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General Information
- Evidence
- Gene
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24618180 | 2014 | Cell line : - Source : Central Hospital of the People?s Liberation Army (PLA) Cancer Center Sample Type : Blood Sample No. of Sample : 70 Healthy Control and 72 CRC blood Stage : - | Mass spectrometry | Up-regulation | - | Alpha-2-HS-glycoprotein precursor and tubulin beta chain could be involved in the pathogenesis of CRC and perform as potential serology diagnosis biomarker. Up-regulated alpha-2-HS-glycoprotein precursor was determined in CRC, which may perform as a diagnosis marker for CRC |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. |
| Chromosome | 3 |
| Location | 3q27.3 |
| Start | 186613061 |
| End | 186621318 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 8258 |
| OMIM ID | 138680 |
| HGNC ID | HGNC:349 |
| Unigene ID | Hs.324746 |
| Ensembl ID | ENSG00000145192 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001622.2 |
|---|---|
| Exon | join(1..294,2625..2735,3383..3467,4127..4290,5476..5577, 6797..6880,7526..8258) | mRNA Sequence | Download Select all |
| Length | 1594 |
CDS Information
| Location | join(82..294,2625..2735,3383..3467,4127..4290,5476..5577, 6797..6880,7526..7870) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS3278.1 |
Protein Information
| Protein ID | NP_001613.2 |
|---|---|
| Protein Name | alpha-2-HS-glycoprotein |
| Molecular Wt. (Da) | 30238 |
| Protein Sequence | Download Select all |
| Length | 367 |
| Uniprot ID | P02774 |
| Ensembl Protein ID | ENSP00000273951 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | Disulfide Bridge | 114;132 |
| S | Phosphorylation | 138 |
| C | Disulfide Bridge | 146;149 |
| N | Glycosylation | 156 |
| N | Glycosylation | 176 |
| C | Disulfide Bridge | 208;219 |
| C | Disulfide Bridge | 230;247 |
| T | Glycosylation | 256 |
| T | Glycosylation | 270 |
| C | Disulfide Bridge | 32;358 |
| S | Phosphorylation | 330 |
| R | Proteolytic Cleavage | 340 |
| C | Disulfide Bridge | 89;100 |
| L | Proteolytic Cleavage | 300 |
| S | Phosphorylation | 138;- |
| S | Phosphorylation | 334 |
| S | Phosphorylation | 135 |
| S | Phosphorylation | 328 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1634 | DCN | 501 | NP_001911.1 | in vitro | 12071714 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00042 | 28-120 | CY |
| cl09238 | 28-120 | CY superfamily |
| cd00042 | 148-247 | CY |
| cl09238 | 148-247 | CY superfamily |
| pfam00031 | 149-239 | Cystatin |
| smart00043 | 31-133 | CY |
| smart00043 | 146-248 | CY |
Ontology Information
| HPRD ID | 11752 |
|---|---|
| Molecular Class | Secreted polypeptide |
| Molecular Function | Peptide hormone (GO:0005180) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.