STKc_MOK
cd07871	619-812	STKc_PCTAIRE3
cd14184	617-858	STKc_DCKL2
cd14087	618-818	STKc_PSKH1
cd14194	619-831	STKc_DAPK1
cd14089	616-835	STKc_MAPKAPK
cd06656	614-861	STKc_PAK3
cd07838	619-890	STKc_CDK4_6_like
cd06651	615-869	STKc_MEKK3
cd07852	616-809	STKc_MAPK15-like
cd08229	616-874	STKc_Nek7
cd14078	619-811	STKc_MELK
cd07851	610-812	STKc_p38
cd14031	597-869	STKc_WNK3
cd14198	616-825	STKc_DRAK2
cd05579	619-818	STKc_MAST_like
cd14153	617-874	PK_KSR2
cd07879	610-812	STKc_p38delta
cd06654	614-818	STKc_PAK1
cd06617	619-867	PKc_MKK3_6
cd14209	614-818	STKc_PKA
cd14662	617-818	STKc_SnRK2
cd14041	609-845	STKc_TLK2
cd14074	616-869	STKc_SNRK
cd14106	616-818	STKc_DRAK
cd08228	616-819	STKc_Nek6
cd14169	611-830	STKc_CaMKI_beta
cd06616	619-869	PKc_MKK4
cd14665	617-818	STKc_SnRK2-3
cd07865	615-812	STKc_CDK9
cd14039	619-818	STKc_IKK_alpha
cd14048	603-811	STKc_EIF2AK3_PERK
cd07872	619-825	STKc_PCTAIRE2
cd14176	619-833	STKc_RSK2_C
cd07854	619-812	STKc_MAPK4_6
cd06637	617-839	STKc_TNIK
cd06657	619-832	STKc_PAK4
cd07839	619-817	STKc_CDK5
cd07862	619-846	STKc_CDK6
cd05602	610-892	STKc_SGK1
cd14047	619-871	STKc_EIF2AK2_PKR
cd07846	618-812	STKc_CDKL2_3
cd14030	597-869	STKc_WNK1
cd14117	619-830	STKc_Aurora-B_like
cd06634	619-890	STKc_TAO2
pfam07647	906-958	SAM_2
cd14181	654-839	STKc_PhKG2
cd06655	614-818	STKc_PAK2
cd13993	618-807	STKc_Pat1_like
cd14183	610-818	STKc_DCKL1
cd13986	616-875	STKc_16
cd14083	616-830	STKc_CaMKI
cd14093	663-819	STKc_PhKG
cd14172	616-835	STKc_MAPKAPK3
cd14170	613-835	STKc_MAPKAPK2
cd14114	619-818	STKc_Twitchin_like
cd14195	619-831	STKc_DAPK3
cd14119	619-818	STKc_LKB1
cd14040	609-818	STKc_TLK1
cd14168	616-830	STKc_CaMKI_delta
cd14177	623-833	STKc_RSK4_C
cd14004	617-868	STKc_PASK
cd05616	617-830	STKc_cPKC_beta
cd05584	617-818	STKc_p70S6K
cd07848	618-810	STKc_CDKL5
cd06638	617-868	STKc_myosinIIIA_N
cd07870	617-811	STKc_PFTAIRE2
cd13988	619-830	STKc_TBK1
cd14131	614-862	PKc_Mps1
cd05603	617-878	STKc_SGK2
smart00060	439-516	FN3
cd14187	615-869	STKc_PLK1
cd06635	593-810	STKc_TAO1
cd06615	690-817	PKc_MEK
cd14070	617-862	STKc_HUNK
cd05620	617-839	STKc_nPKC_delta
cd14178	654-818	STKc_RSK3_C
cd06646	619-810	STKc_MAP4K5
cd06618	619-867	PKc_MKK7
cd14133	617-812	PKc_DYRK_like
cd14012	633-869	PK_eIF2AK_GCN2_rpt1
cd05611	617-818	STKc_Rim15_like
cd14229	619-810	STKc_HIPK3
cd07869	619-811	STKc_PFTAIRE1
cd05574	617-818	STKc_phototropin_like
cd05613	617-818	STKc_MSK1_N
pfam00041	330-424	fn3
cd13975	723-872	PKc_Dusty
cd07877	619-812	STKc_p38alpha
cd13987	619-863	STKc_SBK1
cd05599	617-818	STKc_NDR_like
cd05585	618-841	STKc_YPK1_like
cd14157	619-812	STKc_IRAK2
cd07847	619-819	STKc_CDKL1_4
cd14100	618-869	STKc_PIM1
cd05614	617-818	STKc_MSK2_N
cd07861	619-817	STKc_CDK1_euk
cd07878	619-811	STKc_p38beta
cd06645	619-821	STKc_MAP4K3
cd14200	663-818	STKc_CaMKK1
cd14032	619-869	STKc_WNK2_like
cd05595	617-825	STKc_PKB_beta
cd14088	617-820	STKc_CaMK_like
cd14180	671-833	STKc_MSK2_C
cd07876	617-811	STKc_JNK2
cd14046	617-850	STKc_EIF2AK4_GCN2_rpt2
cd14182	661-833	STKc_PhKG1
cd14101	614-868	STKc_PIM2
cd14104	619-830	STKc_Titin
cd06650	619-817	PKc_MEK1
cd05604	617-830	STKc_SGK3
cd14102	618-867	STKc_PIM3
cd05570	617-818	STKc_PKC
cd14219	617-879	STKc_BMPR1b
cd05619	616-840	STKc_nPKC_theta
cd14185	663-808	STKc_DCKL3
cd07863	619-810	STKc_CDK4
cd14020	614-812	STKc_KIS
cd09490	909-958	SAM_Arap1,2,3
cd05586	619-837	STKc_Sck1_like
cd05573	617-837	STKc_ROCK_NDR_like
cd06639	617-862	STKc_myosinIIIB_N
cd05615	618-830	STKc_cPKC_alpha
cd14094	618-818	STKc_CASK
cd14005	617-869	STKc_PIM
cd07835	616-812	STKc_CDK1_CdkB_like
cd07850	617-809	STKc_JNK
cd14085	642-820	STKc_CaMKIV
cd09555	911-966	SAM_EPH-B6
cd14115	619-865	STKc_Kalirin_C
cd13991	613-867	STKc_NIK
cd09549	906-969	SAM_EPH-A10
smart00060	329-418	FN3
cd07874	617-881	STKc_JNK3
cd05592	617-818	STKc_nPKC_theta_like
cd14049	719-862	STKc_EIF2AK1_HRI
cd05587	617-818	STKc_cPKC
cd14109	661-833	PK_Unc-89_rpt1
cd05630	615-818	STKc_GRK6
cd05593	617-830	STKc_PKB_gamma
cd13968	619-759	PKc_like
cd07875	617-814	STKc_JNK1
cd14141	617-810	STKc_ACVR2a
cd09500	902-962	SAM_AIDA1AB-like_repeat2
cd14138	603-748	PTKc_Wee1a
cd05601	616-818	STKc_CRIK
cd13995	619-868	STKc_MAP3K8
cd14163	617-867	STKc_TSSK3-like
cd14111	639-833	STKc_SPEG_rpt2
cd09527	907-967	SAM_Samd5
cd14118	662-818	STKc_CAMKK
cd05575	723-861	STKc_SGK
cd05624	617-838	STKc_MRCK_beta
cd14199	663-852	STKc_CaMKK2
cd06649	619-810	PKc_MEK2
cd05623	617-838	STKc_MRCK_alpha
cd00185	261-326	TNFRSF
cl22855	261-326	TNFRSF superfamily
cd13416	273-329	TNFRSF16
COG3642	688-766	Bud32
pfam07714	613-871	Pkinase_Tyr
smart00454	902-968	SAM
smart00219	613-871	TyrKc
smart00221	613-871	STYKc
smart00220	617-867	S_TKc
pfam00069	614-868	Pkinase
COG0515	616-876	SPS1
PTZ00024	617-812	PTZ00024
PLN00034	615-809	PLN00034
PHA03209	617-813	PHA03209
PTZ00426	617-888	PTZ00426
PHA02988	642-874	PHA02988
PTZ00263	619-860	PTZ00263
PTZ00267	654-862	PTZ00267
PHA03212	648-812	PHA03212
PLN00009	619-817	PLN00009
PTZ00266	617-837	PTZ00266
TIGR03903	643-816	TOMM_kin_cyc

Ontology Information

HPRD ID	1045
Molecular Class	Receptor tyrosine kinase
Molecular Function	Receptor signaling complex scaffold activity (GO:0030159)
Biological Process	Apoptosis (GO:0006915)

SNP Information

View SNP Geneview Report

Drug Information

Uniprot ID DrugBank ID Name Type
P29317 DB01254 Dasatinib SmallMoleculeDrug
P29317 DB08896 Regorafenib SmallMoleculeDrug

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

Uniprot ID	DrugBank ID	Name	Type
P29317	DB01254	Dasatinib	SmallMoleculeDrug
P29317	DB08896	Regorafenib	SmallMoleculeDrug

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO