Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19384295 | 2009 | Cell line : - Source : Hospital Universitari de Bellvitge Sample Type : CRC tumor and Normal tissue No. of Sample : - Stage : - | Bisulfite sequencing, Real-time RT- PCR, Methylation specific PCR | Methylation | - | Epigenetic suppression along 2q14.2 is common to most colorectal cancers and the presence of a methylated EN1 CpG island in stool DNA might be used as biomarker of neoplastic disease. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / ANTP class : NKL subclass |
| Description | Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. |
| Chromosome | 2 |
| Location | 2q14.2 |
| Start | 118842171 |
| End | 118848183 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6013 |
| OMIM ID | 131290 |
| HGNC ID | HGNC:3342 |
| Unigene ID | Hs.271977 |
| Ensembl ID | ENSG00000163064 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001426.3 |
|---|---|
| Exon | join(1..1878,4930..6013) | mRNA Sequence | Download Select all |
| Length | 2962 |
CDS Information
| Location | join(1017..1878,4930..5246) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS2123.1 |
Protein Information
| Protein ID | NP_001417.3 |
|---|---|
| Protein Name | engrailed homeobox 1 |
| Molecular Wt. (Da) | 39984 |
| Protein Sequence | Download Select all |
| Length | 392 |
| Uniprot ID | P0CG29 |
| Ensembl Protein ID | ENSP00000215780 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3725 | JUN | 1302 | NP_002219.1 | in vitro;yeast 2-hybrid | 11551904 |
| 5080 | PAX6 | 6167 | NP_001595.2 | in vitro | 11069920 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | 305-360 | homeodomain |
| cl00084 | 305-360 | homeodomain superfamily |
| pfam00046 | 305-360 | Homeobox |
| smart00389 | 305-359 | HOX |
| pfam10525 | 361-392 | Engrail_1_C_sig |
| cl11160 | 361-392 | Engrail_1_C_sig superfamily |
| COG5576 | 305-362 | COG5576 |
Ontology Information
| HPRD ID | 3456 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.