CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
ERBB3	2065	V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	12	HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
21900593	2011	Cell line : - Source : Istituto Clinico Humanitas (Rozzano, Italy), University Hospital of Heraklion (Heraklion, Greece), the Dana Farber Cancer Institute/Brigham and Women?�????s Hospital (Boston, MA), Kinki University Hospital (Osaka, Japan), Osaka City General Hospital (Osaka, Japan), Kinki University Sakai Hospital (Osaka, Japan), and the Kinki University Nara Hospital (Nara, Japan). Sample Type : Plasma and tumor specimens from colorectal cancer patients No. of Sample : - Stage : -	Western blotting, SNP analysis, site directied mutagenesis, FISH and Phospho RTK array	Amplification	-	Inhibition of ERBB2 or disruption of ERBB2/ERBB3 heterodimerization restores cetuximab sensitivity in vitro and in vivo. Agents that target ERBB2 signaling, including lapatinib and trastuzumab, are approved.
22895193	2012	Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 70 Stage : TNM Stage I-IV	Exome sequencing, RNAseq and SNP array analysis	Mutation	-	-
19561085	2009	Cell line : A549,HEK293 Source : - Sample Type : - No. of Sample : - Stage : -	RT-PCR, Western blotting, DNA synthesis assay, Tunnel assay and Anoikis assay.	Mutation	-	The enhanced ErbB3/ErbB2 signaling causes tumorigenesis, invasion, and metastasis. ErbB3/ErbB2 signaling is regulated by immunoglobulin-like Necl-2, which is down-regulated in various cancer cells and serves as a tumor suppressor. The extracellular region of ErbB3 interacted in cis with that of Necl-2 and reduced the ligand-induced, ErbB2-catalyzed tyrosine phosphorylation of ErbB3 and inhibited the consequent ErbB3-mediated activation of Rac and Akt, resulting in the inhibition of cancer cell movement and survival.
19876926	2010	Cell line : HT 29, DLD 1 and Caco 2 Source : - Sample Type : - No. of Sample : - Stage : -	Cell proliferation assay (XTT assay and trypan blue exclusion assay), Soft agar colony forming assay	Up-regulation	-	Bacillus polyfermenticus (B.P.), a probiotic bacterium inhibits tumor growth and its anticancer activity occurs, at least in part, through suppressing ErbB2 and ErbB3.
9712416	1998	Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 35 Stage : TNM Stage I-IV	Immunostaining, Northern blotting	Up-regulation	-	Increased expression of erbB3 in colorectal cancer is associated with concomitant increase in the level of erbB2. Immunostaining and Northern blotting indcates overexpression of ERBB3 gene.
19443355	2009	Cell line : - Source : Department of Clinical Pathology, University Hospital, Ume, Sweden. Sample Type : CRC tumor and Normal tissue No. of Sample : 64 Stage : TNM Stage I-IV	Immunohistochemistry	Up-regulation	-	Patient record database at the Department of Clinical Pathology, University Hospital, Ume, Sweden.
19690388	2009	Cell line : - Source : Sample Type : - No. of Sample : - Stage : -	BrdU and TUNEL staining, Histology and immunohistochemistry, Western blotting	Up-regulation	-	ERBB3 pseudo-kinase has essential roles in supporting intestinal tumorigenesis and suggest that ERBB3 may be a promising target for the treatment of colorectal cancers. ERBB3 signaling contributes to tumor growth by activating the PI3K/AKT/FRAP1/RPS6 pathway, resulting in prevention of CASP3-mediated apoptosis. Cre transgenic mice, B6;D2-Tg(Vil-Cre)20Syr (Mouse Models of Human Cancers Consortium, strain number 01XE7) and Tg(Sox2-Cre)1Amc/J, were obtained from NCI-Frederick and The Jackson Laboratory, respectively.
22810696	2012	Cell line : - Source : Biospecimen Core Resources Sample Type : - No. of Sample : - Stage : -	Whole-genome sequencing, Affymetrix SNP6.0 arrays.	Up-regulation	-	Recurrent alteration of copy number.

Gene Details

Chromosome: 12; NC_000012.11 (56473809..56497291)
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Gene Type	protein coding
Gene Family	-
Description	This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Chromosome	12
Location	12q13
Start	56080025
End	56103507
Strand	+
Gene Sequence	>gi\|568815586:56080025-56103507 Homo sapiens chromosome 12, GRCh38.p2 Primary Assembly ACTCCAGCCTCGCGCGGGAGGGGGCGCGGCCGTGACTCACCCCCTTCCCTCTGCGTTCCTCCCTCCCTCT CTCTCTCTCTCTCACACACACACACCCCTCCCCTGCCATCCCTCCCCGGACTCCGGCTCCGGCTCCGATT GCAATTTGCAACCTCCGCTGCCGTCGCCGCAGCAGCCACCAATTCGCCAGCGGTTCAGGTGGCTCTTGCC TCGATGTCCTAGCCTAGGGGCCCCCGGGCCGGACTTGGCTGGGCTCCCTTCACCCTCTGCGGAGTCATGA GGGCGAACGACGCTCTGCAGGTGCTGGGCTTGCTTTTCAGCCTGGCCCGGGGCTCCGAGGTGGGCAACTC TCAGGCAGGTAAGTGGCGCGAGAGCACCGGCGGGCTCGGCACCTGGGAGCCGGAACCCAGTGCGCGCAGC CTCGGAGGGTATGGGCACGGTCTCAGGCGGCGCGGGGTTGTGGGTGCTGCCCCCGGTTTGCCAGGACCAC CTGGGAGAGGGGCGGTCAGGCTCGGGTTATCGGCGTGGTCCGGCCGAGGGCGGCATTCCGGGACCCTCAC GCCACCCTTCTCCAGAGCGTCGCCGACCCTCTAATTGGTCTCCCCAGAAGAGGCTGAGGCCGAAACAGTA GTTCACACTTCTGAGGGGCCCTGCAGGGAGGGGAGCAGGGAACTTCATTCTGTAAACAGGAGGTGCTTGG AGGTGGGGGCCTTGGCGGGAAGGGTCTCGGTTTGCTCGCCAACCCCCTGCCCCCCACCCGCGCCGATTTC AGCTACCCCTAGTTTCGTTGTTTTGCCGACAGGGCGGAGCTACAGAAGGTTGGAGGGGGTTGTTGTTCTC TGGTGTTGGAAAAACAGGAGCGGCACCTCCTCTTCCGTGAGTGAGCCTGCCCTGGGGAGGTCTGAGATTA ACCAGAGGGCCAAGTTCAGGTGACATCAGGCAGGAGGCCCAACAGAGGCTGGCGCCCCCTTTCCTCAGTA TAGCAGAGCTTAAGCAACATCTCTTTGTCAAGACCCAGGTCAACACAACTCATATTTATTGAGCATCTAC TATACACAAGGCCCTGGGCCAGGAGCTGTAAGGGCAAGGATGTCCAGCCTCTGGTCTTTTCTCTCCCCAA CCTGAGGATCAAGAGGGCACCTCTGCTACTTTCTAAGCCTCCTGCCTTGGGGAGTCCTTCCTGGGCTCAG CTTGTGCCTCCCGCCCCCATTTTGCTTATTGTCTGACACTGTCTCTAGGACCCTAGACAGAGCCCCGGAT TGCTCTTCTCCAGTCCTCCCCCGACTCCCATGCTATCTGAGCCCACCCCTTTGGGGTGTCTCTGGGACCG TGGACACCTGAGGACTGAAGTTCTGTGGATCTCCTCCCCTCCCCTCAGATCTCAGCTTGGGGTTTGGCAC AGCCAGGGCCCCTTCCCCAGTGTGGGAGTGGAAGAAACCACCTGTGCTTCCCTCACAGTTGCTGGGCCTA AATTTAGATCCTGGGATTTTTAGATGTGAACACTCCCAGCTGGTGGAGGGGGGTGGTCTGGGGACTGGCG TGGGAGGGAGCAGTGGAGTGACTGTATAACTGTCCCATCCAGACTCCTGCAATCTTCACCCAGAAACCCA GGAGTACCAGAGTCTGGCCACCCTCCCTGGGGAGGCAGGAGGCAGGCATGGTTGGGTCTCTTTACCCTTT ATCTGGGTCCTGCAGCCTCTGGGCATCCGGCCCTGTCTCAGTCCTTCTATAGCCCCTTTGTCCTGGCTGT GATGGGGGTGGGGGATGTTGGAGGGGAGGCCTCTGGTTGAGGAGGGGCTGGAGATTCTGGCTCTATCCCA CCCCTAGTGCTCTCTACCAAAGGAGGGCCTGTGACACTGCCCCTCCCTATGCTCCCGGTTCCTGGGTACA GCAGGGATTTTTATGATTCCCTTCCCCTGCCCTGCTCCCCAAGCTGCCTAGCTCCTCCCCAGAGGTGTTG TTTGTGCTCCCTTCCTGCCCAGGCCCTTTGCCCCCTGTTTGTGTAATATGGACTTTACCCTCAGGGTAGC AGGGAACTGGGCTACCTCTAACACTGTAGCCTTCCAAGCACAGACACAAAGTCTGCACAAACACTTATGG GCACGTGGGATAGATGGGGCCACCTGAAATACTTCCTGCAAGGAAACCCAACTATAGATTCCTGAGCCAG CAGGACCAATGTGTACGTGTTCGTGTGTACATTGTGTGTGTATGTGTGTGCCCACACTACTACTTCCCTG TGCAGAAAGCTTGGCTCCTCCCTTATCTGGGGAGAAGTGTTGGCACTATAACTTGGGAAAGGGGGTATCC TGCCAGGAAGGGGATTGGGGTGGGGCTGTTCCAGAAATGACTAACCTTCCTAGTCTCTTTCATTTCAACC CAAGGACCCTGGAGTTCCCAGCTCCTCTGGAACTAGCTCTCTTTGCTGGGACTAGCCAACCTTCATGGGG AGTGATAAGGAGCCCTCCAAGGTCAAGAAGTCAGACTAGGGGTGTATGTTATAGGAGGGATTGGGGCCTC ACCAGTCTCCCTCCCTCCATTCCCACTGTTGCCTCCCACTGAGCTACCACCGCCTCAGGGAAGGGTGGCT GGAACAGGTGGTATCTACCCCCTACTCCCCACCCCACACATGGTCTTTCCCTGAACCAGAGGAAAGAGAC TGGGGTAGGGCTTCAGAGTCCAGGACTTCCCATAGCCCGTTGTCCACCACATTTGCAAAGAAGAGTGAAC TCCCAAGGCTGACATGCCATGTACCTCTAGTCTAGGCTCTCCCCTAGTGTGGGTGAGGATTGCCATGGTG AAAGGCTTTTTCATGAACCTCTTCTAACAATGAAATTGTGTGGAGGCTCAATATGGGGCATCTGCTACTA TCTCTCTCCAGGTTCCTCTGTATTTGCTGAAAAATACTCTAGGGCTGGAAAGTGATGCTGAGGTTGCTAG AGTGTGTTGGGATGGGGGAGAGAGTGAGAAGGAAACCCTGAGTTTAGGAAGGCGGGGAGGCAACTAGCTC CTTATCTTTCAGCTTTAAAGACAAAGCTCCCATTGACCCCCCCTCACCCCAGCACTGCCAGAGCTCCCCC CTCTACTGAGGTCACTTGTCTGAGCCCAAGGCTTGAGGGTGGAGGGGAGTGCTGCTGAGGACGGGGTGTC TAGGGACAGGGTGGGGCAGCCCCCCTCCTGGATAGAATCGCCTCATTGTGGGCTGGACTGTGGCCCCAGG CACTGCCCCCACCCTCTGCCCCCATCCCACCCTCAGTAGACACAATAGGGGCTGTGTACTAGTCCCAAAG AGATATTTATTCCAGGACCTAGAGAGAGGCAGGATGAGGGTAGAGAAGTGAGTGCCCTAGTTGGAGGGGG AGAGGAGGGTAATCAAAGTTGCGGCCTTTTCCTAACTTCTCTTTTCTAGGGAGAGAAACAAATTCCCTGT CTTCCTTCTCAGTTAACCCCTTAGTACCCAAAAGAAGCACAGAGGGGTCCCAGGTTGAAAAAGGAAATCT TTTCACCTTCCCATTCATGGAATGGTAAGGGGATTCTGAGAAGAGAGAAAGCTCTCAGGCCACTACAGCT TCTGCCTATCGCTTGTGGGAGGGTTGGAGGCAAATGCCATCTGATCCTGTCTAATGTAACTGGAAGAGGG CAACCAAGGGGGTGATCTTTGGGGATGGCAGATGGGCTGAGAATTTGTGTCCAGCCCTCAGCCACTCTTC CCTCTGCTTTGAACAGTGTGTCCTGGGACTCTGAATGGCCTGAGTGTGACCGGCGATGCTGAGAACCAAT ACCAGACACTGTACAAGCTCTACGAGAGGTGTGAGGTGGTGATGGGGAACCTTGAGATTGTGCTCACGGG ACACAATGCCGACCTCTCCTTCCTGCAGGTTAGTGAGCCCACCCTCCTTCCTCAACCTGCTCCTCTTTAT TCTCCCCTAGAACCCTCCTTCCTTCTTCAGGGCTACCTTCTGCTGGAGTTCACCCTTCCTAAGACTCAGG AGTTCCTAAGATTCAAAACCGTGTATTTATGGGGACAGTGGCTGTCATCTGGGACCTATGGTCTCACTGT TGTAGCCAGGGATATATAGGGGGCAGGGTCAGGGGCAGGTGGTGTTCTGTGGATAGTGCAAGGTCAGCAG GGACTAGTGCAGAGAGAAACCTGAGGACCAAGAGGTTACCTGGGGAGATGAGGAAGGGGCCCTACTGGTA TGAGGCACTTTGAGGAGAAAGCTGCCTGTCTTCACTCCCAGAAGTGACACAGCAGTGTGACACAGTCTAC TCCCTACTCCCAAATAGGAATTAGCAAGAGTTAAGGCCAGGTGCAGTGGCTCATGCCTGTAATCCCAGCA CTTTGGGAGGCCAAGGAAGGCAGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGGCAATGTGGTGAA ACGCTGTCTCTACAAAAATACAAAAATTAGCTGGGTATGGTGGCATGCACCTGTAGTCCCAGCTACTTGG AGGGCTGAGGTGGGAGGATTGCTTGAGCCCAGGAGTTTGACGCTGCAGTGAGCGAGATTGTGCCACTCGT AACAGAGCGAGACCCTGTCTCACCAAAAAAAAAAAAAAAGGCCAAGCTCGGATCACCTGAGGTCAGGAGT TCGAGACCAGCCTGACCAACATGGAAAAACCACATCTCTACTAAAAATACAAAATTAGCCAGGTGTAGTG GCACATGCCTGTAATCCCAGCTACTTGGGAGGCTGCGGCAGGAGAATTGCTTGAACCCGGGAGGTGGAGG TTGTGGTGAGCCAAGATCGCACTATTGTACTCCAGCCTGGGCAACAAGAGCGTAACTCCGTCTCAAATTT TAAAAAAAAGAAAAAAAGAAAGGAAAGAAAGAAGGAAGAATTAAAACAGTTAAAGAGTCTTTAATGCCTG AAGGAGGAGAGGAGATTGAGATTATTTTGCCCTGTTGTCTCTCTCATTTACATAATCTGCTCTGTCACAG TGGATTCGAGAAGTGACAGGCTATGTCCTCGTGGCCATGAATGAATTCTCTACTCTACCATTGCCCAACC TCCGCGTGGTGCGAGGGACCCAGGTCTACGATGGGAAGTTTGCCATCTTCGTCATGTTGAACTATAACAC CAACTCCAGCCACGCTCTGCGCCAGCTCCGCTTGACTCAGCTCACCGGTCAGTTCCCGATGGTTCCTTCT GGCCTCACCCCTCAGCCAGCCCAAGACTGGTACCTCCTTGATGATGACCCAAGACTGCTCACTCTAAGTG CCTCTTCCAAGGTGCCTGTCACCTTGGCCGCTGTCTAAAGGTCCATTGCTCCCTAAGCAATAGAGGGCCC CCAGTAGGGGGAGCTAGGGGCATCTGCTCCAGGGAAAGGAACCCTGTGTCCTTGTGGGGCTGGAGTCAGA GCTGGATCTGTTAACCGTTTTTCTAATTTCAAAGTACAGTGTACCGGAGGCCAGGCCTGATGGCTTACAC CTGTAATCCCAGCATTTTGGGAGGCCAAGGAGGGCAGATCACTTGAGATCAGGAGTTTGAGACCAGCCTG GCCAACATGGCGAAACCCTGTCTCTACTAAAAATACAAAAAAATAAAATAAAATAAAAAATTAGCTGGCT ATAGTGGTGCGCACCTGTAATCCCAGCTGTTCATGAGGCTGAGGCAGGAGACTCGCTTGAACCTGGGAGG TGGAGGTTGCAGTGAGCTGAGATTGCACCACTGCACTCTAGCGTAAGTGACAGTGAGACTCCGTCTCAAA AAAAAAAAAAAAAAAAAAAAAAAGCCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGC CAAGGCAGGTGGATCACAAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTAC TAAAAATACAAAAAATTAGCCAGGTGTGGTGGCGGGCGCCTGTAGTCCGAGCTACTCGGGAGGCTGAGGC AGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAAGATTGCACCACTGCACTCCAGCCTG GGCGACAGAGCGAGACTCCAAAAAAAAAAAAAAAAAAAAAAACCAAAGTACAGTATACCTGGATGTCCCT CCTTCCCTAGGAATTCTACCTTTACTCTCCTAAACCAAACCCCTATGAGCTGGAGGAATATAGGGGTTAA AAACCACCTGTCCATCTTCTGCTTCTCCATGTCCCAGTCAGTTGGAAAACATATGGGCAGGGCTTGGGGG AGGGAATGTTGAGTCAGAAATCTCTCCCTCTCTCCCTTCCCCTCCCCCACTAGCTAAACCGGATCTGGAC AGGTGACTGAGGAGGCAGGAGTTTCTTTTGGCCTGACTCCTCATCTTATAAAGGGAGTCTTCTCTGCAGC TTAGATTTAATTGGACCTATCTGTCTGCCTCATTCTCCCACTCCTGAGTCTCAGGTGTCCTTTTGGATGG GTGGAGAGGTAAGGAAGAGGCGTTCCGCTGCGGCCCTTAACCCTGTCACTTCTTTCCCTACCTCAGAGAT TCTGTCAGGGGGTGTTTATATTGAGAAGAACGATAAGCTTTGTCACATGGACACAATTGACTGGAGGGAC ATCGTGAGGGACCGAGATGCTGAGATAGTGGTGAAGGACAATGGCAGAAGCTGTAAGTGGCCGTGATCAA GATTGCTCCCCAGTCCCACCAAACCAGAGTGACTCCCTTCTTTCCATCATCCTTACATTCCTGATCTGAA CCCGCCTCCCCAGTGAACAAACACCTCAGGTCCCTGACTCAGCAGCCCACCAGGGCAGACCATTCCAGTC TCCTGGAATCTAAACCACAGAGGAGGTGTTTCAAGAAAAGGAGCAGGCCGAGCATGGTGGCTCATGCCTA TAATCCTGGCACTTTGGGAAGCCAAGGTGGGAGGATCGCTTGAGCCCAGGAGTCCAAGACCAGCCTGAGT AACATAGCAAAAAATCTACAAAAAATTAAAAAAATCAGACAGGCGTAGTGGCTCGCACCTGTAATCCCGG CTACTCAGGAGGCTGAGGCAGAGGATTGCTTGAGCCCAGGAGGCTGCAGCTGCAGTGAGCTGTGATTGTG CCATTGTACTCTAGCCTGGGCAACAGAGTGAGACCCTGTCTCAAAAAAAAAAAAAAAAAATCCCTGAGTA CTAAGCAGGGAAGCCAGATCTTTAGACTCCACATCTGTTACTCGTTCCACTAGAATATACTCCCATTTCC TTGGAGCCCACCTTCCCCTGACCATTCACATGCATATATTCCTGCATATATTCAGTTTGCCCAGGAGGAA CTAAGTTCCTGGGTTGGGACTAGGACTAAGGTTGGCATTTGCCCCAGTCCCTCCCCTTCAGCTGCCCAGT GGGTGGTGTGGAGGCGTGGCCGCGCCCCTTGTTGACAGGTCCACTTGAGCCCAGCCCTGCTCTCCAAGGG CAGGGAGGGACACAGCCCTGGCTTTTTGCTTCCCGGGATTGAGGTGCCTGTGTACTGACATCATACCCCG TTGATTAAAACAAGCCTTTCTTAGCCCTGATGGCCCCTTGTGTTGCCTTCCTTCCCAACCAGGTCCCCCC TGTCATGAGGTTTGCAAGGGGCGATGCTGGGGTCCTGGATCAGAAGACTGCCAGACATGTGGGTTTGAAA TTCCCTCCAAAAACTTCACTCATACGCTTTCATATCCCTTCCTCCCCAAGCCTGGGTCAACACTGTGGGG GAGGCATGAGCAGTGGCCTCAGAATTCAGTCCTAGGAGCCCTAACAGCCATGCTTTCTCTCCTTCCATAG TGACCAAGACCATCTGTGCTCCTCAGTGTAATGGTCACTGCTTTGGGCCCAACCCCAACCAGTGCTGCCA TGATGAGTGTGCCGGGGGCTGCTCAGGCCCTCAGGACACAGACTGCTTTGTATGTACCCTTTCCATTGCC TGGGTTCTGAAATTGGGATGTGGCCTTTGAGGAGGAGGTAGGGGTACACACGTAACATAAATCTGATGAG CCTCCTTTTTTCCCAGGCCTGCCGGCACTTCAATGACAGTGGAGCCTGTGTACCTCGCTGTCCACAGCCT CTTGTCTACAACAAGCTAACTTTCCAGCTGGAACCCAATCCCCACACCAAGTATCAGTATGGAGGAGTTT GTGTAGCCAGCTGTCCCCGTAAGTGTCTGAGGGGAAGGAACAATGATCAACAATAGTAGATCCAAGATTT TAGACAAAATTGTGGAAGGGAAAAAGAATCCAGTTGGTGATAAATAGGGAGATTGGTGAATGGTTATGAT CATCTAACCACTCCAGTGAGTGACCCTTACGTCCAGTCCTCCCATGACTTCAGCTATCACCCTTACTTCT GCTCCTTGTAGCAACAAATAGTGAAGAGACTTTTGAATCTATAGGGCAGCACTTAAGGGATCTAGGGTGG CAGATGGGGACAAATCCAGTGCAGAGCTGGAGGGAGCCTAGGCCCAGAGCAAGGGTTCCATTGGTAGCTG GTGATGTTCCTCCCTCATCTCTAATGGTGTCCTCCTCCTCTTCCCTAGATAACTTTGTGGTGGATCAAAC ATCCTGTGTCAGGGCCTGTCCTCCTGACAAGATGGAAGTAGATAAAAATGGGCTCAAGATGTGTGAGCCT TGTGGGGGACTATGTCCCAAAGGTGGGTAGGAGATGGTAAGAAGTTGTAAAGAGACAGCCTTTCCTCTGA GCCTGCGCAGACCACCCCCACTGAACCTCTCTTACATTTGCAGCCTGTGAGGGAACAGGCTCTGGGAGCC GCTTCCAGACTGTGGACTCGAGCAACATTGATGGATTTGTGAACTGCACCAAGATCCTGGGCAACCTGGA CTTTCTGATCACCGGCCTCAATGGGTTAGAGATCCTGCCTTCCCTCCTTAGACCCCAGCCCACGCACCCC TCACAGTTCATTTCATTGGCCAAAACTTTCCTATGTGGAGCTGACTAGGAATCAAAGTCATAAAATTCTA GCCTGTTACAAAGGACCTGAAAGAATGCTTAACACATCCTCCATCCAGGCCTTCGGTCCCCTCAGGAACA TCTTTGAGCAATTCAATATCGCCCTGCCAAGGAACAAGGGACAGGAACAACATATCCTCCTTCTTAAAGT TTTCTTTTTTATTCTTTTTTCTTTTTTGAGATAGGGTCTTGCTCTGTCACCTAGGCTGGAGTGCAGTGGC GTGATCTCGACTCACTGTAGCCTCGACCTCCTGGGCTCAAGTGATCCCAAGTAGCTGGGACTATAGGCAC ACACCATCATACTTGACTAATTTTTTTGTATTTTTTTGTAGAGACAGGGTCTTGCTATGTTGCCCAGGCT GATCTCGAACTCCTGTGCTCAAGCAATCCTCCCATCTTGGCCTCCCAAAGTGCTAGGGATCACAGCACCC AACCTCCTTCTTAAAGTTTTGTAAAAGTTCTTCCTTAGATTTGGATAAAAATCTGTCTCCAGGCTGGGCC CGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATTACGAGGTCAGATCGAGA CCATCCTGGCTAACATGGTGAAATGCCATCTCTACTAAAAACACAAAAATTAGCTGGGTGTGGTGGTGCA CATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCACGAGAATCACTTGAACCCAGGAGGCGGAAATTG CAGTGAACCGAGATTACACCACCGCACTCCAGCCTGGCGACAGAGCGAGACTCTTTCTCAAAAAAAAAAA AGAAAAGAAAAGAAAATTCTGTCTCCCCATGACTTTTAGCTGTTTTCACTCATTCTGCTCCTTGGAGCAA AAAGAACAAAGGGACTTTCTAGTCTATAGGACAGCATTTAAAATGTGTGTGTGTGTGTAAAAAAAACCCA CTATGACCACCTGTTTTTTTTTTTCCTTTAATTTTTTATTTTGACATAATTTTAGATCTACACTAAAGTT GCAAGAATGGTATAAAATTCCCCATATACTTTTTTTTTTTTTTTAAGACAAAGTCTCACTCTGTTCCCCA GGCTAGAGTGCAGTGGTGCAATCTTGGCTCACTGCAACCTCCGCCTCCTCTGCCTCCCGGGTTCAAGCAA TTCTCCTGCCTCAGTCTCCTGAGTAGCTGGAATTATAGGTGTGTGCCATCATGCCCGGCTAATTTTTGTA TTTTTAGTAGAGACAGGGTTTCACCATGTAGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCAC CCGCCCCAGCTTCCCAAAGTGTTGGGATTACAAGTGTGAGCCACCGCGTCTGGCCCCCCATACACTCTTT TACCCAGATCCTCCAAATGTTAACATACCACATATGGCCGGGCACAGTGGCTCATGCCTATAATCCCAGC ACTTTGGGAGGCTGAGGCAGGTGGATCACTAGGTGTGGATCACGAGGTCAAGAGATTGAGACCATCCTGG CCAACATGGTGAAACCTCATCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGTGCGCCTGTAG TCCCAGTTACTCAGGAGGCTGAGGCAGGAGAATAGCTTGAACCTGGCAGGCAGAGGTTGCAGTGAGCCGA GATCGCGGCACTGCACTCCAGCCTGGTGAAAGAGCGAGACTCTGTCCCCCGCCAAAAAAAATACCACATA CGCTTTATCACTTCTCTCTCTCTCTGTCTCTCTCTACACACACACACACACACACAAAACACATGCTATT GTTTTTCTGGACCACGTGAGGGTAAATTTTCACACATGGTTCTTTCTTACCCCTGTTATATTTCAGCGTA TATTCCTTAAAAATAATATTTTCTTACATAACCACAGCATAGTTGTTTGAATCGGAAAATTAACATTAAC ACAAAATATTATCTAAGCTACAGACCTTATTCAGATTTCACTAATTGTCCTCCTAAGGTTTGGGATCATA CATTACATTCAGTTATCGTGGCACTTCAATCTCCTTTATAACAGCTCCTCAGGTTTTGTTTATCTTTCAT GATATTCTTGATGAGTATAGATTAGGTAATGGGCAGCATGTTCTTCAGTTTGGATTAGTTTGATGTGTCC TCATGATTAGATTCAAGTTTTTGTAGTTTTTTTTTGAGACAAGGTCTGGCTCTATTGCCCAGGCTGGAAT ACAGTGGCATGATCTCAGCTCACTGCAACCTCTGCCTCCCGTGCTCAAGCGAGCACCTCAGCCCCCTGAG TAGCTGGGATTACAGGTGCATGCCACCATGCTTGGCTAATTTTATATATATATATATATATATATATATA TAAATAATATATATAAATATAAATATATATATATAAATAATATATATAAATATATATAAACATAAATATT ATATACTATTTATATATTTATATATGTGTGTGTATATATATATATATTTTTTTTTTTTTTTGAGACGGAG TCTCGCTCTTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTCAGCTCACGCAACCTCCACCTCTCAGGT TCAAGCCATTCTCTATAGAGACAGGGTTGCACCATGTTGTCCAGGATGGTCTCGAACTCATGAGCTCAAG TGATCCTCCTGTCTCAGCCTCCCAAAGTGCTGGGATTATAGGCATGCGCCGCTGCCAGGCTGGAGTTTGA TAAGAACACCACAGAGGCTGTGAGCTCAGGGCATCCTATTGAGGATGTACGTGATGTTGATTTGTCCCAG CACTCACAATGATGTCTCTGGTCACTTAGTTAAGGTGATATCTGTCAGGTTTTTCTACTGTAAAGTTACT ATTTTTCCATTCACAATTAATGAATGTCTTGGGATAATTGCCTGAATCAATTATTGTTATGATAGTTGCC AAATGATAATTTTCTAATTCCATTATTCCTTCTGCATTTGTTTGTTGGCATTCTACTGTTAGGAAGAGTC TTTCCAGCTGAGCACAGTGGCTTATGCCTGTAATCTCAGCCCTTTGGGAGCCAGTGGGAAAATTGCTTGG GCCCAGGAGTTCAAGGTTACAGTGAGCTATGATGGCACTACTGCTCTCCAGCCAGTGCACTCACTCTGCA CAACAGAGTGAGACCCTGTCTCTTAAAAAAAAAAAAAAAAAAAGGCCAGGTGCAGTGGCTCATGCCTGTA ATTCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACAAGGTCAGGAGTTCAAGACCAGCCTGGCCAGCA TGGTGAAACCCTGTCTCTACTAAAAATACAAAAAATTAGCCAGGCATGGTGGTGTGCTCCTGTATTCCCA GCTACTTAGGAAGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATTG CTGCCACTGTACTCCAGCCTGGGCGATAGAGCAAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAGGTCTTCCTTTCCTATTTACTCTTATGGATACTTATTTTATTCTAGTCAATGGTTATAATCCTT TACAATCATTATTTATTTTAGCCAGCCCCTCCAAGTTGGCTCCTGTGTTCTTTGGGCTGTACCCTTAATT CTTTGAGTCTTGTCTTGTTTGCACAAGATGCTCTGGGCTTATATTATATTTCCCCCATCCCAGCCATTTC TCCAAGGAATGTTTCCTTTTAGTGGAGAATGATATTTAGAAACCAAATGCTGAGGCTGGGTGTGCTCATT GCCATTGAGTTATACCTTTACCTTATTGACTGGTTTCTACTGTTCTATTCAGAGACCCCTGGCACAAGAT CCCTGCCCTGGACCCAGAGAAGCTCAATGTCTTCCGGACAGTACGGGAGATCACAGGTGAGTGGCAGAGA GTTTGCCCTTTCTAGAAGAATAGGTGAACCACTGGCATAAATTGCGGTATAACTACTTGAGAAAATCACG TCCCAAGTTATAGGGGAGGAGCCAGGAGAACCCAAGAAAGAAGAAGGCTCCCTGCCCATATGCCTCTCTC CAACCCCTCAGGTTACCTGAACATCCAGTCCTGGCCGCCCCACATGCACAACTTCAGTGTTTTTTCCAAT TTGACAACCATTGGAGGCAGAAGCCTCTACAAGTGAGTAAAGGGTATGGAGGAAATGGCATCTTCAGGCA ATGAAGCCTGTGTCATAGGCATTCTTTAGTAAAATACAAGGCACTGTCTCATACAGCAGTGCCTCAAAAC CAAAGGGTTTCAGAGTTTCACGAGGAAAAGGCAAAAGGAGGGGGATTCCCTCTCAGTGGATCTGACTAGC ACTGAGCAAATTTCTTGACTAACATGAATCCTTTGAATAGTTAATGTTCCCTTAGTAGTCTCTCCTCTCA TCCTGTCTCCTTATTCTCAGCCGGGGCTTCTCATTGTTGATCATGAAGAACTTGAATGTCACATCTCTGG GCTTCCGATCCCTGAAGGAAATTAGTGCTGGGCGTATCTATATAAGTGCCAATAGGCAGCTCTGCTACCA CCACTCTTTGAACTGGACCAAGGTGCTTCGGGGGCCTACGGAAGAGCGACTAGACATCAAGCATAATCGG CCGCGCAGAGACTGCGGTGAGGGAAAGGGTCTGCTAGGTGGTGAGAATAGGGAGTCAGGGAGGAGAGGGC TGAAAGGACTATTCTGCCCTAGACGTGGGAGTAGGGTTGAGGGATGGAACCAAGGAGAAGGGGGCTGTTA GGCTGGAAGCAGTAACGAGGAAGAATAATGAAGAGAGGGCTTGCTGGGAGTCCTCAGACTCCTCTCCTAA CCCACCCCTTCCTTTCCAGTGGCAGAGGGCAAAGTGTGTGACCCACTGTGCTCCTCTGGGGGATGCTGGG GCCCAGGCCCTGGTCAGTGCTTGTCCTGTCGAAATTATAGCCGAGGAGGTGTCTGTGTGACCCACTGCAA CTTTCTGAATGGGTACAGTAAGGGGAGCCAGTCAAGGATGGGTGGGGGTGGGGCCCTGCAATGGAACTGT TCAGGTGGCATACAATAAAAGTCTTTAGACAGCTTTCTGCATGTGCCTTGGTGGGATTGAGGTAGGAGAC CTGTGGTTGTGAGATCGGAGCATGAAGGTCAGGACTTGGAAGTGACCCCCCCCTCCCTTTATTCCCCACT ACAGGGAGCCTCGAGAATTTGCCCATGAGGCCGAATGCTTCTCCTGCCACCCGGAATGCCAACCCATGGA GGGCACTGCCACATGCAATGGCTCGGTATACTAGTAGCACCAGGATCTCCAAGGGAGACAGAGAAGGGGC AATACTTGGAGCATCTGGGGAATGATATGGCTAAGGATAGCACAGAGAGGCCAGATAATGCTAGGGCCTG CAGATAGAAGATCCTGAATGTCTGGGTTGGTCTTTGCTGGGAGGTATGGAATTGACCTTGGGATCTGATT CTTCCTGACCTTCTCTCTTCCACTCAGGGCTCTGATACTTGTGCTCAATGTGCCCATTTTCGAGATGGGC CCCACTGTGTGAGCAGCTGCCCCCATGGAGTCCTAGGTGCCAAGGGCCCAATCTACAAGTACCCAGATGT TCAGAATGAATGTCGGCCCTGCCATGAGAACTGCACCCAGGGGTCAGTGATGGGATAATAAGGAGAGGGG GTCAGGTGGAAGGGTAGGAGCACAGAACTAGAGTGAGGGAAGCAGAAAGAAGAGAGAGGCTGTGATTCAA GAATCACTCCCAGCTGGCCGGGCGCAGTGGCTCACACCTGTAATCCCAGCACTGTGGGAGGCCGAGGTGG GTGGATCACCTGAGGTCGGGAGTTCGAGACCAGCCTGACCAATATGGAGAAACCCTGTCTCTACCAAAAA TTTAAAATTAGCCCGGCGTGGTGGCGCATGCCTGTAATCCCAGCTACGCGGGAGGCTGAGGCAGGAGAAT TTCTTGAACCCAGGAGGCAGAGGTTGCGGTGAGCTGAGATTGCATCATTGTACTCCAGCCTGGGCAACAA GAGTGAAACTCTGTCTCAAAAAAAAAAAAAGAATCACTCCCAGCTGTGTAGCGAAGGATTGGAGAAAGGG AAAATCAGTAACAGCACAAAATTACACCACAGTTTTGGGAACCTGGAATAACCTCAGTTCAAGGGAGTTT CACAGAAGAGGGGCTTGGGGAGAGCTAGTGAGCTGGAGGTGGAGGCCATGTCTTGGGATCAGCTCTGGGC TCCAGGATGGGATGCCACGGTAAGTTCTGAAACAAGCTTTTATATGTTAGGCTGTTGAAATTGAGCCTCT GCTGTCCAAGCTCTCATTTAAGGTGGTGACTTTCTTCCCTAGGTGTAAAGGACCAGAGCTTCAAGACTGT TTAGGACAAACACTGGTGCTGATCGGGTATGATGGGGTTGGAGATTCTGGAAACTGGGGATATTTGGGAG TTGGGAGAGAGGTGGTTACCTGGAGAGAAGAGGGAGGCTGTCTTCATTCTGGCCTTTTATGTATGCAGTC CACTATCACTGGACACTTGGGACTCAAGAATGCAGGCTTCTGGACTTCCCTTCCTAAAATTAACTTTCAG TAGTCTAAGACTGGTCCAGATTTAGGTTGGTCCCTTCAGTGCTTAAGGATATATATGTGAATGTTAATTT CTTGCCCCAGGTCAGCATCATACCTTCAACACAAGTATAGTTGACATTTGTAAGGAAGATGCAAACCCAG GATAATGTTGGGTTTCTATATATCCCATAGCAAAACCCATCTGACAATGGCTTTGACAGTGATAGCAGGA TTGGTAGTGATTTTCATGATGCTGGGCGGCACTTTTCTCTACTGGCGTGGGCGCCGGATTCAGAATAAAA GGGCTATGAGGCGATACTTGGAACGGGGTGAGGTGAGTACTTAGCTTACTTTTGTTTTTTCTTTTCTTTT TTTGCATGTCCTGGAAGTCTCTTTATAGCTTAATTTTGAGTGGTACCCTGTGCACCCAGGGGTCAGTGAT GGGATAAATGTCACTCCCCTCCTCTTTCCCCAGAGATTTGATCCCTTTCTTCAAGGAAGTAGTGTGGTCC CCTAGAAGAACACTGGTCAGAGAAATGGGAGGCATGCATTCTAGTCCTGATTTTGCCATTAATTTGCCAC ATGACTTTGAAGAAGTTACTTATCTTCTCTGTGCCTCGGTTTATGCATCTATACAGAGGAAATAACATTT GTCCTTCCAGGATGGCTGTAAGGGTAAAGGGGGATGATGTATGTGAAAGTGCTTTGGAAAGCACAGAGCA CTGTATAAAAGGTACTCAAGGTGGTAATAGTACTACCAACTCTCCCTAGCTGTCCCCTTCCCCACTTTGT GCTCCTCCATCAAAGGGAAAACCCAACCCCTTTGATTCCTGATCTCATGAGCACAAATAACTTCCTCAGT TCTCAGGGTCTGTACCTCAATATGCCTATAATCCATTCCAGGACTAACGGTGCTTCCTCTTCCTGCCCTT TCAGCTGTGCTGCTTTTGGCATTCACCTATGAGGAGCGGGTTGGAGTGGGACATGGGAATGGCCTTTCCT GAGTAACTCCTTCCCATTTGCTCCTCAGAGCATAGAGCCTCTGGACCCCAGTGAGAAGGCTAACAAAGTC TTGGCCAGAATCTTCAAAGAGACAGAGCTAAGGAAGCTTAAAGTGCTTGGCTCGGGTGTCTTTGGAACTG TGCACAAAGTGAGTGACCCATAGGAATTCTGGAGAGGTGGGGAAGGCATCTAGGGCAAAGGGGTGAAAGA TTTTTGCATAGGATTGACCTAGGGAGAATGACCTTATGCCAACTCCTGCCCCAAACTTCCCAGGGAGTGT GGATCCCTGAGGGTGAATCAATCAAGATTCCAGTCTGCATTAAAGTCATTGAGGACAAGAGTGGACGGCA GAGTTTTCAAGCTGTGACAGATGTAAGTGAAGGAAATTCTGTATGCCGCTAGGAGAGAGGACAATATTAG ATACAATCATGTAGAAGCAGGGTCCTGTGCTTCTCAGCAGCTACTATGTTAGCCAGAATGTTGGGGGTGG GGGGGCCTGGGCTGGCTGTGCACATGCTGAGTGTATGTGAACCTGTTGGTTTCCTAGATAATACCTTTTG TGTCTCTTAGCATATGCTGGCCATTGGCAGCCTGGACCATGCCCACATTGTAAGGCTGCTGGGACTATGC CCAGGGTCATCTCTGCAGCTTGTCACTCAATATTTGCCTCTGGGTTCTCTGCTGGATCATGTGAGACAAC ACCGGGGGGCACTGGGGCCACAGCTGCTGCTCAACTGGGGAGTACAAATTGCCAAGGTGAGAGAAGCCTG GAGGAATTCTGTGATAAGAACTGCTTGTCTGGGGGCCAGCCAGGAAAAAGTGAGAAGGTTGAAGTTCTGA GAGGTGAGGTCCCCAACCCCCGGGCTGCAGACTGGTACCAGTCCATGGCCTGTTAGGAACCAGGCCACAG AGCATGTGAGCGGCAGGCAAGCGAGTGAAGCTTCATCTGTATTTACAGTCAGTCCCCATCACTTGCATTA CCGCCCGAGTTCCGCCTCCTGTCAGATCAGGGGCAGCATTAGATTCTCTTAGGAGCTTGACTTCTATTGT GAACTGTGCATGTGAAGGATCTAGGTTGTGCACTCCTTATGAGAATCTAACTAATGCCTGATGATCTGAG GTGGAAAAATTTCATCCCAAAACCAACCCTCCCCTTCCCCTGGAAAAACTGTCTTCCACAAAACCAGTCC CTGGTGCCAAAAAAGGTTGGGGACCACTGCTGAGAGGTACCTTCAAGATTTGGGGGAATTCCAGATCTCA GTGACTGATTCCCCCAACCTTAAGAATACTTTCTTCCCCTATACCTACAGGGAATGTACTACCTTGAGGA ACATGGTATGGTGCATAGAAACCTGGCTGCCCGAAACGTGCTACTCAAGTCACCCAGTCAGGTTCAGGTG GCAGATTTTGGTGTGGCTGACCTGCTGCCTCCTGATGATAAGCAGCTGCTATACAGTGAGGCCAAGGTGA GGAGACACAAAGGGTAAGGAGGCGGGGGTGGAGTGAAGCATGGGGATAGGGAGCAGCCAGTGGTCTCTTC CAGAGGCAAGCAGATGCTTCATGGTAAGTTCAAGGAGAGAAGGCTGCAGATGCCAGATATTTTAGTTCAG AGGGCAACAAATAAAATAATGATCAAGAACTTGGGACTGGCCGGGCGCGGTGGCTCACGCCTGTAATCCC AACACTTCGGGAGGCCAAGGCGGGTGGATCACAAGGTCAGGAGATCAAGACCATCCTGGCTAGCACGGTG AAACCCCGTCTCTACTAAATATACAAAAAAAAAAAAAATTAGCCAGGCGTGGCGGCATGCATCTGTACTC CCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCAGGAGGCGGAGCTTGCAGTGGGCCGAGA TCGCACCACTGCACTCCAGTCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAGAATTTG GGACTTGGAAATCCTAAGAAAATTTGTGGAAATAAACTTGTGATACCTCTATCTTTAATCCGCAGACTCC AATTAAGTGGATGGCCCTTGAGAGTATCCACTTTGGGAAATACACACACCAGAGTGATGTCTGGAGCTAT GGTCAGTGCATCTGGATGCCCTCTCTACCATCACTGGCCCCAGTTTCAAATTTACCTTTTGAGACCCCCT CTTAGAATCTCTAAGCACTTCAGATTTTTGTGTTAGATCAGGTTCTGCCTTCCCTTCACTTCATGCCCAT GTCTACTATTTTGCCAGTGACTAGTCCATGTCTTCCTGCAACAGGTGTGACAGTTTGGGAGTTGATGACC TTCGGGGCAGAGCCCTATGCAGGGCTACGATTGGCTGAAGTACCAGACCTGCTAGAGAAGGGGGAGCGGT TGGCACAGCCCCAGATCTGCACAATTGATGTCTACATGGTGATGGTCAAGTGTGAGTTACCTGCTGAGCC CAACCATTTTCTCTTTTTTTCTTTTTTTTTCTTTTTTTTTTTTTTTTGAGACAGAGTCTCACAATTGTCA CCCAGGCTGGAGTGCAATGGTGCAATCAATCTTGGCTCACTACAACCTCCGCCTCTCGGGTTCAAGAGAT TCTCCTGCTTCAGCCTCCGGAGTAGCTGGGATTACAGGCGCCCGCCACACCTGGATAACTGTTACACTTT TAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCTGC CTCAGCTTCCCAAAGTGCTGGGATTACAGGTGTGAGCCATCATGCTCGGCCTGACTGCAGCCATTTTCTG ACTTCCCTCTGTACTCCTCTTATGGCTCTATTCCTTTTTTTTTTATGGAGTCTCGCTCTGTTGCCCATAC TGGAGTGCAGTAGCGTGACCTTGGCTCACCGTGACCTCCACGTTCCAGGTTTAAGTTCTTCTGTCTCAGC CTCCCAGATAGCTGGGACTTTAGGCGTGCACCACCACGCCCAGCTAATTTTTTTTTGTCTTTTTAGTAGA GATGGGGTTTCACTATGTTGGCCAGGCTGGTCTCAAAGTCCCGACCTCAGGTGATCCACCCGCCTTGGCC TCCCAAAGTGCTGGGATTATAGGTGTGAGCCACCGCGCCCGGCCATGGAATGTATTCTCTTTTATGTCTC TACCTCCTACATCTTATCTCCAGGTTGGATGATTGATGAGAACATTCGCCCAACCTTTAAAGAACTAGCC AATGAGTTCACCAGGATGGCCCGAGACCCACCACGGTATCTGGTCATAAAGGTGAGTAGGGAGTAGGAGG TGCTAAGGAAATTTAGAAAAAGGAGGAGTTGGCTGGAACCAGGATTCCCCCTAACAATCACCTATCGATA TAGAGAGAGAGTGGGCCTGGAATAGCCCCTGGGCCAGAGCCCCATGGTCTGACAAACAAGAAGCTAGAGG AAGTAGAGCTGGAGCCAGAACTAGACCTAGACCTAGACTTGGAAGCAGAGGAGGACAACCTGGCAACCAC CACACTGGGCTCCGCCCTCAGCCTACCAGTTGGAACACTTAATCGGCCACGTGGGGTAAGACAACTTCTA ATTACCCAACACTTTGCACCCTGAGCCCTCACAAACCCTACAGATACCCAGATTAACTACTCAAAGGCCC CCATGGTGAATGTAGATTTCTCCCTTCATCTTAACCTTTTCCTTATTTTTTCATCCTAGAGCCAGAGCCT TTTAAGTCCATCATCTGGATACATGCCCATGAACCAGGGTAATCTTGGGGAGTCTTGCCAGGTAAGTTCT GTTGCTGAGAGGCTGGGTTTTAGGATCAGATTGATACGAGTAGTATGGAAGACATTAGAAACCTCTGAGG TTTAATCAGTGTCCTGCAAAAAAGAAGGCAGTGAGGGCCGGGCGAGTTGGCTCACACCTGTAATCCCAGC ACTTTGGGAGGCCAGAGAGAGTGGATCACCTGAGGTTAGGAGTTTGAGACCAGCCTGGCCAACATGGTGA AACCCCGTCTCTACCCAAAATACAAAAATTAGCTGGGTGTGGTGGTGCACACCTGTAATCACAGCTACTC AGGAGGCTGAGACAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCTGAGATTGTACCACT GCACTCCAGCCTGGGTGACAGAGCAAGACCCTGTCTCTTAAAAAAAAAAAAAAAAGGCCAGGTGCGGTGG CTCACGCCTGTAATCCTAGCACTTTGGGAGGCCGAGGTGGGCGGATCATGAGGTCAGGAGTTCGAGACCA GCCTGACCAACATGGCAAAACCCTGTCTGTACTAAAAATACAAAAACTAGCTGCACATGATGGCAGGTGC CTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACAGGGAAGCAGAGGCTGCAGTGA GCCAAGATAATGCCACTGCACTCCAGCCTGGGCGACAAGAACAAGACTCCACCTCAAAAAAAAAAAAAAA AAAAAAAAAAGGCAGTGAACAACCCAATATCCTTCTAAACAAATCTCTCTTCTTTCCTCATCATGTAAAT TTCCTTGCATTATTTTCTGTTTATTTTCTTCCTTAGGAGTCTGCAGTTTCTGGGAGCAGTGAACGGTGCC CCCGTCCAGTCTCTCTACACCCAATGCCACGGGGATGCCTGGCATCAGAGTCATCAGAGGGGCATGTAAC AGGCTCTGAGGCTGAGCTCCAGGAGAAAGTGTCAATGTGTAGGAGCCGGAGCAGGAGCCGGAGCCCACGG CCACGCGGAGATAGCGCCTACCATTCCCAGCGCCACAGTCTGCTGACTCCTGTTACCCCACTCTCCCCAC CCGGGTTAGAGGAAGAGGATGTCAACGGTTATGTCATGCCAGATACACACCTCAAAGGTGCCTGACTCTT CCTAGGGCTTTCCTCAATTTTTCCTCGAATTCTTTCCCCGGGCTCCTCTTTTTTCTTCTCTGATCATATG CCTCTCTGTCCTATTAATTTTTTCAAACTTTCCCCTACCCTCATGAAGTTCTTCACATACCTAGCCTTTC TTCTCAACCCCCAGGTACTCCCTCCTCCCGGGAAGGCACCCTTTCTTCAGTGGGTCTCAGTTCTGTCCTG GGTACTGAAGAAGAAGATGAAGATGAGGAGTATGAATACATGAACCGGAGGAGAAGGCACAGTCCACCTC ATCCCCCTAGGCCAAGTTCCCTTGAGGAGCTGGGTTATGAGTACATGGATGTGGGGTCAGACCTCAGTGC CTCTCTGGGCAGCACACAGAGTTGCCCACTCCACCCTGTACCCATCATGCCCACTGCAGGCACAACTCCA GATGAAGACTATGAATATATGAATCGGCAACGAGATGGAGGTGGTCCTGGGGGTGATTATGCAGCCATGG GGGCCTGCCCAGCATCTGAGCAAGGGTATGAAGAGATGAGAGCTTTTCAGGGGCCTGGACATCAGGCCCC CCATGTCCATTATGCCCGCCTAAAAACTCTACGTAGCTTAGAGGCTACAGACTCTGCCTTTGATAACCCT GATTACTGGCATAGCAGGCTTTTCCCCAAGGCTAATGCCCAGAGAACGTAACTCCTGCTCCCTGTGGCAC TCAGGGAGCATTTAATGGCAGCTAGTGCCTTTAGAGGGTACCGTCTTCTCCCTATTCCCTCTCTCTCCCA GGTCCCAGCCCCTTTTCCCCAGTCCCAGACAATTCCATTCAATCTTTGGAGGCTTTTAAACATTTTGACA CAAAATTCTTATGGTATGTAGCCAGCTGTGCACTTTCTTCTCTTTCCCAACCCCAGGAAAGGTTTTCCTT ATTTTGTGTGCTTTCCCAGTCCCATTCCTCAGCTTCTTCACAGGCACTCCTGGAGATATGAAGGATTACT CTCCATATCCCTTCCTCTCAGGCTCTTGACTACTTGGAACTAGGCTCTTATGTGTGCCTTTGTTTCCCAT CAGACTGTCAAGAAGAGGAAAGGGAGGAAACCTAGCAGAGGAAAGTGTAATTTTGGTTTATGACTCTTAA CCCCCTAGAAAGACAGAAGCTTAAAATCTGTGAAGAAAGAGGTTAGGAGTAGATATTGATTACTATCATA ATTCAGCACTTAACTATGAGCCAGGCATCATACTAAACTTCACCTACATTATCTCACTTAGTCCTTTATC ATCCTTAAAACAATTCTGTGACATACATATTATCTCATTTTACACAAAGGGAAGTCGGGCATGGTGGCTC ATGCCTGTAATCTCAGCACTTTGGGAGGCTGAGGCAGAAGGATTACCTGAGGCAAGGAGTTTGAGACCAG CTTAGCCAACATAGTAAGACCCCCATCTCTTTAAAAAAAAAAAAAAAAAAAAAAAAAAAACTTTAGAACT GGGTGCAGTGGCTCATGCCTGTAATCCCAGCCAGCACTTTGGGAGGCTGAGATGGGAAGATCACTTGAGC CCAGAATTAGAGATAAGCCTATGGAAACATAGCAAGACACTGTCTCTACAGGGGAAAAAAAAAAAAGAAA CTGAGCCTTAAAGAGATGAAATAAATTAAGCAGTAGATCCAGGATGCAAAATCCTCCCAATTCCTGTGCA TGTGCTCTTATTGTAAGGTGCCAAGAAAAACTGATTTAAGTTACAGCCCTTGTTTAAGGGGCACTGTTTC TTGTTTTTGCACTGAATCAAGTCTAACCCCAACAGCCACATCCTCCTATACCTAGACATCTCATCTCAGG AAGTGGTGGTGGGGGTAGTCAGAAGGAAAAATAACTGGACATCTTTGTGTAAACCATAATCCACATGTGC CGTAAATGATCTTCACTCCTTATCCGAGGGCAAATTCACAAGGATCCCCAAGATCCACTTTTAGAAGCCA TTCTCATCCAGCAGTGAGAAGCTTCCAGGTAGGACAGAAAAAAGATCCAGCTTCAGCTGCACACCTCTGT CCCCTTGGATGGGGAACTAAGGGAAAACGTCTGTTGTATCACTGAAGTTTTTTGTTTTGTTTTTATACGT GTCTGAATAAAAATGCCAAAGTTTTTTTTCAGC Download Select all
Length	23483
OMIM ID	190151
HGNC ID	HGNC:3431
Unigene ID	Hs.118681
Ensembl ID	ENSG00000065361
PharmGKB ID	-

mRNA Information

mRNA ID	NM_001982.3
Exon	join(1..358,3727..3878,4971..5157,6507..6632,7553..7618, 7771..7889,7997..8138,8519..8632,8724..8844,12723..12796, 12962..13052,13321..13526,13740..13872,14075..14165, 14378..14532,15233..15286,15641..15782,16479..16598, 16724..16822,17021..17206,17761..17916,18476..18551, 18735..18881,19624..19721,19814..20005,20150..20221, 21037..21337,21505..23483)
mRNA Sequence	>2065 ACTCCAGCCTCGCGCGGGAGGGGGCGCGGCCGTGACTCACCCCCTTCCCTCTGCGTTCCTCCCT CCCTCTCTCTCTCTCTCTCACACACACACACCCCTCCCCTGCCATCCCTCCCCGGACTCCGGCT CCGGCTCCGATTGCAATTTGCAACCTCCGCTGCCGTCGCCGCAGCAGCCACCAATTCGCCAGCG GTTCAGGTGGCTCTTGCCTCGATGTCCTAGCCTAGGGGCCCCCGGGCCGGACTTGGCTGGGCTC CCTTCACCCTCTGCGGAGTCATGAGGGCGAACGACGCTCTGCAGGTGCTGGGCTTGCTTTTCAG CCTGGCCCGGGGCTCCGAGGTGGGCAACTCTCAGGCAGTGTGTCCTGGGACTCTGAATGGCCTG AGTGTGACCGGCGATGCTGAGAACCAATACCAGACACTGTACAAGCTCTACGAGAGGTGTGAGG TGGTGATGGGGAACCTTGAGATTGTGCTCACGGGACACAATGCCGACCTCTCCTTCCTGCAGTG GATTCGAGAAGTGACAGGCTATGTCCTCGTGGCCATGAATGAATTCTCTACTCTACCATTGCCC AACCTCCGCGTGGTGCGAGGGACCCAGGTCTACGATGGGAAGTTTGCCATCTTCGTCATGTTGA ACTATAACACCAACTCCAGCCACGCTCTGCGCCAGCTCCGCTTGACTCAGCTCACCGAGATTCT GTCAGGGGGTGTTTATATTGAGAAGAACGATAAGCTTTGTCACATGGACACAATTGACTGGAGG GACATCGTGAGGGACCGAGATGCTGAGATAGTGGTGAAGGACAATGGCAGAAGCTGTCCCCCCT GTCATGAGGTTTGCAAGGGGCGATGCTGGGGTCCTGGATCAGAAGACTGCCAGACATTGACCAA GACCATCTGTGCTCCTCAGTGTAATGGTCACTGCTTTGGGCCCAACCCCAACCAGTGCTGCCAT GATGAGTGTGCCGGGGGCTGCTCAGGCCCTCAGGACACAGACTGCTTTGCCTGCCGGCACTTCA ATGACAGTGGAGCCTGTGTACCTCGCTGTCCACAGCCTCTTGTCTACAACAAGCTAACTTTCCA GCTGGAACCCAATCCCCACACCAAGTATCAGTATGGAGGAGTTTGTGTAGCCAGCTGTCCCCAT AACTTTGTGGTGGATCAAACATCCTGTGTCAGGGCCTGTCCTCCTGACAAGATGGAAGTAGATA AAAATGGGCTCAAGATGTGTGAGCCTTGTGGGGGACTATGTCCCAAAGCCTGTGAGGGAACAGG CTCTGGGAGCCGCTTCCAGACTGTGGACTCGAGCAACATTGATGGATTTGTGAACTGCACCAAG ATCCTGGGCAACCTGGACTTTCTGATCACCGGCCTCAATGGAGACCCCTGGCACAAGATCCCTG CCCTGGACCCAGAGAAGCTCAATGTCTTCCGGACAGTACGGGAGATCACAGGTTACCTGAACAT CCAGTCCTGGCCGCCCCACATGCACAACTTCAGTGTTTTTTCCAATTTGACAACCATTGGAGGC AGAAGCCTCTACAACCGGGGCTTCTCATTGTTGATCATGAAGAACTTGAATGTCACATCTCTGG GCTTCCGATCCCTGAAGGAAATTAGTGCTGGGCGTATCTATATAAGTGCCAATAGGCAGCTCTG CTACCACCACTCTTTGAACTGGACCAAGGTGCTTCGGGGGCCTACGGAAGAGCGACTAGACATC AAGCATAATCGGCCGCGCAGAGACTGCGTGGCAGAGGGCAAAGTGTGTGACCCACTGTGCTCCT CTGGGGGATGCTGGGGCCCAGGCCCTGGTCAGTGCTTGTCCTGTCGAAATTATAGCCGAGGAGG TGTCTGTGTGACCCACTGCAACTTTCTGAATGGGGAGCCTCGAGAATTTGCCCATGAGGCCGAA TGCTTCTCCTGCCACCCGGAATGCCAACCCATGGAGGGCACTGCCACATGCAATGGCTCGGGCT CTGATACTTGTGCTCAATGTGCCCATTTTCGAGATGGGCCCCACTGTGTGAGCAGCTGCCCCCA TGGAGTCCTAGGTGCCAAGGGCCCAATCTACAAGTACCCAGATGTTCAGAATGAATGTCGGCCC TGCCATGAGAACTGCACCCAGGGGTGTAAAGGACCAGAGCTTCAAGACTGTTTAGGACAAACAC TGGTGCTGATCGGCAAAACCCATCTGACAATGGCTTTGACAGTGATAGCAGGATTGGTAGTGAT TTTCATGATGCTGGGCGGCACTTTTCTCTACTGGCGTGGGCGCCGGATTCAGAATAAAAGGGCT ATGAGGCGATACTTGGAACGGGGTGAGAGCATAGAGCCTCTGGACCCCAGTGAGAAGGCTAACA AAGTCTTGGCCAGAATCTTCAAAGAGACAGAGCTAAGGAAGCTTAAAGTGCTTGGCTCGGGTGT CTTTGGAACTGTGCACAAAGGAGTGTGGATCCCTGAGGGTGAATCAATCAAGATTCCAGTCTGC ATTAAAGTCATTGAGGACAAGAGTGGACGGCAGAGTTTTCAAGCTGTGACAGATCATATGCTGG CCATTGGCAGCCTGGACCATGCCCACATTGTAAGGCTGCTGGGACTATGCCCAGGGTCATCTCT GCAGCTTGTCACTCAATATTTGCCTCTGGGTTCTCTGCTGGATCATGTGAGACAACACCGGGGG GCACTGGGGCCACAGCTGCTGCTCAACTGGGGAGTACAAATTGCCAAGGGAATGTACTACCTTG AGGAACATGGTATGGTGCATAGAAACCTGGCTGCCCGAAACGTGCTACTCAAGTCACCCAGTCA GGTTCAGGTGGCAGATTTTGGTGTGGCTGACCTGCTGCCTCCTGATGATAAGCAGCTGCTATAC AGTGAGGCCAAGACTCCAATTAAGTGGATGGCCCTTGAGAGTATCCACTTTGGGAAATACACAC ACCAGAGTGATGTCTGGAGCTATGGTGTGACAGTTTGGGAGTTGATGACCTTCGGGGCAGAGCC CTATGCAGGGCTACGATTGGCTGAAGTACCAGACCTGCTAGAGAAGGGGGAGCGGTTGGCACAG CCCCAGATCTGCACAATTGATGTCTACATGGTGATGGTCAAGTGTTGGATGATTGATGAGAACA TTCGCCCAACCTTTAAAGAACTAGCCAATGAGTTCACCAGGATGGCCCGAGACCCACCACGGTA TCTGGTCATAAAGAGAGAGAGTGGGCCTGGAATAGCCCCTGGGCCAGAGCCCCATGGTCTGACA AACAAGAAGCTAGAGGAAGTAGAGCTGGAGCCAGAACTAGACCTAGACCTAGACTTGGAAGCAG AGGAGGACAACCTGGCAACCACCACACTGGGCTCCGCCCTCAGCCTACCAGTTGGAACACTTAA TCGGCCACGTGGGAGCCAGAGCCTTTTAAGTCCATCATCTGGATACATGCCCATGAACCAGGGT AATCTTGGGGAGTCTTGCCAGGAGTCTGCAGTTTCTGGGAGCAGTGAACGGTGCCCCCGTCCAG TCTCTCTACACCCAATGCCACGGGGATGCCTGGCATCAGAGTCATCAGAGGGGCATGTAACAGG CTCTGAGGCTGAGCTCCAGGAGAAAGTGTCAATGTGTAGGAGCCGGAGCAGGAGCCGGAGCCCA CGGCCACGCGGAGATAGCGCCTACCATTCCCAGCGCCACAGTCTGCTGACTCCTGTTACCCCAC TCTCCCCACCCGGGTTAGAGGAAGAGGATGTCAACGGTTATGTCATGCCAGATACACACCTCAA AGGTACTCCCTCCTCCCGGGAAGGCACCCTTTCTTCAGTGGGTCTCAGTTCTGTCCTGGGTACT GAAGAAGAAGATGAAGATGAGGAGTATGAATACATGAACCGGAGGAGAAGGCACAGTCCACCTC ATCCCCCTAGGCCAAGTTCCCTTGAGGAGCTGGGTTATGAGTACATGGATGTGGGGTCAGACCT CAGTGCCTCTCTGGGCAGCACACAGAGTTGCCCACTCCACCCTGTACCCATCATGCCCACTGCA GGCACAACTCCAGATGAAGACTATGAATATATGAATCGGCAACGAGATGGAGGTGGTCCTGGGG GTGATTATGCAGCCATGGGGGCCTGCCCAGCATCTGAGCAAGGGTATGAAGAGATGAGAGCTTT TCAGGGGCCTGGACATCAGGCCCCCCATGTCCATTATGCCCGCCTAAAAACTCTACGTAGCTTA GAGGCTACAGACTCTGCCTTTGATAACCCTGATTACTGGCATAGCAGGCTTTTCCCCAAGGCTA ATGCCCAGAGAACGTAACTCCTGCTCCCTGTGGCACTCAGGGAGCATTTAATGGCAGCTAGTGC CTTTAGAGGGTACCGTCTTCTCCCTATTCCCTCTCTCTCCCAGGTCCCAGCCCCTTTTCCCCAG TCCCAGACAATTCCATTCAATCTTTGGAGGCTTTTAAACATTTTGACACAAAATTCTTATGGTA TGTAGCCAGCTGTGCACTTTCTTCTCTTTCCCAACCCCAGGAAAGGTTTTCCTTATTTTGTGTG CTTTCCCAGTCCCATTCCTCAGCTTCTTCACAGGCACTCCTGGAGATATGAAGGATTACTCTCC ATATCCCTTCCTCTCAGGCTCTTGACTACTTGGAACTAGGCTCTTATGTGTGCCTTTGTTTCCC ATCAGACTGTCAAGAAGAGGAAAGGGAGGAAACCTAGCAGAGGAAAGTGTAATTTTGGTTTATG ACTCTTAACCCCCTAGAAAGACAGAAGCTTAAAATCTGTGAAGAAAGAGGTTAGGAGTAGATAT TGATTACTATCATAATTCAGCACTTAACTATGAGCCAGGCATCATACTAAACTTCACCTACATT ATCTCACTTAGTCCTTTATCATCCTTAAAACAATTCTGTGACATACATATTATCTCATTTTACA CAAAGGGAAGTCGGGCATGGTGGCTCATGCCTGTAATCTCAGCACTTTGGGAGGCTGAGGCAGA AGGATTACCTGAGGCAAGGAGTTTGAGACCAGCTTAGCCAACATAGTAAGACCCCCATCTCTTT AAAAAAAAAAAAAAAAAAAAAAAAAAAACTTTAGAACTGGGTGCAGTGGCTCATGCCTGTAATC CCAGCCAGCACTTTGGGAGGCTGAGATGGGAAGATCACTTGAGCCCAGAATTAGAGATAAGCCT ATGGAAACATAGCAAGACACTGTCTCTACAGGGGAAAAAAAAAAAAGAAACTGAGCCTTAAAGA GATGAAATAAATTAAGCAGTAGATCCAGGATGCAAAATCCTCCCAATTCCTGTGCATGTGCTCT TATTGTAAGGTGCCAAGAAAAACTGATTTAAGTTACAGCCCTTGTTTAAGGGGCACTGTTTCTT GTTTTTGCACTGAATCAAGTCTAACCCCAACAGCCACATCCTCCTATACCTAGACATCTCATCT CAGGAAGTGGTGGTGGGGGTAGTCAGAAGGAAAAATAACTGGACATCTTTGTGTAAACCATAAT CCACATGTGCCGTAAATGATCTTCACTCCTTATCCGAGGGCAAATTCACAAGGATCCCCAAGAT CCACTTTTAGAAGCCATTCTCATCCAGCAGTGAGAAGCTTCCAGGTAGGACAGAAAAAAGATCC AGCTTCAGCTGCACACCTCTGTCCCCTTGGATGGGGAACTAAGGGAAAACGTCTGTTGTATCAC TGAAGTTTTTTGTTTTGTTTTTATACGTGTCTGAATAAAAATGCCAAAGTTTTTTTTCAGCAAA AAAAA Download Select all
Length	5765

CDS Information

Location	join(277..358,3727..3878,4971..5157,6507..6632,7553..7618, 7771..7889,7997..8138,8519..8632,8724..8844,12723..12796, 12962..13052,13321..13526,13740..13872,14075..14165, 14378..14532,15233..15286,15641..15782,16479..16598, 16724..16822,17021..17206,17761..17916,18476..18551, 18735..18881,19624..19721,19814..20005,20150..20221, 21037..21337,21505..22031)
CDS Sequence	>gi\|317171925:277-4305 Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3), transcript variant 1, mRNA ATGAGGGCGAACGACGCTCTGCAGGTGCTGGGCTTGCTTTTCAGCCTGGCCCGGGGCTCCGAGGTGGGCA ACTCTCAGGCAGTGTGTCCTGGGACTCTGAATGGCCTGAGTGTGACCGGCGATGCTGAGAACCAATACCA GACACTGTACAAGCTCTACGAGAGGTGTGAGGTGGTGATGGGGAACCTTGAGATTGTGCTCACGGGACAC AATGCCGACCTCTCCTTCCTGCAGTGGATTCGAGAAGTGACAGGCTATGTCCTCGTGGCCATGAATGAAT TCTCTACTCTACCATTGCCCAACCTCCGCGTGGTGCGAGGGACCCAGGTCTACGATGGGAAGTTTGCCAT CTTCGTCATGTTGAACTATAACACCAACTCCAGCCACGCTCTGCGCCAGCTCCGCTTGACTCAGCTCACC GAGATTCTGTCAGGGGGTGTTTATATTGAGAAGAACGATAAGCTTTGTCACATGGACACAATTGACTGGA GGGACATCGTGAGGGACCGAGATGCTGAGATAGTGGTGAAGGACAATGGCAGAAGCTGTCCCCCCTGTCA TGAGGTTTGCAAGGGGCGATGCTGGGGTCCTGGATCAGAAGACTGCCAGACATTGACCAAGACCATCTGT GCTCCTCAGTGTAATGGTCACTGCTTTGGGCCCAACCCCAACCAGTGCTGCCATGATGAGTGTGCCGGGG GCTGCTCAGGCCCTCAGGACACAGACTGCTTTGCCTGCCGGCACTTCAATGACAGTGGAGCCTGTGTACC TCGCTGTCCACAGCCTCTTGTCTACAACAAGCTAACTTTCCAGCTGGAACCCAATCCCCACACCAAGTAT CAGTATGGAGGAGTTTGTGTAGCCAGCTGTCCCCATAACTTTGTGGTGGATCAAACATCCTGTGTCAGGG CCTGTCCTCCTGACAAGATGGAAGTAGATAAAAATGGGCTCAAGATGTGTGAGCCTTGTGGGGGACTATG TCCCAAAGCCTGTGAGGGAACAGGCTCTGGGAGCCGCTTCCAGACTGTGGACTCGAGCAACATTGATGGA TTTGTGAACTGCACCAAGATCCTGGGCAACCTGGACTTTCTGATCACCGGCCTCAATGGAGACCCCTGGC ACAAGATCCCTGCCCTGGACCCAGAGAAGCTCAATGTCTTCCGGACAGTACGGGAGATCACAGGTTACCT GAACATCCAGTCCTGGCCGCCCCACATGCACAACTTCAGTGTTTTTTCCAATTTGACAACCATTGGAGGC AGAAGCCTCTACAACCGGGGCTTCTCATTGTTGATCATGAAGAACTTGAATGTCACATCTCTGGGCTTCC GATCCCTGAAGGAAATTAGTGCTGGGCGTATCTATATAAGTGCCAATAGGCAGCTCTGCTACCACCACTC TTTGAACTGGACCAAGGTGCTTCGGGGGCCTACGGAAGAGCGACTAGACATCAAGCATAATCGGCCGCGC AGAGACTGCGTGGCAGAGGGCAAAGTGTGTGACCCACTGTGCTCCTCTGGGGGATGCTGGGGCCCAGGCC CTGGTCAGTGCTTGTCCTGTCGAAATTATAGCCGAGGAGGTGTCTGTGTGACCCACTGCAACTTTCTGAA TGGGGAGCCTCGAGAATTTGCCCATGAGGCCGAATGCTTCTCCTGCCACCCGGAATGCCAACCCATGGAG GGCACTGCCACATGCAATGGCTCGGGCTCTGATACTTGTGCTCAATGTGCCCATTTTCGAGATGGGCCCC ACTGTGTGAGCAGCTGCCCCCATGGAGTCCTAGGTGCCAAGGGCCCAATCTACAAGTACCCAGATGTTCA GAATGAATGTCGGCCCTGCCATGAGAACTGCACCCAGGGGTGTAAAGGACCAGAGCTTCAAGACTGTTTA GGACAAACACTGGTGCTGATCGGCAAAACCCATCTGACAATGGCTTTGACAGTGATAGCAGGATTGGTAG TGATTTTCATGATGCTGGGCGGCACTTTTCTCTACTGGCGTGGGCGCCGGATTCAGAATAAAAGGGCTAT GAGGCGATACTTGGAACGGGGTGAGAGCATAGAGCCTCTGGACCCCAGTGAGAAGGCTAACAAAGTCTTG GCCAGAATCTTCAAAGAGACAGAGCTAAGGAAGCTTAAAGTGCTTGGCTCGGGTGTCTTTGGAACTGTGC ACAAAGGAGTGTGGATCCCTGAGGGTGAATCAATCAAGATTCCAGTCTGCATTAAAGTCATTGAGGACAA GAGTGGACGGCAGAGTTTTCAAGCTGTGACAGATCATATGCTGGCCATTGGCAGCCTGGACCATGCCCAC ATTGTAAGGCTGCTGGGACTATGCCCAGGGTCATCTCTGCAGCTTGTCACTCAATATTTGCCTCTGGGTT CTCTGCTGGATCATGTGAGACAACACCGGGGGGCACTGGGGCCACAGCTGCTGCTCAACTGGGGAGTACA AATTGCCAAGGGAATGTACTACCTTGAGGAACATGGTATGGTGCATAGAAACCTGGCTGCCCGAAACGTG CTACTCAAGTCACCCAGTCAGGTTCAGGTGGCAGATTTTGGTGTGGCTGACCTGCTGCCTCCTGATGATA AGCAGCTGCTATACAGTGAGGCCAAGACTCCAATTAAGTGGATGGCCCTTGAGAGTATCCACTTTGGGAA ATACACACACCAGAGTGATGTCTGGAGCTATGGTGTGACAGTTTGGGAGTTGATGACCTTCGGGGCAGAG CCCTATGCAGGGCTACGATTGGCTGAAGTACCAGACCTGCTAGAGAAGGGGGAGCGGTTGGCACAGCCCC AGATCTGCACAATTGATGTCTACATGGTGATGGTCAAGTGTTGGATGATTGATGAGAACATTCGCCCAAC CTTTAAAGAACTAGCCAATGAGTTCACCAGGATGGCCCGAGACCCACCACGGTATCTGGTCATAAAGAGA GAGAGTGGGCCTGGAATAGCCCCTGGGCCAGAGCCCCATGGTCTGACAAACAAGAAGCTAGAGGAAGTAG AGCTGGAGCCAGAACTAGACCTAGACCTAGACTTGGAAGCAGAGGAGGACAACCTGGCAACCACCACACT GGGCTCCGCCCTCAGCCTACCAGTTGGAACACTTAATCGGCCACGTGGGAGCCAGAGCCTTTTAAGTCCA TCATCTGGATACATGCCCATGAACCAGGGTAATCTTGGGGAGTCTTGCCAGGAGTCTGCAGTTTCTGGGA GCAGTGAACGGTGCCCCCGTCCAGTCTCTCTACACCCAATGCCACGGGGATGCCTGGCATCAGAGTCATC AGAGGGGCATGTAACAGGCTCTGAGGCTGAGCTCCAGGAGAAAGTGTCAATGTGTAGGAGCCGGAGCAGG AGCCGGAGCCCACGGCCACGCGGAGATAGCGCCTACCATTCCCAGCGCCACAGTCTGCTGACTCCTGTTA CCCCACTCTCCCCACCCGGGTTAGAGGAAGAGGATGTCAACGGTTATGTCATGCCAGATACACACCTCAA AGGTACTCCCTCCTCCCGGGAAGGCACCCTTTCTTCAGTGGGTCTCAGTTCTGTCCTGGGTACTGAAGAA GAAGATGAAGATGAGGAGTATGAATACATGAACCGGAGGAGAAGGCACAGTCCACCTCATCCCCCTAGGC CAAGTTCCCTTGAGGAGCTGGGTTATGAGTACATGGATGTGGGGTCAGACCTCAGTGCCTCTCTGGGCAG CACACAGAGTTGCCCACTCCACCCTGTACCCATCATGCCCACTGCAGGCACAACTCCAGATGAAGACTAT GAATATATGAATCGGCAACGAGATGGAGGTGGTCCTGGGGGTGATTATGCAGCCATGGGGGCCTGCCCAG CATCTGAGCAAGGGTATGAAGAGATGAGAGCTTTTCAGGGGCCTGGACATCAGGCCCCCCATGTCCATTA TGCCCGCCTAAAAACTCTACGTAGCTTAGAGGCTACAGACTCTGCCTTTGATAACCCTGATTACTGGCAT AGCAGGCTTTTCCCCAAGGCTAATGCCCAGAGAACGTAA Download Select all
CCDS ID	CCDS31833.1

Protein Information

Protein ID	NP_001005915.1
Protein Name	V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Molecular Wt. (Da)	18109
Protein Sequence	>2065 MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLE IVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSS HALRQLRLTQLTGQFPMVPSGLTPQPAQDWYLLDDDPRLLTLSASSKVPVTLAAV Download Select all
Length	183
Uniprot ID	P00751
Ensembl Protein ID	ENSP00000382862

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
Y	Phosphorylation	1199
Y	Phosphorylation	1262
Y	Phosphorylation	1276
Y	Phosphorylation	1289
Y	Phosphorylation	1328
S	Phosphorylation	1123
T	Phosphorylation	873
Y	Phosphorylation	1054
Y	Phosphorylation	1197
Y	Phosphorylation	1222
Y	Phosphorylation	1260
S	Phosphorylation	686
Y	Phosphorylation	1327

Enzyme Information

EC	2.7.10.1
Name	receptor protein-tyrosine kinase AATK AATYK AATYK2 AATYK3 ACH ALK anaplastic lymphoma kinase ARK ATP:protein-tyrosine O-phosphotransferase (ambiguous) AXL Bek Bfgfr BRT Bsk C-FMS CAK CCK4 CD115 CD135 CDw135 Cek1 Cek10 Cek11 Cek2 Cek3 Cek5 Cek6 Cek7 CFD1 CKIT CSF1R DAlk DDR1 DDR2 Dek DKFZp434C1418 Drosophila Eph kinase DRT DTK Ebk ECK EDDR1 Eek EGFR Ehk2 Ehk3 Elk EPH EPHA1 EPHA2 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EphB5 ephrin-B3 receptor tyrosine kinase EPHT EPHT2 EPHT3 EPHX ERBB ERBB1 ERBB2 ERBB3 ERBB4 ERK Eyk FGFR1 FGFR2 FGFR3 FGFR4 FLG FLK1 FLK2 FLT1 FLT2 FLT3 FLT4 FMS Fv2 HBGFR HEK11 HEK2 HEK3 HEK5 HEK6 HEP HER2 HER3 HER4 HGFR HSCR1 HTK IGF1R INSR INSRR insulin receptor protein-tyrosine kinase IR IRR JTK12 JTK13 JTK14 JWS K-SAM KDR KGFR KIA0641 KIAA1079 KIAA1459 Kil Kin15 Kin16 KIT KLG LTK MCF3 Mdk1 Mdk2 Mdk5 MEhk1 MEN2A/B Mep MER MERTK MET Mlk1 Mlk2 Mrk MST1R MTC1 MUSK Myk1 N-SAM NEP NET Neu neurite outgrowth regulating kinase NGL NOK nork novel oncogene with kinase-domain Nsk2 NTRK1 NTRK2 NTRK3 NTRK4 NTRKR1 NTRKR2 NTRKR3 Nuk NYK PCL PDGFR PDGFRA PDGFRB PHB6 protein-tyrosine kinase (ambiguous) protein tyrosine kinase (ambiguous) PTK PTK3 PTK7 receptor protein tyrosine kinase RET RON ROR1 ROR2 ROS1 RSE RTK RYK SEA Sek2 Sek3 Sek4 Sfr SKY STK STK1 TEK TIE TIE1 TIE2 TIF TKT TRK TRKA TRKB TRKC TRKE TYK1 TYRO10 Tyro11 TYRO3 Tyro5 Tyro6 TYRO7 UFO VEGFR1 VEGFR2 VEGFR3 Vik YK1 Yrk
Class	Transferases; Transferring phosphorus-containing groups; Protein-tyrosine kinases
Sysname	ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
Substrate	ATP [CPD:C00002]; [protein]-L-tyrosine
Product	ADP [CPD:C00008]; [protein]-L-tyrosine phosphate
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
1950	EGF	578	NP_001954.2	in vitro	12093292
1956	EGFR	579	NP_005219.2	in vivo	10527633
2064	ERBB2	1281	NP_004439.2	in vitro;in vivo	11 173 924 753 865 600 000 000
2316	FLNA	2060	NP_001104026.1	in vitro;in vivo	16729043
2885	GRB2	150	NP_002077.1	in vitro	1 117 392 416 729 040
3084	NRG1	802	NP_039250.2	in vitro	75 926 811 155 564 900 000 000 000 000
4582	MUC1	1152	P15941	in vivo	1 127 886 812 939 400
5295	PIK3R1	1381	NP_852664.1	in vitro;in vivo;yeast 2-hybrid	1 038 315 111 546 790
5296	PIK3R2	4404	NP_005018.1	in vitro;in vivo	16729043
6654	SOS1	1681	NP_005624.2	in vitro;in vivo	11173924
10156	RASA4	12135	NP_008920.4	yeast 2-hybrid	16169070
10193	RNF41	11520	NP_005776.1	in vitro	12411582
57489	ODF2L	11134	NP_001007023.1	yeast 2-hybrid	16169070
84256	FLYWCH1	13222	NP_115672.2	yeast 2-hybrid	16169070

Pathway Information

Pathway Name	Pathway ID
Calcium signaling pathway	hsa04020
Endocytosis	hsa04144
ErbB signaling pathway	hsa04012
MicroRNAs in cancer	hsa05206
Proteoglycans in cancer	hsa05205

Structure Information

PDB ID	1M6B
Resolution	2.6
Method	X-RAY DIFFRACTION
Chains	A,B
Molecule	Receptor protein-tyrosine kinase erbB-3
Model	View

Domain Information

ID	Location	Description
cd05111	701-979	PTK_HER3
cl21453	701-979	PKc_like superfamily
cd12095	638-676	TM_ErbB3
cl17045	638-676	TM_EGFR-like superfamily
cd00064	226-266	FU
cl00066	226-266	FU superfamily
cd00064	552-592	FU
cl00066	552-592	FU superfamily
cd00064	500-553	FU
cl00066	500-553	FU superfamily
cd05057	701-979	PTKc_EGFR_like
cd05108	702-979	PTKc_EGFR
cd05109	702-979	PTKc_HER2
cd05110	702-979	PTKc_HER4
cd00192	713-966	PTKc
cd05060	715-972	PTKc_Syk_like
cd05040	713-961	PTKc_Ack_like
cd05038	704-969	PTKc_Jak_rpt2
cd05056	713-962	PTKc_FAK
cd05039	705-967	PTKc_Csk_like
cd05034	713-965	PTKc_Src_like
cd05059	708-966	PTKc_Tec_like
cd05033	713-968	PTKc_EphR
cd05053	689-968	PTKc_FGFR
cd05052	715-968	PTKc_Abl
cd05068	707-961	PTKc_Frk_like
cd05116	715-958	PTKc_Syk
cd05148	708-964	PTKc_Srm_Brk
cd05058	713-964	PTKc_Met_Ron
cd05045	713-968	PTKc_RET
cd05115	715-963	PTKc_Zap-70
cd05041	715-966	PTKc_Fes_like
cd05044	713-964	PTKc_c-ros
cd05051	704-961	PTKc_DDR
cd05032	715-961	PTKc_InsR_like
cd05035	713-961	PTKc_TAM
cd05055	713-961	PTKc_PDGFR
cd05083	713-968	PTKc_Chk
cd05114	707-969	PTKc_Tec_Rlk
cd05063	711-963	PTKc_EphR_A2
cd05081	704-962	PTKc_Jak3_rpt2
cd05112	707-966	PTKc_Itk
cd13999	715-965	STKc_MAP3K-like
cd05048	709-963	PTKc_Ror
cd05082	708-961	PTKc_Csk
cd05080	704-968	PTKc_Tyk2_rpt2
cd14205	704-962	PTKc_Jak2_rpt2
cd05065	713-968	PTKc_EphR_B
cd05099	689-968	PTKc_FGFR4
cd05085	713-966	PTKc_Fer
cd05113	708-961	PTKc_Btk_Bmx
cd14204	713-973	PTKc_Mer
cd05072	709-961	PTKc_Lyn
cd05066	713-968	PTKc_EphR_A
cd05067	709-963	PTKc_Lck_Blk
cd05047	714-968	PTKc_Tie
cd05075	713-973	PTKc_Axl
cd05100	704-968	PTKc_FGFR3
cd05043	710-961	PTK_Ryk
cd05101	704-968	PTKc_FGFR2
cd05064	713-968	PTKc_EphR_A10
cd05049	713-962	PTKc_Trk
cd05089	714-968	PTKc_Tie1
cd14203	713-961	PTKc_Src_Fyn_like
cd05073	709-961	PTKc_Hck
cd05036	709-958	PTKc_ALK_LTK
cd05079	704-968	PTKc_Jak1_rpt2
cd05054	704-964	PTKc_VEGFR
cd05098	713-968	PTKc_FGFR1
cd05074	713-965	PTKc_Tyro3
cd00180	715-961	PKc
cd05070	709-961	PTKc_Fyn
cd05092	715-967	PTKc_TrkA
cd05046	703-964	PTK_CCK4
cd05050	715-961	PTKc_Musk
cd05088	714-976	PTKc_Tie2
cd05090	707-961	PTKc_Ror1
cd05071	715-961	PTKc_Src
cd05091	707-963	PTKc_Ror2
cd05097	704-961	PTKc_DDR_like
cd05103	704-961	PTKc_VEGFR2
cd05069	715-959	PTKc_Yes
cd05094	715-973	PTKc_TrkC
cd05084	767-965	PTKc_Fes
cd05093	715-976	PTKc_TrkB
cd05102	704-961	PTKc_VEGFR3
cd14207	704-961	PTKc_VEGFR1
cd05061	712-963	PTKc_InsR
cd05095	715-961	PTKc_DDR2
pfam01030	56-167	Recep_L_domain
cl08303	56-167	Recep_L_domain superfamily
pfam01030	353-474	Recep_L_domain
cl08303	353-474	Recep_L_domain superfamily
cd05106	704-970	PTKc_CSF-1R
cd05096	704-961	PTKc_DDR1
cd05105	811-963	PTKc_PDGFR_alpha
cd05104	704-961	PTKc_Kit
cd14060	716-968	STKc_MLTK
cd14061	714-968	STKc_MLK
cd05107	811-968	PTKc_PDGFR_beta
cd05062	715-963	PTKc_IGF-1R
cd14066	715-968	STKc_IRAK
cd14146	714-966	STKc_MLK4
cd14145	707-966	STKc_MLK1
cd14059	715-961	STKc_MAP3K12_13
cd14147	708-968	STKc_MLK3
cd14058	715-961	STKc_TAK1
cd14148	714-966	STKc_MLK2
cd06627	715-961	STKc_Cdc7_like
cd05037	715-966	PTK_Jak_rpt1
cd05122	708-912	PKc_STE
cd14206	765-961	PTKc_Aatyk3
cd06606	708-906	STKc_MAPKKK
cd14664	715-925	STK_BAK1_like
cd05087	712-961	PTKc_Aatyk1
cd14014	710-920	STKc_PknB_like
cd05042	713-961	PTKc_Aatyk
cd14062	715-961	STKc_Raf
cd14150	708-915	STKc_A-Raf
cd06632	710-964	STKc_MEKK1_plant
cd13978	715-964	STKc_RIP
cd14151	715-971	STKc_B-Raf
cd06610	712-961	STKc_OSR1_SPAK
cd06642	706-961	STKc_STK25
cd06612	706-961	STKc_MST1_2
cd14149	707-916	STKc_C-Raf
cd14063	708-970	PK_KSR
cd14009	715-933	STKc_ATG1_ULK_like
cd06623	708-961	PKc_MAPKK_plant_like
cd06609	708-961	STKc_MST3_like
cd06628	714-961	STKc_Byr2_like
cd14064	715-960	PKc_TNNI3K
cd06631	710-961	STKc_YSK4
cd13979	708-957	STKc_Mos
cd06640	706-961	STKc_MST4
cd06641	706-961	STKc_MST3
cd14154	715-971	STKc_LIMK
cd08530	712-961	STKc_CNK2-like
cd06625	710-965	STKc_MEKK3_like
cd05117	713-899	STKc_CAMK
cd05078	715-961	PTK_Jak2_rpt1
cd14065	715-964	PKc_LIMK_like
cd08222	710-963	STKc_Nek11
cd08215	710-907	STKc_Nek
cd06613	712-961	STKc_MAP4K3_like
cd14158	715-906	STKc_IRAK4
cd14208	715-964	PTK_Jak3_rpt1
cd14003	712-912	STKc_AMPK-like
cd06605	708-913	PKc_MAPKK
cd06917	707-926	STKc_NAK1_like
cd14121	715-926	STKc_ULK3
cd14222	715-969	STKc_LIMK2
cd05086	766-961	PTKc_Aatyk2
cd14098	712-927	STKc_Rad53_Cds1
cd14221	715-961	STKc_LIMK1
cd06611	715-961	STKc_SLK_like
cd06614	709-963	STKc_PAK
cd14008	715-914	STKc_LKB1_CaMKK
cd06629	711-964	STKc_Bck1_like
cd14000	714-957	STKc_LRRK
cd06626	711-915	STKc_MEKK4
cd14027	765-966	STKc_RIP1
cd08225	712-914	STKc_Nek5
cd14155	766-970	PKc_TESK
cd06620	705-961	PKc_Byr1_like
cd08529	712-907	STKc_FA2-like
cd14192	713-919	STKc_MLCK3
cd06652	707-906	STKc_MEKK2
cd06643	715-954	STKc_SLK
cd06644	715-904	STKc_STK10
cd07832	715-905	STKc_CCRK
cd14010	715-926	STKc_ULK4
cd06651	710-906	STKc_MEKK3
cd06607	712-904	STKc_TAO
cd14120	715-913	STKc_ULK1_2-like
cd08220	711-961	STKc_Nek8
cd13983	714-913	STKc_WNK
cd14071	736-922	STKc_SIK
cd06633	712-904	STKc_TAO3
cd14081	713-926	STKc_BRSK1_2
cd13992	729-959	PK_GC
cd06653	710-906	STKc_MEKK3_like_u1
cd05118	710-906	STKc_CMGC
cd06624	714-912	STKc_ASK
cd14202	708-935	STKc_ULK1
cd14070	713-912	STKc_HUNK
cd06630	754-912	STKc_MEKK1
cd14080	712-912	STKc_TSSK-like
cd14156	715-969	PKc_LIMK_like_unk
cd14072	710-928	STKc_MARK
cd06621	708-904	PKc_Pek1_like
cd14137	705-906	STKc_GSK3
cd06634	712-904	STKc_TAO2
cd13998	714-904	STKc_TGFbR-like
cd06636	712-911	STKc_MAP4K4_6_N
cd06622	708-963	PKc_PBS2_like
cd06635	712-904	STKc_TAO1
cd14054	714-906	STKc_BMPR2_AMHR2
cd05578	712-912	STKc_Yank1
cd14012	748-961	PK_eIF2AK_GCN2_rpt1
cd06608	712-904	STKc_myosinIII_N_like
cd14002	712-912	STKc_STK36
cd14161	712-914	STKc_NUAK2
cd08219	712-907	STKc_Nek3
cd14099	710-912	STKc_PLK
cd05592	713-914	STKc_nPKC_theta_like
cd14068	714-933	STKc_LRRK2
cd06638	712-961	STKc_myosinIIIA_N
cd14193	709-914	STKc_MLCK4
cd07870	712-926	STKc_PFTAIRE2
cd05123	781-912	STKc_AGC
cd14045	739-968	PK_GC_unk
cd14006	715-914	STKc_MLCK-like
cd06645	700-904	STKc_MAP4K3
cd06618	816-967	PKc_MKK7
cd14073	712-914	STKc_NUAK
cd14162	713-912	STKc_TSSK4-like
cd06647	710-912	STKc_PAK_I
cd14152	715-970	STKc_KSR1
cd13994	765-906	STKc_HAL4_like
cd07841	711-905	STKc_CDK7
cd14186	712-912	STKc_PLK4
cd13997	708-961	PKc_Wee1_like
cd05076	737-966	PTK_Tyk2_rpt1
cd14201	708-935	STKc_ULK2
cd06637	701-911	STKc_TNIK
cd08221	766-961	STKc_Nek9
cd13996	704-904	STKc_EIF2AK
cd14077	712-905	STKc_Kin1_2
cd14055	713-906	STKc_TGFbR2_like
cd05077	715-964	PTK_Jak1_rpt1
cd06619	708-912	PKc_MKK5
cd05580	707-912	STKc_PKA_like
cd06646	715-904	STKc_MAP4K5
cd14056	713-913	STKc_TGFbR_I
cd05602	705-935	STKc_SGK1
cd08223	711-906	STKc_Nek4
cd14097	715-928	STKc_STK33
cd14082	713-902	STKc_PKD
cd06648	768-912	STKc_PAK_II
cd14042	739-971	PK_GC-A_B
cd14663	712-928	STKc_SnRK3
cd14075	715-916	STKc_NIM1
cd06650	793-911	PKc_MEK1
cd14167	713-912	STKc_CaMKI_alpha
cd14076	712-912	STKc_Kin4
cd05613	712-912	STKc_MSK1_N
cd14033	715-913	STKc_WNK4
cd07830	712-856	STKc_MAK_like
cd07869	705-926	STKc_PFTAIRE1
cd05616	712-914	STKc_cPKC_beta
cd14153	713-970	PK_KSR2
cd06659	780-912	STKc_PAK6
cd08218	710-906	STKc_Nek1
cd14142	712-904	STKc_ACVR1_ALK1
cd14190	713-983	STKc_MLCK2
cd05615	705-914	STKc_cPKC_alpha
cd05581	713-906	STKc_PDK1
cd14048	707-905	STKc_EIF2AK3_PERK
cd14007	712-920	STKc_Aurora
cd05620	713-914	STKc_nPKC_delta
cd05614	781-935	STKc_MSK2_N
cd14100	714-963	STKc_PIM1
cd14001	712-906	PKc_TOPK
cd05619	782-914	STKc_nPKC_theta
cd14087	712-912	STKc_PSKH1
cd07836	710-906	STKc_Pho85
cd14078	715-905	STKc_MELK
cd14044	818-968	PK_GC-C
cd07840	710-906	STKc_CDK9_like
cd14191	715-914	STKc_MLCK1
cd14107	715-914	STKc_obscurin_rpt1
cd07845	707-906	STKc_CDK10
cd14031	715-913	STKc_WNK3
cd07862	715-904	STKc_CDK6
cd14079	713-905	STKc_AMPK_alpha
cd07833	765-961	STKc_CDKL
cd14179	706-912	STKc_MSK1_C
cd07829	710-856	STKc_CDK_like
cd06615	707-906	PKc_MEK
cd14118	818-953	STKc_CAMKK
cd05582	817-934	STKc_RSK_N
cd05583	781-913	STKc_MSK_N
cd14032	715-913	STKc_WNK2_like
cd14043	754-970	PK_GC-2D
cd14166	712-912	STKc_CaMKI_gamma
cd06616	704-968	PKc_MKK4
cd05612	708-914	STKc_PRKX_like
cd14026	712-906	STKc_RIP2
cd14086	715-905	STKc_CaMKII
cd08224	713-907	STKc_Nek6_7
cd07838	715-856	STKc_CDK4_6_like
cd06658	780-912	STKc_PAK5
cd06655	715-912	STKc_PAK2
cd14083	713-899	STKc_CaMKI
cd14180	785-916	STKc_MSK2_C
cd14116	713-912	STKc_Aurora-A
cd14069	713-906	STKc_Chk1
cd05579	781-910	STKc_MAST_like
cd14165	715-912	STKc_TSSK1_2-like
cd14164	712-933	STKc_TSSK6-like
cd14143	714-904	STKc_TGFbR1_ACVR1b_ACVR1c
cd13988	715-912	STKc_TBK1
cd14084	708-899	STKc_Chk2
cd14047	704-935	STKc_EIF2AK2_PKR
cd14144	713-904	STKc_BMPR1
cd14049	817-926	STKc_EIF2AK1_HRI
cd06656	711-970	STKc_PAK3
cd14173	713-914	STKc_Mnk2
cd14133	712-906	PKc_DYRK_like
cd14157	768-906	STKc_IRAK2
cd13975	816-956	PKc_Dusty
cd06654	711-970	STKc_PAK1
cd14168	713-912	STKc_CaMKI_delta
cd14093	714-912	STKc_PhKG
cd06649	704-904	PKc_MEK2
cd14181	714-912	STKc_PhKG2
cd14169	715-912	STKc_CaMKI_beta
cd07834	712-906	STKc_MAPK
cd14046	706-856	STKc_EIF2AK4_GCN2_rpt2
cd06617	707-913	PKc_MKK3_6
cd05618	781-922	STKc_aPKC_iota
cd14053	785-906	STKc_ACVR2
cd14005	713-906	STKc_PIM
cd14091	740-913	STKc_RSK_C
cd14025	715-964	STKc_RIP4_like
cd14200	766-912	STKc_CaMKK1
cd14175	741-913	STKc_RSK1_C
cd08228	713-917	STKc_Nek6
cd07863	715-904	STKc_CDK4
cd08528	712-907	STKc_Nek10
cd05587	783-914	STKc_cPKC
cd13993	709-964	STKc_Pat1_like
cd13989	715-912	STKc_IKK
cd07873	711-906	STKc_PCTAIRE1
cd05611	780-922	STKc_Rim15_like
cd14108	817-914	STKc_SPEG_rpt1
cd07835	765-856	STKc_CDK1_CdkB_like
cd14187	765-964	STKc_PLK1
cd14038	715-912	STKc_IKK_beta
cd14176	741-913	STKc_RSK2_C
cd14189	765-919	STKc_PLK3
cd07839	711-926	STKc_CDK5
cd14220	713-904	STKc_BMPR1a
cd05603	713-922	STKc_SGK2
cd14103	715-914	STKc_MLCK
cd05604	712-937	STKc_SGK3
cd08217	712-963	STKc_Nek2
cd06657	780-912	STKc_PAK4
cd14174	713-914	STKc_Mnk1
cd14197	781-914	STKc_DRAK1
cd14113	715-912	STKc_Trio_C
cd14092	739-899	STKc_MSK_C
cd14171	703-912	STKc_MAPKAPK5
cd14140	713-906	STKc_ACVR2b
cd05630	709-928	STKc_GRK6
cd08229	713-917	STKc_Nek7
cd14209	712-913	STKc_PKA
cd12087	639-675	TM_EGFR-like
cd05572	715-914	STKc_cGK
cd14114	712-914	STKc_Twitchin_like
cd14212	712-904	PKc_YAK1
cd14106	817-914	STKc_DRAK
cd13990	765-964	STKc_TLK
cd14085	765-912	STKc_CaMKIV
cd14163	713-905	STKc_TSSK3-like
smart00261	548-592	FU
cd07866	715-856	STKc_BUR1
cd14198	817-914	STKc_DRAK2
cd07831	767-907	STKc_MOK
cd14105	715-979	STKc_DAPK
cd05584	712-914	STKc_p70S6K
cd14178	741-913	STKc_RSK3_C
cd05617	781-912	STKc_aPKC_zeta
cd14104	715-914	STKc_Titin
cd06639	767-904	STKc_myosinIIIB_N
cd14110	754-906	STKc_obscurin_rpt2
cd14665	712-912	STKc_SnRK2-3
cd07846	712-961	STKc_CDKL2_3
cd14160	768-906	PK_IRAK3
cd14199	820-917	STKc_CaMKK2
cd14052	710-903	PTKc_Wee1_fungi
cd07871	711-906	STKc_PCTAIRE3
cd07864	712-906	STKc_CDK12
cd14096	707-905	STKc_RCK1-like
cd14177	741-913	STKc_RSK4_C
cd14119	816-914	STKc_LKB1
cd13986	766-965	STKc_16
cd05632	814-914	STKc_GRK5
cd05601	782-914	STKc_CRIK
smart00261	225-261	FU
cd07861	711-856	STKc_CDK1_euk
cd05570	818-914	STKc_PKC
cd07842	716-906	STKc_CDK8_like
cd07872	711-904	STKc_PCTAIRE2
cd14102	714-912	STKc_PIM3
cd05608	817-905	STKc_GRK1
cd13982	713-912	STKc_IRE1
cd07880	710-906	STKc_p38gamma
cd14188	766-919	STKc_PLK2
cd07853	817-905	STKc_NLK
cd07860	710-906	STKc_CDK2_3
cd13987	715-906	STKc_SBK1
cd07856	699-905	STKc_Sty1_Hog1
cd14050	793-906	PKc_Myt1
cd14185	741-912	STKc_DCKL3
cd14159	768-906	STKc_IRAK1
cd05586	781-912	STKc_Sck1_like
cd14195	715-978	STKc_DAPK3
cd14219	708-904	STKc_BMPR1b
cd05624	783-937	STKc_MRCK_beta
cd14662	712-912	STKc_SnRK2
cd07844	711-926	STKc_PCTAIRE_like
cd05577	783-912	STKc_GRK
cd14074	713-912	STKc_SNRK
cd14089	713-905	STKc_MAPKAPK
cd05595	713-905	STKc_PKB_beta
cd07847	783-906	STKc_CDKL1_4
cd14095	713-899	STKc_DCKL
cd05631	814-979	STKc_GRK4
cd05607	783-912	STKc_GRK7
cd05593	712-905	STKc_PKB_gamma
cd05588	781-922	STKc_aPKC
cd07851	710-906	STKc_p38
cd14183	713-914	STKc_DCKL1
cd14101	714-912	STKc_PIM2
smart00750	793-911	KIND
cd14182	824-912	STKc_PhKG1
cd07843	765-906	STKc_CDC2L1
cd14141	713-904	STKc_ACVR2a
cd14011	726-913	PK_SCY1_like
cd07876	710-905	STKc_JNK2
cd07859	817-906	STKc_TDY_MAPK
cd14090	703-914	STKc_Mnk
cd14184	713-912	STKc_DCKL2
cd07877	710-906	STKc_p38alpha
smart00261	498-534	FU
cd14194	715-979	STKc_DAPK1
cd13985	708-907	STKc_GAK_like
cd05605	817-912	STKc_GRK4_like
cd07852	817-906	STKc_MAPK15-like
cd07837	711-904	STKc_CdkB_plant
cd07878	817-905	STKc_p38beta
cd14112	817-914	STKc_Unc-89_rpt2
cd05627	708-912	STKc_NDR2
cd14196	715-914	STKc_DAPK2
cd14111	816-912	STKc_SPEG_rpt2
cd14094	817-914	STKc_CASK
cd14057	768-968	PK_ILK
cd14117	766-912	STKc_Aurora-B_like
cd07848	712-904	STKc_CDKL5
cd14088	731-912	STKc_CaMK_like
cd14004	712-912	STKc_PASK
cd14226	702-911	PKc_DYRK1
cd07855	817-898	STKc_ERK5
cd07879	711-906	STKc_p38delta
cd14015	792-870	STKc_VRK
cd05585	714-912	STKc_YPK1_like
cd05594	783-905	STKc_PKB_alpha
cd07867	817-911	STKc_CDC2L6
cd05597	828-919	STKc_DMPK_like
cd07854	710-914	STKc_MAPK4_6
cd07868	817-911	STKc_CDK8
cd07849	817-906	STKc_ERK1_2_like
cd05610	712-939	STKc_MASTL
cd05571	783-905	STKc_PKB
cd14131	827-963	PKc_Mps1
cd14051	708-923	PTKc_Wee1
cd05591	783-912	STKc_nPKC_epsilon
cd05599	828-912	STKc_NDR_like
cd13995	768-912	STKc_MAP3K8
cd05623	781-933	STKc_MRCK_alpha
cd14036	768-863	STKc_GAK
cd13977	817-907	STKc_PDIK1L
cd05596	825-912	STKc_ROCK
smart00261	180-215	FU
cl00066	180-215	FU superfamily
cd07858	817-906	STKc_TEY_MAPK
cd14122	809-870	STKc_VRK1
cd05590	783-912	STKc_nPKC_eta
cd07857	817-905	STKc_MPK1
cd07874	817-905	STKc_JNK3
cd05621	782-955	STKc_ROCK2
cd14039	818-912	STKc_IKK_alpha
cd05622	783-912	STKc_ROCK1
pfam11437	190-262	Vanabin-2
cl20094	190-262	Vanabin-2 superfamily
cd07875	817-908	STKc_JNK1
pfam07714	709-965	Pkinase_Tyr
pfam14843	499-630	GF_recep_IV
pfam00757	179-332	Furin-like
smart00219	709-965	TyrKc
smart00221	709-965	STYKc
smart00220	710-961	S_TKc
pfam00069	709-961	Pkinase
COG0515	708-926	SPS1
PLN00034	707-903	PLN00034
pfam14843	185-260	GF_recep_IV
TIGR03903	739-920	TOMM_kin_cyc
PHA03209	817-907	PHA03209
pfam00757	493-592	Furin-like
PTZ00263	715-912	PTZ00263
PTZ00036	714-914	PTZ00036
PHA02988	765-961	PHA02988
PHA03212	818-906	PHA03212
PTZ00024	713-906	PTZ00024
pfam14843	179-243	GF_recep_IV
PTZ00426	691-912	PTZ00426
PTZ00267	817-990	PTZ00267
PLN00009	711-856	PLN00009
PTZ00283	816-920	PTZ00283
PRK13184	817-912	pknD
PHA03207	824-904	PHA03207
PHA03211	817-903	PHA03211
TIGR04105	284-331	FeFe_hydrog_B1

Ontology Information

HPRD ID	718
Molecular Class	Receptor tyrosine kinase
Molecular Function	Complement activity (GO:0003811)
Biological Process	Immune response (GO:0006955)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

Mechanism	Amplification/Mutation
Biomarker	-
Drug Target	-
Biological Process	Cell communication

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO