CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
CTTN	2017	cortactin	11

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
20532661	2010	Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 205 Stage : TNM Stage II,III	-	Up-regulation	-	Cortactin may be a good biomarker to be applied in the clinical setting to predict the prognosis of patients with completely resected pathologic stages II-III CRC.

Gene Details

Chromosome 11 - NC_000011.10 (70398506..70436584)
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Gene Type	protein coding
Gene Family
Description	This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
Chromosome	11
Location	11q13
Start	70398506
End	70436584
Strand	+
Gene Sequence	>gi\|568815587:70398506-70436584 Homo sapiens chromosome 11, GRCh38.p2 Primary Assembly GATGCGGCCCCGCCCCCGCCCTCGGAACCGGAAGTAGAGCCTGGTGCCTGGGAGCGGCTGGCGCGGCGGA ATCCAGGGCCGACCCGGGCCGGACCGACCCCAGGCGGCGGTGAGCGAGCGCGGCGTCCGCCCGGGGTGCA GGCCGGGCTCTGCTTCTTCCCTCCTGTGGCGTCGCCTGGCCGCGAAAGGGGAAGGAAGCGGCGGCCGCAG CGGTCTCACCGCTCTTCCGCTTGCGGTTTCGGGGGCCGGGGCAGAGTGGCGAGGCTTTCCCGGCCTGGGG CGGGGCAGGGCGAGGGCCGGGGGTCCGCGAGGGCCACGAGGACGGGTCTGGGCCCAAGGAGGCCGGGCAG GGGGCAAGGGGGCACGGAGGGCTTGGGGCTGGGGTCCGCGGAGGAAGGTTAGAAAGGGGCCAAATTGGGG TATCAGCTCTGAGGGGAGGGTCCCTGGGCGCCGGGGGGCTCCAGGGCAGGAGAGGGGCCAGGCTGGGAGG GGTCTTGGGTCCGAGGGAATAGGAGAGGGGGATGGGCTCCGAGGGGGAGGGTATTAGGGCCCGAGGGAGA GGGGCTGGGCCTGTGGGGTTCGGGGGTCTGAGCGGAGGGGGCCGGGGTTCGAGGGGCCAAGGAAGGTGGG TGTGGGGGGTCTCAAGGAAAGGGCGAGGGGTCTGAGAGGGAGGTGTCTGGGTGCAGAGGGAAAGGGATGA GGTCCGAGGGGAGGAGATTGGGGTCTGACGGGAAGGGGTCCAGGCGCAGAGCTACTGGGATGGGGTCCGA GGGAAGGGAATTGGGGTTCGAGGGGAAGGGGTCGGGGCTCGGAGGAAAGGTATAGGGTCCGAGGGGAGGG GATTGGGGCTCCAGGGGAAGGGATCCAGGCGCAGGGAAAAGGGATGGGGTCCGCGGGGTCAAGGCGGTTG GGGTGCGCGACTTTGAGGGGCTCGCTGTGGGACGTGGCGGAGCAGCTGGGGATCCGCCCGGCCTGCACCT GAGCGGAGGTTTTGCAATCAGGTCAGTGGAGGCAGCGAGGCGCGGCTGCAGCTAGTCGTGAGGCTCTAAA TTTGGAACCGTCCCTCCTTCGGGGTGTGTTTAAAATCACCAGAACGGTGCTTTGGGGCTTTCTGTTACGT TTCCATCACCTGGATAGTCTAAGGGATGCCTGATCCCTGAAGCTGGAAGGCCTTGGGTGAGAAGGGACAG GGCTTCCTCCCGCTGGAATCTGTGGACGTTTGGGGCCCCTTGGGGAGGAATTCATTTTCTGCTGAAGGAA GCTCCGGAGGCATCCGGTGAGCGCTCCCTGGAATCCCATGCGCTCCCTTTGGGCTCAGTGTTGACTTGGC TGCGCAGGCTCTGTCGGGGGGACTTCACCCACTAGGTCCTTCAGGCATGATCCAGCCCTCAAGCCCGGCC GGGCCCAAGGCCGTGGCGCAGGAGGGGCTGGCCGCCTGCCCCTGTCTCCATTCACGTGTTTGACCGTGTG GGTGAGTCACTGGCTCCAGAGCACTGAGTCAGTCCTGTTTCTCCTCTGGTTAGAGAAGTATTCGCCAGAT ACTCAAGGAACAAGGAAGAGTCTTTTAAGTGGGACTCAATAAAAAGTTGGGGAGGCAGGGTTGTTTTGAT ATTAGGTCCCCTAGAACTAGAAGCTAACCTTCTGCTATATCTTACTGAAAAGAAATTTCTTTTGACCTGG GGCAGGGGTGCGGTGGCTCACACCTGTAATCCCTGCACTTTGGGAGGTCAAGGTGAGAGGATCGTTTGAG GCCAGGAGTTCCAGACTAGCCTGGGCAACACAGGGAGACCTTGTGTCTACAAAAAAAGAAATTCGCTGGG CATGTTGGCTTGCACCTGTTGTCCTAGCTACTTGGGGCGCTGAGGCAGAGGATCTCAAGCCCAGGAGTTG GAGGCTGCATTGAGCTCGATCGCACCACTGTACTCCAGCCTGGGTGACAGAGCGAGACCCTGTCACCCAG GCTGGAGTGCAGAGGCTCTTCACAGGTGCCATCTAGCACACTGCAACCTTGAACTGCTGGCCTTAAGCGA TCCTCCCACCTCAGCCTCCCAAGTAGCTGGGACTGCAGGCCCAGCTAAAGCTGACTTTTAATTGTAGCAT TTTGATGGACTTGTTTTTAAAACACTTTTAAAATGACAGCACACATAATCGGCAATTCAGATCTTCAGTC TGTGCCACGCAGTAGGTGCTCAGAAAAGGTGTCCTGAGAGTGTGAATTGCTGTGAGCGCTGGTTGCTGCC TTGTGTTGCAGTATTCCCATGGCCTGGGCCAGCCAAGAGCAGGGGACTGTGCTCCAGGAGCAGGCTTGGC TTTCACTGTGGCCCAGGCCCACCCCATCTGCTCACGCACTGCTTTGAGTAAACGGAGTAAATGTTGGGGG CGGGGTTTCCCTTGAGTAAGTGTGGTGTAGGGAGTGTGCCTGTGATGGTGATTTTGGCTACGCAAGTGTC TGTTTCCTTTCTCCTCCTGCTCTGCCATAGATGCTGAGGCTAATGGAAAGCTGATGGTGGACGGATGGTT CTGTCCTGTCATTTAAAACATTCTTCTGCCAGGCTCGGTGGCTCACACCTGTAATCTCAGCACTTTGGGA GGCTAAGGGCAGGTGGATTGCTTGAGCCCAGGAGTTTCGAGATCAGCCTAGGCAACATGGGGAAACCCCA TCTCTGTTAAAAATAGAAAAATTGGCCGGGTATGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGC TGAGGTGGGCAGATCACGAGGTCAGGAGATTGACACCATCCTGGCTAACACAGTGAAACACCGTCTCTAC TAAAAAAAAAAATACAAAAAATTAGCCGGGCGTGGTGGTATATGCCTGTAGTCCCAGCCACTCAGGAGGC TGAGGCACCAGAATCGCTTGAACCTGCGAAGTGGAGGTTGCAGTGAGCCGAGATCACACTATTGCACTCC AGCCTGGGCAAAAGACTGAGACTCCATCTCAAAAGAAAAAAGAAAAAGAAAAATTAGCTGGGTGTAGTGA CAGGTGCCTGTAGTCCCAGCTACTCAGGAGGGTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAGGT TGCGGTGAGCTGAGATCACACCATTGCACTCCAGCCTGGGCAACAGAGTGAGACTTCGTCTCAAACAAAA AAAAACAAAAAAAAAAAGAGAGAGAAAAATCAGCTTGGTGTGGTGGTGCATTCCTGTAGTCCTAGCTACT CGGGAGGCTGAGGTGGGAGGATCACCTGAACCTGGGACACAGAGGTTGCAGTGAGCTGAGATTGTGCCTC TGCACTCTAGCCTGGGCCACAGTGCAAGACCCTGTCTCAGAAAAAAAAAAGAAAAAAAAGGCTGGTGGGG GGCTTTTAGGCGCGGTGGTTCGTGCCTGTAATCCCAGCACTTTGAGAGGCTGAGGCTGGCAAATCACTTG AGGCCAGGAGTTGGAGATCAGCCTGGACCAACATAATGAAACCCCATCTCTACTAAAAATACAAAAAATT AGCTGGGTGTGATGGCGCATGCCTGTAATCCCAGCTACTCGGGAAGCTGAGGCAGGAAAATCACTTGAAC CTGGGAGACAGAGGTTGCAGTGAGCCGAGATCGCGCTGTTGCACTCCAACCTAGGCAACAGAGCAAGACT GTCTGAAAAAGAAAAAAAAAGTTATTGTGTAGAGGAATTTTTCACTCTGTCTAGACAGCAAGATTACTTC ACGTTTGTGCAATCTTGATTTGTACACTGACGTTTGCAAGGAAGGTTTAATGTTGAGGATGGACAGAGTC ATTATCTTCTTTTGAACCGTATTGTAACAGCTTTATCGAGATATAATTCACATACCATACAATACGCCTG TGTAGTGTGTACTCTCCACTGGTTTTTAGTATCTTCATGCAGTTGTACAACTGTCACCACAGTCAATTTC AGAATAATTTTATCACCTCAAAAAGAAGCCCTTGTACCTTTTAGCCATGACCTCCCTATCCTCACCACCA CCATCCGCCCAGCCCTGGGCAACCAGCAATGTATCTTTTGTCTCTGTAGATTTGTGAACTCCAGACATTT CCTAGAAATTGAATCGTATAATATGTGGTCTTTTGTGCGTGGTTTTCCTTTGCGCAATGGATTTGAGGTC CCTCCACGCTGTAGCAGGTGTCACTGCTGGATCCTCTTTGTGGCAGAATAAAATGCCTTTGTGTTAGGTA GACCACATGTTATGTATCTATCAGTTGATGGACATTTGGAGTGTTTCTGTTTTTTGGCTGCTATGAATAG TGCTGTTCTGAACACTCACGCACAAGTTTTTGTGTGCTTATACTTTATTTCTCTTGGGCATAGACCTAGG AGTGGAGTTGCTGAGTCATACAGTACCTGAGTTTAACCTTCTGAGGAACTGCCAGACCTTTTCCATTTAA CATCCCTGTCAGCAGTCTATGAGGCTTCCAGTTTTTCAACACTGTTGCTGAGATTTGTCATTGGCTGTTT TATTTTAGTCATCCTAGTGGGTATGAGGTGGGTTCTCATTGCAGTTTTGATTTGCATTTCCTTGGTGGTT AATGACATTGAACAAACTTTTCCTGAGCTTGTTGGCCATTTGTATATCTCCTCTGAAGAAATGTCTCTTC AGATCCTTCAATCATTTTTAAATGGGGTTATTCGTCCTTTTTATTGAATTATAAGAGTTCCTTTTTTTTT TTTTTTTTTTTTGAGATGGAGTCTCACTCTGTCGCCAGGCTGCAGTATAGTGGCGCAATCTCGGCTCACT ACAGCCTCTGTCTCCCGGGTTCAAGCAGTTCTCCTGCTTCAGCCTCCCAAGTAGCTGGGACTACAGGCAT GCGTCACCACGCCCTGTTAATTTTTGTATTTTTCGTAGAGACGGGGTTTCACCATGTTGGCCAGGATGGT CTCGATCTCTTGACCTAGTAATCCGCCCGCCTCGGCCTCCGAAAGTGCTGGGATTACAGGCGTGAGCCAC CTCACCTGGCCAAGAGTTCTTTATATATTCTGGATCTACAGTTCAAAATACTTTTCTCTCAGGATCGTCT TGTCACCTTCTTGATGAAGCACAAAATTTTTAATTTTGTACAATTTATTTTTTTCCTCTAGTGTTTTGGT GTCATATCTAAGAAACTATTGCCAAATTCAAAGTCACAAAAATTTACACCCTTTTAGGATTTTAGTTCAT TTTTGAGTTAATTTTTCTGTATGGTTTTGAGGTAGGGCTCTAGAGGCTTTTTATCTTTGGATCCACAAAA CAATCAAACTTATTTCCTATTGGTTATTTTTGTGATTGTTTTTTAAATTTCCAATATTGAGAGTATAAAA TTGTGGATCTGAGCCTATCCTTAGCTGCTCATGAGTAGATTTTTATTATTTACTTTATGATTGATTTATG TATGAGACAGGGTCTCTCTCTGTCTCCCAGGCTGGGGTGCAGTGGTGTGATCATGGCTCACTGCAACCTT GAGCTCCTGGGCTCAAGCAGTTCCCCCACCTCAGCCTCCTGAGTAGCTGGGACTACAGGTATACACGACC ATGCCTGGCTAAATTTTTAGGCAGAGTTGTATAGATGCTTGCCGATTACACTAATAACTGCAGTAACCAG AATGTAGCAAGCAATCTGTAGAAGTTAGGATTGCCGAAGGGAACTGGGGAGAGAGATGGAGCAAACAGTT GGGTCAGAAACCAGATAGGAAATTAATTAATTACCAGGAGGGCCAGCCAGGCACCATCCCCTAGTTCCTA ATGCGTGAGAAACCACTCTGCCTGTGACCGGCTTGTTCCTAGGGACAAGGGGATTTCATTCGTCCATGTG TGTTGTCTAGCAGTATGGTGTCCAGTTGAGGCTGATGTGTGGTCCTAGGGAAGGGGTCGTGTGCTTGGCC ACCCTCTGGGGAGCTGGAGTCTTGCTCCCTGCGCGGTAACCGTGTACGTTCATTAGGAATGCAGCCCGCC TCCTCCTCGGCTCTCCAGCTGCCAGTCTCATGTCTTGATAGACAGTCACCATACTGGTTTTTCCTCCCGG CCATATCATGATCCTCTCAAGGAGTGTTTTTCTTATATTATTGTTTTAAAAAGCTCACAGTAACAATTTT ATTTTATAATGTCATTAATTAGAATGAATAAAAAGTGAAAATCTCTAAGAATTATGGCAAACAGTAAATG CATACTAGCAATTAAGGCAATAATTTCTGTTTGCATTCATAAGAAACATCATGTAGGCCGGGCGCCATGC CTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCGGATCACCTGAGGTCGGGAGTTTGAGAC CAGCCTGACCAACATGGAGAAAACCCGTCTGTACTAAAAATAGAAAATTAGCTGGGCGTGGTGGCGCCTG CCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGTGGAGTTTGCGGT AAGCCGCGATTGTGCCATTGCACTCCAGCCTGTGCAACAAGAGTGAAACTCCATCTCAAAAAAAACAAAA CAAAAAAGACAAAAAGTCATCATGTAGTTAGAAATCTTTTAAAACTTATTTCTTTAGTTTCTCTCTGTTG AACTTTTTTATTAGTAAAATGCAAGTCTTCCCATCCTCCTCTCAGATTTCATTACAAAACCTTGTTACGT TTGGGAAGATTTCTGAAGTTTTCTAAAAAGATCTCCACACAGAAGGGTTTGCCCAGGGAGCTGCTCAACA TACATCCTTCTCAGCTTTTTACCCTTAATCTTTTTACAGACGGAATCAGTCCCCAATGCCTGGAAATTCC TCATTGGATTACTGTGTTTTAAACAGAATTTCGTGAACAGCCTTTTATCTCCAAGCGGAAAGAAAGGTAC TTGTGCATTGTGAACATCCTAACATTCTTTTCCTGTGGATGGTAAGGGCAAAAATCCCTTTAACAGGAAA CGGGGGAGGTTGCTGTTTCTGTGGATTTACTGGGAGAGAGATGATAATATTCTGGAAGGAAATTTCATTG TTTAAAAAATAAAGTCAGGTTTCTGTTGCATATGACTTAGAGGAGACAATTGCAGAAAACTCTGGAATTG AGGAAGAGAACCATTCCTGTCCTCCCTGAGGGGAAATCTGGCCCCTTCCCCACCCCATGAACATGGGTGG GGCCCCCAGGCACAGGATTGTGAAGCTCGCAAGTGCCCACCCCGCTCGCTGGTGAAGCTGTGTCCGGGAA GATGAGCAGAGACTGTGCTCTGCTAATCTCTCCCCGATGAGCCTGAAAAAGTACCAGGCAAAGACACCTG CCGCCTTTCTCCTTTGCCTTGGGGGTGAAGGTGGCCTCGCCAGCCCTGCAGGGACTCCCATCCTTTCTTG CAGCCACCTTCTCAGTGGTGGGAACCATGGGCAGCTGAAGTCCTGCAGGCGGGCAGCCCCCTCGCCAGGG CAGCATGGTGCCATGGGGCGGCCGGAGACCAAGCATCCCGTTTCTCTTTCCTGCAGCCGTTGCTTCATTT ATAAATGGGCGCGTTGGGACAAGATGGACTGGTTGTGCCTTTCCGTTCTGAGATTCTAGTTCATCTGTTT TCTAAAATCCTGGCAAAAGCAGATCACTCTGGAAATTCTTGCCATGCTTTGGGCATTGACAGAAGGTTCC AGGGGCACTGTTAGTCCTGCTACACCCCTTGGCAGACGGTTCTTCCCCAAGAGACAAAGTCGCACCTAGA AATTTGAGAGCACGCTGCCCTGATTGGTCCCTCACTGTCACATTGGATTTGGACTTGAGACCCAGCCAGG CTGGAGGGAGAGGAGCCAGATGGGACATTCTCAAGCTGCGAAGGGGTTTTGTCCAGTCCTGATTCAGGGC GCTAGAGTCCCAACATGGCACCTGAGAAAAAGTGAATTGGGTGTCCTCAGTTCAGACCCCTGGGCACAGC TTATGGTTGTTTGATTTAAAATAATCTCTCAGTTGCTCTGTGGCCTATGTGTAATTGTATTACTATTTCT GTGGAAAAGGAATCACTTCTTTTTATACATAGTTTGAAAAAAAAAAAAAAACCTTAAAATTTTATATTTT ACCACTGCAGTTACAAGAATTGTCTTGTTAGGGTTTACAGATGTGCCATTGTTCTGTATAACAGAGAAAA CCTTCCAGTCTTCAAGGGCTGAGGGAGAAGGTGGCTGCCCACTTGCAGAGCTGCCTGATAGAGGAAAAGG TGGCATTTTATATTCCTGTTTTCTTCCAAGTAGAGAGTAAAGCAATTCTCCAATAAACTACTTGAAACAT TTATTAAATTGTAAGTCTGAATTAGGAAAATTATTGTTATGGTTTCAGTAAGCACTTGAAATCAAAATGG GTGCACTTTTTAAAAATGTGTGATAAAATACACATACCATGAGATTTACCATTAGTAACATTTAGTATAT TTATAATACATAATCCAAAATGGTGCTTTTATTTTTGGTTGGAAACTATCATCATATGATTGAACAGAAC AGGAATATGTTCTTAATGAATAAATAAGTGCACACACGACTTTTTTATTTTCCAGAAAATTTTCTCACTC AAGGTGAAGCCAAATAGTATTTCCAGTATATTTCTGACGTCAGGTGACGGCAGTGTTAGAACCCCGAGGT GAAATTTCTTTTACTCCTGTGGTTGTCAGTCAGGCTTATGGATCATGAAGGATTGGCTGGTCCTGCAGCC TCGTCCTCCTGGGTTGCCTAGAATCTCGGTAGTTTTGGCCAAAGGGCTCATCTGCTGGCCTCTGTGGATG GCGCCCTGAGGCCTCCGTAACCCTCCCCGGCTGCTCTTTCAGATGTGGAAAGCTTCAGCAGGCCACGCTG TGTCCATCGCCCAGGATGACGCGGGGGCCGATGACTGGGAGACCGACCCTGATTTTGTGGTAGGAGCCGC CAGCCTTTGCTTTCCTCTTTCATGAAGTGGAAGTGGCTCTCCTGGGTTTTTCTTTGATGGGGTGGTGGTT TGTCTGTGTCACAATCCAGGCTGTGAGATTTACTGGTCGCTTTTCTTTTCAGAATGATGTGAGTGAGAAG GAGCAAAGATGGGGTGCCAAGACGGTGCAGGGCTCCGGGCACCAGGAGCATATCAAGTAAGAGGCGTCGC CACCACCCTCCCGAGGGCCCCTCTGCGGATGGAGCCCCAGGTGCAACAGGGCCCATGGTCATCTGTGGAG GGACAGCCCGTGTGGAAACTGCATTTATCTTCTTGACCTGATACCCATGCAGTAAATGAATATAAGACAC ACACATATATGTGTATTTGTGTAATGTGTGTGTTTATATGTGTATATTTAGATACTTCTGTGCTCAGTAA TTTTTAAATTCCCATTGCAAACAATTTCCGTATTTATAATTTTAGAGTGTCCGCTTCTCAGTATTGTGGC TTTTATCAGGGAACATTTGTCCCTAAGCTCTACCTTACAAGCGAGAGGTTTCTAAAGTATGAGATGTCTG AATAACTGAGACCTTAAATGCCCTGTCCCTTTTTTTATTATCTGGAAATGATTATGTGTTAATAGTGAGG TACTGTGAGCTTTGTGTTCTTATCGAAAGCCCAGAGTTGGGCACTGAGTGAACCCTGTCATTGTTTCTCA CTTGGCACTATCTAAAATGCCAGCTCTTGGGGCAGTTTTTTTTTTCGTCAGAAAGTGTAGATAAAAGGAA CTTTTAAAATATGCTCAGACTTTTATTTTAGGCCACGCTGGGTTCAGAGTGGATCCTCCTTTCCCTGGCT GTGAAGGCAGCACCACTGACCCGGTGACCGCCTCAGTATCCCGGGAAGACTGTCCCGCTTGACCACGGTC CCTTCAGCTGAGAAAGATTTAGTCCTTCCTCCAGAAAAGAAGGCACAGCCTGCACAATGGCTTTTTATTT TGTTGTTAAAGATTTATTTATTTATTTATTTATTTATTTTGAGACAGGGTCTCACTCTGTCACCCAGGCT GGAGTGCAGTGGTGCAATCATAGCTCACTGCAGCTTTGACTTCCTGGGTTCAAGCGATCCTCTCACCTCA GCTTCCTGAGTAGCTGGAACCATGGGCGCACACCACAATGGCTAGCTAAGTGCTTTTATTTCTTGTAAAG ATGAGGTCTTGCTTTTGTTGCTCAGGCTGGTCTTGAACTCCTGGGCTCAGGTGATTCTCCTGCCTCAGCC TCCCAAAGTGCTGGGATCACAGGTGTGTGCCGCCGCACCTGGCCCCCAGTGGCTTTTTATACACAAGTTT TAGTCCCTCTCTGGCTTGCTCAGCACACTCCCTTCCACAGAAGCAGCTTCGGAACTCCGGTGGCCGTGCG GCTGCCCAGGACAAGAGACTGGAATGGGGCTGACTTGGGAGTCCACTGTAGCCTTGGGTATTTGCTATGG CGTTAAGCAGACTCCTGAATTCGTTGAGTCATCATACCTCTTCTCATCTCTTCTGTTCCCTGTGGCTTCA AAACATGTCTCGGAGGGTGGCTTGGAGAAAAAACAACTCTCCAGTACAAAACCCTTGGGCTGGTTAGGAT TCAGAGAGGAACACATGGGGAATAAGCCCATTCTTCATGCTCTGGGGCCTTCCCAGGTTTTAGGAGTGGT GTCTTTCTTTCTCCTGCTCATAAGGGTATTGGGCGGTTTCCAAGCCTGGTTTGTATTTCATCTTCAATTC TAGGATTGTCGTCCAGATGTCAAAGGTGGCGTCCTGGTGTCTCCTGGGCAGAAAGTCCGAATGCCAAAGT GGCCTTCTTATCACTCTGGGGTCTCTCAATGACAGCTGTGTCTGGCCTACCAGATTTGAGCAAACCTTGT CATCTGTTTCATTATCTGCTGTATTAAAATTTTTTAATGGCATTTAGATGTTAAATTCTGAAACGCTTTC CTCTCATCTTTGAATGTATAAAAAAGCTGGAGTACTTCAAGTACAGACGAATCATCTGAATGTTCAGCAC CACTGGACTTCTGCCAGTGGCCGAGGAAGGGACCATAGCCTCGTGTTTCCCCCTCTACCTCTGGATGATT ACAGACTAGCTTTCCTATTTTCTGCGTGTGAAATAAAGGTCAGGCTTCAGTAGAGCCATCTTTAGCGGGG ATTTGGGATGATCCCAGTGTCTGCCTTCAGATTCGTGTTCTGTCTCCCACAGAGCATGCGTCTGATACTG CAGACTGCCGAAGTGGGTGTACCAGCCGGCAGAATAGTCAGGAAGGCACAGTGCAGGGAGAGAATCGGTG AACATCAGATAAGCAGATTTACAAATTTACAAAGATAATGTCACCTGTTCTTATTTATCATACCAGGAGG CAAAGCTGCACGTCTGTTTTATTGATCTGTTCCTATTTTCATCTCTTCCATCAAGCATACACAAGCTGAG GGAGAATGTCTTTCAAGAGCATCAGACCCTTAAGGAGAAGGAACTTGAAACAGGACCAAAAGCTTCCCAT GGCTATGGAGGGAAATTTGGTGTGGAACAAGACCGAATGGATAAGGTAAGTGGCCCGCGGCTGCCTATGC CAGGCTCCTGGTGTGCTTGGACCACTAGACTGGGTGGCAGAGTCGTCCCTCAGTCTTTCCTTAGATCAGC AGTTTTGAGTCCATCTGCTGAGGTTGCGATTTGCCCGGAGTAGACCCCTGTTGATTGGACTTACTCATGA AGTACTCTAGCTTTCTTCAAAGCTCTTTAGGAATCCTCAGAGGTGCTGGAGCACGGGTGTTAGTGGGGAG GCCCAGAGAGGGAGATTGGCCCTCAGAGGCAGCCTTGTGATAGGACAGAAGTCCAGAAGCATCCTGGCTC TAGGTGTCATCACTGTCAATGCCTGTGGTTCCAGTCTGTAGCCTAAGTCATGCCAGTCCGAAGACCAAAG TCAAATCTGTAGGTCCCCATGGTTCACAGCACACACGGAATCCAGCCAAAGGCCTGGCTAACATCCTTCA TGCGTTCAGTGACCATCAGAGCAGTCTCCCTCGTGTAAATTCGGCGCGTACCAGGCTGGGGACAGTGCTC ACTCTATTCGAGAGGTCTGGGCAAGCCTCCCAGCAGCTGTCATTGATGGGATGCAGACTGCCACGCAGAC GTTGATTGAGGACGTTGGCCAAATGCATCCGGCTGCACCCGTGCTTTAGGTCCTCTCTACCTTAAGAAAG GGAGCCACGTTAGCTCAGGAGGGCTACCTTTTCCTTCCTGGAGAGAAGATGGAAGAGATCGCAGTGTGTT TGCATGTTTCTTCAGTAAAACAGACATCCTGGAGGTGAACTTTTGAGTCTGAGCAACATAAGCTTGTTCT GACCTGACAGATGCTTGCCTTTACTCTGTGGAAAGAAGTGTGTTAGCCAGTGTCGGATTCCAGCCGGTAA TTCCATACCCCTCTCCCACCTCATGCACCAGCCAGATGAACATTTGAGCTGGGCACGGGATGATGTTGCC GTGTCACAGTGAGCTGCACCTTGCTCTGTCCCCCGCAGAGTAGATGATGTGGTGGGCCGGCAGGGCACCC CAAACCACGACCATAAATAGCCTGGGGGAGGAGTGGGGTGAGGGACCTTCTGCAGGAAAGAGACATGGAT GTTGCTGCGTCACTACCACAGAGATGCCCTGACACCGAGAAGAGCAATGTGTGCAGAATCATCATCTTTG GAGTCTAAAAAAAGTCTGGTAGCTTTTAGGAGTGTAAACAGGCAGACGGACCCCTGAGTTCAGTGCAGCG AGCGAAGCAAGTGCACACGGACAGACGGAATCCATGTGTTCAGTGCAGCGAGCGAAGCGTGTGCACACGG ACAGACGGAATCCATGTGTTCAGTGCAGCGAGCGAAGCGTGTGCACACGGACAGACGGAATCCATGTGTT CAGTGCAGCGAGCGAAGCGTGTGCACACGGACAGACGGAATCCATGTGTTCAGTGCAGCGAGCGAAGCGT GTGCACACGGACAGACGGAATCCGTGTTCAGTGCAGCGAGCGAAGCGTGTGCACACGGACAGACGGAATC CATGTGTTCAGTGCAGTGAACGAAGCAAGTAGATAGGAGCCTTTCCCACTGCAGACTGAGGCGAGCCCTG TGCTTAGGGGGCTTGTGGGGAGTTAGCGCAGAGAGACATTTATTCTAAAAATGGGGCTCCCTGCTGTGGG TTGGGAAAATTACATATTGGGGAAAAGAAAGGCAACGTGTCAGGAGAGCCTGGTAGGGAAGCTGCTGTGG CTTCTCTGCTGCTGCTCGGCCTGCACCTTTTTTCAGCGCGAATCTCGCTCACCCTAGAACCTGCAGCTCA GGCCTTCCCGAGTGCCAGGAGCTCCCTGGAAGAGCCCTCACTTCCCTCTCTCCTGTGCGGTCTCCACAGC AGCCTCTGCTTCCCTCATGAGCTGTCCTTGCCTCATCCTGCTGTCCTTCCCAGGGAGACTCCCCTCCGGG CTGGGCTTTTCAAGGGTCGGGACTTGTCATCCTCACCTTGTGCCTGGCTCAGTGCCACGTGCCCCCCCCT TAGGCCAGTGCTCTCATGGAACCAAGGAGGCTTATGGAGCCTTGCTCTCACCTCTCAGCCGGCAAGTTGG AGAGCTGTCCTAGCAGGGCGAGTCCAGCAAGGGATGCTGCTGCTGCTCAGTCCCAGCTGGCATCGGGGCC AGGTTAGCGCTCAGCTCAGGTCAGCACCATGGGACAGATACGTTGTCAAAAATAACTCAGGGCCAGGTAC GGGACTGGCACCTGTAATCCCAGCATTTTGGAAGGCCGAGGCAGGATGATCTTATCAGCCCAGGAGTTTG AGACCAGCCTGGGCAACATAGCAAGACCCTATCTCTACAAAAACATAATTAACTGGGCATGGTGGTGCAC ACCTGTAGTCCCAGCTGCTTGGGAGGCTAAGCTGGGAGGATCACCTGAACCTGGGAGGTGGAGACTGCAG TGTCCTGTGATCGCACCATTACAGTCCAGCCTGGGCGACAGAGAGAGACGCTGTCTCAGGAAATAAATAG ATTAAACTCAGATTCCAAACCGAAGGGGAAACGGCTTAAGTTATTTGTAACTTGCCCACTCCAGAAACTA AAAAAAAAATAAAAAATTGAAATCTCTGCGTTAAGACTTGAGGAATATGTGCTAGAGACTTCCAGAACAA AAGAAGACATTGAGGACAAGCACACGCGAGAGGAGCCTGGACGGGCTGTCAGGATTCTGTTTATGCTGGG GCCTGAGCACACTGCACCTTTCCCTTGCGGCCAGCGGTGGCTGCATCCATCACGCGGGGCAGGCTTCCTT CTTGATCCCTTGTCTCCTTGCATCCCGTAGCCCTGAGTCTACATATTCAGGCTTCAAGATACAATCTCCC CAGCGTGATTGTTTAATAACAGATTTTGTCAATGTGAAATCGAAGGCAATTTTGGAGATGAATCCCTTTC AATCAAAAAGCTGGAAACTTTGCCTAGTTGTCATTCTGGGCATGTCTTTAGATCAGTTTTCCTGTAACTT CCTTCTGATGAAAACTCATGCTGGGGAATCCCTTTGGCACGTCTGCCTCTGCCACTCCTTCATCTCTGTT TTCTGGGTGAGACCCCGGAGGACACGGATGGGCAGTCTCTGCCACAGAGGGTTTGGAGGTGATGGCTCAT GTGGAAAGAGAGTCAGCTGCCAACCTCAAAACAAACGTGGGAAGAAGAGGGCGCAGCACAGGCCCAAGGC TTAGGGCAAGACCTGCTTTTTCAATAGGGGAAATAGTGGACACTCTCTGAGTTGCCTGCTGCGTCAGCAC CGGTGTGGGATGCTGCTTGGGTTAGCAGGTTAGCATGAGTGGCTCCACATGCTAGAGGGAGTGAGAAGAG GGGTCCCGATGTGCCGTGGACTTTCTCCACGCCCTCTGCTGGGCCATGTGCCCGCACTGTCTGTGAAGGA GTCCTTGACCCGGCTCTGCTGTGAGGAGGGAGCCTCAGAACCCTGGGGCCTCGGTGTCAGGACTGGAGCA GGGCCAGTGCTTTGAGGTAGGAGATCTTTTCCACTTTGTGGACCAGAGGGTCTCTCAATAGAACTGCCGA ACGGAGTTGCTGAATCACACAAGCAGCTGTGGACAGCACACCTGTGAATGGCTGTGGCTGTGTCCCAGAG GCGTTATTTACAGAAGAGCTGGGTGCCGGGTCTGGAAAGCCCAGGGGAACCTTGGGCTTTACCTGCTGGC TTTGGCGAACAGAAGGTCCCCAAACCTGTGTGCGCTGATGGGGGCTGACGACATTAATGATGCTGAAATG AGCTGGCATGGGAGCCGGCAGCTGGCTCCTGCCTGAACAGGGTGCTGCTCAGCGGAAATCCAGTGTGAGC CTGTGTCTTGCAGACTATTTTTGTTTATAGTCTATTAGAACAAAATAGTTTGCTGGCAGACTATTTTTTG TGCCGATTCTTTGGTCATGTGATTCACAGAGGTCCCACTTCAGTAGATGCCAGCAGTCTCCACACCAGCG GGTCTCACGGATCCTGCCACAGGCTGCCAGCTCTGTGTACCTTCTTCATGCCCGGTCGTGTCAGAAATCC CCACTGGTGGCCCCGACCTGTGTCCAGGGTTCGTGTGCAGCTTCCAGGAGCCCAAGGGCTGGGGTGGGCC GTGAAAGCCTGCACCAAGGGCTGGGCGCGGTGTCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGG CGGGTGGATCACAAGGTCAGGAGATGGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAA ATACAAAAAATTAGCCAGGCATGGTGGCGGGTGCCTATAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAG AATGGCGTGAACCTGGGAGGCGGAGCTTGCAGTGAGCCGAGACCCCGCCACTGCACTCCAGCCTGGGCAA CAGAGCAAGACTCTGTCTCAAAAAAAAAAAAGCCTGCACCAAGGACCCGGGCCTCCCAGGAGTCGTGTCG CCTTCCTTGGCTCCCCAGATGGGTGTGTTAATGTAAGGTTTCCCTGCACTGACCAGGATGTGGCCTCCCC CAGCCCTGCTCTGGGAGGAAGTGAAGCGCCGCAGTGTTGTTGGTGTCTAATGCTTTGTGTTTGAACCCTG TTCCAGTCAGCTGTCGGCCACGAATATCAGTCGAAACTTTCCAAGCACTGCTCGCAGGTGGACTCGGTCC GTGGCTTCGGAGGCAAGTTTGGTGTCCAGATGGACAGAGTTGATCAGGTGAGTGATGTGGCACTGGGACT GGGGCAGGTTGGGGCAAGGGGGGCGTTCCCCGTAGATCTGAGCCCTGTTGGGCCACTTGTAGTAGCAGGC AGGTGCCCTCCAGCTCTGGGGGACTGCAGAGAGGGGCATCTGCCTCCCAGGATGCTCTGAGAGCCTGGGC TCTCAGAGAGAGGAAGCAGGATGCGGCGGGCTTGCTGTAGCAGTCCCTGCGGTCGCTCTTCACTACGTGC CTCAGTACTGGATGGCCCTGTGTCTGTCCCAATGTGCCAGCAGGGACCGTTTCCACCCGTGTTTCTCACA TGTGTGTTACTGTGACAGAGTGACATCAGAGCCTATACCGGGGGGGCAGGATGCGCTCGTGTCCAGGACC CAGGCTTTGCGTCCAGGTGTTGTTGCAGTCATCCTAGGCCCGAGCCTCTTTGATTCTCTTCGGCTCGGGT CTGTTGGCTCTTTTGTTTAATAGAGGAGCGATCAGGAGCCTGGAGGGAGCAGGGAGCTGATGCTGGTCGC AGATTGTGGCTTTGTGACATATTAGCCACGGTTCTGAATTTATGTGTCTGTGAAAGGAGGATGATCATAC CTATCTCACGGGTGTTTGCTCAGATGCCCATCGCAGTGCCTGGCTGGTGGGAGTGCACCCCTGGTGGCCA CTGCTATTCTCATTACTAATACTAATGTTCTCAGCATGACTTATTTGAGAAGCGAGTTTTTGTGAAGCCC GTGGAATGAATCAGCTGAGCATTCCCTGCTGCCGCATGCTGGGGAGGGCAGGTCACCAGGGATATGGCTT GGCCTGCGCCGCCCACTGGGCCTTGCAGTGGGCCTGTCCGTTTAGGATGCCAGAGCTCTTGCGTCACTGC CACCTGCACCTGGCTTAGGAACCCAGAGGTCACAGCATCATGTGTTTCATATTTTTTTAAATGTCATGTC ATGAATTCAGAGAGATTGTTTCAGGGACATTGGAAAGTATTTCTCCCCACTTTTTCATGTGTTTTTGGTC GTCACAGTCTGCTGTAGGCTTTGAATACCAGGGGAAGACTGAGAAGCATGCCTCCCAGAAAGGTAAGACG CGAAAGGTGCAGAAAGAGCCCGCTCCGGGGGCCCCGATGGGGAGAGTCACAGCCACCTGAAGCCGTTTCC CCGCGCTCCGGGGGCCCTGATGGGGAGAGTCACAGCCACCTGAAGCCGTTTCCTGAGCGGTGGCTGTTGC CACAAGGAGGACTCTGCCCTCCTCTTCATGTTTCTGGATCATCTGGATACCACATGATGGATGTATTCCC CGTTACACATCCCCCTCGGAGCCCTGGCATCTGCTGTCATTGTGGGGCTTCTCCCCCTTGTAGCGGAAGC CGCCTTCCCTTCATCTGGGCAGCGCTCCTCCTGGAAAAGAGAGCTCACAGATTGATCGGCAGAAAGCTAA CTTCCCCCCAAGGCTAGAAACCAGAGTTGTTAAATTCTTGTTTTCCTTATACACATACGGTCTTAACTGC TGGTGATTAATCTTGATTACATCATGCAGTCTCTTTTTTGAAAGACCAAAGCATATCGCCACCTTAAAGT TCTCAGTTTATTTTTTGCAAGCTTATTTAGTTCTTCCTCCTTTGTGTCATTGCATCATCCGCGGAACAAG CTCTCAGTCCTTACGCAGTCTCGGTGCAGTCTAGGTGGAGGTAGCTGTGGTGTGGGCAGGCGGAGGATCA GGGTCTTGTCTCCCATGTTCAGCTGCATGGCTTTCTTCATATGAGGCTTTCTCTTTCCATTTTTTTCATT TTGTTTTGTTTGTTTGTTTGTTTTGAGACAGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACG ATCTCGGCTCACTGCAACCTGCGCCTCCTGGGTTCAAACGATTCTCCTGCCTCAGCCTCCCAAGTAGCTG GGATTACAGGTGTGTGCCACTACCCCTGGCTAGTTTTTCTATTTTTTAGTAAAGATGGGGTTTTGCCACG TTGGCCAGGCTGGTCTCAAACTCCTGGCCTCAAGTGATCCGCCCACCTCAGCCTCCAAAGTGCTGGTTCT TTGTATGAAGCTTTCCAGCTTTTACCTGAGCAGTTGATTTTCAAAGTGGGCATGCAGCGTCATTTCTGAC TACACAAAGGAACTGCCCTGTAACAGCTGACAGGGCCCAGAACCCCCCCATGCACCTGTTGTGAAACAGG GTCCAGCGTCACCTGTATGGAGCAGTGGGTGGCTTGTTGTACATTTTAAAATGTGCGCTTGATGTGTTTG TGAGTTGTAACCCCTACACACTTTTGCTTAGTTTAACAAAAGGAACAGTGTAGTTCGTCCTCAGGCCCCC GTGCTAATTGCTGCCCTGTCTCTCCAGACTACTCCAGTGGTTTTGGCGGCAAGTATGGCGTGCAGGCCGA CCGAGTAGACAAGAGCGCGGTGGGCTTCGACTACCAGGGCAAGACGGAGAAGCACGAGTCACAGAGAGGT GGGGCGGACCCCACGGTCTGTAATCACGCGTTTGCTCCAGAAACACCCACGAGGGCATTTTCTCTCTGCA CACGTGATTGTTGTAGATTTTTTAACTGAAAATGTTTGGTGTTCTTTTCGTACCAGTGTATGTGGGCTTT TCCTAATTCGAATGGCTGCACAGTTCCCCATCGTATGAGGATTCCATAGTCCATGTAACCATTCCTTTTT TGAATGTGGAATTTAGGTTATTTATTTATTTATTTATTTATTTTTGGTAGAGATGAGGTCTTGCCGTGTT GCCCGGACTGGTCTTGATCTCCGTGGTCTCAAGCAATCCTCCCCCACCTTGGTTTCCTTAAGTGCTGGGA TTACAGGTGTGACCTGTAAATTTTTTTTTTTTTTCTTTTAGACGGAGTCTCGCTCCGTTGCCCAGGCTGG AGTGTAGTGGCGTGATCTCTGCTCACTGCAACCTCCACCTCCCTGGTTCAAGCAATTCTCGTGCTTCAGC CTCCCGGCTAGCCGGGATTACAAGCACACGCCACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACG GAGTTCTGCCATGTTGCCCAGGCTGGTCTTGAATTCCTGACCTCAGGTGATCGCCCTGCCTTGGCCTCCC AAAGTGCTGGGATTACAGGTGTGAGCCACTGCGCCCAGCTGAAACTTGACTGCAGGGAACATTCTTGTAC CTGTGTTTTGTTCACAAGTGATTATTCAAAAGAATCAACTCCTAGACATGGAATTGCTGGGTCGAAGGCT ATTGAATGTAAAATTTCCATAGATACTGCCAAGTTGTCCTTGGAGGCTGTGCTGAGTTCTTCCTTCCCCA CTGCATAGCCTGTACACCATCACTCAGAGCGTTTCCCAGGGCTGCAGAGGCTGTGGCCTGCCTGTTTCCC TGTGCCTCTTGTTTGGCCTGCACATTTAAATTTTTAAAAATATTTGCCAACATTTGAAAAGTGAGAGCTT GACTATTTAAAAACTCAAAAAAAAAAAAAATTACCCCAAAGCAAGAAACACCACTGGAAGATCCGACCAT GCTGGCTTGGCATTTCCCTGAGGAAAGTGCCGGTGGCCTGGAGGGCAGCTTGGCTTGTAGTTTGTCGCGG CCTGGCCTGGCCTTGCCTTCCTGCCGGTCAGGCCTTGCCTGCCGCACAGAGCTGCTTGCCTCTGCTCTCT GCCTCTTTCCTGGGAACAGTCCATTCCTCCTCTTCCCGACACCACACAGTTGTGAGCAGCGCATGCTCCG CGAAGCTGCATGAGTGTGTGACTCCAGGGAGCCAGGGAGCACAGGCCGAGCACCTGGGCAGACGCAAGGC TCCTTGGATGCTTCAGGCCTTCTCTCCCAGGCCTTGATCCTCTGCCTTGTGCTGTTAGTGGGTCCATGAG AGAGTCATGTTTTGGTGTCACAGTGACATGCTAAATGGCTTCATTCTGAGTAGAACTGAAGTTTCTGGAG GATGCTGTGTGTGTCCTATTTCCTGGCATCCCCCTGCGTGCTTCAGTTTGTGAAGAGTGGCCTTTGAAAG CCTTGCCCTTCTGCTGCCTCCTGAGCTTAGAGCCTTATCATAAACTCTCATCTCCTGCTAGCTTCTGGAT GCAATGGATGATGTTACAGGAATTCATCTGCTGTACTTTATTTCTTTTTTTTTTTTTTTTGAGACGGAGT CTCTCTCTCTCGCCAGGCTGGAGTGCAGTGGTGCGATCTCAGCTCAGTGCAACCTCCTCCTTCCGGGTTC AAACAATTCTCCTGCCTCAGTCTCCTGAGTAGCCGGGATTACAGGCATGCACCACCAAGCCCAGCTAATT TTTGTATTTTTAGTAGAGGCGGGGTTTCACCATGTTGCCCAGGATGGTCTTGATCTCTTGACCTCATGAT CCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGTGTCCAGCCTCTGCTGTACT TTAAAAAAAAAAACTTTTTTTCTTAATTCTTTTTTTTTTTTTGAGATGGAGTTTCACTCTTGTTGCTCAG GCTGGAGTGCAGTGGCGCAATCTCGGCTCACTGCAACCTTCACCTCCTGGGTTCCAGTGATTCTTCTGCC TCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGGGCCACCACGCCCAGCTAATTTTGTATTTTTAGTAGA GATGGGGTTTCATAATGTTGGTCAGGCTGGACTTAAACCCCTGACCTCAGGTGATCCACCCACCTCGACC TCCCAAAGTGCTGTGATTACAGGCGTGAGCCCCCTCCCCCAGCCTGTTTTTTGAATTTTTAAAATATTAG CTAATGATTTAACTTAGAGATGGGGTCTTGCTATGTTGCTCAGGCTGGACTCCGCCTCCTGGGCTCAAGT GATCCTCCCTTCTCAGCCTCCTGAGTAGCTGGGCTGCAGGCACACACCCCCACCTCTGGTTACCACTGTT TGTGTTTCTGTTATTACACATAAATAGCACCTTTAAATACTGTCTGTATTATTCAGTGGTCCTACAGTGG ACCTGAAAGATTTTTGTTTTTTTAATCAAAGGATAAAATACTTGCATGTTCACTGATTTCGTTGCTCCTT TTAAAGTAGTCCTTTTTTGTTTGTTTTTAGATTACTCCAAAGGTTTCGGCGGCAAATACGGTATCGACAA GGACAAAGTGGATAAGAGCGCCGTTGGCTTTGAGTATCAAGGCAAAACGGAGAAGCACGAGTCCCAGAAA GGTGTCTTCCGTTTTATCTTACCCTCCAGCCAGCAGCTAGTAATGTGACAGGTGGTAGCCACACCGGAAA AGGAAAAACAAAGCGTTATTGATAGCCCTTAACGTAGATGTCTCTTTTTCATGAAATGCCCAACTTGAAA ACGGCACATCCAGAAACACAGCTGCTAAATAGGAACTCGCAGCTTGAGTGTTATGGCGCTCCAGCCCCAG CGGCGTTGCTTATCGTGGTGGCCACACCCCGCACGTCTGTGTTGCCCGTGTGAGCCTGTGCTGTCTCATG GTGCGGGTGGAAGCCGCATGCGTGGGAGCTTCCATGGGGTCCTGTCTGGCTTAGTCACGATGCTGAGGTC ATAGACTAGGTTATTTCCTGCCACTCTCCAAGGAGGGCCTCTTCATGGATGTTATCTAAAGTATTACCAA AGATCCGGAAGGGAAGAGTAGATTGAGTGAATCATATGCGTTTAACTGTATTGAAAACATACTTTCCACC TGTGACCTGCACTACCTGTTAATGATGGGTTCTGGCCTTTCATTGTGCATGTAGACTATGTGAAAGGGTT TGGAGGAAAATTTGGTGTGCAGACAGACAGACAAGACAAATGTGCCCTTGGCTGGGATCACCAGGAGAAA TTGCAGCTGCATGAATCCCAAAAAGGTACATTCACTCTGCCTGTATGCGAGATGGTTTTAGAAGTTTGTT TTTGTTCCTTGCGGGGTCAGTTGGTATGTGTTGTGTCTGCGTGTGCCTGCTGCACATTGTTTTGTCTTCA CTGTTTGAAGTTGTCCTGTGTGCCCCCCCAATCCCCCAGTTCCCTCCAGCTAGTGTAGTCACAAACCCTC CCTGCTGACACGGGGTGGTACCCCAGAGAGCTGGGTTTACCTGGAAGTGGGTTGCACGGGCCAAGCCTGC AGCAGGGGGCTGGGTTTACCCAGGAGTGGGGACATGGGTCAAGCCTGCAGCGGGGGGCTGGGTTTACCCG GGAGTGGGGGCATGTGTCAGGCCTGCAGCGGGGGGCTGGGTTTACCCGGGAGTGGGGACATGGGCCAAGC CTGCAGTGCTCCTCATCCAGGCTTCTTGTCTATAAAGTGGGCCACGGTTTTTGGCAGGAGATACTTACTT TTGAACCGAAAGTGTTTTCTTGTTGGAATGGGTGCCCCTTCCCTGGAAAAAGGAGCCTGAGGGGGCTGAA AGCCTCTCAGTGTGACCCAGCCCTGAGAGAAGCAGGAGCGGGGCTAATGGGGCTGCAGCGCCCTCCGAAT CTGCAGGGTCTCTCCTCCCGTGTACACAGATACGCACACTCGTCTGCAGTGTGCGTAGGACGCTAAGAAT GAACTGCACAGCCGGGAGTGCCTTTACTGAATTATTTGAAGTACAGTTCTTAGGCTGTTCCAGATCTTCG CTGAATGTTCAGATTTTAAGTTCATTCTTTAACGTTGACCTCTGGAGCCACCTTCTGGCGCTGAGCCTGG GAGTAGGATCTCAAAGGCCCTAAGCTCAGGAGAGCCCTTGCTTTCTGGAAACTGTGTTTGATTTTTGCGC ATGCTCATGCAATTCTAACCCAACTGTGTTTCCTCTTTTGGTTGTTTTCCCCACCGTTGCTTGTGGATTT TCAGATTATAAGACTGGTTTTGGAGGCAAATTCGGTGTTCAGTCGGAGAGGCAGGACTCCGCTGCTGTGG GGTTTGATTACAAGGAGAAGCTGGCCAAGCACGAGTCCCAGCAAGGCACAGTTGCCACCAGCCTCCTACC CTCCCCCCGACCCTCCTGTGCGGCCACTTCTAGCACAGACTTCAGGGCTCACCGTCAGCACCTGCAACAC AGTCCTCCTGTGTCACCACTTGTCAGCTGTCAGGCTGTTCGGCACTTTAAACCCATTTCTAGTAGAGCGA CACTGATTTTGAGTGGTTCACTTTCTTCCCTGTGAACTTGTGATCTGTGTATGGCAGGATGCGCCAGTTA GTGTGTGGGTGCCATCTTTCTAACCCGGTGACCCATCCAGTCTCTGGACTGGGGCATCTCCGGTCTCCAG CAGCATTCTGCCCGAGGCTGTTCTGCTGTTATTGGTGACTGCCGTGAGCCACTGAGTCAGGCCTTCCAGA TGAGGAGAGAGGTGTTGGTTCAACCAAACCACTGGCCATTTGACCAGGGGCTTCGTAGCAGCAAGGGCCA GGAGACAGGCGTGTTCTGTGTGGTTTCTGTGTTTCATTTGTGGTGGTGTTTTTGGCCGGGGTTGGGAGGT TTTTTGTTTGTTCTGTTTGATGACACCATATGTGTGTAACATCTCCACACAGAGCCACACAGTATGTACG TGAAGCCAGCTCTGCATCCTTCCTTAGAGCAGTTATGTTGTTACCTTCAAAATTTGGACTTGGTTATTAG AACCTGAACACATAATTGGAAAAACAGTAATTCCCTAACCTTGCAGGGAAGACTCTAGGCTTTCCACCTG CAGCGTTAGAAACACACAGCAGTGTTCAGGTGTGGGCAGGTAGACACACCTGGGGTGGTCCCGCAGACTG CATGGAGATGGCAGTGGCTCTCCGTGGCATCACTGCTGCATGACAGTGTGACTTTCATGTGGATCTGTGT TGCTGCAACGGAAGTCTTTGGCTGGTAGAATTTCCACATGGATTTTTTTTTTCTCTTAAAAAGCAAGAGA ACAAACTGCGATTGAGCCTCTTTTTAGCGCTCAGTAGAGCAGGCGCACAGGAAGCAGATGAGAATAAGCC CGTGCTGGTGCGGAAGACTGTGCTATTGAAGTGGCGCGTTGCAAAGGCCTGTCCGTGCCCTCTTTCCTCG CTTAGCTCCTGCCTGCTGCCCGCCGCCCCTCCTGCCCCTCCTGCCCCTCAGGGAATGCTGAAGCCTCTGC CCCTGGCCTGTGCTCTGCTTCTCACTGCCTGTGTCTCACGACCATGGGTGGAAGCAAAACTTGCCTTGCA AGTGAAGCCTCGCTTGGCCATTCTCGTTTCTTCCCGCTGTGGTGCACCTTCTTGGGCTGTTTCTGGATCT GTCTGCATGCACCCACGGCCACCCCCATGCTCGCCTCCACCTCAGAGTAAGTGTTGTGTTTTGCCACGTT TCAGACTACTCCAAAGGATTCGGCGGGAAGTATGGGGTGCAGAAGGATCGGATGGATAAGGTAAATATTC CAGCCCCGGAGCTTAGTGTCTTCTGCCTGCAGGGGCTCTTGGTGGGCGTGGCTCACCGTGCTGGCCAACA TCCACGCGCTGGGGTGGGGCACAAGTGATTTCCGTCGTGGTGGTGGTGGTGGTGGCGATGACTGACTCGG ACAGTCTTGTGCTCCTCATGGCCGTGCTGTGGGATAGGCGCTGGCACCGGCCCACCTCCTAACTGGGGGC CCCAGGCCAGGCAGGCTCAGCACCTGGCTGCAGCCATAGGAACCCAGATGTTTAACATGAGAGGTGAGAG CCTCGAGGGCTCATGTCCATTTGAACTTAAATTCTTAATAGTAAATCAGATTGGAACCTGAGTGTGTTAG ACTGCGTGTGGGGCTACCTCGCTGGCAGCCAGCGCTGCGTGTGCGGTGATGAGCCATGTCTCCCGTCTTC AGCCTCGTAGAGACGCGGGCTCCACACTGCCTGCTCCTGCGCGTGGCCTGTGGTCAGGGGTGGCAGGGTC AGTCCTTGCCTCGCAGCTGACCACACAGCACCATCCAGGGGCGTAGGCAGGCAGAGCAGGTGTTCGGGCT GGGCTCCCCAGGGAGCAGTAGCCTGGGCTCATTTCTGAGGGCAGGCGCGAGTTCACCAGGAGAGAAGGCT CAGGAGACCACGGAGGGGCGAGGTGTGGGCCTGGGTGGGACAGGAGTCACTGCAGGTTCTCAAGGAGCCT AGCTGCAGAGGGAGGGTGGGGAGCGGGGATAGAGCTGGCCCTGGAGAGCCCCACACACCACAGAGCATTC TGCATGTCGTGACATGCGTCACACACCACAGAGCATCTGACGTGCGTGGCCCCAGAAAGGTTAGCAGGCA AGGAACACTGGGGGGGTCTACTTTGAGAAGCCCCCGGCCTCAGCGTGGAGTCTGGGTTGTGGGGGTTGGC CTGGGCAGAGGGGTGTGGTCCTGAAGAGAGCTGGAGGGGCTCGGGTGGTGGAGAAGCAGGGCATGGTGTT TGGCGCCAAGGGACGCAGGGGAGGGAGCAGTCGGGTGGATGTGGGGTGGACGTGGGGCCAACTGTGGAGC CGAAGAACTGGGAGGAGCAGATGTGGGTGTCAGCGAGAGAGAGCTGGGGTAGGGCCGGGGCCGGGTCCGG GTGGCGTGCAGAGTTGGGAGGGGAGTAGGCACGCGGTCAGAGGACACTGGGCAGGGGGACCCAGTGAGGT AGCAGGGGCCTTGCAAGGCACTGGGACAGACGGAGGGAAGGAGCTCCCCTGTGGGTGAGTCAGAGGTTGT GGCTTTGAGGCCGGAACCTGAGGGACTGCCTGTGTTGTGGGTGTCTGTGGTCAGCATTGCTGGTGTTGGC GGTGACCGCTGAGCTTGTGAGCACGTGAGGAGGCAGTGTGTGGGTGTGGCCTTTCGTGTCATTGTCTTTC ATCCAGGAGGGGGTGGAGCTTCTCTCTCTGTTTGCTGTGTGATGGAGGAGTCCAAGGCTTAGAGAGGGTG ACGTAACTGCCCGGGTCCCCATACATTGTGGGGATAGGGCTACAACCCAGGCTGGGAGGTGAAGTTGCCC CCTCAGGGCAAGGTGATGTCTGCAGAGGGCCCAGTGGGTGATGGGACCCAGTAAGGCTGATGGCCTTGCC TTTGAACAGGTGCAAGCAGCTCAAGGGACATGGAGTAGACGCTGGAGCTGACTGATGGGAGGAGGGAGCG GGGTCCGAGGAAGGACAGGCGGGCCAGGAAGGGGGCAAGCAGGAGGTGCTGGGCAGAAAGGGGCCATGGT ATGGGGGCTCTGGTGGCTTCTGAGCCTCAGGTGTTCTCATCAGAGGTAGTGAAACCCACAGTGAAACTGG GTACGGCCACTGGTCTCCATGAGCCCTGACAGTCTCCACCTGAGTCAGCACGTAAGAGTCATCGCCGTCG CTTGGTCAGACCATAGTTGAGTCCCCTGCAATGCAGAAAGGTGTGATTGCACCACTGGGTAGTGTGTAGG ACGGGCCACTGGAGGCTTGCATGTGTCCCCAGCGTCTTCGCTTCCTGTAAATGCTCACACCTCTGGGTGG CGACGGAGGGTGGGGAAGGCTTGAGGCTGATCCCAGAATTGGTTTGTGGTAGAGCAGATGGAGATACATG CATTTCTTATGCTAATGCTGACCCACGATTGCCTGCAAATGTGGTTGGTAATAGTTTTCATGCCTCAGTT AGTTTGCAAAACCGAGAGGCCATGAAGAGTGCTCTGGGCTGTGTGGCTGGGCCTTTGGGAAGATCTGGGG AAGGCATTTGCATCTGGCAGGAGCTACCACAGGGCATGGAGAAAAGAGAAAAGTGCTCTCCTGACGCCCA TGTCCTGTCTCTGCAGAATGCGTCAACCTTTGAGGATGTCACCCAGGTGTCCTCTGCCTACCAGAAGACA GTACCTGTCGAAGCTGGTGAGTCCCGGCTGATACCAGGAGCACCGTGTGGTTTCCCAGGAAAACACTGAG GGGAAGGACAGTTGTGAAACAGCCAGGAGCAGATGCACCACTAGTTGAAAGCGTGGTTGTTGCTGCGTAT TTTTGGGAAAGAAAATGATCGTTCTGATGAAGATCTTGTTTCTCCTGCAGAGGTTTAGAGTCACCTTTTA GACGCAGCATGGTGCAGCCGTTTCAGTGGGGCCCGTTTCAAGGGGCTCTTCCCAGAGCAAAGGGGCTAAG TGCACATTCACAAGGGCCTCCACACTGCCAGTGACCAGCTTCTGGGAGCAGCTGGGGCCTGCCCAACTCC CTGAGCCGCTCGGTCGCAGCTGTGACAGGAGGAAGACATCATGACGTCGATGTGCAGGCGACAGCAGACA TTCTCTCTGCTGCTCGTTCTTGGGCCCTTGACAGGGAGCTCGAAACCTGTCCTTTTCTGTGCTGGACACA CGATGGAGTCAGATGTGGGCCCTGCCCCGGAGAGTCAAGTAGTTGGGGAAAATGTTATACATACATGAGA GCAAGTGCTAAATTTAACACAGGATGCAGAGAGCCACCACTGACTTCCTTCAGGGGCTATGGACCCACAG TTCTCAGAGATTGAGGGCCCAGGACGCTTTGACACTTTGACCACTCGTGAGAACCCCCAAGATGTTGATG TATTTGATGACATTGACTATATTAGAAATTAGAGGAATGTGGCCCGGCACAGTGGCTCATGCCTGTAATC CCAGCACTTTGGGAGGCCAAGACGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGA TGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCAGGCATGGTGGCGGGCGCCTGTAGTCCC AGCTACTCGGGAGGCTGAGACAGGAGAATGGCGTGAACCCAGGAGGCGGAGCTTGCAGTGAGCGGAGTTT GCGCCACTGCACTCCAGCCTGGATGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAGAGAGAGAG GAATGGTTTATTTATTTATTTATTTTGAGACCGGGTCTTGCTGTGTCATCCAGGCAGGACTGCTGCCTCA GTCTCCTGGGCTCAAGCAGTCCTCTTGCCTCAGCCTCTGGAGTAGCTGGAACTATAAGCGCATGCCCCCT GCCCAGTTAAATTTTTTTTTTTTTTGAGACAGAGTATCACTTTGTCGCCCAGGCTGGAGTGCAGTGGCGC GGACTCGGCTCACTGCAAGCTCCGCCTCCCATCCCGGGTTCACGGCATTCTCCTGCCTCAAGCCTCCGGA GTAGCTGGGACTACAGGCGCCTGCCACCACGCCCGGCTAATTTTTTTGTTGTTGTTGCTATTTTTTAGTA GAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCATGATCTGCCCGCCTCGGCC TCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGTGCCCGGCCAAATTTTTTTATCTTTAGTAGAGATG AGGTCTCACTGTGTTGCCCAGGCTGGTCTTGAATTCCTGAGCTCAAGTGATCCACCTGCCTCGGCCTCTC AAAGTGCTGGGATTACAGGCATGAGCGACATTGGAAAGTTATTAATTGGTTCACTTAAAAAGAATAAACC TTGGCCGGGTGTGGTGGCTCATACCTGTAATCCCAGCACTCTGGGAGGCCGAGGTGGGTGGATCACCTGA GGTCAGGAGTTTGAGACCAGACTGGCCAACATGGTGAAACCCTGTCTCTACTAAAGATACAAAAAGTAGC TGGGCATGGTGGTCCACGCCTGTAATCCCAGCTACTCAGAAGACTGAGGTACGAGAATTGCTTGAACCTG GAGGCAGAGGTCGCAGTGAGCCTTGATTGCGCCACTGCACTCCAGCCTGGGCGACAACAGCTAAACTCCA TCTCAAAAAATAAAAATAATAATATAACTGGCCATGCACAGTGGCTCATTCCTGTAATCCCAGCACTTAG TGAGAAGACCGGCATTGTTTTGTTTTGTAAATCTCTTTAATAGAAGATGGCTGCACTCTCACATCTGCCT CTGCAGTCTATCGATGTTACGTTGTTTAGGAAGAACATGTGGAATCACCTAGGTAGGCGATTGGGAAAGG GAGGAGTGTTTGTAACCTTGAGGGCAGCGTGGGTGTCCTTCTGCGACGCCGCCCAAGCGTGCCAGGCAGT GGTGGTCCTGCAGGCCGGCTCCTCTGGCCCTGTGAGGGACTCGCTACCCACTGTGCTTGGGCAGCACTGT GTGTTGGTCATTTGGAAAATGCTGGGTCTCTGAGTTGTGCTCGTCTTCCAGTTGTGGACACTTCTCATTC CACAATACCAAAAAAAATCACATTTGCTGTCATCATCTATTTCATCTGCAGAAGCTGAGTGGAAATCAGC ATGTTCATGTGGCAGCCTCACATTTTTCAAAATTCTGTCTTTTACTTGAAAGCTGGAATTTTCCCGTTGG CAACAAATACTCCAGTAATTTTTCTTGACACAATAGGCTTAGTTCATTCACTTGGGAGAAAACTGTTGCC AGATACCCAGCTTTGCATAACCATAGTTGGACTGTCAGTTGTTATTTCAGGGAAAAACGCTATTCCATGA GAAAACAGTCAACTTGCAGCTCTCATGGTTCTATTCATGGTCCTTGAGACACAGACAGCCACCGCCACAG TCCCGGACACAGCAGGGAAGGCTCATGTGTCTTCCCACTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTG AGACAGAGTCTCGCTCTGTCGCGAGACTGGAGTGCAGTGGCACAATCTCGGCTCACTGCAACCCCTGCCT CCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGCCTGCCACCAAGCC CAGCTAATTTTTCTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGATGGTCTTGATCTCTTGA CCTCGTGATCCGCCCACCTTAGCCTCCCAAAGTGCTGGAATTACAGGTGTGAGCCACCATGCCCGGCCAT ATTCCCCACTTTTGACTTAAATTTTTATCATTTTTTCTTAATAGACACGGGGTCTCACTGTCTTTCCCAG GCTGGTCTCAAACTCCTGATCTCAGTCTTCCCGTCTCAACCTCCCAAAGTGCTGGGATTACAGGCATGAG CCACTGCCCTCTTTTCCATTTTTGTCACACACAATATAAAAAAATGTATACTCTGGTTGAGATTTACTAT ACTCAGTATACGTCAATTACAGTATACATCAGTACCTTAACTGCTTTATCAAGGACAGATGTCTTTAAGG GAAATTGGCTGTTTTTATTTAAAAAGGTGAGTGTGGTGGTGAAGATACCGTCTTATTTAGAGATCTTCCT GATGCCAGGCTTAGGGGGATTGCCAGTCCCACCAGGTACGCAGTGCCCTGCGGCAGGTGCCCAGTGCTGG CTCCGGACCAGTGGGCTGAGCTGGCAGCTGCAAGAACCTTTCCCTCCTTGGGGGTTAGGGGGATGACCGG TTCCTGGGGAGGTCACTCTGTGTGGGTGGGGCTGTTGTCCAGGAGCAGTGTTTTTGCTGTGCTCAAGGCA CACGTCCTCCCTCCTTCCTCTATAGTGACCAGCAAAACAAGTAACATCAGAGCTAACTTTGAAAACCTCG CTAAGGAGAAAGAGCAGGAGGACAGGCGGAAGGCGGAGGCGGAGAGAGCCCAGCGGATGGCCAAGGAGCG GCAGGAGCAGGAAGAGGCCAGGAGGAAGCTGGAGGTGAGTGGCAAGGAGTGGGCCGCAGCGCACCCTCCC TGGGACCTGTGCCGAGGGGATTGGGAGCTCTGGGGCCTGGGCGGGGCTTATTCTCTCCTGGCCAGGTTTT CCTTGGAAGGCATGTTTAACTCTCCTTTAAGGCTCTCCATTAAGGCACTTGTCACTTGCAGCCACACATA GGCTGAGTCTCTGGCCACAATGCTCCAGGCAGCCGGCTAGCGCTATCCTGGTCTTGCCGGTCCAGCCCCA GGACCCGCCAACCTGCCCTGCCCTCTGTCCCTGAGCTGACGGCAGAGTCTTGTCGGCTTCCACCTCCACG GGGCTCCTGTCCAAATGTCAGCCTGAGTCTCTTCTCACCCCTCCCCCTCTGGAAGCCCCTCCTTTCCCAG GTGGAAGTTTGGGGTTTGGAGGGGACTCTGTGCAGAGGCAGCCTGCTCTCGGGGCCTGCTTCTGCTTGGC CAGCCCAGCCCCGCTCACCCAAGCCCCTGGGCTGTGGAGAAGCGCTCCCAGAGAAAGATGCCAGAAGTGC ACCCCTGGCAGGGGCGGAGCACGAGCCTGTGTCTGGGTGCTTTGGGTCTAGCCTGGGTGGCTTGCCACTG ACAAGGACTTTCCTTGTGCTCAGCTGGATCAGGGGGGTTGTGAATAGAGCCTGAGGCCTACAGATGTGTG TGTGTGAAGTTACCAGGTGTGGTTCTGCAGCTGGGGCATCTGCAGTGTGGGGCAGGCCCAGCCTGTCTGG AAGCCTGGGCTTCTCCTATCCACCCCAGGCCCTGCCCCTGCAGGGCCACACAGGACGTGCTACTTTGGGT GTTTAACCTGTGGATGGCATCAGGTGACGTGGGAATTTACAACTGTCCTGTTGGGGTCAAGCAAGGCCAT AGATGCCAGGAACCGTGCTAGGGTCTCAAGACCAGGGGTGGTTTTCTCTTCAAAAAGACAAGACAGCACT ACCATTGTTCCCGTTAGAGCAAGGCCGCCTGCAGAGGGAGAGGAGGGAAGGGGTTTGGAGTGGACACCTG GGGTTCAGATCCTGCCTGGGCAGCTCCCTGGCCAGTGTGCCTGTGCCTGCCACCTCACCCTCAGACTCAG CGTCTGGCACTGGAGCCCACAGGCTGTCAGTGAGTTTCCTGTTGCTGCCGTAGTCACCACCACACACAGC ACACAGCTAGTGTCTTATAGCTCTGGAGGTCAGAGGTCCTCAAAGATGTCAGCAGGGCTGTGTTCCTCCT GGTGGCCCCTCGGCCCTGTCTTCCCATCTCCAGCCTCTGCTTTTGTTGTCACCGCCCCTCCTCTGTCCCT CACACTCCTGCCTCCCTCCTCTCAGGACCTTGTGATTACATTGGGTCCACCCAGGCAGTCCAGAGTTCTC CCCATCACAGAACCCTTAGTTTCATCACATACACAGTCCCTCCCCATGGGGTCTGGGGACTGCGATGTCA GCAGCTTTGAGGGGCTATTATCCTACCCCAGTTCATCCTTTGGCCCCTAAAGCTTCATGTCCATCCCATG TGCAAACATACTCAGCCCATTTTAAGGTCCCCAAAGTCTCAACCCATTGCAGCATCAACTCAGACTCCCA AATCTGTGCCTAAACTATCTAATCGTGTGTGGGCGAGAATGAGCTGTGGCCCAGTCCCGGCACTGTCGCG TCACTGGCTGTGTGATCTCGGCCTCAGAGCACACCTGCCCCTCGAATCCTGCCTAGGTGCTGGTGGGATC TGAGGCTTGGTGCTCCAGCTCCCCTGCCCCTCGGATCCTGCCTGGGTGCTGGTGGGATCTGAGACTTGGT GCTCCAGCTCCCCTGCCCCTCGGATCCTGCTGGGGTGCTGGTGGGATCTGAGGCTTGGTGCTCCAGCTCA GCCTTGGTGTGGGTGTTTTCCACTCCTTTCCCCAGAGCATGCCTAGAGCTTGCACACGATCTTCTGAAAC ACGGCAGGCGTGACAGTGCAGAGTGTCATGGCAGCATTCTGATTGCTGTTTGTTTTCAATCACAGGAGCA AGCCAGAGCCAAAACGCAAACGCCCCCTGTGTCGCCCGCACCTCAGCCAACCGAGGAGAGGCTGCCCTCG AGCCCCGTCTATGAGGTTGGTGTCTTTGGTGTTTGAATGAGCGTGAGTGACTTACTGCCAGAGCCCAGGT CCTGTTTGTGGAGTGGAGGAAGCCCTTGCAGGCAGGCAGTGTGGCGTGGGTGTAGAGGGCATCGCTGCAT TCCACGCCCGGAGAGGGGTGGGCCAGGAGCGCCTGGGGGGTGGGTGACATGCCTCAGTGCTGTCAGGGGA TAGCTGTGCAGGCCCACATGCCATCCTTTCACCCCTCTGCAGCCTGTTGTAGTCTGGCCACTGTCACTGC AGTCCCTGCTGTAGTCACCTGCTATCAGATAATCAGATGGGGGTGTCTTCACCCCACTTGCTCTCTGCTG TGCAGGACGCCGCCTCACTCCCTAATGGCAGTGCTGCCCTCCTTCATCACTGAGCCCCTGCCTCCCGCAC AATCTGCCTTCTATGCCTGCCCCATTCAGCTCTCCAGCCTTGCAGCCCCTCATGAGTGTGGCTGCAGACA TGCTGTCCGGCCCCTCCCTGTGCTGCTGACCCCCTCTCATGGGTCCCCCAGTGTTCCGTCCCCATCCCTG AGTTACGGAGCCGCCTGCCGATGCCCCGCCCATCCCTGACTTTGGGTCTCCTGCTCCCCGCCAGCACCTC TGCGCTAACCACACCCTCTACCTGTAACCACCTCTCCTGTCCCCAGCCCTTGCCCTTTCTCCATCCCATG GCCATCATCCTGGTCTATGCATTCATCTCTGCTCGCCCAGGAGCCAGTCAGTTACAGGGGTCACACTCCA GACCATGGTAGTTCAGGAGCCCAGAGAGAGCCCTGGAGACAGGCCGGGTCTGGGATCTGGGCCTCGATGG CCGTGGCCTTGTCACCACCCGACTGTCCCTCCTTGGCTACGCTGCTGCCTGCTGCCTTTACCCTGCCGGG CCCTGGGGGGATGTGGTAAGTGAGGCCTTGCAGCTTGTCAGGAACCGGCCTCCCCCTCTAGTCCCTCCCC TTGGCAGCCAGCGCCATCTGCCTCAAGGAAGCTCCGACCCTGCCCCTCCCGTGCAGTTCAGCCCTTGTGT GGTTCCTGGTGCCTGTGCTGAGGGTGGAGTCGCTCTCCCTGCCCGATTACTCTCCCTGGCTAGCAGCTCT CCACCACTGGCTCTTCCCAGATCTCCTGGGTGCGCGGTTCTGAGCTGTCGGCATTGCTTTCTTTCAGTCA CTGCCGGTGACATCAGGTGGACCCTGGTCAGAAACATTGATTAAAGCCACTGTCGGTGATAAGCAGTTCA GAATTTTCGCTGGGGCTCCGAAGCGGCAGTGGTTATAGATAGAGAGGTGTTCCACTGCGCACCTTTGTAG TTGAATGTGATTCTTTGGCGATGCCCTGTCTGTAGGCTCAGCTGCTCTGGAGCCACGTGGTGAAGCCGCT GTCAGGCAGGGCCAGGGTCGAGCAGCACAGGCAGGAGGGTGGCCGCTCGGCCCAAGGGTGCCTTGTGTGG CCTTGGAGATGAGGCCTAAAAAAAGAAATCAGCCAAATTAACCCAACAAAGACAGGCTCTACCCCCAGGC AACAGTGTGGGCAGGGGCGTGTCTCCTAACCTGCTGTGTGGGCGTGGTTATTGCAGGACTGGAGTGTCGG TGGTGAGGACCGGGTCATCATCGGGAAGGAAATGGCATGTGGGCACTCACCACCATGGTGAACACACCGG CAGGCCTGGCCTTCCTATACCGCGTCTGTTTTCTCAGTCCTGGCTGGGACTGAGAATTAGATGGCCCGTG GGTTTCTGCTGGCTGTGGCAGTACAGCTACTGCTCTCTAGAAGCCAGCATGGGCCCCGTGCCATGTGCGT GTGACCCTTCCCCAGGATGCGGCTTCCTTCAAGGCAGAGCTGAGCTACAGAGGCCCTGTGAGTGGGACGG AGCCGGAGCCCGTGTACAGCATGGAGGCCGCTGACTACCGAGAGGCCAGCAGCCAGCAGGGCCTGGCCTA TGCCACAGAGGCTGTCTATGAAAGCGCAGAGGCCCCGGGCCACTATCCCGCAGGTACTGGGGCCCCACGC TGCAGCGCCCTGCCCAGGGCAGGGAGCTCCCGGGACATCCTGCTCGACCTGTGGCGTCGTTGCGAGGAGC GTGGGTTTCCCACTGACACGCCTTTGCTTGCTTGCTATAGGGTCTTCTTGTCCCTGGAGGGAAGTGCTCT AGGCACATTTGGGGCATCGGCTCCTGTGCTGGGTCCCAGGAAGATCCCCATTGTGCTGGGGACGGGTGGG CAGGGGCAGAGGAAGGGAGGGTTTCAGCTGCCGCCCTGTGTCCTTGAGACAAAATCTTAGGAAGTGTCGT CTAAAACTTGAGAAGGCTGGGAACCTGTGTGGGACTTTGTATTGTTCAGCTCTGTCATGGCTTTCTTTTA GAGGACAGCACCTACGATGAGTACGAGAACGATCTGGGGATCACAGCCGTCGCCCTGTACGACTACCAGG CTGGTGAGCGGCCTGCAAAAGCACTTGGAGGGGAGACCCAGGCAGCTGCGCCTGCCTCTGCTTGTTTTCT GAGAATTCACTTCTCTAGCGTTGTTAGTTTTAGAAGTAATTTATGTTGAGATAATTTCAGAGATATAGAA AAGTTGCAGGTATAGTGCCAAGAACTCCCATGTTCCCTACCCGGATTCCATCTCTGCACACACACGCACA CACCCCCTGTTATCTTTAGTATTCTCTGAACCCTTGGAGAGCTGCAGGGGTGCTGCCACCCCCAAAGACT CCAGCGTGTTTCCCAAGATCAAAGATGCTGTCCCACAGGGACACCCCACCCTCCAGGTGAGGGGGCCGCA CAGATGCCTTGATGTTCGAGACCCCATTCCTGCCTGTCCTGCCCCGGCCGCCAGCTCCCGTGTGGCCTGC ACGTTCCCCTGAGTTCCCTTTGCGGCCTTGGCAGTTTAAGAGCAGCCTCAGCTCCTGGGCTGGCCTCAGC CGCCCGCCCCGTGTTCCCTCAGGGCCAGGCTGAGCTGTGCTCTGGTGGCGGTGAGGTCTTGGAGACCATG CGGTGGGGCTCTCTGCTGGGCCGCATAGCATCCACTTGTCCCTCTGTCTCAGCCACCACCTGGTCCACAA AGTCACCACCACCCCTCTGCAGTTGACAAGCATCTTACGGGTGGCGTGGGATTCCCCTCAGAACCCCCGG CCTCTGCCTCTTGAGTGCTTCCCGTTTGCAACTTTCCATCAGCGCGGAAGCTGGCATTCTACCATAAGTG AGCGCTGGCCGTCCCCGTTCAGTGCCTTTTGCACACGTGCATTTGCGTACACGCATGTGGGTGTGTCTGT GGCATCTCGGCACCTGTGCGTGGATTCTCATCACCGTGGCTTTTGCCCTCCATTCCCATTTCAGCCATCA CCTCGGGCTTCTCTCCGGGTGTCCCCTGGCTGTCCTTCCACTGCGGCCTCCGCAGCCCATCTCCCCACCC CCTCCACAGACACGTCTGCCAGAGAGAGGGGAAGGGAGGGCAGGCGGGGCTGGAGTTATGTGGTGGAAAC CTGCTCCTGAGGAAGGGGTCCGGGTGGGGTTGGTGCTTGTGTGAAGGGCTCTGTGCCTCTTTGTACTCTC TCGGTTCATGTTCACAAATCCTGGCCTTGGTGGCATGGGAGAGGCAGCAGGAGCCTCCGCGGTGGTCCGC ATCTCTGCAGGGGGCATCTCTGAGCAGGCTGCCTGGGAGCTTGCTCTGGGTTGTGCTTTTTTTCTGGCAG ACCAGGAAACGCTTGCACTTCAGCATCTTTCTCTGTGTTCTCTTCCCCAGCGGGCGATGATGAGATCTCA TTTGACCCTGATGACATCATCACCAACATCGAGATGATTGACGACGGCTGGTGGCGCGGGGTGTGCAAGG GCCGGTACGGGCTCTTCCCAGCCAACTATGTGGAGCTGCGGCAGTAGGGCCCCCAGCCCCCCCCCGGAGC TGCGCCCTGGATCCTCACACTACAGATCAGGCCTTCTTTGGTTCTTGGGTGGTTTTGGGTTTTTTCTGTT TTTTTTTTTTTTTTTTTTTTTTTGAAGGTGGGGAGGGGAATATACACATTGCTTTTATATTTAATACTTT TGCTGATGCTTTTGAAAATGTTTATGCCACAGAATTTGCTAATATATTGTAATCACATTCCTTAGGAGGA CTTTGGTAATTGGTTTTATGCATTGATGGTTTTTTTTTTCTTTTTTGCCAAATTGACTGTCACGCGGCAG CTTCAGGGAGCTCGCATTCTCTTGTGTTCGTGTTGCCCTCGTGCCCATCAAGTGCAGTCGGGACCTCCCA GGACAAGCACGAGGCCTCAGGTCGGCCCTGTGGCGGGTAGGCAGGAAGGACTGTCCCAGACGAGGGGCTT CCTCTAGAGTCTCACTGCTGGGGAGGAGAGGACTGGGCCTGATGGAAGTTAACCCGGAGCTAAGTCACCC AGAGCACAGGAGCTGCCATGTCAGATGGGAAATCTGCCTATGTCATACCGTGACAGCCCGCAGGATCAGG TGACTTCTAGCAGAGACCCTGGTTTTTTTCCTGTGCCCACTCCGGCTTGTCCTCATCTCTACCCATCCCC TGATGCCCAGGTCACCGGGAGGGCTGCTGGGAGCCTCTCCTGTCCCCGCCGGGCAGTGTCACTGAGTCCT TGAAATCCTCCCCTGCCCCGCGGGTCTCTGGATTGGGACGCACAGTGCAGTTGAGGTCTGCGTCGGGCTT GGCTTTTCACAAAGGCTGATGTCTTAACTGTCACCCATATGGTCCCTGGGCCACCGGGCAGCCTGGGGCG GTGTGTGTGCCATGTCACAGCATGGCCTCTCGGCCTTGGGAAGGAAGGCAGTGCCTGCTCTGCTGTGAGC CGCCAGGAACCCTCCTCCTGTCAATGGGGGTGTAGTATTTTTGCCAAAATATCATGTTCAATTTCAGTAG TTTGATCAGTTGAAGGCTAGAAGTGTGAAGTGCAGATGAGTGTGTGTTCTTCCCCAAGGTCCCCCCACAG CTCCAGGACACCGCTGTCCTGGCATTTGTGGCCACTCACTTTGTAGGAAACTCATCTCCTTCCTGAGGAG CCGGGAGGCTGGACCAGTCCCGTCGTGCAGTCAGGTGGGCGGTGTGTCTTTCCAGAAGGTCACGTGGAAA TGTCTCGGGACTTGGGTCCCGGAGTGCCCGTGAAGCGTGTTTTTGCTCCTGAGGTGCATTTTCTCATCAT CCTTGCTTTACCACAATGAGCAATGAGGTCGGGTTTTATATGCAACTTATTGTATCTGAATTCCTGTAGC ACACCTCATAGGTATGATTTTTTTAAATTAAAGAATTCAGAATAAACATTTTTTGATCCACTTGCGTGA Download Select all
Length	38079
OMIM ID	164765
HGNC ID	HGNC:3338
Unigene ID	Hs.596164
Ensembl ID	ENSG00000085733
PharmGKB ID	-

mRNA Information

mRNA ID	NM_005231.3
Exon	join(1..109,6760..6856,8793..8879,9013..9086,11326..11455, 16037..16147,17158..17212,18508..18618,21241..21351, 21895..22005,22965..23075,24435..24490,26827..26896, 30546..30694,32686..32775,34596..34773,35142..35213, 36521..38079)
mRNA Sequence	>2017 GATGCGGCCCCGCCCCCGCCCTCGGAACCGGAAGTAGAGCCTGGTGCCTGGGAGCGGCTGGCGC GGCGGAATCCAGGGCCGACCCGGGCCGGACCGACCCCAGGCGGCGACGGAATCAGTCCCCAATG CCTGGAAATTCCTCATTGGATTACTGTGTTTTAAACAGAATTTCGTGAACAGCCTTTTATCTCC AAGCGGAAAGAAAGATGTGGAAAGCTTCAGCAGGCCACGCTGTGTCCATCGCCCAGGATGACGC GGGGGCCGATGACTGGGAGACCGACCCTGATTTTGTGAATGATGTGAGTGAGAAGGAGCAAAGA TGGGGTGCCAAGACGGTGCAGGGCTCCGGGCACCAGGAGCATATCAACATACACAAGCTGAGGG AGAATGTCTTTCAAGAGCATCAGACCCTTAAGGAGAAGGAACTTGAAACAGGACCAAAAGCTTC CCATGGCTATGGAGGGAAATTTGGTGTGGAACAAGACCGAATGGATAAGTCAGCTGTCGGCCAC GAATATCAGTCGAAACTTTCCAAGCACTGCTCGCAGGTGGACTCGGTCCGTGGCTTCGGAGGCA AGTTTGGTGTCCAGATGGACAGAGTTGATCAGTCTGCTGTAGGCTTTGAATACCAGGGGAAGAC TGAGAAGCATGCCTCCCAGAAAGACTACTCCAGTGGTTTTGGCGGCAAGTATGGCGTGCAGGCC GACCGAGTAGACAAGAGCGCGGTGGGCTTCGACTACCAGGGCAAGACGGAGAAGCACGAGTCAC AGAGAGATTACTCCAAAGGTTTCGGCGGCAAATACGGTATCGACAAGGACAAAGTGGATAAGAG CGCCGTTGGCTTTGAGTATCAAGGCAAAACGGAGAAGCACGAGTCCCAGAAAGACTATGTGAAA GGGTTTGGAGGAAAATTTGGTGTGCAGACAGACAGACAAGACAAATGTGCCCTTGGCTGGGATC ACCAGGAGAAATTGCAGCTGCATGAATCCCAAAAAGACTACTCCAAAGGATTCGGCGGGAAGTA TGGGGTGCAGAAGGATCGGATGGATAAGAATGCGTCAACCTTTGAGGATGTCACCCAGGTGTCC TCTGCCTACCAGAAGACAGTACCTGTCGAAGCTGTGACCAGCAAAACAAGTAACATCAGAGCTA ACTTTGAAAACCTCGCTAAGGAGAAAGAGCAGGAGGACAGGCGGAAGGCGGAGGCGGAGAGAGC CCAGCGGATGGCCAAGGAGCGGCAGGAGCAGGAAGAGGCCAGGAGGAAGCTGGAGGAGCAAGCC AGAGCCAAAACGCAAACGCCCCCTGTGTCGCCCGCACCTCAGCCAACCGAGGAGAGGCTGCCCT CGAGCCCCGTCTATGAGGATGCGGCTTCCTTCAAGGCAGAGCTGAGCTACAGAGGCCCTGTGAG TGGGACGGAGCCGGAGCCCGTGTACAGCATGGAGGCCGCTGACTACCGAGAGGCCAGCAGCCAG CAGGGCCTGGCCTATGCCACAGAGGCTGTCTATGAAAGCGCAGAGGCCCCGGGCCACTATCCCG CAGAGGACAGCACCTACGATGAGTACGAGAACGATCTGGGGATCACAGCCGTCGCCCTGTACGA CTACCAGGCTGCGGGCGATGATGAGATCTCATTTGACCCTGATGACATCATCACCAACATCGAG ATGATTGACGACGGCTGGTGGCGCGGGGTGTGCAAGGGCCGCTTCAGGGAGCTCGCATTCTCTT GTGTTCGTGTTGCCCTCGTGCCCATCAAGTGCAGTCGGGACCTCCCAGGACAAGCACGAGGCCT CAGGTCGGCCCTGTGGCGGGTAGGCAGGAAGGACTGTCCCAGACGAGGGGCTTCCTCTAGAGTC TCACTGCTGGGGAGGAGAGGACTGGGCCTGATGGAAGTTAACCCGGAGCTAAGTCACCCAGAGC ACAGGAGCTGCCATGTCAGATGGGAAATCTGCCTATGTCATACCGTGACAGCCCGCAGGATCAG GAAACTCATCTCCTTCCTGAGGAGCCGGGAGGCTGGACCAGTCCCGTCGTGCAGTCAGGTGGGC GGTGTGTCTTTCCAGAAGGTCACGTGGAAATGTCTCGGGACTTGGGTCCCGGAGTGCCCGTGAA GCGTGTTTTTGCTCCTGAGGTGCATTTTCTCATCATCCTTGCTTTACCACAATGAGCAATGAGG TCGGGTTTTATATGCAACTTATTGTATCTGAATTCCTGTAGCACACCTCATAGGTATGATTTTT TTAAATTAAAGAATTCAGAATAAACATTTTTTGATCCACTTGCGTGAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAA Download Select all
Length	2325

CDS Information

Location	join(8793..8879,9013..9086,11326..11455,16037..16147, 17158..17212,18508..18618,21241..21351,21895..22005, 24435..24490,26827..26896,30546..30694,32686..32775, 34596..34773,35142..35213,36521..36614,36961..37239, 37777..37903)
CDS Sequence	>lcl\|NM_001184740.1_cds_NP_001171669.1_1 [gene=CTTN] [protein=src substrate cortactin isoform c] [protein_id=NP_001171669.1] [location=207..2111] ATGTGGAAAGCTTCAGCAGGCCACGCTGTGTCCATCGCCCAGGATGACGCGGGGGCCGATGACTGGGAGA CCGACCCTGATTTTGTGAATGATGTGAGTGAGAAGGAGCAAAGATGGGGTGCCAAGACGGTGCAGGGCTC CGGGCACCAGGAGCATATCAACATACACAAGCTGAGGGAGAATGTCTTTCAAGAGCATCAGACCCTTAAG GAGAAGGAACTTGAAACAGGACCAAAAGCTTCCCATGGCTATGGAGGGAAATTTGGTGTGGAACAAGACC GAATGGATAAGTCAGCTGTCGGCCACGAATATCAGTCGAAACTTTCCAAGCACTGCTCGCAGGTGGACTC GGTCCGTGGCTTCGGAGGCAAGTTTGGTGTCCAGATGGACAGAGTTGATCAGTCTGCTGTAGGCTTTGAA TACCAGGGGAAGACTGAGAAGCATGCCTCCCAGAAAGACTACTCCAGTGGTTTTGGCGGCAAGTATGGCG TGCAGGCCGACCGAGTAGACAAGAGCGCGGTGGGCTTCGACTACCAGGGCAAGACGGAGAAGCACGAGTC ACAGAGAGATTACTCCAAAGGTTTCGGCGGCAAATACGGTATCGACAAGGACAAAGTGGATAAGAGCGCC GTTGGCTTTGAGTATCAAGGCAAAACGGAGAAGCACGAGTCCCAGAAAGACTATGTGAAAGGGTTTGGAG GAAAATTTGGTGTGCAGACAGACAGACAAGACAAATGTGCCCTTGGCTGGGATCACCAGGAGAAATTGCA GCTGCATGAATCCCAAAAAGACTACTCCAAAGGATTCGGCGGGAAGTATGGGGTGCAGAAGGATCGGATG GATAAGAATGCGTCAACCTTTGAGGATGTCACCCAGGTGTCCTCTGCCTACCAGAAGACAGTACCTGTCG AAGCTGTGACCAGCAAAACAAGTAACATCAGAGCTAACTTTGAAAACCTCGCTAAGGAGAAAGAGCAGGA GGACAGGCGGAAGGCGGAGGCGGAGAGAGCCCAGCGGATGGCCAAGGAGCGGCAGGAGCAGGAAGAGGCC AGGAGGAAGCTGGAGGAGCAAGCCAGAGCCAAAACGCAAACGCCCCCTGTGTCGCCCGCACCTCAGCCAA CCGAGGAGAGGCTGCCCTCGAGCCCCGTCTATGAGGATGCGGCTTCCTTCAAGGCAGAGCTGAGCTACAG AGGCCCTGTGAGTGGGACGGAGCCGGAGCCCGTGTACAGCATGGAGGCCGCTGACTACCGAGAGGCCAGC AGCCAGCAGGGCCTGGCCTATGCCACAGAGGCTGTCTATGAAAGCGCAGAGGCCCCGGGCCACTATCCCG CAGAGGACAGCACCTACGATGAGTACGAGAACGATCTGGGGATCACAGCCGTCGCCCTGTACGACTACCA GGCTGCGGGCGATGATGAGATCTCATTTGACCCTGATGACATCATCACCAACATCGAGATGATTGACGAC GGCTGGTGGCGCGGGGTGTGCAAGGGCCGCTTCAGGGAGCTCGCATTCTCTTGTGTTCGTGTTGCCCTCG TGCCCATCAAGTGCAGTCGGGACCTCCCAGGACAAGCACGAGGCCTCAGGTCGGCCCTGTGGCGGGTAGG CAGGAAGGACTGTCCCAGACGAGGGGCTTCCTCTAGAGTCTCACTGCTGGGGAGGAGAGGACTGGGCCTG ATGGAAGTTAACCCGGAGCTAAGTCACCCAGAGCACAGGAGCTGCCATGTCAGATGGGAAATCTGCCTAT GTCATACCGTGACAGCCCGCAGGATCAGGAAACTCATCTCCTTCCTGAGGAGCCGGGAGGCTGGACCAGT CCCGTCGTGCAGTCAGGTGGGCGGTGTGTCTTTCCAGAAGGTCACGTGGAAATGTCTCGGGACTTGGGTC CCGGAGTGCCCGTGA Download Select all
CCDS ID	CCDS53676.1

Protein Information

Protein ID	NP_001171669.1
Protein Name	cortactin
Molecular Wt. (Da)	70828
Protein Sequence	>2017 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRENVFQ EHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRGFGGKFGVQ MDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQGKTEKHESQRDYS KGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEKL QLHESQKDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENL AKEKEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPVY EDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYPAEDST YDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRFRELAFSCVRVA LVPIKCSRDLPGQARGLRSALWRVGRKDCPRRGASSRVSLLGRRGLGLMEVNPELSHPEHRSCH VRWEICLCHTVTARRIRKLISFLRSREAGPVPSCSQVGGVSFQKVTWKCLGTWVPECP Download Select all
Length	634
Uniprot ID	P30711
Ensembl Protein ID	ENSP00000481741

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
T	Phosphorylation	401
T	Phosphorylation	364
Y	Phosphorylation	421
Y	Phosphorylation	384
Y	Phosphorylation	421
Y	Phosphorylation	470
Y	Phosphorylation	486
Y	Phosphorylation	384
Y	Phosphorylation	433
Y	Phosphorylation	449
S	Phosphorylation	405
S	Phosphorylation	368
S	Phosphorylation	418
S	Phosphorylation	381
Y	Phosphorylation	446
Y	Phosphorylation	409
Y	Phosphorylation	334
Y	Phosphorylation	297
Y	Phosphorylation	453
Y	Phosphorylation	416
T	Phosphorylation	24
S	Phosphorylation	135
S	Phosphorylation	150
S	Phosphorylation	172
T	Phosphorylation	182
S	Phosphorylation	209
S	Phosphorylation	345
S	Phosphorylation	348
S	Phosphorylation	11
S	Phosphorylation	282
T	Phosphorylation	24
S	Phosphorylation	135
S	Phosphorylation	150
S	Phosphorylation	172
T	Phosphorylation	182
S	Phosphorylation	308
S	Phosphorylation	311
S	Phosphorylation	11
S	Phosphorylation	209
S	Phosphorylation	418;-
S	Phosphorylation	381;-
T	Phosphorylation	399;-
T	Phosphorylation	362;-
S	Phosphorylation	405;-
S	Phosphorylation	368;-
T	Phosphorylation	401;-
T	Phosphorylation	364;-
Y	Phosphorylation	141;-
Y	Phosphorylation	141;-
S	Phosphorylation	417;-
S	Phosphorylation	380;-
S	Phosphorylation	426;-
S	Phosphorylation	389;-
T	Phosphorylation	411;-
T	Phosphorylation	374;-
S	Phosphorylation	113
S	Phosphorylation	113
S	Phosphorylation	117
S	Phosphorylation	117
K	Acetylation	235
K	Acetylation	235
K	Acetylation	198
K	Acetylation	198
K	Acetylation	309
K	Acetylation	272
K	Acetylation	87
K	Acetylation	87
K	Acetylation	272
K	Acetylation	304
Y	Phosphorylation	433
Y	Phosphorylation	396
S	Phosphorylation	261
S	Phosphorylation	261
Y	Phosphorylation	289

Enzyme Information

No matching records could be found.

PPi Information

No STRING Network could be found.

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
58	ACTA1	30	NP_001091.1	in vivo	768 065 411 018 051
2885	GRB2	150	NP_002077.1	in vitro	11439336
9026	HIP1R	10412	NP_003950.1	in vitro;in vivo	17318189
55139	ANKZF1	7673	NP_060559.2	yeast 2-hybrid	16169070

Pathway Information

Pathway Name	Pathway ID
Bacterial invasion of epithelial cells	hsa05100
Pathogenic Escherichia coli infection	hsa05130
Proteoglycans in cancer	hsa05205
Shigellosis	hsa05131
Tight junction	hsa04530

Structure Information

PDB ID	1X69
Resolution
Method	SOLUTION NMR
Chains	A
Molecule	cortactin isoform a
Model	View

Domain Information

ID	Location	Description
cd11959	496-548	SH3_Cortactin
cl17036	496-548	SH3 superfamily
cd11960	496-548	SH3_Abp1_eu
cd11819	496-548	SH3_Cortactin_like
cd12073	495-548	SH3_HS1
smart00326	496-547	SH3
cd11961	496-548	SH3_Abp1_fungi_C2
cd00174	496-545	SH3
pfam14604	499-547	SH3_9
cd11789	498-548	SH3_Nebulin_family_C
pfam02218	157-193	HS1_rep
cl03489	157-193	HS1_rep superfamily
cd11823	498-547	SH3_Nostrin
cd11962	497-548	SH3_Abp1_fungi_C1
cd11826	498-547	SH3_Abi
cd11772	499-547	SH3_OSTF1
pfam02218	120-156	HS1_rep
cl03489	120-156	HS1_rep superfamily
cd11825	496-547	SH3_PLCgamma
pfam02218	194-230	HS1_rep
cl03489	194-230	HS1_rep superfamily
pfam00018	498-543	SH3_1
pfam02218	268-304	HS1_rep
cl03489	268-304	HS1_rep superfamily
cd11877	499-548	SH3_PIX
cd11840	498-548	SH3_Intersectin_5
pfam02218	231-265	HS1_rep
cl03489	231-265	HS1_rep superfamily
cd11766	496-547	SH3_Nck_2
cd11882	496-548	SH3_GRAF-like
pfam02218	83-119	HS1_rep
cl03489	83-119	HS1_rep superfamily
cd11827	499-547	SH3_MyoIe_If_like
cd11933	494-547	SH3_Nebulin_C
cd11873	496-547	SH3_CD2AP-like_1
cd11805	499-547	SH3_GRB2_like_C
cd11950	497-547	SH3_GRAP2_C
cd11935	499-548	SH3_Nebulette_C
cd11843	499-547	SH3_PACSIN
cd11934	499-547	SH3_Lasp1_C
cd11803	497-548	SH3_Endophilin_A
cd12052	497-546	SH3_CIN85_1
cd11970	499-547	SH3_PLCgamma1
cd11971	498-547	SH3_Abi1
cd11836	499-547	SH3_Intersectin_1
cd11824	497-548	SH3_PSTPIP1
cd12142	500-548	SH3_D21-like
cd11820	499-546	SH3_STAM
cd11875	496-548	SH3_CD2AP-like_3
cd11815	497-547	SH3_Eve1_2
cd12058	499-546	SH3_MLK4
pfam07653	497-547	SH3_2
cd11996	498-548	SH3_Intersectin2_5
cd11778	499-545	SH3_Bzz1_2
cd11874	499-548	SH3_CD2AP-like_2
cd11780	499-547	SH3_Sorbs_3
cd11833	496-546	SH3_Stac_1
cd11964	499-546	SH3_STAM1
cd11796	497-546	SH3_DNMBP_N3
cd11842	496-548	SH3_Ysc84p_like
cd11818	497-545	SH3_Eve1_5
cd11828	496-548	SH3_ARHGEF9_like
cd11949	496-547	SH3_GRB2_C
cd11812	496-546	SH3_AHI-1
cd11995	498-548	SH3_Intersectin1_5
cd11781	496-548	SH3_Sorbs_1
cd12057	500-548	SH3_CIN85_3
cd11762	499-547	SH3_FCHSD_2
cd11816	497-546	SH3_Eve1_3
cd11817	497-545	SH3_Eve1_4
cd11972	498-547	SH3_Abi2
cd12054	500-547	SH3_CD2AP_2
cd11763	499-547	SH3_SNX9_like
cd11841	496-546	SH3_SH3YL1_like
cd11786	497-547	SH3_SH3RF_1
cd11963	499-546	SH3_STAM2
cd11838	498-548	SH3_Intersectin_3
cd12046	498-547	SH3_p67phox_C
cd11837	496-548	SH3_Intersectin_2
cd12059	499-546	SH3_MLK1-3
cd11876	498-546	SH3_MLK
cd12061	499-546	SH3_betaPIX
cd11830	496-547	SH3_VAV_2
cd11948	497-548	SH3_GRAP_N
cd11951	499-546	SH3_GRAP_C
cd11969	496-547	SH3_PLCgamma2
cd11902	495-546	SH3_Nck2_2
cd11771	499-548	SH3_Pex13p_fungal
cd11804	497-546	SH3_GRB2_like_N
cd11916	499-548	SH3_Sorbs1_3
cd11901	495-546	SH3_Nck1_2
cd11839	497-548	SH3_Intersectin_4
cd11809	497-548	SH3_srGAP
cd11821	499-545	SH3_ASAP
cd11999	494-547	SH3_PACSIN_like
cd11773	499-545	SH3_Sla1p_1
cd11856	498-547	SH3_p47phox_like
cd12000	497-548	SH3_CASS4
cd12055	499-547	SH3_CIN85_2
cd11782	497-547	SH3_Sorbs_2
cd12060	499-547	SH3_alphaPIX
cd11978	497-547	SH3_VAV3_2
cd11870	498-547	SH3_p67phox-like_C
cd11813	497-548	SH3_SGSM3
cd11998	499-547	SH3_PACSIN1-2
cd11787	496-545	SH3_SH3RF_2
cd11895	497-547	SH3_FCHSD1_2
cd11912	496-548	SH3_Bzz1_1
cd11769	494-547	SH3_CSK
cd11997	494-547	SH3_PACSIN3
cd11920	497-547	SH3_Sorbs2_1
cd11985	496-547	SH3_Stac2_C
cd11976	496-547	SH3_VAV1_2
cd11844	497-548	SH3_CAS
cd11845	498-545	SH3_Src_like
cd11989	497-548	SH3_Intersectin1_2
cd11894	499-547	SH3_FCHSD2_2
cd11767	497-548	SH3_Nck_3
cd11986	498-546	SH3_Stac3_1
cd11946	497-549	SH3_GRB2_N
cd11987	499-547	SH3_Intersectin1_1
cd11790	499-547	SH3_Amphiphysin
cd11849	499-547	SH3_SPIN90
cd11855	496-548	SH3_Sho1p
cd12051	497-549	SH3_DOCK1_5_A
cd12053	501-547	SH3_CD2AP_1
cd12056	499-546	SH3_CD2AP_3
cd11990	497-548	SH3_Intersectin2_2
cd12013	498-547	SH3_RIM-BP_3
cd12001	493-548	SH3_BCAR1
cd12003	497-550	SH3_EFS
cd11918	499-546	SH3_Vinexin_3
cd11897	497-548	SH3_SNX18
cd11783	498-548	SH3_SH3RF_3
cd11956	495-548	SH3_srGAP4
cd11797	497-542	SH3_DNMBP_N4
cd12012	498-547	SH3_RIM-BP_2
cd11784	498-546	SH3_SH3RF2_3
cd11829	499-546	SH3_GAS7
cd12007	498-546	SH3_Yes
cd11991	498-548	SH3_Intersectin1_3
cd11927	497-548	SH3_SH3RF1_1
cd11988	499-547	SH3_Intersectin2_1
cd12066	497-547	SH3_GRAF3
cd11977	496-547	SH3_VAV2_2
cd11928	499-548	SH3_SH3RF3_1
cd12047	498-546	SH3_Noxa1_C
cd11761	495-548	SH3_FCHSD_1
cd11774	496-546	SH3_Sla1p_2
cd11887	496-547	SH3_Bbc1
cd11929	497-548	SH3_SH3RF2_1
cd11917	499-547	SH3_Sorbs2_3
cd11919	497-548	SH3_Sorbs1_1
cd11872	497-549	SH3_DOCK_AB
cd11974	495-548	SH3_ASEF2
cd12002	497-548	SH3_NEDD9
cd12065	497-548	SH3_GRAF2
cd11775	496-548	SH3_Sla1p_3
cd11884	497-547	SH3_MYO15
cd11992	498-546	SH3_Intersectin2_3
cd11758	499-547	SH3_CRK_N
cd11851	498-547	SH3_RIM-BP
cd11886	498-545	SH3_BOI
cd11806	498-546	SH3_PRMT2
cd11864	496-548	SH3_PEX13_eumet
cd12016	498-547	SH3_Tks_2
cd11835	497-546	SH3_ARHGAP32_33
cd11921	501-548	SH3_Vinexin_1
cd11896	497-548	SH3_SNX33
cd11973	495-549	SH3_ASEF
cd11904	499-546	SH3_Nck1_3
cd11791	499-547	SH3_UBASH3
cd11883	496-545	SH3_Sdc25
cd12006	498-546	SH3_Fyn_Yrk
cd11808	498-547	SH3_Alpha_Spectrin
cd11924	497-548	SH3_Vinexin_2
cd11911	496-548	SH3_CIP4-like
cd11930	499-546	SH3_SH3RF1_2
cd12064	497-548	SH3_GRAF
cd11869	497-548	SH3_p40phox
cd11982	496-546	SH3_Shank1
cd11793	497-547	SH3_ephexin1_like
cd11947	497-548	SH3_GRAP2_N
cd11923	497-548	SH3_Sorbs2_2
cd11952	499-548	SH3_iASPP
cd11858	496-548	SH3_Myosin-I_fungi
cd11926	498-546	SH3_SH3RF1_3
cd11801	496-546	SH3_JIP1_like
cd11954	497-548	SH3_ASPP1
cd11768	498-547	SH3_Tec_like
cd11965	500-548	SH3_ASAP1
cd11922	497-548	SH3_Sorbs1_2
cd11906	496-546	SH3_BTK
cd11832	498-543	SH3_Shank
cd11925	498-546	SH3_SH3RF3_3
cd11770	498-548	SH3_Nephrocystin
cd11945	497-548	SH3_Endophilin_B1
cd11953	499-548	SH3_ASPP2
cd11955	497-546	SH3_srGAP1-3
pfam02218	305-325	HS1_rep
cl03489	305-325	HS1_rep superfamily
cd11931	499-546	SH3_SH3RF3_2
cd11975	495-548	SH3_ARHGEF9
cd11993	497-548	SH3_Intersectin1_4
cd11944	497-548	SH3_Endophilin_B2
cd12021	499-547	SH3_p47phox_1
cd12076	498-547	SH3_Tks4_2
cd11984	496-546	SH3_Shank3
cd11807	499-548	SH3_ASPP
cd12068	498-548	SH3_MYO15B
cd11810	499-545	SH3_RUSC1_like
cd12022	498-547	SH3_p47phox_2
pfam07946	345-398	DUF1682
cl20352	345-398	DUF1682 superfamily
cd11759	501-548	SH3_CRK_C
cd12141	499-546	SH3_DNMBP_C2
cd12008	496-546	SH3_Src
PRK10811	347-482	rne
PRK05035	348-468	PRK05035
COG5373	370-484	COG5373
TIGR02468	356-389	sucrsPsyn_pln
pfam14303	345-394	NAM-associated

Ontology Information

HPRD ID	3450
Molecular Class	Cytoskeletal associated protein
Molecular Function	Transcription factor activity (GO:0003700)
Biological Process	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO