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General Information
- Evidence
- Gene
- mRNA
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- Enzyme
- PPi
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19846965 | 2009 | Cell line : - Source : - Sample Type : CRC tumor and adjacent normal tissues No. of Sample : 96 Stage : - | Immunohistochemistry | Up-regulation | - | The relationship of Bak with EPO and EPOR is evidence of their co-expression suggesting competition between EPO mediated cell survival and Bak associated apoptosis in colorectal carcinomas. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008] |
| Chromosome | 7 |
| Location | 7q21 |
| Start | 100318423 |
| End | 100321323 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 2901 |
| OMIM ID | 133170 |
| HGNC ID | HGNC:3415 |
| Unigene ID | Hs.2303 |
| Ensembl ID | ENSG00000130427 |
| PharmGKB ID | PA27833 |
mRNA Information
| mRNA ID | NM_000799.2 |
|---|---|
| Exon | join(1..194,759..904,1163..1249,1865..2044,2179..2901) | mRNA Sequence | Download Select all |
| Length | 1340 |
Protein Information
| Protein ID | NP_000790.2 |
|---|---|
| Protein Name | erythropoietin |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 193 |
| Uniprot ID | Q02750 |
| Ensembl Protein ID | ENSP00000302486 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 110 |
| S | Glycosylation | 153 |
| C | Disulfide Bridge | 34;188 |
| N | Glycosylation | 51 |
| C | Disulfide Bridge | 56;60 |
| N | Glycosylation | 65 |
| S | Phosphorylation | 111 |
| S | Phosphorylation | 127 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytokine-cytokine receptor interaction | hsa04060 |
| Hematopoietic cell lineage | hsa04640 |
| HIF-1 signaling pathway | hsa04066 |
| Jak-STAT signaling pathway | hsa04630 |
| PI3K-Akt signaling pathway | hsa04151 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 3951 |
|---|---|
| Molecular Class | Cytokine |
| Molecular Function | Protein kinase activity (GO:0004672) |
| Biological Process | Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.