Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ELF3 | 1999 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 1 | ERT; ESX; EPR-1; ESE-1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17408644 | 2007 | Cell line : HCT 116 Source : - Sample Type : - No. of Sample : - Stage : - | - | Unknown | - | Result shows potential clinical connection between ELF3 and colorectal cancer involving transforming growth factor beta insensitivity. Elf3, is the critical upstream regulator of Tgf-betaRII in mouse small intestinal epithelium. |
| 17374985 | 2007 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 22 Stage : DukeStage A-D | cDNA microarrays, chromatin immunoprecipitation | Up-regulation | - | Cells treated with selenomethionine,ELE3 gene downregulated and selenomethionine-induced growth arrest.
|
| 22993316 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR and Hematoxylin-eosin staining. | Up-regulation | - | ELF3, as a gene marker, may be sufficiently practical to detect LN metastases of CRC, rather than CEA.. Found a statistical correlation between the expression levels of ELF3 in patients with CRC compared with each Dukes' stage. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | - |
| Chromosome | 1 |
| Location | 1q32.2 |
| Start | 202010519 |
| End | 202017188 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 6670 |
| OMIM ID | 602191 |
| HGNC ID | HGNC:3318 |
| Unigene ID | Hs.603657 |
| Ensembl ID | ENSG00000163435 |
| PharmGKB ID | PA27746 |
mRNA Information
| mRNA ID | XM_005244942.2 |
|---|---|
| Exon | join(1..188,611..781,1439..1660,1826..1918,2122..2241, 2333..2518) | mRNA Sequence | Download Select all |
| Length | 3263 |
CDS Information
| Location | join(619..781,1439..1660,1826..1918,2122..2241,2429..2518, 2664..2780,3311..3506,4691..4805) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS1419.1 |
Protein Information
| Protein ID | NP_001107781.1 |
|---|---|
| Protein Name | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
| Molecular Wt. (Da) | 41323 |
| Protein Sequence | Download Select all |
| Length | 371 |
| Uniprot ID | Q07817 |
| Ensembl Protein ID | ENSP00000302564 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 212 |
| S | Phosphorylation | 215 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2033 | EP300 | 4078 | NP_001420.2 | in vitro;in vivo | 15075319 |
| 4790 | NFKB1 | 1238 | NP_003989.2 | in vitro;in vivo | 11036073 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd08537 | 53-132 | SAM_PNT-ESE-1-like |
| cl15755 | 53-132 | SAM_superfamily superfamily |
| smart00413 | 272-359 | ETS |
| cl02599 | 272-359 | Ets superfamily |
| pfam00178 | 272-357 | Ets |
| cd08757 | 63-130 | SAM_PNT_ESE |
| smart00251 | 48-131 | SAM_PNT |
| pfam02198 | 48-132 | SAM_PNT |
| cd08203 | 63-130 | SAM_PNT |
| cd08539 | 59-128 | SAM_PNT-ESE-3-like |
| cd08538 | 59-128 | SAM_PNT-ESE-2-like |
| cd08532 | 64-125 | SAM_PNT-PDEF-like |
| cd08542 | 64-128 | SAM_PNT-ETS-1 |
| cd08535 | 63-128 | SAM_PNT-Tel_Yan |
Ontology Information
| HPRD ID | 2497 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Apoptosis (GO:0006915) |
Drug Information
No matching records could be found.