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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ERCC6 | 2074 | excision repair cross-complementation group 6 | 10 | CSB, RAD26, ARMD5 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17119055 | 2006 | Cell line : - Source : Washington County, Maryland Sample Type : Population based case-control study No. of Sample : 22,887 cases Stage : - | Laboratory Assays,Dietary Data,Statistical Analysis | Polymorhpism | - | Genetic polymorphisms in the NER genes, ERCC6 and XPC, may be associated with an increased risk of colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Naturally-occurring readthrough transcription occurs between this gene and the adjacent PGBD3 gene (GeneID:267004), and results in a fusion protein that shares sequence with the product of each individual gene. The readthrough locus is represented by GeneID:101243544. [provided by RefSeq, Mar 2013] |
| Chromosome | 10 |
| Location | 10q11 |
| Start | 50662526 |
| End | 50747169 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 84644 |
| OMIM ID | 609413 |
| HGNC ID | HGNC:3438 |
| Unigene ID | Hs.49063 |
| Ensembl ID | ENSG00000225830 |
| PharmGKB ID | PA27852 |
mRNA Information
| mRNA ID | NM_000124.3 |
|---|---|
| Exon | join(1..162,6146..6581,8284..8404,10599..10707, 14347..15091,33112..33240,38428..38586,45872..46007, 55608..55778,56261..56437,60654..60770,62814..62909, 64882..65097,65537..65647,66096..66215,66654..66748, 68004..68149,68235..68942,77568..77772,78673..78751, 79890..84644) | mRNA Sequence | Download Select all |
| Length | 8993 |
Protein Information
| Protein ID | NP_000115.1 |
|---|---|
| Protein Name | excision repair cross-complementation group 6 |
| Molecular Wt. (Da) | 168286 |
| Protein Sequence | Download Select all |
| Length | 1493 |
| Uniprot ID | P01236 |
| Ensembl Protein ID | ENSP00000302150 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 486 |
| S | Phosphorylation | 489 |
| S | Phosphorylation | 1461;- |
| S | Phosphorylation | 438;- |
| S | Phosphorylation | 430;- |
| S | Phosphorylation | 158 |
| S | Phosphorylation | 429 |
| S | Phosphorylation | 1009 |
| S | Phosphorylation | 1142 |
| T | Phosphorylation | 1347 |
| S | Phosphorylation | 1348 |
| T | Phosphorylation | 1350 |
| S | Phosphorylation | 893 |
| S | Phosphorylation | 124 |
| S | Phosphorylation | 1345 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 142 | PARP1 | 1435 | NP_001609.2 | in vitro;in vivo | 16107709 |
| 1161 | ERCC8 | 7523 | NP_000073.1 | in vitro | 7664335 |
| 2073 | ERCC5 | 595 | NP_000114.2 | in vitro | 8652557 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Nucleotide excision repair | hsa03420 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00079 | 830-960 | HELICc |
| cl21455 | 830-960 | P-loop_NTPase superfamily |
| cd00046 | 527-677 | DEXDc |
| cl21455 | 527-677 | P-loop_NTPase superfamily |
| pfam00271 | 874-952 | Helicase_C |
| smart00490 | 869-952 | HELICc |
| pfam00270 | 535-651 | DEAD |
| pfam00176 | 510-812 | SNF2_N |
| COG0553 | 459-1007 | HepA |
| PLN03142 | 462-975 | PLN03142 |
| smart00487 | 499-707 | DEXDc |
Ontology Information
| HPRD ID | 3330 |
|---|---|
| Molecular Class | DNA repair protein |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.