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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18705403 | 2008 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 103?colorectal and 60 gastric carcinoma tissues Stage : - | Immunohistochemistry | Up-regulation | - | Increased expression of EndoG in colorectal and gastric cancer cells compared to their normal mucosal epithelial counterparts suggests that neo-expression of EndoG may play a role in both colorectal and gastric tumorigenesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008] |
| Chromosome | 9 |
| Location | 9q34.1 |
| Start | 131580779 |
| End | 131584955 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 4177 |
| OMIM ID | 600440 |
| HGNC ID | HGNC:3346 |
| Unigene ID | Hs.745161 |
| Ensembl ID | ENSG00000167136 |
| PharmGKB ID | PA27783 |
mRNA Information
| mRNA ID | XM_011518347.1 |
|---|---|
| Exon | join(1..775,2329..2438,3278..3404,3918..4268) | mRNA Sequence | Download Select all |
| Length | 1363 |
Protein Information
| Protein ID | XP_011516649.1 |
|---|---|
| Protein Name | endonuclease G |
| Molecular Wt. (Da) | 37139 |
| Protein Sequence | Download Select all |
| Length | 338 |
| Uniprot ID | Q13131 |
| Ensembl Protein ID | ENSP00000346148 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Apoptosis | hsa04210 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00091 | 65-282 | NUC |
| cl00089 | 65-282 | NUC superfamily |
| smart00477 | 78-284 | NUC |
| smart00892 | 78-282 | Endonuclease_NS |
| pfam01223 | 78-284 | Endonuclease_NS |
| PTZ00259 | 63-282 | PTZ00259 |
| COG1864 | 65-281 | NUC1 |
Ontology Information
| HPRD ID | 1498 |
|---|---|
| Molecular Class | Deoxyribonuclease |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.