Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ERBB4 | 2066 | v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4  | 2 | ALS19  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25916654    | 2015 | Cell line : - Source : The Cancer Genome Atlas colorectal cancer (CRC) data set, Moffitt Cancer Center and Vanderbilt Medical Center CRC expression data set and CRC tissue banks Sample Type : - No. of Sample : - Stage : - | western blotting, immunohistochemistry | Up-regulation | - | ERBB4 as a novel therapeutic target in a subset of CRC |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]   |
| Chromosome | 2 |
| Location | 2q33.3-q34 |
| Start | 212240442   |
| End | 213403879   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 1163438   |
| OMIM ID | 600543    |
| HGNC ID | HGNC:3432    |
| Unigene ID | Hs.390729    |
| Ensembl ID | ENSG00000178568    |
| PharmGKB ID | PA27847    |
mRNA Information
| mRNA ID | XM_005246377.1 |
|---|---|
| Exon | join(1..707,414253..414404,591540..591726,750997..751131, 788452..788517,813962..814080,816622..816763, 825508..825621,826980..827106,833765..833838, 834962..835052,836990..837189,859972..860104, 865899..865992,873679..873833,881162..881206, 908562..908694,915112..915234,919881..919979, 977068..977253,1108056..1108211,1110673..1110748, 1114855..1115001,1117052..1117149,1118545..1118715, 1152006..1152303,1155096..1163439)   | mRNA Sequence |    Download   Select all |
| Length | 12372   |
CDS Information
| Location | 626..4474 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS2394.1 |    
Protein Information
| Protein ID | XP_005246434.1 |
|---|---|
| Protein Name | v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 |
| Molecular Wt. (Da) | 143838 |
| Protein Sequence |    Download   Select all |
| Length | 1282   |
| Uniprot ID | Q13163 |    
| Ensembl Protein ID | ENSP00000178640   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| V | Proteolytic Cleavage | 673 |
| Y | Phosphorylation | 733 |
| Y | Phosphorylation | 984 |
| Y | Phosphorylation | 1022 |
| Y | Phosphorylation | 1056 |
| Y | Phosphorylation | 1162 |
| Y | Phosphorylation | 1188 |
| Y | Phosphorylation | 1202 |
| Y | Phosphorylation | 1208 |
| Y | Phosphorylation | 1221 |
| Y | Phosphorylation | 1242 |
| Y | Phosphorylation | 1268 |
| Y | Phosphorylation | 1284 |
| Y | Phosphorylation | 733 |
| Y | Phosphorylation | 984 |
| Y | Phosphorylation | 1022 |
| Y | Phosphorylation | 1242 |
| Y | Phosphorylation | 1268 |
| Y | Phosphorylation | 157 |
| S | Phosphorylation | 173 |
| S | Phosphorylation | 183 |
| Y | Phosphorylation | 157 |
| S | Phosphorylation | 173 |
| S | Phosphorylation | 183 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 685 |    BTC |    2643 |    NP_001720.1 |    in vivo |    11254912    |
| 960 |    CD44 |    115 |    NP_000601.3 |    in vitro;in vivo |    11825873    |
| 1398 |    CRK |    1267 |    NP_058431.2 |    in vitro;in vivo |    16729043    |
| 1490 |    CTGF |    412 |    NP_001892.1 |    in vitro |    12297288    |
| 1741 |    DLG3 |    2177 |    NP_066943.2 |    in vitro;in vivo;yeast 2-hybrid |    1   217   585   310   725   390    |
| 1839 |    HBEGF |    526 |    NP_001936.1 |    in vitro;in vivo |    9135143    |
| 2064 |    ERBB2 |    1281 |    NP_004439.2 |    in vitro |    16767099    |
| 2065 |    ERBB3 |    1820 |    NP_001973.2 |    in vitro;in vivo |    7689552    |
| 2885 |    GRB2 |    150 |    NP_002077.1 |    in vitro;in vivo |    16729043    |
| 3084 |    NRG1 |    802 |    NP_039250.2 |    in vitro;in vivo |    80   628   281   053   735   600   000   000   000   000    |
| 4582 |    MUC1 |    1152 |    P15941 |    in vivo |    1   127   886   812   939   400    |
| 5296 |    PIK3R2 |    4404 |    NP_005018.1 |    in vitro;in vivo |    16729043    |
| 6464 |    SHC1 |    2780 |    NP_001123512.1 |    in vitro;in vivo |    16729043    |
| 6645 |    SNTB2 |    2491 |    NP_006741.1 |    in vitro;in vivo;yeast 2-hybrid |    10725395    |
| 6777 |    STAT5B |    5037 |    NP_036580.2 |    in vitro;in vivo |    16729043    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Calcium signaling pathway |    hsa04020 |    
| Endocytosis |    hsa04144 |    
| ErbB signaling pathway |    hsa04012 |    
| Proteoglycans in cancer |    hsa05205 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05110 | 710-1012  | PTKc_HER4 |
| cl21453 | 710-1012  | PKc_like superfamily |
| cd12092 | 642-685  | TM_ErbB4 |
| cl17045 | 642-685  | TM_EGFR-like superfamily |
| cd00064 | 229-274  | FU |
| cl00066 | 229-274  | FU superfamily |
| cd00064 | 554-596  | FU |
| cl00066 | 554-596  | FU superfamily |
| cd00064 | 503-553  | FU |
| cl00066 | 503-553  | FU superfamily |
| cd05057 | 710-988  | PTKc_EGFR_like |
| cd05108 | 710-1022  | PTKc_EGFR |
| cd05109 | 710-988  | PTKc_HER2 |
| cd05111 | 711-988  | PTK_HER3 |
| cd00192 | 722-974  | PTKc |
| cd05060 | 724-982  | PTKc_Syk_like |
| cd05056 | 717-975  | PTKc_FAK |
| cd05040 | 722-970  | PTKc_Ack_like |
| cd05038 | 718-978  | PTKc_Jak_rpt2 |
| cd05034 | 722-974  | PTKc_Src_like |
| cd05033 | 716-977  | PTKc_EphR |
| cd05068 | 716-970  | PTKc_Frk_like |
| cd05059 | 717-970  | PTKc_Tec_like |
| cd05052 | 724-977  | PTKc_Abl |
| cd05039 | 713-976  | PTKc_Csk_like |
| cd05115 | 724-967  | PTKc_Zap-70 |
| cd05053 | 713-977  | PTKc_FGFR |
| cd05058 | 722-975  | PTKc_Met_Ron |
| cd05116 | 724-967  | PTKc_Syk |
| cd13999 | 724-974  | STKc_MAP3K-like |
| cd05041 | 724-973  | PTKc_Fes_like |
| cd05148 | 714-975  | PTKc_Srm_Brk |
| cd05032 | 717-970  | PTKc_InsR_like |
| cd05063 | 718-970  | PTKc_EphR_A2 |
| cd05044 | 722-968  | PTKc_c-ros |
| cd05112 | 716-975  | PTKc_Itk |
| cd05048 | 708-970  | PTKc_Ror |
| cd05085 | 722-975  | PTKc_Fer |
| cd05066 | 722-977  | PTKc_EphR_A |
| cd05067 | 718-970  | PTKc_Lck_Blk |
| cd05035 | 722-977  | PTKc_TAM |
| cd05113 | 713-970  | PTKc_Btk_Bmx |
| cd05065 | 722-977  | PTKc_EphR_B |
| cd05114 | 713-970  | PTKc_Tec_Rlk |
| cd05051 | 715-970  | PTKc_DDR |
| cd14203 | 722-972  | PTKc_Src_Fyn_like |
| cd05081 | 714-973  | PTKc_Jak3_rpt2 |
| cd05036 | 718-967  | PTKc_ALK_LTK |
| cd05099 | 722-977  | PTKc_FGFR4 |
| cd05083 | 722-977  | PTKc_Chk |
| cd05075 | 722-980  | PTKc_Axl |
| cd05045 | 722-977  | PTKc_RET |
| cd05082 | 713-970  | PTKc_Csk |
| cd05079 | 718-977  | PTKc_Jak1_rpt2 |
| cd05072 | 718-970  | PTKc_Lyn |
| cd05049 | 721-972  | PTKc_Trk |
| cd05084 | 724-974  | PTKc_Fes |
| cd14204 | 722-977  | PTKc_Mer |
| cd14205 | 713-971  | PTKc_Jak2_rpt2 |
| cd05074 | 712-974  | PTKc_Tyro3 |
| cd05055 | 722-970  | PTKc_PDGFR |
| cd05098 | 722-977  | PTKc_FGFR1 |
| cd05073 | 718-972  | PTKc_Hck |
| cd05101 | 722-977  | PTKc_FGFR2 |
| cd05100 | 713-977  | PTKc_FGFR3 |
| cd05080 | 718-977  | PTKc_Tyk2_rpt2 |
| cd00180 | 724-970  | PKc |
| cd05047 | 723-977  | PTKc_Tie |
| cd05089 | 717-985  | PTKc_Tie1 |
| cd05070 | 718-982  | PTKc_Fyn |
| cd05050 | 721-970  | PTKc_Musk |
| cd05064 | 713-977  | PTKc_EphR_A10 |
| cd05071 | 724-972  | PTKc_Src |
| cd05061 | 717-970  | PTKc_InsR |
| cd05090 | 724-974  | PTKc_Ror1 |
| cd05069 | 724-982  | PTKc_Yes |
| cd05043 | 723-970  | PTK_Ryk |
| cd05046 | 712-975  | PTK_CCK4 |
| cd05054 | 718-975  | PTKc_VEGFR |
| cd05092 | 724-976  | PTKc_TrkA |
| cd05088 | 712-985  | PTKc_Tie2 |
| cd05091 | 714-970  | PTKc_Ror2 |
| cd05096 | 748-972  | PTKc_DDR1 |
| cd05097 | 724-970  | PTKc_DDR_like |
| cd05095 | 724-970  | PTKc_DDR2 |
| cd14061 | 723-977  | STKc_MLK |
| cd05093 | 724-985  | PTKc_TrkB |
| cd05094 | 713-970  | PTKc_TrkC |
| cd05062 | 724-970  | PTKc_IGF-1R |
| cd14207 | 718-970  | PTKc_VEGFR1 |
| cd05103 | 718-970  | PTKc_VEGFR2 |
| cd14060 | 725-977  | STKc_MLTK |
| cd05106 | 716-979  | PTKc_CSF-1R |
| cd05102 | 722-970  | PTKc_VEGFR3 |
| cd14148 | 723-967  | STKc_MLK2 |
| cd14145 | 716-970  | STKc_MLK1 |
| cd05105 | 722-971  | PTKc_PDGFR_alpha |
| cd14147 | 717-977  | STKc_MLK3 |
| cd14059 | 724-970  | STKc_MAP3K12_13 |
| cd05107 | 722-977  | PTKc_PDGFR_beta |
| cd14146 | 723-967  | STKc_MLK4 |
| cd14058 | 724-970  | STKc_TAK1 |
| pfam01030 | 55-167  | Recep_L_domain |
| cl08303 | 55-167  | Recep_L_domain superfamily |
| cd14066 | 724-977  | STKc_IRAK |
| cd13978 | 724-969  | STKc_RIP |
| cd05104 | 820-970  | PTKc_Kit |
| cd14063 | 717-979  | PK_KSR |
| cd14062 | 724-972  | STKc_Raf |
| cd06627 | 724-970  | STKc_Cdc7_like |
| cd14151 | 724-980  | STKc_B-Raf |
| cd14014 | 721-944  | STKc_PknB_like |
| cd06606 | 717-920  | STKc_MAPKKK |
| cd05037 | 724-970  | PTK_Jak_rpt1 |
| cd14064 | 724-972  | PKc_TNNI3K |
| cd14003 | 721-935  | STKc_AMPK-like |
| pfam01030 | 358-478  | Recep_L_domain |
| cl08303 | 358-478  | Recep_L_domain superfamily |
| cd05122 | 717-970  | PKc_STE |
| cd06623 | 717-970  | PKc_MAPKK_plant_like |
| cd14008 | 724-970  | STKc_LKB1_CaMKK |
| cd14150 | 717-979  | STKc_A-Raf |
| cd05087 | 721-970  | PTKc_Aatyk1 |
| cd14065 | 724-970  | PKc_LIMK_like |
| cd05117 | 722-937  | STKc_CAMK |
| cd14664 | 724-922  | STK_BAK1_like |
| cd08215 | 719-944  | STKc_Nek |
| cd14154 | 724-980  | STKc_LIMK |
| cd14009 | 724-945  | STKc_ATG1_ULK_like |
| cd14149 | 724-970  | STKc_C-Raf |
| cd08222 | 721-970  | STKc_Nek11 |
| cd14080 | 722-935  | STKc_TSSK-like |
| cd14000 | 723-965  | STKc_LRRK |
| cd05042 | 722-970  | PTKc_Aatyk |
| cd14208 | 718-975  | PTK_Jak3_rpt1 |
| cd14027 | 724-974  | STKc_RIP1 |
| cd06632 | 722-970  | STKc_MEKK1_plant |
| cd14206 | 724-975  | PTKc_Aatyk3 |
| cd13992 | 735-968  | PK_GC |
| cd13983 | 723-921  | STKc_WNK |
| cd14221 | 724-970  | STKc_LIMK1 |
| cd06628 | 720-970  | STKc_Byr2_like |
| cd05078 | 724-970  | PTK_Jak2_rpt1 |
| cd14098 | 721-944  | STKc_Rad53_Cds1 |
| cd14158 | 724-934  | STKc_IRAK4 |
| cd14054 | 723-915  | STKc_BMPR2_AMHR2 |
| cd06605 | 717-970  | PKc_MAPKK |
| cd14202 | 717-943  | STKc_ULK1 |
| cd13996 | 715-913  | STKc_EIF2AK |
| cd14162 | 722-923  | STKc_TSSK4-like |
| cd06614 | 718-970  | STKc_PAK |
| cd06612 | 721-929  | STKc_MST1_2 |
| cd06630 | 719-920  | STKc_MEKK1 |
| cd08529 | 724-970  | STKc_FA2-like |
| cd14099 | 719-929  | STKc_PLK |
| cd13979 | 723-965  | STKc_Mos |
| cd05578 | 723-923  | STKc_Yank1 |
| cd07832 | 724-914  | STKc_CCRK |
| cd14222 | 724-978  | STKc_LIMK2 |
| cd14155 | 724-979  | PKc_TESK |
| cd14120 | 724-920  | STKc_ULK1_2-like |
| cd05581 | 722-920  | STKc_PDK1 |
| cd14006 | 724-915  | STKc_MLCK-like |
| cd14068 | 723-942  | STKc_LRRK2 |
| cd06609 | 717-932  | STKc_MST3_like |
| cd14121 | 724-935  | STKc_ULK3 |
| cd08530 | 722-972  | STKc_CNK2-like |
| cd06620 | 713-970  | PKc_Byr1_like |
| cd06631 | 719-920  | STKc_YSK4 |
| cd07840 | 719-920  | STKc_CDK9_like |
| cd07834 | 721-1020  | STKc_MAPK |
| cd05086 | 721-970  | PTKc_Aatyk2 |
| cd14137 | 714-920  | STKc_GSK3 |
| cd14097 | 724-937  | STKc_STK33 |
| cd06610 | 723-929  | STKc_OSR1_SPAK |
| cd14007 | 722-920  | STKc_Aurora |
| cd14103 | 724-908  | STKc_MLCK |
| cd06642 | 716-927  | STKc_STK25 |
| cd06647 | 720-970  | STKc_PAK_I |
| cd14072 | 719-940  | STKc_MARK |
| cd14002 | 723-920  | STKc_STK36 |
| cd08225 | 721-970  | STKc_Nek5 |
| cd14156 | 724-978  | PKc_LIMK_like_unk |
| cd06643 | 724-964  | STKc_SLK |
| cd14663 | 722-922  | STKc_SnRK3 |
| cd06625 | 719-970  | STKc_MEKK3_like |
| cd06611 | 724-970  | STKc_SLK_like |
| cd06917 | 716-940  | STKc_NAK1_like |
| cd07838 | 724-869  | STKc_CDK4_6_like |
| cd06641 | 715-970  | STKc_MST3 |
| cd06644 | 724-913  | STKc_STK10 |
| cd07829 | 719-922  | STKc_CDK_like |
| cd05118 | 721-920  | STKc_CMGC |
| cd14201 | 717-944  | STKc_ULK2 |
| cd14082 | 722-911  | STKc_PKD |
| cd14025 | 724-973  | STKc_RIP4_like |
| cd06629 | 722-971  | STKc_Bck1_like |
| cd06616 | 716-970  | PKc_MKK4 |
| cd14053 | 722-969  | STKc_ACVR2 |
| cd08220 | 719-973  | STKc_Nek8 |
| cd14153 | 722-983  | PK_KSR2 |
| cd05123 | 724-920  | STKc_AGC |
| cd14081 | 722-935  | STKc_BRSK1_2 |
| cd14026 | 721-979  | STKc_RIP2 |
| cd14191 | 724-923  | STKc_MLCK1 |
| cd14031 | 724-915  | STKc_WNK3 |
| cd14192 | 717-923  | STKc_MLCK3 |
| cd06608 | 721-970  | STKc_myosinIII_N_like |
| cd06656 | 720-979  | STKc_PAK3 |
| cd06624 | 716-920  | STKc_ASK |
| cd06626 | 720-921  | STKc_MEKK4 |
| cd14067 | 724-981  | STKc_LRRK1 |
| cd13994 | 724-915  | STKc_HAL4_like |
| cd06619 | 717-921  | PKc_MKK5 |
| cd14152 | 724-983  | STKc_KSR1 |
| cd06617 | 716-970  | PKc_MKK3_6 |
| cd14042 | 748-980  | PK_GC-A_B |
| cd06640 | 716-920  | STKc_MST4 |
| cd05076 | 746-975  | PTK_Tyk2_rpt1 |
| cd14186 | 717-922  | STKc_PLK4 |
| cd14071 | 722-923  | STKc_SIK |
| cd06654 | 720-979  | STKc_PAK1 |
| cd13998 | 723-913  | STKc_TGFbR-like |
| cd14070 | 722-969  | STKc_HUNK |
| cd14048 | 716-914  | STKc_EIF2AK3_PERK |
| cd14079 | 722-935  | STKc_AMPK_alpha |
| cd14161 | 721-954  | STKc_NUAK2 |
| cd14193 | 722-923  | STKc_MLCK4 |
| cd06655 | 720-979  | STKc_PAK2 |
| cd06618 | 717-970  | PKc_MKK7 |
| cd07841 | 719-921  | STKc_CDK7 |
| cd05077 | 724-973  | PTK_Jak1_rpt1 |
| cd13990 | 724-921  | STKc_TLK |
| cd14076 | 724-925  | STKc_Kin4 |
| cd14032 | 724-915  | STKc_WNK2_like |
| cd14055 | 722-964  | STKc_TGFbR2_like |
| cd14033 | 724-915  | STKc_WNK4 |
| cd14030 | 724-915  | STKc_WNK1 |
| cd14069 | 721-922  | STKc_Chk1 |
| cd08224 | 722-965  | STKc_Nek6_7 |
| cd14190 | 722-923  | STKc_MLCK2 |
| cd05572 | 724-923  | STKc_cGK |
| cd14077 | 721-922  | STKc_Kin1_2 |
| cd07830 | 721-866  | STKc_MAK_like |
| cd06613 | 724-913  | STKc_MAP4K3_like |
| cd06650 | 713-948  | PKc_MEK1 |
| cd06621 | 724-942  | PKc_Pek1_like |
| cd06638 | 721-970  | STKc_myosinIIIA_N |
| cd08228 | 722-944  | STKc_Nek6 |
| cd14045 | 775-977  | PK_GC_unk |
| cd14075 | 724-915  | STKc_NIM1 |
| cd07870 | 721-935  | STKc_PFTAIRE2 |
| cd05582 | 722-923  | STKc_RSK_N |
| cd14164 | 724-923  | STKc_TSSK6-like |
| cd14056 | 722-965  | STKc_TGFbR_I |
| cd08528 | 724-975  | STKc_Nek10 |
| cd13982 | 722-965  | STKc_IRE1 |
| cd14057 | 730-977  | PK_ILK |
| cd07863 | 721-920  | STKc_CDK4 |
| cd07866 | 724-920  | STKc_BUR1 |
| cd05611 | 721-931  | STKc_Rim15_like |
| cd14084 | 722-928  | STKc_Chk2 |
| cd14209 | 720-922  | STKc_PKA |
| cd05615 | 713-923  | STKc_cPKC_alpha |
| cd14001 | 722-915  | PKc_TOPK |
| cd05580 | 716-915  | STKc_PKA_like |
| cd06636 | 721-929  | STKc_MAP4K4_6_N |
| cd07842 | 725-922  | STKc_CDK8_like |
| cd07852 | 711-920  | STKc_MAPK15-like |
| cd06652 | 722-915  | STKc_MEKK2 |
| cd14113 | 721-921  | STKc_Trio_C |
| cd08219 | 721-916  | STKc_Nek3 |
| cd14165 | 724-948  | STKc_TSSK1_2-like |
| cd05587 | 722-929  | STKc_cPKC |
| cd07851 | 721-920  | STKc_p38 |
| cd08223 | 721-915  | STKc_Nek4 |
| cd06651 | 719-970  | STKc_MEKK3 |
| cd13993 | 718-973  | STKc_Pat1_like |
| cd14105 | 724-923  | STKc_DAPK |
| cd08218 | 720-915  | STKc_Nek1 |
| cd14073 | 722-923  | STKc_NUAK |
| cd14116 | 722-920  | STKc_Aurora-A |
| cd07860 | 719-915  | STKc_CDK2_3 |
| cd14200 | 768-921  | STKc_CaMKK1 |
| cd14106 | 722-919  | STKc_DRAK |
| cd07869 | 714-866  | STKc_PFTAIRE1 |
| cd08229 | 722-944  | STKc_Nek7 |
| cd14101 | 717-970  | STKc_PIM2 |
| cd05619 | 722-992  | STKc_nPKC_theta |
| cd07862 | 721-867  | STKc_CDK6 |
| cd06649 | 713-913  | PKc_MEK2 |
| cd14093 | 723-914  | STKc_PhKG |
| cd14110 | 759-936  | STKc_obscurin_rpt2 |
| cd13988 | 724-921  | STKc_TBK1 |
| cd05570 | 722-923  | STKc_PKC |
| cd06653 | 722-915  | STKc_MEKK3_like_u1 |
| cd05592 | 722-923  | STKc_nPKC_theta_like |
| cd14199 | 757-921  | STKc_CaMKK2 |
| cd14078 | 712-922  | STKc_MELK |
| cd14194 | 724-928  | STKc_DAPK1 |
| cd13997 | 717-974  | PKc_Wee1_like |
| cd06637 | 721-929  | STKc_TNIK |
| cd14046 | 715-881  | STKc_EIF2AK4_GCN2_rpt2 |
| cd07836 | 719-920  | STKc_Pho85 |
| cd14196 | 724-923  | STKc_DAPK2 |
| cd05616 | 721-923  | STKc_cPKC_beta |
| cd14086 | 724-914  | STKc_CaMKII |
| cd14043 | 730-979  | PK_GC-2D |
| cd05579 | 726-925  | STKc_MAST_like |
| cd14195 | 724-987  | STKc_DAPK3 |
| cd14187 | 720-920  | STKc_PLK1 |
| cd14119 | 724-923  | STKc_LKB1 |
| cd14038 | 724-921  | STKc_IKK_beta |
| cd07864 | 721-915  | STKc_CDK12 |
| cd14118 | 768-969  | STKc_CAMKK |
| cd08217 | 721-970  | STKc_Nek2 |
| cd06639 | 721-970  | STKc_myosinIIIB_N |
| cd05589 | 721-931  | STKc_PKN |
| cd07833 | 721-920  | STKc_CDKL |
| cd07879 | 720-1012  | STKc_p38delta |
| cd06645 | 715-929  | STKc_MAP4K3 |
| cd05573 | 721-921  | STKc_ROCK_NDR_like |
| cd14074 | 722-913  | STKc_SNRK |
| cd14114 | 724-923  | STKc_Twitchin_like |
| cd14010 | 724-920  | STKc_ULK4 |
| cd05577 | 724-914  | STKc_GRK |
| cd14167 | 722-922  | STKc_CaMKI_alpha |
| cd14083 | 712-908  | STKc_CaMKI |
| cd05612 | 717-924  | STKc_PRKX_like |
| cd14096 | 716-935  | STKc_RCK1-like |
| cd06648 | 740-921  | STKc_PAK_II |
| cd14005 | 722-972  | STKc_PIM |
| cd14087 | 723-922  | STKc_PSKH1 |
| cd05613 | 721-923  | STKc_MSK1_N |
| cd14044 | 827-977  | PK_GC-C |
| cd07861 | 720-866  | STKc_CDK1_euk |
| cd07845 | 716-920  | STKc_CDK10 |
| cd14197 | 722-923  | STKc_DRAK1 |
| cd07835 | 719-866  | STKc_CDK1_CdkB_like |
| cd06646 | 710-943  | STKc_MAP4K5 |
| cd14047 | 719-914  | STKc_EIF2AK2_PKR |
| cd07846 | 723-970  | STKc_CDKL2_3 |
| cd14166 | 722-921  | STKc_CaMKI_gamma |
| cd13989 | 724-921  | STKc_IKK |
| cd07856 | 724-920  | STKc_Sty1_Hog1 |
| cd14198 | 722-928  | STKc_DRAK2 |
| cd08221 | 721-970  | STKc_Nek9 |
| cd12087 | 646-683  | TM_EGFR-like |
| cd13987 | 724-915  | STKc_SBK1 |
| cd07876 | 716-914  | STKc_JNK2 |
| cd13986 | 776-970  | STKc_16 |
| cd05584 | 722-948  | STKc_p70S6K |
| cd07831 | 724-916  | STKc_MOK |
| cd07873 | 715-920  | STKc_PCTAIRE1 |
| cd14142 | 721-925  | STKc_ACVR1_ALK1 |
| cd07850 | 722-866  | STKc_JNK |
| cd07847 | 724-875  | STKc_CDKL1_4 |
| cd05595 | 722-914  | STKc_PKB_beta |
| cd07871 | 715-920  | STKc_PCTAIRE3 |
| cd14163 | 748-940  | STKc_TSSK3-like |
| cd14184 | 722-914  | STKc_DCKL2 |
| cd05571 | 722-914  | STKc_PKB |
| cd14133 | 721-920  | PKc_DYRK_like |
| cd05620 | 722-923  | STKc_nPKC_delta |
| cd06634 | 721-913  | STKc_TAO2 |
| cd14115 | 724-921  | STKc_Kalirin_C |
| cd06607 | 724-913  | STKc_TAO |
| cd06633 | 724-913  | STKc_TAO3 |
| cd05614 | 721-1060  | STKc_MSK2_N |
| cd14012 | 761-915  | PK_eIF2AK_GCN2_rpt1 |
| cd06635 | 705-913  | STKc_TAO1 |
| cd14117 | 724-922  | STKc_Aurora-B_like |
| cd05602 | 714-931  | STKc_SGK1 |
| cd14041 | 723-973  | STKc_TLK2 |
| cd05608 | 722-918  | STKc_GRK1 |
| cd14049 | 711-914  | STKc_EIF2AK1_HRI |
| cd07865 | 719-866  | STKc_CDK9 |
| cd07877 | 724-915  | STKc_p38alpha |
| cd14169 | 724-914  | STKc_CaMKI_beta |
| cd14050 | 719-970  | PKc_Myt1 |
| cd13968 | 724-863  | PKc_like |
| cd06659 | 748-921  | STKc_PAK6 |
| cd14095 | 721-865  | STKc_DCKL |
| cd14085 | 722-921  | STKc_CaMKIV |
| cd07880 | 719-920  | STKc_p38gamma |
| cd14109 | 766-928  | PK_Unc-89_rpt1 |
| cd05605 | 722-921  | STKc_GRK4_like |
| cd14181 | 723-921  | STKc_PhKG2 |
| cd05607 | 722-921  | STKc_GRK7 |
| cd07849 | 723-921  | STKc_ERK1_2_like |
| cd14177 | 743-925  | STKc_RSK4_C |
| cd14040 | 721-971  | STKc_TLK1 |
| cd07872 | 715-943  | STKc_PCTAIRE2 |
| cd07853 | 826-914  | STKc_NLK |
| cd07859 | 722-920  | STKc_TDY_MAPK |
| cd05603 | 722-921  | STKc_SGK2 |
| cd06622 | 717-921  | PKc_PBS2_like |
| cd14094 | 723-927  | STKc_CASK |
| cd06615 | 716-915  | PKc_MEK |
| cd14089 | 722-914  | STKc_MAPKAPK |
| cd14143 | 723-913  | STKc_TGFbR1_ACVR1b_ACVR1c |
| cd14175 | 749-935  | STKc_RSK1_C |
| cd05631 | 718-921  | STKc_GRK4 |
| cd07839 | 724-935  | STKc_CDK5 |
| cd14160 | 724-915  | PK_IRAK3 |
| cd14039 | 724-921  | STKc_IKK_alpha |
| cd14185 | 749-943  | STKc_DCKL3 |
| cd14176 | 742-935  | STKc_RSK2_C |
| cd06658 | 748-925  | STKc_PAK5 |
| smart00261 | 549-596  | FU |
| cd05630 | 718-937  | STKc_GRK6 |
| cd14183 | 722-923  | STKc_DCKL1 |
| cd07878 | 718-935  | STKc_p38beta |
| cd14004 | 721-921  | STKc_PASK |
| cd05594 | 717-914  | STKc_PKB_alpha |
| cd05618 | 826-941  | STKc_aPKC_iota |
| cd14159 | 724-937  | STKc_IRAK1 |
| cd05593 | 721-914  | STKc_PKB_gamma |
| cd14052 | 720-912  | PTKc_Wee1_fungi |
| cd07844 | 719-866  | STKc_PCTAIRE_like |
| cd14140 | 722-964  | STKc_ACVR2b |
| cd14171 | 712-871  | STKc_MAPKAPK5 |
| cd14107 | 771-915  | STKc_obscurin_rpt1 |
| cd13985 | 721-965  | STKc_GAK_like |
| cd05624 | 677-1061  | STKc_MRCK_beta |
| cd13975 | 719-965  | PKc_Dusty |
| cd07854 | 721-920  | STKc_MAPK4_6 |
| cd07843 | 727-919  | STKc_CDC2L1 |
| cd14189 | 826-928  | STKc_PLK3 |
| cd05632 | 718-923  | STKc_GRK5 |
| cd07857 | 826-920  | STKc_MPK1 |
| cd05583 | 834-921  | STKc_MSK_N |
| cd14178 | 749-925  | STKc_RSK3_C |
| cd14665 | 721-922  | STKc_SnRK2-3 |
| cd05604 | 721-931  | STKc_SGK3 |
| cd14179 | 715-921  | STKc_MSK1_C |
| cd05623 | 709-1066  | STKc_MRCK_alpha |
| cd14182 | 722-921  | STKc_PhKG1 |
| cd05601 | 717-923  | STKc_CRIK |
| cd07858 | 826-921  | STKc_TEY_MAPK |
| cd14144 | 722-913  | STKc_BMPR1 |
| cd14102 | 723-922  | STKc_PIM3 |
| cd14092 | 719-868  | STKc_MSK_C |
| cd14188 | 826-928  | STKc_PLK2 |
| cd14131 | 720-970  | PKc_Mps1 |
| cd13995 | 727-921  | STKc_MAP3K8 |
| cd14168 | 722-914  | STKc_CaMKI_delta |
| cd06657 | 748-925  | STKc_PAK4 |
| cd14662 | 721-922  | STKc_SnRK2 |
| cd07855 | 715-875  | STKc_ERK5 |
| cd05586 | 724-941  | STKc_Sck1_like |
| cd14220 | 722-913  | STKc_BMPR1a |
| cd05621 | 713-921  | STKc_ROCK2 |
| cd13991 | 724-905  | STKc_NIK |
| cd14111 | 825-921  | STKc_SPEG_rpt2 |
| cd12093 | 648-684  | TM_ErbB1 |
| cd05617 | 823-941  | STKc_aPKC_zeta |
| cd05575 | 722-924  | STKc_SGK |
| cd05574 | 718-865  | STKc_phototropin_like |
| cd14091 | 724-871  | STKc_RSK_C |
| cd05588 | 826-941  | STKc_aPKC |
| cd07848 | 723-913  | STKc_CDKL5 |
| cd05585 | 723-1007  | STKc_YPK1_like |
| cd05590 | 722-922  | STKc_nPKC_eta |
| cd14173 | 722-923  | STKc_Mnk2 |
| cd14141 | 722-913  | STKc_ACVR2a |
| smart00261 | 229-266  | FU |
| cd07874 | 716-921  | STKc_JNK3 |
| cd14108 | 722-923  | STKc_SPEG_rpt1 |
| cd14180 | 777-923  | STKc_MSK2_C |
| cd07837 | 717-913  | STKc_CdkB_plant |
| cd05610 | 721-867  | STKc_MASTL |
| cd14011 | 826-922  | PK_SCY1_like |
| cd14090 | 723-923  | STKc_Mnk |
| cd14172 | 722-914  | STKc_MAPKAPK3 |
| cd07875 | 716-917  | STKc_JNK1 |
| cd05609 | 833-914  | STKc_MAST |
| cd14219 | 717-913  | STKc_BMPR1b |
| cd14174 | 722-923  | STKc_Mnk1 |
| cd14210 | 721-920  | PKc_DYRK |
| cd05598 | 840-921  | STKc_LATS |
| cd07867 | 724-915  | STKc_CDC2L6 |
| cd14136 | 826-915  | STKc_SRPK |
| cd05622 | 713-921  | STKc_ROCK1 |
| cd14037 | 721-916  | STKc_NAK_like |
| cd05599 | 721-914  | STKc_NDR_like |
| cd05600 | 713-866  | STKc_Sid2p_like |
| cd05591 | 722-920  | STKc_nPKC_epsilon |
| cd14104 | 724-923  | STKc_Titin |
| smart00261 | 501-537  | FU |
| smart00261 | 611-634  | FU |
| cl00066 | 611-634  | FU superfamily |
| pfam07714 | 718-974  | Pkinase_Tyr |
| pfam14843 | 502-634  | GF_recep_IV |
| pfam00757 | 186-334  | Furin-like |
| smart00219 | 718-974  | TyrKc |
| smart00221 | 718-974  | STYKc |
| smart00220 | 719-970  | S_TKc |
| pfam00069 | 718-970  | Pkinase |
| COG0515 | 721-1054  | SPS1 |
| PLN00034 | 697-912  | PLN00034 |
| PTZ00024 | 722-920  | PTZ00024 |
| PHA03209 | 705-926  | PHA03209 |
| PTZ00036 | 723-914  | PTZ00036 |
| PTZ00263 | 713-941  | PTZ00263 |
| PTZ00267 | 826-1003  | PTZ00267 |
| PLN00009 | 719-866  | PLN00009 |
| pfam00757 | 496-596  | Furin-like |
| PTZ00283 | 825-970  | PTZ00283 |
| pfam14843 | 189-265  | GF_recep_IV |
| PTZ00426 | 713-921  | PTZ00426 |
| pfam14843 | 230-336  | GF_recep_IV |
| PRK13184 | 721-933  | pknD |
| PHA02988 | 733-975  | PHA02988 |
| PHA03212 | 768-915  | PHA03212 |
| TIGR03903 | 748-920  | TOMM_kin_cyc |
| PHA03390 | 713-944  | pk1 |
| pfam14843 | 183-246  | GF_recep_IV |
Ontology Information
| HPRD ID | 4309 |    
|---|---|
| Molecular Class | Receptor tyrosine kinase |
| Molecular Function | Protein threonine/tyrosine kinase activity (GO:0004712) |
| Biological Process | Signal transduction (GO:0007165)   |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q15303 | DB08916 | Afatinib | SmallMoleculeDrug |
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
