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General Information
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24752087 | 2014 | Cell line : - Source : Institute of General Surgery, Department of General Surgery, General Hospital of PLA, Beijing 100853, China. Sample Type : CRC tumor and normal tissue No. of Sample : 180 Stage : Stage III | Chi-square test and logistic regression | Up-regulation | - | LNR is independently correlated with distant organ metastasis of colorectal cancer and serves as an important predicative factor for estimating the prognosis of colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a protein that is one of the two components of elastic fibers. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Chromosome | 7 |
| Location | 7q11.1-q21 |
| Start | 73442119 |
| End | 73484237 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 42119 |
| OMIM ID | 130160 |
| HGNC ID | HGNC:3327 |
| Unigene ID | Hs.647061 |
| Ensembl ID | ENSG00000049540 |
| PharmGKB ID | PA27757 |
mRNA Information
| mRNA ID | XM_011515870.1 |
|---|---|
| Exon | join(1..498,7593..7643,8784..8813,9936..9968,14843..14935, 15213..15263,15332..15397,16108..16149,17451..17522, 18417..18446,18925..18996,19904..19945,20371..20430, 20732..20785,23979..24068,24153..24212,25392..25538, 26945..26998,28500..28664,28901..28942,29869..29925, 32115..32276,32369..32413,32605..32730,33330..33368, 35382..35453,35539..35598,35850..35924,37923..37961, 38173..38226,38961..39005,40886..42136) | mRNA Sequence | Download Select all |
| Length | 3777 |
Protein Information
| Protein ID | XP_011514172.1 |
|---|---|
| Protein Name | elastin |
| Molecular Wt. (Da) | 62034 |
| Protein Sequence | Download Select all |
| Length | 717 |
| Uniprot ID | Q9Y2T4 |
| Ensembl Protein ID | ENSP00000335083 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1634 | DCN | 501 | NP_001911.1 | in vivo | 11723132 |
| 1991 | ELANE | 554 | NP_001963.1 | in vitro | 10471600 |
| 2201 | FBN2 | 416 | NP_001990.2 | in vivo | 10825173 |
| 4016 | LOXL1 | 8861 | NP_005567.2 | in vitro;yeast 2-hybrid | 16251195 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Protein digestion and absorption | hsa04974 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 4115 |
|---|---|
| Molecular Class | Extracellular matrix protein |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.