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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
EPS8 2059 Epidermal growth factor receptor pathway substrate 8  12- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22876043   2012Cell line : -

Source : -

Sample Type : CRC tumor and Normal tissue

No. of Sample : 58 colorectal tumors (19 adenomas and 39 carcinomas) and 8 colon cancer cell lines

Stage : TNM Stage I-IV

Microarray analysis,loss of heterozygosity (LOH) analysis, immunohistochemistry, mutation analysis.Down-regulation--

19648079   2009Cell line : SW 480, SW 620, LS 174T, WiDr, HCT 116

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Clontech AB500 arrays and Tissue microarray.Unknown-Twelve potential markers were immunohistochemically validated on morphological level by using tissue microarrays (CYCA1, HSP60, TOP1, APC, CBP, ERK, EGFR, C-myc, Cald, DARPP32, MRE11A, AR, EPS8).

17496330   2007Cell line : -

Source : Department of Pathology of Wrocaw Medical University.

Sample Type : -

No. of Sample : -

Stage : -

-Up-regulation-Within 62% of colorectal tumor specimens examined, >2-fold enhancement of Eps8 as compared with their normal counterparts is observed, especially for those from the advanced stage.

Eps8 is one of the significant players in the progression of colon cancer. Notably, Eps8 could modulate the expression of FAK via mTOR/STAT3, which confer the ability of cells to proliferate and migrate.

22968445   2012Cell line : -

Source : -

Sample Type : CRC tumor and Normal tissue

No. of Sample : 10 duke B and 6 Duke D stage sample

Stage : Dukestage B,D

Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation.Up-regulation5.3-


Gene Details



Chromosome: 12; NC_000012.11 (15773075..15942510, complement)

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Gene Type protein coding
Gene Family -
Description This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]  
Chromosome 12
Location 12p12.3
Start 15620141  
End 15789576  
Strand -  
Gene Sequence

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Length 169436  
OMIM ID 600206   
HGNC ID HGNC:3420   
Unigene ID Hs.591160    
Ensembl ID ENSG00000151491   
PharmGKB ID -   

mRNA Information


mRNA ID NM_004447.5
Exon join(1..416,106605..106684,108275..108351,118654..118721, 119752..119913,120041..120190,123055..123137, 123685..123821,127478..127551,128837..128963, 130992..131080,131424..131498,135284..135432, 138571..138754,142317..142450,147747..147855, 148731..148874,157913..158135,165170..165350, 166290..166419,168147..169436)  
mRNA Sequence

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Length 4088  



CDS Information


   
Location join(56814..56825,106605..106684,108275..108351, 118654..118721,119752..119913,120041..120190, 123055..123137,123685..123821,127478..127551, 128837..128963,130992..131080,131424..131498, 135284..135432,138571..138754,142317..142450, 147747..147855,148731..148874,157913..158135, 165170..165350,166290..166419,168147..168260)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_004438.3
Protein NameEpidermal growth factor receptor pathway substrate 8
Molecular Wt. (Da)91751
Protein Sequence

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Length 822  
Uniprot IDP11274
Ensembl Protein ID ENSP00000303507  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation525;-
YPhosphorylation774;-
SPhosphorylation811;-
SPhosphorylation815;-
SPhosphorylation664;-
SPhosphorylation662;-
SPhosphorylation476
SPhosphorylation659
SPhosphorylation661
TPhosphorylation317
YPhosphorylation484

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                  
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
58ACTA130NP_001091.1in vivo1   152   443   612   127   560   
1956EGFR579NP_005219.2in vivo753   229   312   127   568   
3688ITGB1628NP_391987.1in vitro12606711   
3690ITGB31428NP_000203.2in vitro12606711   
3693ITGB5949NP_002204.2in vitro12606711   
5108PCM12624AAA60120.1yeast 2-hybrid16189514   
6714SRC1819NP_005408.1in vitro;in vivo10395945   
7802DNALI13681NP_003453.2yeast 2-hybrid16169070   
7965AIMP22915NP_006294.2yeast 2-hybrid16189514   
11007CCDC85B16101NP_006839.2yeast 2-hybrid16189514   
26258PLDN16055NP_036520.1yeast 2-hybrid16189514   
29911HOOK29698NP_037444.2yeast 2-hybrid16189514   
51168MYO15A4049NP_057323.3yeast 2-hybrid16169070   
55052MRPL2014746NP_060441.2yeast 2-hybrid16169070   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0121064-191  PTB_EPS8
cl1717164-191  PH-like superfamily
cd09540720-784  SAM_EPS8-like
cl15755720-784  SAM_superfamily superfamily
cd11764535-588  SH3_Eps8
cl17036535-588  SH3 superfamily
pfam0841664-194  PTB
smart0046264-196  PTB
cd11765535-583  SH3_Nck_1
cd0093465-183  PTB
smart00326532-585  SH3
cd00174535-583  SH3
cd11900538-586  SH3_Nck1_1
cd11899538-586  SH3_Nck2_1
cd11768538-583  SH3_Tec_like
cd11775534-587  SH3_Sla1p_3
cd11767540-583  SH3_Nck_3
cd11845540-583  SH3_Src_like
cd11771535-587  SH3_Pex13p_fungal
pfam00018537-581  SH3_1
cd11761540-587  SH3_FCHSD_1
cd11763535-581  SH3_SNX9_like
cd11855540-585  SH3_Sho1p
cd11758535-581  SH3_CRK_N
cd11769539-583  SH3_CSK
cd11976536-586  SH3_VAV1_2
pfam14604539-586  SH3_9
cd11824540-585  SH3_PSTPIP1
cd1315964-168  PTB_LDLRAP-mammal-like
cd11947536-587  SH3_GRAP2_N
cd11770540-585  SH3_Nephrocystin
cd11912536-587  SH3_Bzz1_1
cd11830536-586  SH3_VAV_2
cd11904540-587  SH3_Nck1_3
cd11946536-587  SH3_GRB2_N
cd11858536-585  SH3_Myosin-I_fungi
cd11804536-583  SH3_GRB2_like_N
pfam07653535-585  SH3_2
cd11951535-583  SH3_GRAP_C
cd12009540-583  SH3_Blk
cd11852541-587  SH3_Kalirin_1
cd11773536-583  SH3_Sla1p_1
cd11903537-588  SH3_Nck2_3
cd11840540-583  SH3_Intersectin_5
cd11819536-583  SH3_Cortactin_like
cd12007540-583  SH3_Yes
cd11808535-585  SH3_Alpha_Spectrin
cd11847540-585  SH3_Brk
cd11864536-583  SH3_PEX13_eumet
pfam00640103-183  PID
cd11837540-583  SH3_Intersectin_2
cd11907537-583  SH3_TXK
cd11800540-586  SH3_DNMBP_C2_like
cd11849537-585  SH3_SPIN90
cd12006540-585  SH3_Fyn_Yrk
cd11911540-581  SH3_CIP4-like
cd11908540-585  SH3_ITK
cd11964540-585  SH3_STAM1
cd11812538-583  SH3_AHI-1
cd11906540-583  SH3_BTK
cd12072535-587  SH3_FNBP1L
cd11820537-583  SH3_STAM
cd11960536-583  SH3_Abp1_eu
cd11827536-583  SH3_MyoIe_If_like
cd12141540-585  SH3_DNMBP_C2
cd11772540-583  SH3_OSTF1
cd11805535-575  SH3_GRB2_like_C
cd11856540-586  SH3_p47phox_like
cd11898536-588  SH3_SNX9
cd12001536-588  SH3_BCAR1
cd11949535-583  SH3_GRB2_C
cd11877536-583  SH3_PIX
cd11846540-583  SH3_Srms


Ontology Information


   
HPRD ID1044
Molecular ClassAdapter molecule
Molecular FunctionProtein serine/threonine kinase activity (GO:0004674)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO