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Search results:

General Information

• Evidence
• Gene
• mRNA
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Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
19075230	2008	Cell line : - Source : M. D. Anderson Cancer Center, Houston, TX, ATCC Sample Type : - No. of Sample : - Stage : TNM Stage IV	Immunoblotting, Tissue Microarrays, Immunohistochemistry, Athymic Nude Mice and Metastasis Model	Up-regulation	-	Akt2 overexpression play an important role in metastatic colorectal cancer and establish a mechanistic link between Akt2 overexpression and PTEN mutation in metastatic tumor establishment and growth.

Gene Details

Chromosome: 19; NC_000019.9 (40736224..40791302, complement)
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Gene Type	protein coding
Gene Family	Pleckstrin homology (PH) domain containing
Description	This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008]
Chromosome	19
Location	19q13.1-q1
Start	40230317
End	40285531
Strand	-
Gene Sequence	>gi|568815579:c40285531-40230317 Homo sapiens chromosome 19, GRCh38.p2 Primary Assembly GCGCAGGCGCCCTGCTGTGAGCCCGCCTCCTTCTCTGCCCTGCTCTTGCGCTCTCGCTCTCTCAGAGTTC GTCTCTGGCTCTTTGTACGTCACTTCCTGTTTGTGGCGCGAGAGGGCGGTATTTCCGTCCAGAGGGTGGG AGGGGGCGGTAAGCGGGGGCTGGGGGGAGGGGGCGGGGGGGGCCGCGCCGTGCTAGCCGTTGGGCCTGCC TCGGAGGAGGCGTCGCCGCCGCCGCTGCCGCTGCCGGCGCCGTTGCCGCTGCCGGGAAACACAAGGAAAG GGAACCAGCGCAGCGTGGCGATGGGCGGGGGTAGAGCCCCGCCGGAGAGGCTGGGCGGCTGCCGGTGACA GGTGAGTGCGCCAGCGCGTGTCCCCGAACGCCCCCCCCACGATGGTCGCGTCCGGGCCCCCCGCGGTGCC GCGATGGGCTGTACCACCCGTGCCCGGCGGGGGGACCGCGGCCCTCGAGCCCCTCCTTCAGGAGCTGAGT GGGGGTGGCCGAGCGGGGGCGGTGGGACCAGCCTCGGGGGGCCGGGGCGGTGGCGGCGGGCCATACCACT GAGGCGGTGGGGGGAGCGCTGCAAGTTTGCGGGACGGGGAGCGCAGGCCGCAGCGTGCGCGGGCCGGGGG CTGGACCTTTCGGGCGCGGCGGGCAGATCGAGCCTGGCGTGCGCGGGCTAAGCTATCGAGGGGGCGCGCC GCATCAAGTGTAGAGGGCTGTACCTTTTTGGCGCTGTGGAAGCCGTTGCTGTGCTGTATTTACAGGGGTG GGGGCTTCTGGGGAGGATGCTTCCCCAACTGTGGCTGGGTTATATCACCACGGCGTTGGGGGAGCCCTGC TTAGAACGTAGGGGAACCCAAATCAGAGGACTGTGATGTTTGTGATCTTTAAGGGACTGGGACGGGGCGG GACAGGCCCTAGTGGGTTTTAGGGGCGTATTTTGGGAGGACTGTGATGCCGATTGGTGAGGAGGGGTTTC TGTTTCCTGTATTTGACGTGTGTGGCGTTGGGGGTTTACACTGATCTCAGCCTTTATTGAACTTCTTAAC GACTCTGGAGGGAACGTCATGGTTACTGGGGTGCTTTGGACCATGGAGGTGCTGCTCTGGATTCCATTAC CCTCTCAGATTATTTACCAGGCAGTAACAGTTCTTTCCTTCCATAGGGGAGGGAGGAAAGCTGTGTTAGA AGTCACTGAAGTTGTCTGAGCCTTAACATTCTGAAGAGGAAGAGGGATTGGGCTTGGATTTGAGGAGCCG TGCCCCTGCACCCGCTTGTTAAAACTTGGGAGGAAGGAGTGTTTGGGGGAACACCTCTTCCCCCCAGGGA AGCTCTCTGGGGGCATCTTGATCTTGGGATTGTGAGGACCTCTTCCTCTCATTTGGAGACCTCTTGGGGC TCAGCAAGACGCCTGGGCTGGAGTAACTAGAGCCTCCAATGGGCTGCTTTTCAACTTCATCCACTCCTAC CTTCCCAGAGAAGCAGCAGGAGTTCACTCGTGGGCTGAACTTGGTTGGCAGTGGATGTGAAGGGTCCAGG AACCAACGCAGACCACTACATGCTCCTCTGTCGCTGGCCACGAAGCTGTTTGTGTCTCCCAGTTACCAGC TCGGTCACACATCATGTTTACACTCCCCACCAAGGCAGTAACAGTTGGCCTTGCAGTGAGGCCGGGAGCT GTTTTCCCAGCTGTTCCTCTTTGCATAGGCCAAGGGGACTTGGAGTGGGGGTGCCCCTGGCCCAGCCTGG CCCAGGGAGGAAGGCTGCTCTGAAGGGCTTGGGACAGTCAGATCCCCCATGGATCTGGTGTCTTATTGTG GTCTGTGGGCTGGTGCTGGGAGCAGCCAGCCCCAGAGGTCTGTGGCCAGTGTCCCTGCTCCCTAGGCCAG ATCATGACCTTGGCTTGCCCTGTAGCCTTTGCTCTGGGTCTGGAGTTCCCAGAGGACTGGCTGCAGTCCC TGATTGACCCAGCAGACCTGGGCTGGTGATGTGGTCAGAGGGGGCAGATGGTTGCCCCTAGTCCGCAGCA GTGACTTCCAAGCTGACTGGCTTCCGTGGCTCGTGGTTCCTGGAGAGAAAGGTCCCACAGTCTGTGAGGC AGCGGCGACTCTGTAGAATCTTTCTCCACTAGGGGTTTGTTCCTCTGGTCCTCTCCTGCCAGCTTTTAGA GGGTTTGCCTGATGGGGCTAACAGTGGCAGTGAAAACAGTAATCATGAAATTGATGGCTGACAGTAACTG AGTGCATTCTGTGGGCCACACACTGTTTGGAATGCTTCATATAGATAAACTTGCTGAATACTTGAATTCT AGAGCGGTAGGCGCTGTTGTTATGCTCTCCCTTTTAGATGAGAAAACAGCATCTCAGAGAGGCAGATCAT TTCCAGAGCTAGTGGATGCCCAGTGTTTATAGCATTCACCCCATGCCAGGCGTGTGACAGGGCTTTTGTA CATGTGATCTCACTTAAGTCTCAAAACATACCTGTGGTTAGGCCTATTTTATGGAGAGCTACGAGCTAGT TAGAAGTGTGATACCATTTTACAGATGAGGAATCATTTCACTCACTGTGAAGTGCAAAGATTTCCCAGAG GTCTCATAGCTGAAGTGGGAGAGGTGTGATGTGAGCCCTTGGCCAACCTTGGCCTCAGATCGTCTTGTCA AGGAGAAACTGGAGGAGTGGCTTTTGTCTGTGAGCATATACTCTGCCCAGCCCTGTGCTTTGGGCTTTAT ATGGTATTTGTGTCCTTTTTTGCAGAGTCCGAAATTGAAGTTCAGAGGAAGAATTGCCTTCCACCGCATC TTATCAGACCCTATGGGTGCCAGGGTAGGATTTGAACCCAGGTCACTGAGCCCCTAGTGCCATGCATTCC TTGCTCACCAGGTTCCAGGCTGGGTGAAAGGAAGGAAAGACATAGGATAGAGTCACCTCTGTCCTCTGTC CTCTACCTATAGAGGTGACTGTCCTATGTCTTTCCTTCCTCTTACCCCTGAGCCTCAGGCTGCCCTGAGC ATCTCTGCCTACAGCCAGTCCAGCATTTCTTGGTCCCTCCTCAGAGTGGAGGCAAGGCATCCTTTAACCC TGGGCAGGTGTGTGCTGGGAGAAGAAGACAGCAAGAGAGCCATGCAGGGGGTGACACAGCTACCAGGGAC CTGCGTTAGCTAGCAGCAGGACGGTGAAGTCGGTTCTAGCTCTGCGACCTTGGACCACACTGTTCACTCC CATACAGTGGTCTCAGAAGGACGTCCACCTTGGGCTGTTGTGAGGATTAAATGAATTAATCCACGAGAAG CTCCTAGAATGGTGCCTGGTACTGTGTAAGTCTTGGTTGGCAGTCATGATTATGTTATGGAACGGAGGCA TCCAGCCTCCCCCACCCCCTACTTTTGGTCCCCTCGAGCATTCCGGGATCCAGCTCCCCAGCCTGGCCCA GCTAGGATCCAGAACTTCAATGTTCTGGTTTCCAGCCTCTGTAAAGAGGTGTATGGAAGCGAGTGAGAGC ACAGGGTTCAAATCCAGCCGTGCCACTCCATGGCTGTGTGACCTTGAGCAGGCTCCCCAACCCTTGTGAG CTCATTTCATCATCGGTGCCATGGGGATGATGATAATTCCCACCTGATAGGATTATTGTGAAGGCTGAGT GGATTAATTTGTGGGAAGCATTCATAACTGTTCTGGCATACAATAAGCCTACCGGAAATGTCTCCTCACT AAGAACAGTGCCCGACACATGGTGAGCTGTTGGTCTGTCTTAGCAATTGTAATTCTTAGTATTTCTGCCG GGACTTTGAAGGCCTTTGCCAGTTCACAGAACCGTGTCAGAGAGCACTAGGAGGAGATCAGGGCTGAAAT TAGCATCTCAGTTTTACAGATGCAGAAACAGAGGTCGGGGGAGACATGCAATCAAGTCAGAACTGACAAG GGCAGCTCCCGGGCCCACTCCTCTTCCACGCAGTGGCTTTGCAGCCCTGAGCGCCTCCAAGGTAGACACA CTGGAGTCTTTTCAGAGGTCAGGCTCTGTGCTTGTTTTTTTTTTTCTTTTGAGACAGGGCCTCCCTCTGT CACCCAGGCTGGAGTGCAGTGGTGTGATCACAGCTCACTGCAGGCTTGACCTCCTAGGCTTTAGTGATCC TTCCACCTCATCCTCTTGAGTAGCTGGGACTACAGGTGCATGCCACCATGCCTAGCTAATTTTTAAATTT TTTGTGGAAACGGGAGTCTCGCTATGTTGCTCAGGCTAGTCTTGAACTCCTGGGCTCAAGTGATCCTCCT GCCTCAGTCTCCTGAGTAGCTGGGACCGTAGGTGCATGCCACTGCCCCTGGTTCCCAGCCCACCACAGCT CACAGCTCTGGGAGTGGCAGGAAGGCTGGGCCTGGGCAGGGGGAGCAGCAGAAGTGCCTGCAGGGGTTGG CAGGGGCTGTGCTGCACTGGCCTGTGGGCCTGGGTGAGAGGTGAGGATGGATCCTAAGGGTATTGTGGAG CCGAGGAAAAGGTTTCACTCATCCGCCACCATTTACTGAACACCTCGTATGTGCCAGCGTTGCATCAGTA CTGGGAATACAGCAGTGTACTTGCCAAAGTCCCTATCCTTGTGGGGCTAAGCAAGACCAACCCGAAACAG GTTAATAAGCAAGGAGCCGGTTAGAGGGGGAGGAGCTAGGCAGCGAATTCAAATCAGGTGACAGACTGGG CACTTCTTTAGATGCATGCGGCTGTGGGGAGGGCCTCTGAGCTGATCCCAGTTTGGCAAGGTGAGGCAGT CATGTGGGATGGGAGGAGAAGGAACAGCCCTCCAGGTGGAGGGAACCACAGTGCAAAGGTCTGAAGGGAG GACAGAGCTTGGTGAGGTGCAGGGACAAGCCTCACGGAGGCCTGTGTGGCTTGGCAGAGCGAGGGAGCAG GGAGGAGATGAGTCCTGGGGCTGCGGGGCAGGCAGGGCCCTTTCACTGGGAGCCTTGTGGACTGTCTGTG AAGGAGTTTGGAATTTCAGCAGGAACAGCCTGGTCAGATTCAGGGTGTTAGCAGGTGACCCAGGAGCCGG TCACAGGCTCCTGCCTGGGGGCGTGGGTAGATTTGACTGAGCGGAGCAGGGCGTTTCACAGGCCTCCCAC TTCCCCTCCAGTAGCATCACTGCCTTACAGCCAGCAAAGGCCTGAGGGTTGCCTCCCTCCTGTGGTTTTC ACACCGTGTTCTCCAGAGCCCGTGGCTGTTACTTTTAGGGAAAGAGGAGGGGAGGCTCATTGGGCTGATT TCTCTGCCCATTCCTCCCCAACCCAACCAGCCGGACTAATACTGAATAGCAACGCAGGGCAGCAGTCACA CCTGATACAGACAGCACCCGCTGACCCTGCGTCCACGCTGCCGTGGGCCTGTAGGCCTGCGCCATTCCCA GTGCTCCTCTGGAATTGGAAAGACCAGGGCTTGTGACTGGCGCCCAGCACCCAGGTCTCTGGTTGGGCTC AGGTGTGGTTGATATTACGAAGGCAAAATAAATGAGGGCCAGGTTGAGAGTGTGGGCATGTTTCTCCACT ATAGCTGGGTGATCAGGGAGGACCTCCCTGAGGAGGTGACGTGTGGGTAGGGACTGGAGTGCTGTGAGGG AGCCATGGGAGGATCTGGGTGAAGACCCATTAGACCCAGGAGGAATCTTCTCTGATTCCCGCTTTACAAG TGGTGAGAACTGAAGCCTGGAGAGCCTCTGTAGCTTGTGCTGAGTCCCCCAACCAGGAAGTGTTGGGGAC AGGCTATGAATCTGGGCTTCCAGAGATTCCCCCACCACAGCTCAGTAGCCCCTGGTGAGTGTGACTTCTG ATCCCACCCATGGGCTCACCCCTAAGGCTTGGTGCGGGAGCAGGCGCTCTGGCTTTTTTTTTTTTTTTTG AGGTGTGTTCCAGGGTATCTTCCTAGAAGGAGCAGAACCCCTCAGAACAAACCACTAGGGTCTCCAGAAG GCCCCCGGGATGGGTTGGGATGGAAAGGAGTGTCTTTCAGACTTGAGCTCCAAGCCCCTGGAGGACCCAG GGTCACCCCTCCCCGGGCCTCTCTTCAGCTTCCCAGAGCTCTCAGCGGAAGGCCCTCAACCACAGGCCTC CGGGCCGCACGGTGGGGTGGTTCCATGGCAGGCTCTTCTGGACAGCCAGCCAAGCAGCGAGAGGCCCAGC TGGGGGAGACAGCCTGGGAGCAGGACCAGGAGGGAGGGAGTGAGTGTGGGAGGGGCGCTGGGTGGGAGCT CAGCCTGGCCCCCTTGGGGCAGGACCCACTGCCAACTCGGCACCCACAGCAGGGCCCAGGTGCTCTGACT GTGCCGAGCGAGGGACAGCAAGCCGGGTCGGCCAAGAGGAGACTGCATGTCAGAGGTCCCAGCAGGAGTT TCTTCAGCCCAGCCGTCCTGCTGGAGAAGCTCGTTCGCAGATGTTGTTTCTAAGGGTGAGGCCAGAAACC CAAGTCTTCCTCGGTTTGCCACTTTGTGGGCCCTTTCCGAATGGGCTGGGGCAGTTGCCGCTCCCCGGTT CTCTTCTCCAGCCTGGCTTCAAGTTCTTCATGGTCTGGTGGGTTTTTGGTGTACACTTACCCAGCTGGGG CTGCTGAGTGACCTGGTCCCGGGGGTAGCTGACGTGGGTGAGAACCCTGCTCTTGGCACCCCTCTCGGTG GCTGTGGAGCTCTGGGGCCTTATTTCTTCTCCCTAAGGTGCATTTTGCTCAGCTGTAAACGGGAACCTTC CTGCTGAGTGGGGCGGTGGGGAGGATGCACGGAGCTGCTGCGTTGGAAAGCACAGGCCTCCTGAGGAGGC GGCGGGATGAATTTGGGCTGATGCTACTCCTGGTGATTGCCAGACAGGACTGAGGGCACCTGAGAGCACA GAAGGGGCTCTGCAGGGCAGTGGGCACAGGCTCGTTGTTGGTCCTTGGGAGAGAGTGGTAGGGCCTGTTA GCTGATGGGAGGGCTCCAGACAGGAATGTGAATCACTCCCACCACTGTACTCCTGCCCAACCAGACGCTG CATATTAGCTCTACAAACCTGCACAGCAGCCTGGGAGGTGGGCAGTGTTAGCACTCCCATCTCGTAGATA GGAAACTGAGGCCCAGGAAGCCACATAGAATATTGGGGTCATTCTCGTGAGTAGTTCGCCTCTCAGTGCT GGGCACTGCTGCAGAGCTTAAGGTGTCTGCTCTCACTCATCCTCACCACAGCCTGGCAGCTCGCTGTCCC GATCGTCCCCGTTGTACAGGGGAGGAAACGGGCATAGAGAGGTTATTGGATTTGCTGGAAGTCAGTAATA GGCATGATGGTTGAACCCTGCTCTGTCGGCGAAGCTGCCTTTTGAAGACAGCCTCATCTTCTTGCCCTGC CTGCTATGACTGGAGTTGTCACTGTTGTCATCATGATTTCTTTTCTGCTTTCTCTTCTCCTAGACAGAGC TGGCACAAAGTAGGCCTCAGTAATCCAGAAATGACTCCATTCCATGCCTGCTTGGGATGTGGGGTGTGGC TGCTTCTCTCCACCCCCAATACCATGACCTTGGCCCCTCCCAAGGGGGGCCCAGGGGGAAGAGATGAGGA TGGGAGGCACCCCCTCCCCACTGCCCTAGGGGCCTGATTGCTGAACAGCCTCAGGAGCCAGCCTTTGGCT GTTCTTGGTCATTTGTGTGTTCCATCTGTCTCCAAATATTGATTGAATCACTTCTATGTGCCACGTGTAG TTCTGGATGCGATCGGAGGTGGCAGAGAGGTTGCATTGGCCTGTGAGTGCTTGGTGTGGCTGAAGGAGGG AACAGAGATCTAGCTGGACTGGGTGGGAGAGGGGCTTGGGAAGGCTGCTGAGGAGCCCCTGTGATGTGAG AGCCCGAGGAAGTGGGCTGGACGGGGTGCAGCCAGGTAAAGGCCGCAAGGAAGGCGATATCTGGATGTGC TGGTGGAACAGCAGGCCCATGTAGCTGGAGCCGGGGGAGTGGGTGAGGGGGAGAGAGCAGGGTGGCAGGG CTCAGGGCCTGGGCTATGATGGGGATCCAGGGCTTTATCCCCAAAGAGAAGGGACACAGGTGGGTGGGGA GGGACCTGTGTGGGAGAGAGCTGGCTGGATTCAGGTGGCAGCCAGGGATGGAGAAAGCAGACCATATTCT GCTTTGGAGACAGGGCGCCCTAGAGCCCAGCTTCTCAAACTGGTGTCCGAAGGCCTTGGCGGGTGGGAGG AGGTGTCTGCAGGGCATTGACTCTTTTTAGCTGTGTGTTTTCATTTAGATGATATTTTCAAAAAGTTAGT AGGGGCATGTTGGAAATTATTGGGATGATTCCTTTAGAACCAAGTAGTGACAGCAGTAACATTAGCTGCC ACTGCATGGCTCTGACAGGCTCAGGACGGCCCCTGATGTCAGAGTCCTTTATGTAATTGCCACCTATTTT TCAAGCACTGGCCCTGTCCCCAGCTGTGTGTGAAGCCATCTCATTGGGTCCCCAGGACAACCCATGGTTA TCAGAAAAATCATCTTTTTAAATTTTTCATTATTTTTTTGAGACAGGGTCTGGCTCTGTCACCCAGGCTG GAATGCAGTGGCACCATCATGGCTGATTGCAGCCTTGACCTCACTGGCTCAAGTGGTCCTCCCACCTCAG CCTTCTGAGTAGCTGGGACTACAGGCATGCACCATCATACCTGGCTAATTTTTTTAAAACAATTTTCAGT AGAGATGGGAGTCTCCCTATTTTGCTCAGGCTGATCTTGAACTTTTGGGCTCCAGTGATCCACATCCCTC AGCCTCCCAAAGTGCTGGGATTACAGGCGTGAATCACTGCACCTGGCCTGCAAAAATTATCTTTTGAGAT AACATAAACATGTGCTTGGGCAGATTGGTGTTAAGATTCCATTCTACAGGCTGGGCACGGTGGTTCACAC CTGTAATCCCAGCACTTTGGGAGGCCGAGGAGGGTGGATCACGAGGTCAGGAGTTCAGTACCAGCCTGGC CAAGATGGTGAAACCCTGTCTGTACTAAAAATACAAAAATTAGCCAGGTGTGGTGGTGGGTGCCTATAAT CCTAGCTATTCGGGAGGTTGAGACAGGAGAATTGCTTGAACCTGGGAAGCAGAGGTTGCAGTGAGCCAAG ATCGCACTACTGCACTCCAGCCTGGCGACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAGATTCCATTTTACAGATGCGGAAGCTGAGGTTCAGAGAAGTGACCTGTGTAGCC TGGAAGTGGTAGAGTCAGGATTTGAGTTGACTAGAGGTGTGAGTTTGGGCCTGAGTCCTGCTCCAATTCC CCAGGTAAGCTGCGTTGGGGTGCGGGAGAGATGGGGTATAGCATGGGAGCTTCCAGCCGCACTGGGATGA TCTGGCTCCTCTTGGGCCTGTGAGAGTCACATCCCTGCCTCCTGCCTTTAAGCTCCCGGTGCTTAATTAG CAGGAATTCTATAGAATTGCACTCCAGAATGGTAGCTACTAGCCATGTATGGACTTTTTTTTTTTTTTTT GAGACGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGTGATCTTGTCTCACTACAACCGCCGC CTCCCGGGTTCAAGCGATTCTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGCCTACCACCACGC CTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATCTTGGCCAGGCTGGTCTTGAACTCCTG ACCTTGTGATCGCCCCCCGCCCACCCCCCCCCCCCCCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAG TCATCGTGCCCGGACTCACATATGGCTTTTTAAGTTTTAATTAATTACAATTAAAGAAAAGTAAAAAGTC AGTTCTTTAGTTGCACTAGCCATCATTCAAACATTTAGTAACCACATTTCTGTCGTTATGGAAAGGTCTG TGGGCTAGTTCTGCTCTGGTTGCGGTCCCTCTCCTGCACCTACTCGCTGTGACTGTGTGCATGTGGCTCT CTCCCTGGGCCTCAGTTTTCCCATGTGAGGAACGGGGATAGTAACACAGGCTGGCTGTGAAGATGAACAT TAATCCATGCCTGGTGCTTTGTGAGTGCTCACTGAGTATTAGCCTTGATGCAGACCCACTGGTTTCTCCT TTTGCCACTGGGCCCTGCCCTGGAGCTCCCAGGGAGGTGGTGGCGATGCAGAGCGACGTGGGTCAGGGAT TCCCCATGCAGTCCAACTGGAGGGCTCCCGTGCATGCGTGCACATCAGGGGCGGTAAGGAAGGGCTGGCC GGGGTGTGGGAGGAGGCGACACAAGATGGGAGGTGGCCCTGTCTCTTGGGAGCAAAGGCAGAAGGAGGTG GAGGCAGCTCAGGGCTCGGAGGAGAGGGGTCCGGGCTCCTTGGCTGTGTCCCTGCTGTCTCTCGCTGTGG GTATTCACCGAATCTCTCCCATCCTCGGTTTTCACATCTGCTGCATGCAGGTCCTCATGGTTCTCAAGTG AGGCAGGTGGTGAGCCCATCAGGCCAGTGCCCAGGGCTTATTCTGGGGACAGCTCCTGGAGAGGAAGGGC TGCCTCCCTAAGGACTCCTGCCCTGCCCTGGGTGCAAGGGGTTCCACCTGCTGCCCCTCCCCCACTCCCC AGCTCGCCTCAGGCGGATAGTTCCCCTCTCACTCCAAATAAGAGCCACAATGCTGACAGTGGCCCCCAAG GCCCTGCCCAGCGGTCCCCAGCTTCCTCTAGCTACATCTCCCGGCCCTCCCCTTCACCCACTCCTGTAGG CGCCTCGAACGCGCCTCAGCCCTGCTCCTCCCCTGCCTGCAGCGTTCCTCCCCAGGTCTCCCCCGGCTCT CTCACCTGCTTCCGGTTTTGCTCAGACTGCGCTGCCTCAGTGCGCCCTTCTGTCACCATCCTGTGTATAG TCGGAAACCCCTGCTCCCTTTCCCTGCACTGAATCTTCCGTGTGCTCCTTTTCTCCATGGCATTTGTTAG CTTTGGCTATCCTGTCTAATTTGCGTATGTATTTATTTTTTATTTTGCTGCCTGTTCCCTCATTCCCCCA ACTCCCCAATGGCAGGGAGTTCTGTTTTGGTCACTGCTGAATCCCTGGTGACCCGAGCAGTGATGATGCA GAGTTGTTGTGATATTTGTGGAATGAATGAATGCAGGATTTTTTGTTTTACCTTCACTTGGCACAAATGC TGTGGTTCTGTTCACCACTCCCCCCTGAAGTAATGAAAGTTATGGGCCCATCCCTGTGCTGAGTGGAGCT GGGGACACAGTGGGGGCTAGGACAGACTGTATCCCTGCCTTGTGGAACCCACAGTCCAGTGGGAGAGGCG ACATTACCCACATAGTCATGCAGGTGACAGAGGCAAGTGCTGTGAGGGGAAGGGAAGGCTGAGCTCTGAG AGTCCGCTGCTCGTGGGAGAGGGGTGGTCAGGGAAGGCCTCCGTGAAGAAGATGGGTGAACAGAGTGCCA GGCAAGGGGTACAGCATGTGCAAAGGTCTTGGGGTGTGAGAGCAGGGAGTCTTCATGGGGCCAGGAGAAG GGGAGATTGTGTGTTGGAGCGAGCAGACCAGTGAGGCTGGAGAGCAGGCGGGGCCAAGGCAGATGGCCCC TGGCAGCCTCCATAGGGGCCTTGGACGTGATCCATGGGCACTAGGGAGAGGTCCTGAGCAGGGGAGGGAC AGGGTCAGAACTGCGTGGAGGATCCCGCTGGTTGCAGCATGGAGCCCTCAGAGTGTATGGAGCCCGTGGC CAAGCAGACTAGAATATTTGACATGATTTCTGTGGGTGCTGTAAGGCCCTGGGTGGCGTGAGGGGGAAGG TGTGTGTGTGGGGTGGCAGGGAGGAGAAGGAATCTGCTCTGTGCTTATTCTTGTCCCCGTTTCTTTTGCA GCCTGCCCACGGCTTCAACCTGCCTCCAGCCCCACCTGCTCCAAGCAGACAGATGGGGCGAGTGTAGGGA GTGTGTTTAAAAGAAAAAAGAAACAAAAAGTCTCTCTCTTTTTTTTTTTTGAAGTACCCAGACCTTTTCA GGAAAAAAAAAAAAAAGTTTCTTCAGTGCCACCTTCTCACCAAGGAGGTAGAATAGGTAAAAATTCACCT GTTCAGAAACATACAGTATAGAAAGTGAAGTTTCCCATGTCTCCACCCATCAGAGGAAATAATAATTTTT TTTTTTTTTTTGAGATGGAGTCTTGCTCTGTCCCTCAGGCTGGAGTGCAGTGGTGCAATCTCTGCTTACT CCAACCTCTGCCTCCCGGGTCCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGTGC CTGCCACCAGCCCGGCTAATTTTTGAATTTTTAGTAGAGACAGAGTTTCACCATATTGGCCAGGCTGGTC TCGACCTCCTGACCTTGTGATTTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGTCATGAGCCACC GCGCCTGGCCAGTGATGATAATATTTGATACGTGTTGAGCAGTTGCTCTTACAGGCTCTTTTGGGAGGAC TTCATGTGGATTAACTCACTGAACCCTCCAATAGCCTTAGAGATAGGTATATGCAGTTATTATCTCTAAT ATACAGATGAGGAAACAGAGGTGAAGAAAGGGAACATGACTTGGTGACTTGCCCAAGGTCTCACAGCAGG TGACACAGCCAGGGCTGAAAAGCTGGCATTTGGTTCCTGAGGCTGCCTTGCCTCCCGCACCCACTCTCCT GCCTCTTAGTGTGGCGTATTTCCTTCGGATTTCTTTTTTCTGTGCGTGTGACATTTAAACACATACCTCC CCGTGCCCTGAAGTCTAAGACAGTATGCCCTATAAGGTCCATCATTGATCATATAACTGCTTTTCTGAAA AGAATGCGATAGGTGAGTTTTGTCCATGGATTGCAAGGTACATGCCAATCTCAATGACATCAGCATGTGA AACAATACGCATATTGTAGAATTGAGGTGACAGGGCGTGTGTGTGTGCGTTTCAGAAAAGGCATCCCGCC TGCATTCTGTCGTGCCGCGAGCCTTCGTTAGCGAATGCTGATGGTCCCAGTGTCAGCACAGCAGGGCTGG TTTCTGTGTTTCTGTGCTCAGGATGGCTTGTTGTGTTGTGTGGCCAGACCGTCTCCACGTGCTGGGTGCT GTGCTGAGCCCTTCCCTGCATTAGCCTGTGATGAAAGCGCTGCTGTCTGTCCTTGCAAGGACAGGAGGAA ACGGAGGCTTGGGAGTCTAGAAAGTGGGCAAACAAGGACCCCAGTCCAGATCTGCCTAACTCTCAAGGCT GTGTGGCATGGTGTTGTGGGGGAGCCAGGCCGCCTGTACTTCCTGAGATGAAGTCATAGGGCAAGTCATT TCACTTCTGTGCCTCAGTTTCCTCATTGTCATAGAAACAGTAGGAGTGTCTGCCTCAAAGTGTTGCTGTG AGGGTTATATTGGTATGTGCGAAGCACTCAAATGGGCCTGGCACGTGGTATGGGCTATGTGAGCCTTGCT CTTTTTAGTAGAGTCATGATATTAACCAATATATAGCACCAGACCCCTGTTGTGAGCTTTTAGATTGTTG CCAGGTTTCCCTATTTCAGCAGTACATACTTAGGACAGCGGTTGTCAGCTGGTGGTGGTTTTGTACCCCA GGAGACATTTGGTGATGACTGAAGACATGTTTGATTGTCGTAACCAGGGGAAGGTGTTCTGTTGGCTTTA GTGAGTAGAGACCCAGGATGCTGCCAGACCTCTTCAGGGTGCAGAAGAGTCCCCACATCAGGGATTCTCT ATCCCCAAATGTCACTAGTGTTGAGGCTGAGAATTCCCAGCTTAGAACTTCTGTGCCCTGGCACTAGCAT TTTCTGCAGGAGAAATTCCTCCAAGCACATGTACATTTTCCACTTTATGAGTTTTACCAGAATGTTCTCA CAAGACGCTGGGACCAGTTTATAGAGTGGTGAATGGCTGGTGGCAGATGAGGGAGTTGGTTCCCTCACGT CTTGCCCCAGGTGCCTTTCTCCTGAGTTCCCATGAGCAGATGCTGCCTGTTACACCACTAGTTCCTGTTG TCTTTGGGTTTTTTGGTTTTTTTTTTTTTTTTTTTGAGACAGGGTCTGGCTTTGTCACCCAGGCTGGAGT GCAGTGGCACAATCTCAGCTCACTGCAACCTCTACCTCCCAGGCTCAGGTCAACCTCCCACCTCAGCCTC CCAGGTACCTGAAACTACAGGTGCACACCACCACACCTGACTACTATATATATATATATGTATATATACG TGTATATATACATATATATGTGTGTATATATATATATATGTATGTATGTATGTACGTATGTTTTTTTTTT TTTTGGCAGACACAGGGTTTCACCATGTTGCTCAGGCTGGTCTCAAACTCCTGGGTTCAGAGGATCCTCT TGCCTTGGCTTCCCAAAGTGCTGAGATTACAGGTGTGAGCCACCGTGCCCGGCCAGCTTTTTTTGTTTGT TTGTTTGTTTGTTTGTTTGTCTGTTTTTTGAGACACAGTTTTGCTCTGTCTCCCAGGCTGGAGTGTGGTG GTGTAGTCATAGCTCACTGCAGCCTCAACCTCCTGGGCTCAAGCAATCCTCCTGGCTCAGCCTCCCAAGT AGCTGGGACTACAGGTGTGCACCACCACACCTGGCTAATTTTTATATTTTTTGTAGAGATAAGGTCTTGC TATGTTACCAAGGCTGGTCTTGAACTCCTGGTCTTAAGAGATCCTCTTGCCTCAGCCTTCCAAAGTGCTG GGATTACACGCGTGAGCCACCACGTCCAGCTTCCTGTTGTCTTTGAATTTATCTCCTGAGCAAGTCTTCC TCCGGGCGCTGTGGAAAGGCACAGATCTGAGTGCAGGCGACAGAGGCTCCTGAGGGGGTCGCTGCCACCT CCCCAATGAGCCTCCGCAGCACCAGGAAGGAGCCCCACCCACCAGCTCCAGCTCCAAGAGACGCAGATCT CTGCTTCCCCACCTGCCTCCCTAGCCCATCTGTGCTGTCTGGCATCAAAATCAGGTCAGTGAGAGGGGGC GAGAGAAAAAGGACTTAGTAAGTGGCAAGGAAAGGAATTGAGCTTATTTTGAGCCTGTTCTGGGCACAGG GCTTCACTCTGTACATGTTCATTCCACAGATACTTATTAAGTACCCACTCCACTCTGTGCCCAACACCCT ACAAAGCTCTGGGGATCCAGCTGTGGCTAAGGCAGCCAAGAGTCCTGCCTTTGTCGTGCTGACATTCCAG TGTGGGTGGTGGGCTGTCAGCGTAAGCAAACACATACAGTAACATCGGTGGTGATGGGTGCTTAGGGGAA AATGAAGGGTAAGGGTAAGGGGAGGTAGGGTGGGCATGCTTTGCCTAGGGAGGTTAGGAAGGCTTCTCAA GAAAGGGACGTGAGCAGAGGCTGAAGAGAGTGGAGAGGGGCCTGAGTTTCCACCTGAGGGTGCAGTGCCT GCAAGGCCCTGAGGTGGGGCGTCCCCATGTATCCTGGCAGCTGAGGGAGCCAGGCACTGCTGAAGTGAAG TGCCCTCAGAGAAGCAAAGGGGGATGTTGCAGGCCGCGTAGGGTCCTGGGGCTGCTTTGGGGATTTTGGC TTTTATGTTGCATGGGAGGGTTCGAGCGGAGAAGGGGTGGGAGCTGACTCAGGTGGTCACGGGGCTCCAG GCTGCAGGAGGGGCGTGGGCAGAGTGCTGACTTCTTTCACTCTATAACATTCTCTCACTCCTTCCCTGCT GTATTCAGCAGCAGTTTAGTCCTTTTCGTTGCTGAGTAGTGTTCTACTGTGGATCTACGTGTTTGTTTAT TCATTCTCTTGTGGGTAGACTCCTGGTCTGTTACCAGTTTGGGGTTACTGTGAATATTGCTGCTGTCAAC ATTGTAGTACAAGTCTTTTGTACATACACTAATTTCCTTGAGACGAATTGCTAGGTCGTGGGATAGGCAT ATATTGAGCTTTGATTTTGACTGCTTAACAGTTTTCCACAGTAGTTGAACCATTTTGCACCTCCCACCAA TAATGAGTAAGGGTTCTGGTTCCTCTACATCCGAGCCAGCAGTTGGCCTTGTCAGTTTTTAAAATTCGAG CCATCCCAGGTAGGTGGTTATGATTTGCATTTGCCTGTAACTAATGAGATTATGTATGTTTCTTGGTTGT GTGGGTGTCCTCTCCTGTGAGGTGCTCTTGCTCTTTTTACCTTGTCTTGAGTCAACAGCTGCAGCTCTGG CCCAGGCACTCAGAAGACTCATGCCCAGGAACCTTAGGAAGTAATGAGTGTGGTGGGGCCGTGCAGGGAC TCCCCTCCGCAGGGCGTGCTATGGGGGTTCCATAGGCGAGTCTCTGTCCCCCTGCCTGAGTGTCCTCCAT TGGCAGCCCCCCGAGTGATCAGGCCATCTTTTTTTTTTGAGATGTAGTTTCGCTCTTGTTGCCCAGGCTG GAGTGCAATGGCGCGATCTTGGCTCTCCACAACCTCCACCTCCCGGGTTCAAGCGATTCTCCTGCCTCAG CCTCCCAAGTAGCATGTGCCACCACGCCCAGCTAATTTTCTGTTTTCAGTGGAGACAAGATTTCTCCATA TTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCCGCCCACCTCAGCCTCCCAAAGTGCTGGGAT TACAGGCGTGAGCCACCGTGCCCGGCCTAAGCCAGCCATCTTCTTGGCTGCAGTGGCTGGTATTTCATCA CCACAGGACTGCGTCACGGACACCTCAGCTGAGGCACCACCCTCAGTGGGAGGACAGGGCAGGATCCAGG CGGGACGCAGGGGATCTTCCAACTCCTCCCCCTGCTCTCCCTCCAGCTGTGCTGACTCCTTAGTTGCTGA GATGAGCTTGTAAAAAGCAGCTCTGTTGATCCCAGCAGCGGCCAGGGCCTCCGCTGCTTCTCGGCTGGGA GACCCGAGGTAAACAGCTTCCCTTCTCTCAGCTTCTGTCCTCATCTGGGCATGGTCACTGACTGTCTGGT GGGGTGTTGGGAGCATTCAGGAGAGACTCCATGGGAGCGCCGGCACCCTGCCCAAGGCCACCCAGCTGGC GGTGGCTCTTGGACTCTGGAACCCAGACCACTCTTGGCCATACCTGGCTGCCTTTGCTTCTCTCTGGAAT AATGGCAGCCATGTGTTTGGCTGTTCACTGGGCGCCAGGCAGTAGGCCGAGCCCTGGGCCCACAGTGGGT ACTTTAGTGCTGCTGCATTACAAGGGCCCTGAGAGGCGATGTCCCTGGGCCGCTGTGGGCCAGCGAGAGG GGAGATGAGACATGGAGCCCCTGTTCTATTCCCTCCACATCAGCCCCTCCTTTGGACTCTGAGTTCTCCC TCCCAGCCATTTGGGAAGTATTTTGAACTGAGCTTGCATCAGGGAAGGTGTGGTGTAGGTCCGTGTAGGG GACGGGCTTCTCTCAGTCCCAGCCATAGCCCAGAAGGCCCTTGGTGTTCTCCCCTGTCCACCTCTCTCGT GTTTCTCCTCACCAGGCCCCCTCCTGCCTCAGGTCCTTGCATTTTCTGTTCCCCTGCTGAAATACATTTC CTCATGTGTTACACAGCTCACTCCCTCAGTTAACTCGGGTGTCTGCTCGCAAGTCCCGCACACCAAGCTA ACATCCTGTTCTTCCACTCTCCAGCCTCCCCACCACCTGATTATTTGCATATTCGTGTATTTTTCTGCCC CTCACACCAGACTGTGAGCCTCATGAAGGCAGGGCTGTGTCTTAGTGACATTCTGTTGCTGGTACCATCC GGGGTCTAGGATGCACCCCAAAAAAGATTGGTGTCATGAAGAGAGTCTGGTAGTGTGTCCCTGGCTGTGT GTGGTCCTGGGGTGGGGGTCAGTTGGGGACACTTGGCCTCTTTCTTCATGTGCTCATTAGATAAGACGCT TTGCTGGTCTACTGCATTAGCGTTAATAGGTGTTGGGAGGGTTGCTCCGAGGGTGCACAAAGAGCACACA GTGCAGCCTCTGAGGTGGGGAAGGCTTCCTGGAGGAGGCACTGGTTTAGCTGAGACCTCAAGGAAGAGAG AGAAGAACGCCCAGAAGGAGGTGCTGTCCCTGATGGAGGCCAGAGGGAAGGGCTTGAGTGACAGAAGCAT AACATGGAGAGTCAGGTAGGGCGGAGAGGCTGGAGAGGTGCAATAGTCAACGTCATGGTCCTTAGCCTTT CCCGAGGGCTTTCTAGGTGCACGTCTCAGCTCATGCACCTGGAACGCAGGGCAGCAGAGGCGAGGTCCTG AAGGGCCTTGGATCCTCAGCTGAGGAGTTTGGCTTTTTTGCTGGGAACACCAGGGAGCCACAAAGGTTCT GAGCAGGAGAAAGACAGGTTCAGCGTTGGGGATCCCTCTAGCTGCTGAATGTGGGGTGAGTGGGAGGGAG CAAGAGTGGAGCGTAGGAACTCGGGGAAGAGGTGGGGGCAGATGGGGGCAGACCTGACTAGAGCCAGGCC GCGGGCAGGATGGGGAGAGATGGTCACGTTAGAGGTTGACACACAGAACAGTGGGAGATACAGAAATACA TACATATTTATATATTTTTTGAGACAGGGTCTCATTCTGTCACCTAAGCTGGAGTGCAGTGGTGCAATCA AGGCTCACTGCAGCCTGGACCTCCCAGGCTCGAGTGATCCTCCTGTCTCGAATAGCTGACATTACAGGTG CACAGCACCATGCCTGGCTAATTTTTTAATTTTTAATTTTTTTGTAGAAAAAAATTAGGTCGTGAGACAA GTTCTCACTACGTTGCCCAGGCAGGTCTCAAACTCCTAGGCTCAAGGGATTCTCCTGCTTTGACCTCCCA AAGTGTTGGGATTACAGACATGAGCCATTGTGCCCGGCCGAGATGTGGGGATGCTGAGGATTGAGAGTCT GGCAGTCCTGTGTGCTTGGGTTGTGGGGTGCCGGGCATGTTGCTGGCAAGGGGAGCCCCTTATTGCTGCT CCCAGCCTCGCATCATTGCCTTTGCAGCTTGGAGCCCAGAATGTGATTTCTCACCCTCTTGTTTACTTCC CTGTCATGTCCATCTTGTCTTTCCTCCCGCTTCCTACCACTTACCTCCCTTCTTTCTGCCGGGACCTGGG CAGCCTGCCACTGTCACATGCCAGGCAGTAGCGTGTCCGGCCCACCAGCTCCCCTGGGGCACGAGAGAAA GCTGATGCCCATGGTGTCCCTAGAGCCAGCTGCCACTTCTCTGGGCGCCACCGTAGCTCCCGACCTGCTG TCCGCAAATAACCCCAGGCTGGGAAAGGCAAAGGCGCCTTGGTCTCTGTGGACCCTGGCCAGGCCCCAGG CTCCAGGTAGGGGCCCAGCTGGCGCTGCCTCGCGCCCTCCTCCCCTCCGTTCTGGGAACCTGAGACGAAG CAGTGGCCTCGGCGTCCCTCAGTCTGTTGGTTGCTGGTCCCTGAGGACAGAAGTGAAGGTCTTGGGGTAG GGATCAGGGCCTCGGTCAAGCCCCCAGGACTGGCTTCTAGGCCCCAGACCGTGCATACGCAGTAGGTTGC TTTCTTGTTCAAGATCCCGGATTGTCTGAGACCTGTCTTTTCTCTGTCATCTGATGGGGGGAGGGAGGCC GCTGAGGCTCAGGGAATGGCATGGGATGGCATGGGGGGACGGGAGTGTGCTTAGTTTGTTGAAGGTGGCA GGTTGGTGGCTTCCTGGTTTGGAAAGAAGGGAGAGGGGAGAGAGAGAAAAGAGTGTGTGTGTGTAAGATG GTGGAGGGACAGGCAGATGCTGGTGGCTCTGCGCATTCCCTCAGGTACCCTGGGCTGCCTCATTCATACT GGGTTACCTCAGTGTTGGGCCATGGGAATGACACGGGGAGGGCAGGGCACGGCTACCTTGATGCTTGCTC AGTCAGGAGTGACTGTGGGTGGAGGGGCCACCTCCCCCCAGCATGGGTGTCCTGAGTTTGGGGTCTGGCC TGCGCTTAGGCCGGGGAGCTCTGCTTCCCCCAGATTGGGGTCGCTGGGGACATTGCCACATCTCTCTGCT CAGAATGGGTCCTTGAGAGCGGGCTCCACGCCACCCTTGCTGGCCTTACCCTTTGCTGAGTGGGCAGAAC AGCCAGAGGGCCTCAGAGCCCGGCGTCCTCAGGGAAGGGGCTGGTGTGGAATCCCCTCCCGCCCTGACCA GCTCCTCTCTTGTCTTGCAGACTGTGCCCTGTCCACGGTGCCTCCTGCATGTCCTGCTGCCCTGAGCTGT CCCGAGCTAGGTGACAGCGTACCACGCTGCCACCATGAATGAGGTGTCTGTCATCAAAGAAGGCTGGCTC CACAAGCGTGGTAAGAGGCCGCTTTTGCCCGCCAGATTCTTTCTCCCACGCTGGCTCCTCCTGGAAAGCT GTGCCCTGAGAGGCAGAGGCGGAGGGTCTTACCAGCCTGAGGAGCCAGCATTCCGCAGCCCCAGGCCCAC AGCTGCTTATGCCCCCATTTCGTGGACTCCTTCAGTGGTCATCTGGGCAGGAGAGCAGGGATCTGACTGT GCATGAGTGATCTCATTCATAGCCCCATTTTATAGATGAAGAAACTGAGGCCCAGAGAGGGGAAGTCACG TCACTGAACTAACACAGTGAGGCAGTATTCAGCATTCATTCAGTTAGCAAGTATTCATTGACTGTGTGCT GTGCCGGATAGCCCCGGGCTCCGAGACACAGTGGTCCCCTGATGGAGCTTACATTCCAGTGGGGGTGGGG CAGGCAGTAAATAAGTAGACATGGAATGTCGGGGTGGCAAGTGCTGGGGTGAAAAGTGGGAACTGTGAGT GAGGGACAATGGGCTGGGGGCGGGGGGGCATCAAGAGGCTGCCCGGAGGAGACGGCAGTGGTCAGAGGCC TGGAGCCTGGAGGAGGTGAGACGCTGGCTGGGCAAGGGTGTCCCAGGGAGAGGGACAGCAAGGACAGAGG CTCCCAGGTGGGGATGTGCCTGGTGTTTTCTGGTAACAGCGTGGCTGGAGCAGTGTGAGCTAGGGCGAGC TGGGGGAGGCAAGCAGAGGAGCAACGCGGAGTCCAGCTGTGTCGCGCCTGCAGGTCATGGAAAAGGACCT TGGCTTTGGCACTCCAGACGAGAGCAGCCCTGTGATGTCGTGAGCCGATGCGTGGCCTGATCCATTTGTA CTAGTGGGAAGCTGAGGTCCCCTTTTAGTGAAGTTAGGACAGGGAAGAGACCCTTTTTGACCCCAGGGCT GTTTGTCCCAAAGTGGCTGCCACGCAAGACTGGGAGGCAGATGGGGAGAAGCGCCACCTGCTGAGAGATG GCTTTGTCCCAGGCCAGCTTCTGTGGGCCTCCCCCTGGAAAGAAGGTCCCCAGGTGTGGCGGTTGGCTGC CCTGTGTGCACTTGCATTCATTCAGCAAACACGTGCTGAGCAGCGCCTGTGGGCCAGGCGCTGTTCTAGG TCCTGGGGTCCAGCAGTGAGCCCGACAGGCAAACATCCCATCCTCGTGTTAGTATCTTGGGCGCTGACAG GGAGGCAGACAGCTCCCAGGCAGACATGCATGTCTCACGGTGGCGCGAGCCATGGAGAAAAAACAAGCAA CGTGAGGATGGGAGGGCATGAGGCAGGCAGGGCGGCCAGAGGGGGCTTCGCTGAGAAGGGGGCATCTGAA TAAAGGCCTGAAGGAAATCGGGGATTGAGCCTCACAGTTATGCCAGAGGCGACAGCCAATGAGTCCTGAG GGGGTAAGTGGGCTTGTTCAAAGAGGGGGCAGGAAGCTGGCGCTGCAGGCATCGGGAAGAGCCACGCATC CTGCACTGTACCAGCCTGCAGACGCAGACAGGGAGCAGCGATGAGGGATGGACGCCCCTCCCTGGGAGCA GCCTCCCCACCTGACTGAGCAGAGGAGATTCGTGTCCTGCTGCTCTTTCTGGACAGAGATGGCTTTTAAG GTCCCTTGGCCCAGTCCCCCAGCCTGAGCCTGGAGTCTGGGTTTGTTGATGGAGCTTCCTGAGTCTTGGC AGCTATCAAGGTTCTAACCCTGGTTCTGCTGCTTCCTCTTAGTGCAACTGTGAGCAAGCCATGTCACCTC ACTGAGCCTTGGTTTCACATCTATAAAGTGGGTTAACAAGCCAGATCTCTGATGTTGTCAGCTCTACAAG GGTAGGCATTTTCATGAGGCTTCTTCACAGTGGTATCCCCAGCACGTCTAAAAGTGGTGGGCATACAGTA GGCACTCAGTAAATGGTTGTTGAATGAATGGTTGGCGTGGTGTGTGGGTGGTGTGCTGGGGAACACAGGG TCATGGGCTCCTGTCCCGTGGCCTGCACGTGCGGAGGCCATGGCTCATTAGGCTGGACTGTGAGAGCCTT GGGATGGGTGTGGAACTGTTGGAGGGGCAAGAGTTTCTCTCTGGTCTAGGATTACTGATGGCATTAAATG AGTCTTGGCCCCTCTTGGGCCTTCAGTGTCCGCATTCATGTTACAAGGGGCCAGATGACCCAGCCACAGG CCTGCCTCTGTCATCTGGGATGGCCTAGCTCTGACACACCTGTCTCAGGTTTGCACCCTACACACACGCT TGTGCACACCTGCACTCTTGGGCCTTCCCAGTGCCCATCTTTCTGAGTAGCAGCTGGCAGAGGTGGGCAA GGTGAGGTGGGCCCTGCTGACTACTGCTGTTTTGGGACCTGTACCACCCCACCGACCCCCTTGGTGGTTA AAATAATGGCAGTGCTGGTTTACTGAGCACTTACTGTGTGCCAGACACCTGTCTCTGCTCTAGGCAAGCC TGATTTTGTTGAATTTTTATAGATGCCCTGTGGAGCACATGCCACCTTACAGACTGGAAAGCTAAGGTTC AGTAGGAAGAGTGACTTGCTTGAGGTTTCAGCAAGGAGTGGGTAGAGCTGAGGTTGGACTCAGGCCCTCT GACTCCTGAACTAGTGCTCTCAAGGCCTGGCCCACGTGCTGCCTCTCACCCAGCAAGCTGTGCTTAAGGC CAAGGGTGTAGTAATAGCACATCTAATCAGAGTCACTCATGCCATGTGCTGGTCCCACTTCTGACACAGC TGCAGCACACCACCATTAGCAGAGCACCTGCCCTCTGCCACGCCCCATGCTGGGCTCCATCTGCCGGTTT AGAGGCAGACGGTATAGTAGTCAAGATGTGGGCTGTGCTTTCCAATTCTGGCTCTCCCAGGTAACAGCTG GGAAGGTTGGGCAAACTAATAGGACCTCTCTGTGACTCAGTTTCCCCATCCGCAAAATAGGAATACAATT GTGAGGATATTTTTCCTTCTACCTGTTTTTTGTCTTTTTTTTTTTTTCATAGATATATGGTCTTGCTATA TTGCCCAGGTGGGTCTTGAACTCCTAGCCTCAAGTGAGTCTCCTGTCTTGGCCTCCCAAAGTGCTGGGAT TACAGTTGTGAGCCACTGCGTTCAGCTTTTAGGTTTCTTTTCTTAGCTTGTTACCAAAGTATGAAAGGCC ACAGATAAATGCCTGGATAATAAACTCGCCCCAATCCCAGTGTACAGTTCAAGAAATAGAATAAGACGGT CCCCGGAAGCTCTCCCAAGTGCTCCTCCCAAGCAGTTACCGCTCTCCTAACCTCCAGTAACACAGATGAG GTTTTTTTTAGTTTTTATCCTTTAAAAAAAAAAAAACGGGGATGAAATTTACATAACGTGAGATTAACCA TTTTGAAGTGTATGATTCATTGGCCTTTAGTATATCACAATGTTGTGTAACCACTACCTCTATCTAGTTT CAAAACCTTTTCATTACCCCAAAATAAAACTTTGTACCCATTAAGCAGTCAGTTTTTGTATCCTATGTCT TAGTTCATTCTGTGCTGCTATAACATATTACCCGAGACTGGGTAATTTATAATGAACAGAAACTTATTTC TTACCGTTCTGGAGGTAGGGAAGTCCGAGATTCAGGGTTGGCATCTTCTTGTCACACGTCCCATGGTGAA AGGGGAAGGGTAAGAGAGAACAAGACAGGGCTGAACTTGTCTTGTTTTTTTTTTTTTTTGAGATGGAGTC TTGCTCTGTCGCCCAGGCTGGAGTGCCGTGGCGCGATCTCGGCTCACTGCAACCTCTGCCTCCTTGGTTC AAGGAATTCTCCTGCTTCAGCCTCCTGAGTAGCTGGGATTACAGGCGTGTGCCACCATGCTTGGCTAATT TTTGTATTATTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTG ATCCACCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCATTGCGCCTGGCCGAACTCGTC CTTTTATAAGGAACCCACTCTGTGATAATGTCATTAATCCATTCATGAGGGTGGTGCTCCCTTCACCCAA ATACCTCCCATGAGGCTGCATTGGGGATCAAGTTTCCAACACATGAACTTTGGGGGACAATTCAATTCAT AGCACCCCCTGTCTCCTGGTGTCTGCTAACCACCAGTTTACTTTCTGTCTCTATGAATTTACCTACTCTG GACATTTCATGTAAATGGAATCATATGTGGCCTTTTGTGACTGGCTTCTTTAACTTAGCAACATGATTTT TTGTTTTGAGTCAGGGTCTTGGGCTATCGCCCAGGCTGCAGTGCAGTGGTGGGACCTTGGCTCATGGCTC ACTGCAGCCTCAACCTCCTGGTCTCAAGTGATCCTCCTGCCTCAGCCTCCAGAGTAGCTGGGACTACAGG CAGGTGCCACCACACTTGGCTAAGCTTAATGTTTTTGAGGTTCCTCTATGTAGTAGCGTATATCAATATG TCGTTCCTTCTTATGGATGAATAATCTCTATGTTGTAGATGTATCACATTTTGTTATCTGTTAATTTGTT GATGGACATTGGGATGATATATTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGATGGAATCTCACTC TGTCACCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCTGGGTTCAAGTGAT TCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGTGCGCCACCATGCCTGGCTAATTTTTATAT TTTTAGTAGAGATGGGGTTTCACCATATTGGCCAGGATGGTCTTTATCTCTTGACCTTGGGATCCGCCCA CCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCAAGCCCGGCCTCGGGGTGATATATTCTA TATTTAACTTTTTGAAGAAGCAGCTGCACCATTTTACATTCCCACCAGCAGTGCATGAGGGTGTCAGTTT ATATCCTTGCCAACACTTGTTTTTTTTTCATTACAGCCATCCTTGGGCATGTAAAGTTGTACCTCATTGT GTGTGTGGATTTTTTTGTTTTTGTTTTGTTTTGTTTTTTTGAGACAGAGTCTTGCTCTGTCTCCCATGCT GGAGTGCAGTGGCACGATCTCAGCTCACTGTAACCTCCACCTCCTGGGTTCACATGATTCTCAGGCCTCA GCCTCCCAAGCACTGGGACTATAGGCATGTGCCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGAT GGGGTTTGATCATGTTGGCCAGGCTGGTTTTGAACTCCTGACCTCAAGTGATCCGCCTGCCTCGACCTCC CAAAGTGCTGGGATTACAGGTGTGAGCTACCGCGCCCGGCCTTCATCGTGATTTTGATTTATGTTTGCCA GATGACTAATGATGCTGAACATCTTTTCATCTTTCTGTTGACCATTTGTGTATCTTTGGAGGAATATCTC TTTGAGTCCTTTGCTCATTTTAAAATCAGGCAGTTTGTCTTTTTGTTGTTGCATTGTAAGAGTTCTTTAT GTGTTCTGGTTAATAGACCCTTATTAGATTTCCAAGTATTTCCACCCATTCTGTAGGTTATCTTTTTACT TTCTTGACAGTGTCCTTTCATGCACAAAGGTTTTTAATTTTGATGAGTTCACTTGAAGTTTTTCTTTTTG TTGCTTGTGCATTTGGTGTCATCTAAGAATTCATTGCCAAATTCAAAGTAATGAGATTTACTCATGTATT CTTAGACTTTTTTTGTAGTTTTAGCTCTTATATTCAGGTCAATTCATTTTGAGTTTATTTTTGTATATGG TTTACAGTGTGAAGTAGGATATCACAAAAGAATGTGATATCCATTCTTTTGAATGTGGATATCCAGTTGC CTCAGTTTCTTCATCTGCAAAATAGGGATAAGATTGTGAGGATAGGCTACTCTGGGCACATTGCCTATGG GTCACTGTTCCCTGCTCTGCAAGGAACAGTATTTAAATTAACAAAAAAAATTGTAAGGATATTTTTTCTT CTAGGTTTCTTTTCTTTCGTTTTGAAAAAATATAGTCTCTTTGTTGAAGAAACTGTTCTTTCCCCATTGA ATGATCTTGGCATCTGTGTTGAAAATCAGTTGAATGTAGATATTTGGGTTTATTTTTTGGCTCTGAATTC TCTTCCATTGGTCTGTATGTCTGTCCTGTATAAACTGTACTGTTTTGATTACTATAGCTTTGTATAGTAA ATTTTGAAATTGGAAAGTATTTAACTTTATTTTTCTTTTTCAATATTATTTTGGCTCTTTGGGGCCCTTT GAAATTCCATGTGAATGTGAGGATTGGCTTTTCTATTTCTGAAAAAAGAAAAAGCCTGTTGGAATTTTGA TAGGGATTGCATTGAATCTGTATATTGCTTTGGGTAGTATTGCCATCTTAACAATATTGTCTTCTAATCC ATGCACACAGGATGTTTTTGCATTTATGTAGATCTCTAATTTCTTTAAACAATGTTTTGTAGTATACAAG CCCTTCACCCCCTTGGTTAAGTATTTTTTTGGAGGCTTTTGTAAATGCTTTTTTTTTTTTTTTTTAAGAG CTAGGGTCTTGCTCTGTCACTGGGCTGGACTGCAGTGGCACCATCATAGCTTCAATTTCTTGAGCTCAGG TGATTCTGCCATTTCGGCCTCCTGAGTAGCTGGGACTTCAGGCACACGCAACGACTCCTGGCTAATTAAA AAACATTTTTTGTGGAGACCAGATCTCACTATGTTGCCCAGGCTCGTCTCAAACTCCAGACTTAAGCCTG CCTCAGCCTCCCAAAGTGCTAGGATTTTACAGGTGGGAGCCACTGTGCTGGTGTTTAATAGCCATGTTGA GGTAAAACTGATGTACTACATGATTCATCCATTTAAAGCATACAGTTCAGTTGGTTTTAGTATGTTCAGA GTTGTGCATCCATCACCATACTCAGGTTTTTTTTTTTGTTTTTTTTTTTTTTTTTTCGAGACGGAGTTTC GCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACGGCAACCTCTGCCTCCCAGGTTCA AGGAGTCTCCTGCCTCAGCCTCCCAAGTAGTGGGATTATAGGCATGCACCACCATGCCTGGCTAATTTTG TATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCCAACTCCCGACCTCAGGTGATCC GCTCGCCTCGGCCTCCCAAAGTGCCGGGATTACAGGTGTGCGCCACCGTGCCGGGCCCTACTTTTCATCT CTGTAGATTTGCCTGTTCTGGGCATTTTATATAAATGGAGTCATAATGATACGTGGTCCTTTGTGACTGG CTTCTTTCACTTAGCATAAGTTACGGTCCCTCCACATGGCAGCATGTCTCAGTACTTCGTTTCTTTTTAT GACTGAATAGTTTTCCGTTGTATGAATCTGCTACATTTTGTTTATCCATTCGTTGTTGATGGACATTAGG GTCGTTTCCACTCGATGGCTGTTATGAATAATGCTGTTGAGGACATTTGTGTGTAAGTTTTTGTGTGGAT GTGTTTCACCATCTCCTTTTAATCCTTAGCAGCTCTCTGATGAGTGGGTTCGTGTGTGTGTGTGTGTGTG TGTGTGTGTGTGTGTTTGTGTGCATAGGGTGCTTGGATATTCATGGTGAAGAACAGTTGGAAAGAGTCAA GGGGCGCTGGGAGGGTGTGGCAGCAGTGCCACCCTGCCTGGCACAGAAGTGTTTTGGCATTGGAGCTACC TGCACAGCTGTATTGGTGAATCCCAGCCCATGGGATTTGGCCTTACAGGGCCACAGGGCATGTGTGTTTG GAAGCCTGGGCCTCCCCTGGGACTAGGCCAGGAGCTGGCACAGACAGCTTGCTCCTTGCCACACGCTGAG GCAACTGGTGCCCCAGGGCACTGCTGCTGGCACCTTCCTGCCAGGCATGACCTGTGGATCACCCGGGCTC AGCCCAGTGCCCCAGCCTGCGTCAGCAGGGGCCACCTGGAGGGCTCCTCTGGGAGAGGCATTCTCGTGTG TCCCCCGCACCTCCCCGCCCCGTGGTACCCCTTGTGAGTCACCGTCACACTGGGCCTCCTGCCGCCTACC TGGGACATCACTCAACCTTGTCCTAACCTCTCTCCCTCCCTTCCTGCCTCATTTCAGGTGAATACATCAA GACCTGGAGGCCACGGTACTTCCTGCTGAAGAGCGACGGCTCCTTCATTGGGTACAAGGAGAGGCCCGAG GCCCCTGATCAGACTCTACCCCCCTTAAACAACTTCTCCGTAGCAGGTGTGTCTTGGGATGAGTGGGTCA GTGTTCTGGTGCTCACAGGATGGCTGGCACGTCTTAGGGGCTTGTGGGACTTGGTCATTGAGCCATGGGC CTGTCCTGGGCCTGCTTGCCCTTGGATCTGTTTTCACCCTTCCCCTGCTCTCCCTCCTTGTTAGCTGGCC AGGCGGGGCTGTCCTGCGGGGAGATGCAGAGTGGGAGGGAGGGAGAAGCCAGGGCATTTGCCCACACCCA GCCCCATGCATCGCCTCCTTGTGGTTCCAGCTTCTGTCAGCCAGGCCTTGGAGTCCCCAACTGGTGGCAG GTGCCTCCCATCCTGTGCTTTGGTAACAGCCTCCATCCTCTGTCCCTCGGACGTAGAGGGGTCACAGCTT CCCACTCAGCTGGTCACAGGGCTGGCCTCGCGTCCTCTGTCCCTCTGTAATACCCAAAGGGATGTCTTCC AGCCAGACCCTGGCAGTGAAGTTTCACAAGCCCCAAGCTCTTGACTGAGCCTTGGAGAATATGGTCCTGT CCACATCGCTGCCCCTTTCTGCCGCCTTCCTTCCTTGCTGACCTGATGGGTCACCATGTCCTGTTGTTCT GCCTGCTAAGAACATTACAGAGGCACCCCCATCTCCACTGCCAGTGCCTTAGCTCAGACCACTATCCTCT CCTGCCATGCTGTGGAACCCAGTCCCCGTCCCACGCTGCTCTGCATGAAGCCTTTTCCTGATTGCTCTCC ACATGTGCTGGTGACCCTGACACATCTGTTCCCAACCTCAGTGTCTCACTAGAACTCCCAGCCTGTCCCA GGCTGCTCCTTGGACACATCTCCCCAAGTGTCTTCAAGGTCCTCATAAGTGCCACATCCCAACCTGACCT TCAGGCCTCTCCCAGCTCTATTCCTGTCTCTGTCTCAGGGACAGCAGGCCGAGAGGCCTGGGCCTGGTCC TCAGTGCCCTCTTCCCATGGCCTGTCTGCAGGGCTCCACTCTGGTGTGGCCCCATCCTCCCTAGCTGGCT CCCCACCTCCCTGGCCTTCCAACCTCCAGCCTCACCCTCTACATGGCAGCCAGAGGGATCATTCTCAGTC TGTTTGTGTCTCTTCCCTATCTAAAGCCTTCTATGGCTCCCTGCTGCCCTGAGGACAAAGTCCAGATTCT TTCCCATGGCCTCCAAAGCCCTGCCTGGCTGGCCCCAGCCCACCTCTCCAGGGCTGTCTCTCACTTACCC CTCCTCACCCTTGGAGCAGAATTGGCCACCCCCTGAGGATGTTGAACCTCCTCTCACCTCTGAGCGTCTG TTCTCCGTGTACCCTCTAAGTTCCCTTTTCCTTCAGGGCTTAGTTCAGAGAAGCTGCTTCCTCTGGGAAG CCCCCCAACCCCCCAGGCTGGGTTGGATGCTACCTCTGAGCTTCTGCACACCTCTAGGCTTGTCCCCATC GCGGCCCTGTCTATGGAGCCATCACTCTCTGGTGGGCTTCTCTCCTTCCACACACACACACACTAGACCC TGAGCCCTGTGAGAACAGGACCAGGGCTGTCTCAGTCCCTAGAGTGTCCCCAGCACCATCTAGCATGGGG CTAGGCCTGTGGGAGGTGGCTCGGGCACTTTGGGCTGCAGGCTAGCAGGGCTATCCCCTCAGCCCCCTGC TGTCTGTTCCCTCTGCCTGCAGAATGCCAGCTGATGAAGACCGAGAGGCCGCGACCCAACACCTTTGTCA TACGCTGCCTGCAGTGGACCACAGTCATCGAGAGGACCTTCCACGTGGATTCTCCAGACGAGAGGTCAGT CTGGGCCTCTGTGTGGCTGCCCTTGAGAGGGAGCAAGCCTGGTGTGAGGAGAAAAGGTACAGCTGGAGAG ATTTTCCCTGGGACCCTACATAGGGGTTTCCTATCTGCGCTTCTGGTTGGGGGGTCTCTCCAGCTGGGGC TGAGAAGAGCTGGGGTTCTTAGTCTGAAGACCCTACTCTGCCCTTTGACTTGCGGGTGCATCGGAATCAC AGGCAGAGCTCGTGAAATGTCTAGACCGCTGGGCCTCGCCTCAAGACCTGTGACTACCTGGAGATCTGCC CAGGGTCAGGGAGCTACATTCTTTTTTTTTTTTCTGAAATGGAGTTTCGCTCTTATTGCCCAAGTTGGAA TGCAGTGGCATGATCTTGGCTCACTGCAACCTCCAACCTCCACCTCCTGGGTTCAAGCGATTTTCCTGCC TCAGCCTCCCAAGTAGCTGGGATTACAGGCGTGTGCCACCATGCCCGGCTTAGTTTTTGTATTTTTAGTA GAAAAGGGGCTTCTCCATATTAGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCTGCCTCGG CCTCCCAAAATGCTGGGATTACAGGTGCAAGCCACCACACCTGACCCCCTTTTTTTTTTTTTTTGAGACA GAGTCTTGCTCTGTTGCCCAGGCTGGAGTGTAGTGGTGCCATCTCAGTTTACTGCAACCTCCGCCTCCCG GGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACGTGCCACCACATCTGGC TAATTTTTGTATTTTTAGTAGAGACAGGATTTCGCCATGTTGGCCACACTGGTCTCGAACTTTTGGCCTT AGGTGATCTCCCTCGGCCTCCAAAGTGCTGAGATTACAGGTGTGAGCCACCCTGCCCGGCAGGACCTACA TTCTTAATGAGCATCTCTATTGATTTTGAGGCAGGTGGTCCAGAGAGTCATTTTAAAAAGATCAATTTAG TAATCAGAAGAGATGATAAAGACTCATCTATTTCAAAATTGAAACAGTATAAGGAGGTGTCTAGTGGGAG CTTCCCCTACCCTGCCCTTTCCATCCACCTCCCTGCCCCCCAGTTAATCACTGTTCTTAGGTGCCCTCAA AGAGCAGAGGGAGACCTTTGTGCCTGGCTGCCTTTTTTTTTTTTTTTTTAAATACAAAAGGTAGCATTGT ACATGCTTCTGGACTTGCTTTTTCCCTTAGTGTACCTTGGGGAATTTGCCTTGATATATGGAGAGATGCA GCTGCTTTGTTTCATGTTTTGCTTTTTTTTTTGGACAGTTGGACATGCGTGTCCCAAGTGTGTTTATTTA GCCGTTCTTTATTGTGATGACTGGGGTTGTTTCCAGCCTTTGGCTCATTATAAGGAATGCTGCAGTGAAA TAGCCGTGTCTGTCTCGTTTGATGTGTGCACAGGTAGACCTGTGTGACGAGTGCTTAGATGCAGGATTGC CGAGGCACAGGGAAAATAAGTTTGTGGTTTTGCGATGTTTCTATTAGGCGATGTCTGAGAGTGCCCCCAT GGCCTTGTGTTTTCAAACATTTGGATTTGTACCAGTCTGAGCAGTGGAAAAATTCAGCACCTCGGGGTGT TTAACTTTCCTTTCTTTCTCTGTGGATGAGTTTGACCCTCAAGGGCCATGTGAGTTCCTATTCTGAAGTG TCTATATTGTCTATTTTTCTGTTGGGTAGTTGGTCTTTTTCTTATTTATGTATTAGCTCTTTATAGATTA AGGAGCTTTGCCCTTTGTAATCAGTGGGAAATGTTTCTTTTTCCCACTTTGTCCTTTTGGGCCTCACTTT GAGAAACAGTCTTCTAGCTTATCTATGGGGTAAGGTTTCAGCAGACCCTCTAGAGAGCCCTAAAATCATG CCGTCCAAGAAAACTTCCGGCCATTGTGGAAATGCCCTTTATCTGCACTGTCCAGTAGGCACCTGTGCCA ATTGCCTGTGCCGATTGCCTGTGCTGACTGCTTGTGCCGATTGAGCATTTGAAATACAGCCACCAAGGAA TGGATTTTTTCTAGTTTATTTTAATTGATTTAAAGAGCCACATATGGCTAGTGGCTACCTTCTTGGACAG TACAGCTCAGGAACCCACAATATCATGAGACTTGTTACTATAATCTATACTATAATTATTGTTGCACATC CTCCCAAGGTAAAAAATATACTTGCCCCACTGAGGGGAACAAAATTACCATCTCAAGCCAGCTGAGGTGC TACTCAGTTGAAAACTATGGACCAAAACATGAATGGCCAGTAAAAACAGATCGAGACCAGTGGGTGTATA GGTCCTGGGTGTTGAGCTGGGTTTTGAAGACTGGATAGGATTTGGCCACGGAGATAGCAAGGAGAAAGTT CAGAAGGGACAGCATATGCAAAGACCTGGAGGTGAAATAGCTCATGCATTCCAGAGACTACAGGGGGTTC TGTGTCACCAGAGAACCAAGGGGCCAGGAGTGTTGGAAGAGGGGAAGTGGAGGCGCTCGAAGCTGGAGAG CTCAGCCAAGGCCTTGGACTCCAGGTGGAGATCCCCACAGGGCTTGGCAGGCACTTAGTAAATTGCGGTT TGTCCCAGGGTAGTTACACGATGCAGGGGAATGATAAATAGGAGCGGCTGATGCAGCAGTACCTGGCACA TCAGGTACTGACAAGGTGGAGCTGACAAGGTGTTTTAGTAGGCAGGAGAGATGGTCTCGTTTCCATTTTC ACAAGACAACATGCCCTTTCCTTTACCAAGATTCTGTAGGCTGGAGAGCCCCACCTGCCTTTTCTTCTTG GTACCTGCTGCTGTTGCCAAAGAGAAAACTGCTGGAACGACTAAGAGACCAGGTCCCAGATTTCTGACCT TAACTATGGGTGGGTGGAGGGGGTGAACCAGAAACCCAGCAAGAGGGAGGCCCCCTCCACTCTGCTCCTG GCTGACTGATGCTGTCCTCACAGCCCTGGCCCACACAGGCTGATGTCAGCTGGCCTCTCTTAAGCCTGGG GAGGGAGGCAGGGGTTGCAGGGCAGGTGGGTGCCAGTCGGTGACTGCTTGTTGGCTAGGTGCTGCAGCGC CTCCTCACTGGGCTCCTGGTTGCCTCTCCAGCTGGAGAGACCCTCCTCCCTGTCCCCCACTTCACTGCAG ACGTGTTTCACATGGAGAAAAGTTGAAAGAATAGTATAATGAATGGACATCCACGCGCCCCACTCCTAGA CTCTGCAGTCCCGCATTCACCGTGTCTGCTTCATCTGGTTGTGTTTTATGCTGAACTTGAACTTGTGTTC ATACTTAGTGACATTCTTAGTGTTTCAGCAGGCATCTCCTAAGAATAAGGACTTTCTCCTACAGAATCAT GATGCTGTCACGCCTGAGATGATTATAATCTTTGTTTACTAGTAACTTCTCCTTATCCATGCCGTACTTG AATTTCTTTAGTTACCTTTTGAAGGATATGCAACCTTTAGAACATTGTTTTAAAACCAGTATTCATTCAA GGTACATGTCTCTTTGACTTGTTTTATTTAATCTAGTTCAGCCCTTTGTCTTTTTTTTTCCTCCCCAAGA CATTGATTTTTTATTAATTTATTTATTTTTTTGACAAGCCAGGCTAGTTGTCTTGTAGAATGTCACACCT TCTGGGTGTGTCATATTATTGCCTTTTGGTGTTGTTTACTTTTGTTCCCCATGTTTGTATTTCTTGTAAA CTAGAATTAGGCCAGGAACAGGGTTGGCAAACTATGGCCCTGCCTTCCATTTTTGTAAATAAAGTTTTAT TGGAACATGACCATGTCCATTTGTTCATGAATAGTCTGGCTGCTTTTGGCTTACTGTGGCTGGGTTAAGT AGTTGTGACAAAGACTGTCTTGCAAAGCCTAAAAAATTTAATAATTGGCCCTTTTAAAATTTTAATTAAA ATTTTTTAAATTTAAAACTTTTTTTTTAGAGACAAGTTCTTGCTCTCTTGCCCAGGCTGGAGTGCAGCGG TGCAATCATAGCTCACTGCAGTCTCAAACTCCTGAGCTTAATCCATCCTTACGCCTCAGGATCCTGAGTA GCTGGGACTAAAGGTATGCACCACCATGCCTGGCGAATTTTTAAATTTTTTTGTGGAGACAGAGTCTTGC TATGTTGTCCAGGCCGGTCTGGAACTCCTGGTCTCAAGCAATCCTCCCTCCTCCACCTCCCAAAGTGCTG GGATTATAGGCACAAACCACCACACCCAGCTTTCTGGTCCTTGATGGAAAAAGTTTGCAGACCCCTGGTC TTGGCAGGCAAGAATACTTAATAGTGCATCAGGTGAGTATGATCTTTTTGTTGTTGTTTTGATGGGGTCT CTGTTGCCCAGGCTGCAGTGCAGTGGCAGAATCACGACTCACTGCAGCCTCAATCTCCCGGATTTAGGTG ATCCTCCCACCCCAGCCTCCCTAGTAGCTAGAACTACAGGCGCCTGCCACCACACCAGGCTAATTTTTGT ATTTTTTGTAGAGATGGGGTTTCACCATGTTGCCCAGGCTGGTCTTGAACCCCTGGGCTCAAGTGATCTG CCCATCTTAACCTCCCAGAGTGCTAAGATTACAGCCATGAGCCACTGTGCCTGGCCATCTGTGATCTTTT TGACGTAAATCTTTCTTTCTTTTTTTTTTAGACAGAGTTTCACTCTTGTTGCCCAGGCTGGAGTACAATG GTGCAATCTTGGTTCACTGCAACATCTTCCTCCTGGGTTCAAGTGATTCTCACGCCTCAGCCTCCTGAGT AGCTGGGATTACAGGCACGCGCCACCATGCCTAGCTCATTTTGTATTTTTAGTAGAGATGGGGTTTCTCT CATGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCTGCCCGCCTCGGCCTCCCAAAATGCTG GGATTACAAGCGTGAGCCACCGTGCCTGGCCTTGATGTAAATCTTATCATGTATTTTCTCTGCTTAGAAC TCTGAATGGCTTTCACTCCCACTCAGAGTAAACTCCAAGGTCCGTGCTGTGTCCTGCAGAGTCCTGTATG ATCCAGCGACCTCTCCAGAAGCATTTCCTACCACAAGCACCCTCACTTAGCCACGTGTCTCCTTGCTGTT CCTTAAACATGCCTAGCACATCTCTTGCCCGAGGGCCTCAGCGCTTGCTGTCGCGTTTGTCTAAGGCCTT CCTCCCTGAGATGCCATCACAGCTCTCCCCGACTCCACGAGGTCTCTGCCCCAGTGTTGCCACCCCAGTG CGTCCTGCCCTGCCTCCCTTCGCTGTCTTGCCCTTCCCCAGCTGTGCTTTTCTTCATAGCACCTGTCCAC CAAGTGGGACATTTATATTTATGTATGTATCTGGCACACAAATGGGTGTTCAGTAAATGTTTGTTGGATA AATAAAAAATAATTAAATTCTCTGAGCTAGATCCTGTTCCGAGGACTTTTCATATATTAATTTATTTTCT CCTCACAAGGCAGACTATCTGTGCACAGGGAGGGCCCCAGATGCCCTCCAGCTGTAAATGCCCCTCTAGG TCGGGGAGGTGATGGTTAGGGGAGAGTCCCCACAGTCAGCTGTCACTCCTGAAGCGGTGAGGACGGGCTT GTGCATGAAGGACAGCCCTGCCACCTCTGCTTCGCCGAGCTTCTCTCTGGGGTGCCCCGCAGGATGGCCC AGGGCTGGGGTCCAGGCCCTGGATTCAGGCCAGCTGCCGTGTCTCTCCCTCAGTGGGGCTCAGTTCCCTG GCTGTCATGTGGTGTAGAGGAGGAAGTAAACATGAAGGCACTGGCGCAGGGCCTGCCCATGGCAGCTTTG GCACACGCAGCACTGGTACCTTTCTTACCTCTGTCTCCTCTGCCACCAGCATCTCTTTCCTGGAGGATGC CGGGGTCTCCTCTCACTGCCCCCAGTCCGTAGCCCACACAGCAGCTACTGACTTAAAACAGAAATTTGGA GCCTGTTCCCCCCTGACTAAAACCCTTCAGCGACTTCCTGTGGTGCTGAGGATAAGACCCAGATCTCTAA CATGGTGGCACGTAGAGGCCGGAGCGGTCTGGGCATGCTCTCCTCCCTGTCCTCATCTCCTCCACTCCTC CCTGTCCTCATCTCCTCCACTCCTCCCTGTCCTCATCTCCTCCACTCCTCCCTGTCCTCATCTCCTGCAC TCCTCTCTCTCCTCATCTCCTCCACTCCTCCCTGTCCTCATCTCCTCCACTCCTCCCTGTCCTCATCTCC TGCACTCCTCTCTCTCCTCATCTCCTCCACTCCTCCCTGTCCTCATCTCCTCCACTCCTCCCTGTCCTCA TCTCCTGCACTCCTCTCTGTCCTCATCTCCTCCACTCCTCCCTGTCCTCATCTCCTCCACTCCTCCCTGT CCTCATCTCCTCCACTCCTCCCTGTCCTCATCTCCTGCACTCCTCTCTGTCCTCATCTCCTCCACTCCTC TCTGTTGGCTCCAGCCATTCTGGCACCTGTGTGCCTTTCACAGACACCCCAGCTTGCTCCTGCCCTGGGG TCTTTGCCATGCAGTTCCCTCTGCCTGGGTTCCTTTCCCTCCCAATCCCCTGCCTCCTTCCCTCCATTTC ATTTATTTCATAGCTGTGTGCCAAGGGCCTGTTCTAGGCACTGGGGATGGCCATTGTTCAGGTCCTGGTT TAAACGTCATCTCCTCAGGCCTCCCCTGACTGCCCTCTGAGAAGGAGTCTCCCTGTTTGGCCCCCGCCTT GGAGCTTCTACACACTTGTCCTCCCCTTGAGGTCAGGAGCCATGATGGGCTTGTCCCCTGCTGCATCCAC AGTGCCCTGAACAAGCCTGGTGCACAGAAATGCTCCACATTTGCAGGCCGGCTGGGTGAACTCTCATGAC AGCCTTCTGAGACCTCAATGTGCTGGGCACCGCTCTCAGCACTTTATGTCTAGTGTCTCATTTCACCCTG ATAGGACCCTCTAGTGCCTCACCCACCGAGGCACAGGAAGGGCATACAACCTGCCCAGTGTTGCCTGCAG GAAGGGGCAGAGCTGGGATCCACGTCCAGGCCATCCCCCAGAGCCTGTCCTCTCACCCACTGTGAGGTCC CCAGCTGGTACGGAAGGCAGGCAGCGCATTGGGTGGCAATGACCCCACAGCTCCTGGCCCAGAGCCTGTG CTTGCCCCGTACTGTGCCCTTCCCAGTGTTGGTATGGCGAACGTGGCTCCCCCATGTCCCTCCCCTGGCC CTGAGCCCAAATGAGGATGAGAAGGTTCCAGAAAATACCGATGGGGGAAGTGCTCTTGGAGGTAGAAGTG CCTGGGCACTTCTTGTGTCCCTGGCCTCTGTCGGTGGGCAGATGAGCCTCTCTGTGCTTCGGTCTTGTCA TTTTAGCATGAAGTGAATGGCAGTACCTACTACACAGGGTTGCTGGGAGGGCGACAGGAGTCCTCCACCA TAACGCACAGTGGTACCAGCCTCTGCAAGTGGAAGGTGTTCTTGGGACTGCTGTTGAGTGGCAGGGGTGG GGGCCCCTCTCTGAAAAGCGGGTGCAGATCATGGCTTACGAGGAGAGTTCTTCCTTTGCTTTTCCCGTGG GCTCCCTGGCTGGGTGTCCCATGAGCCTTCCCTAGAGAGGGTCCCTGCTTTACCCTCCTGAGTCTCGTGT AGCTTTCAGCGCTTCACTGAGGCTCAGGGACAGGCGGGTGGTGCTAAGGAGGAGTAGGCTGTGCACAGGT GAGTGCCAGCTCTGCCACATCCCTGCTGTGTGACCTTCACAGGTGACTCCACCTCCATGTGCCTCAGTCC CCACAGCAGAAATGCTGGCTCTTGAGAATTGCAGTGCTCTTGAGAATCAAGCGAGGTGGTGTCTGGAGCT AGCCACTCAGTGCTGTTATTTTTACAGTCGTGGTTTACCCAGGGGCTCTCCTCTGGGGGCTAGAAGATAC TTGAGGCCCAGCTTCATGGGGAGCTCCCCTTTGCCCCAGACGCCATGTTGCAAACCCTTGAGAAGGATCC TGGACAGAGGCCCTTGCTTTTCATCTGGAATTCTGAGTGCTGCAACCTTGCAACTTTGGTCCAGTTAGAA TTGGATCGGAAGCTAGTCAGGCAGCAGGCGAGCCCCAGTTACTCCCAGATAACCTCCTGCATTGCTGTGG TTTCTGGAGCTTTCTGTAGGGTGGGCAGTGGGAGCCAGGGTAGGTGGGGTAGGCCCGCCCCTGCGAGTGT CTTCGGCACCCTCCCTTCCACCCCGCCCTGCGCGCGGTGCTCTGCGCCGACAGCCCGCCAACCTCTTAGC CCCAGGCCCAGGCCCTGGTGGAGGGGAGAGCTGGGAGGGCTGAGCTGGTCCAGGTGGCAGAGCCACTCTT GGAGCCCCAGCTGGGGTGGGTCCAGGGCCTGTGCTCCTGATTCCCATCTGGAGTAGCCTCCCAGAGCTGC TTCTGGGCTGGTGGTGTGGCAGTGCCATCCTTCATGTATTTGGGTTCTCTCCACAGAGGGACCATCTGTG TTCTCTCCACCCCTGTCTTTGAAAACAAAGATGATACCACGCTGTACATCTTAGTCTGCAATCTGCCATC TTCACGTGACAGTCTCTCAAGATCTTTATATATGAGAGACATATTTTCCTTTTTAATATCTTCACTGTAT CTCTTAGGAGATCTGTGATTTTTTTTTTCCCAATCCGCCATCATTTACTCAGAGTCAGCATTAAAAAAAT TTAAAATTTGTGAGAGGACAACTATGTCTGATAAAGCATGTCATGGAAGGCTGGGCACAGCAGCTCACAC CTGTAATCCCAGCACTTGGGGAGACCGAGGCAGGCAGATCATGAGGTCAAGAGATCGAGACCATCCTGGC CAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTATGGTGGCGGGTGCCTGTAGTTCCAGCTA CTCTGGAGGCTGAGGCAGGAGAATCGCTTAAACCTGGGAGCCACTGCACTCCAGCCTGGCAGCAAAGCGA GACTCTGTCTCCAAAAACAAAAAGAAACAAAAAAGAAAAAAGCCTGTCATGGAATGGGCTCCTGCCCTGT CCCCGGCCCCTGCTTTTTTTTTTTTTTTTTTTTGAAAAACAGGAATATTAGTGTAGGGTTTGGGAATTAG GCTGTAATTTGTTCCTAAGGGGGCATGGGTTAAAGCAAGTTGAGAAATACTGGCTTGAGATGTTGGGCCA GGGAGTGCAGAAGCCAACACCGCTCTGCCCGGGTGTGCACCAGGGCTCAGTGCGTGCTCTGCCCGGGTCT GCACTGGGCCCTGCTGCGCCCTGGCCCTGGGGCCACTTGGACTTTGGCTGCCTCACTCTTTCATTACCCA AGTATCTACTGAGTATCCACCATGAGTTCTGGGGGCAGAACTGTGTTCAAAGCAGGTGGAAATCTCTGCC TCCGTGGGGTGGACATAGATGGGTTATGGGGACTCCAGTCTCTGAGTGGGTGGGGAGGGCAGCGTGCCTT TTGTAATTCCAGCTACCAAGCCTGGAGCAACTGCTGTTTTTCTGGAATCTGTTTTTTCAATCTGTGCCCC AGTTCCTCCTTCATAATGGGTGGGAGTAGGGATAGTTGATGATAGCAAGTGCTTCCCATTTGTTATTAGA GGCTGTTCCTTTCCTTCGACTCCCAGTTCCCCTCCCTTGGAGGCAGGCAGGGCTCCAGGATCATGACTTC TCTTCTGGAGATGTTTGTGCCTATGTGAGCATGTGTCTGCAGAAGTTCATTATTTTCTAACTTAGGAGCA CAGAACTGTATACTGTTCTTCACCTTCCTTAATTTTGAAATTTTTTATAAAGGCGTGGTCTTCTTATGTT GTCTAGGCTGGTCTGGAATTCCTGGGCTCAAGCAGTCCTCCAGCCTCTGCCTCCTAAATTGCAGGGATTA CATGAGTGAGCTACCTTGCCCATCCCTGCACCTTCCTTTTTCTCTTAAGAAGTCTCAGATCATCCCAAGT CAGCATACAGACCTGCCTCAATCTTTCCCCCAGCTGCAGAATGTCTCATTGCACAGATGCCTCACAGGCA TTCTACCTCACGACAGCCTGTGTATTAAACACTGCTGTGATATTTCATCAAATCGAAGGCGCTGTCATTG GGGAGGCACCCTGTTTCATATAGTGCCAAGAAAAAGGCGTGCCCAGTTAAATCAAGACAGACCCCAACTG TGAGATTAATCTGCATTCCAGCAGTGTCAAAATGTGGAAGAGGGTGCGTTGTGGGATGGATGGAAATAGA AGTAGTTTCGCGTGGTACACCAGGAAACGAGACTGGGGAGGAATACAGCCCAGCAGGGTGTCCCGGCTTG GATTTTGAAGCCCAGTCCCAGCCACACTTGTTCCCTGCCTGACCTTGGGTAGGGGCCCCAGTGTCTCAGG AACACAGGAGCAGTGACACTTGCCCTGGGGCGGGGGCCATCCTGGAAGATGCTGTGAAGGGCTGGCTGCA CTCCCTGTGGCTTATTTAAATCACTGGGATTTGCGTGATTACACTCTCTGAATTTTCTCATTCTTAGTGA ACATTTTATTTTTCTTGTTGGTCATATGAGTATTTTCTAGATACAAGCAAAATACACGGGGGGTTCAAAA TGCGTTGGGTTGAAACACCTAATTGCAGTGTGGTCAAAAATGGGGGATGTGGACAATTTGGTGTAATTCA GCCTAATATATTTTTCATTTTGGTCTCTGGTCATTTTCACTTATTAGACAGAACAGTTTGTAAGTATCCA AAGAAAATTATTTTGTTTTTTTTTTAGCTGATTGCAGTGGTATGATCATGGCTCACTGCAGCCTCCACCT CCTGGGCTCAAGCAGTTCTCCCACCTTAGCCCCCTGAGTAGCTGAGACCACAGGCATGTGCCCCCACACC TGGCTAATTTTTTATCTTTGGTCTCTACAAAGTGGGTATCCATGTTGCCTAGGCTGGTCTCAAACTTCCG GATGCAAGCCATCGTCCCGTCTCAGTCTCCCAAAGTGCCAGGATTGCAGGTGTGAGCCACCGAGCCCAGC TCAAAGACAGTTCTTTCTCAGCAAGTTCTAAACCATGAGTGACAGAACTAGTTTATTGTTCTTTATTTTA TTATTATTATTATTATTATTATTATTATTATTATTTTATTATTATTTTGGGATGGAGTCTCGCACTGTTG TCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAACCTCCGCCTCCCGGGTTCAAATGATCCTC TTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGCCCGTCACCACGCCCGGCTAATTTTTTGTATTTT TAGTAGAGACTGGGTTTTACTATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCTCCACC TTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCATCGCACCTGGCCTGTTTTTATTTTTTATTTTT GTTTTTTAAAAACTTTTTAAGAGATGGGTCTTGCTTTGTTACCTAGGCTGGTCTTGAACGCTTCGGCTCA AGCACTTGGTCCACCTTGGCCTCCCAAAATGCTGGGATTACAGGTGTGAGCCACAGTGCTTAGCCTCTAG TTAACTGTTCTTAAACCAGGCTCCCTTCTGCTGGGACCTACTTCTTGTCCACCAGCTTCTCTCCTCTACA TCCCTGGGCTGCCAGGACCTCTGTCCCTGCCATGCAGACTCCCTGCTCCCAGTGGACTGTCCCCTCCAGG GAGTCCTGCGGGCCAGCTCTTGCCTTGCAGTGTCTTCAGCTCCTTTGGCTAATGAATGCTGCTTCTTACT CTTGGTTTAACTTTACAAAACATTGGTAACTTATAAACTTGAGCTTGTCATTTGTTCCGAAGAATTCACA GGAGCACTCTCTCTCCCTCATTCAAGGCTCAGGGTGGTGGCTCATTTTCAAGGGGCTGTGAAAAGAGAGG GTCACTCCTTTTTGATCATTTCCCTGCTGCCTGGCTTCAAATGGCCCTCAGGCCAGGTCACTTTAGGGAA ATTGGTGATCGCTCTTGGTATTCCACTTTTTTTTTTTTTTTGAGACGGAGTCTCGCACTGTCACCAGGCT GGAGTGCAGTGGTGCGATCTCTGCTCACTGCACCCTCCGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCA GCCTCCTGAGTAGCTGGGATTAGGCGAATGCCACCCCTGACTAATTTTTGTATTTTTAGTAGAGACGGGG TTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTTGTGATCCATCCGCCTCAGCCTCCCAAAGT GCTGGGATTATAGGCATGAGCCACTGCGCCTGGCGTGGAATTTCACTCAGGTCCCTTCAGCTCTCTCTGG TTCTGACAGATCTTGCCCAAATTCCCATGGTTATGTGGTCATTTGCTTGCCTGTTGCTGGGGGTGGCTGG GAGGTGGCACTCAGCTGTTCGACTCTGAGGCCCAGGACTCCTGGCTGCTGGGACTCACGTGTGTCCCTGC ACAGGGAGGAGTGGATGCGGGCCATCCAGATGGTCGCCAACAGCCTCAAGCAGCGGGCCCCAGGCGAGGA CCCCATGGACTACAAGTGTGGCTCCCCCAGTGACTCCTCCACGACTGAGGAGATGGAAGTGGCGGTCAGC AAGGCACGGGCTAAAGTGGTAAGTGCTGGGAGCAGGGGTGGGGCTGCCAGCCTGCGGTGCCCCCACCCCC AGTGCTGGCCTGCTCTCCTTGGTTTCCATAACACAGTTCAGGGGGCTCAGCTGAGAGACAAGGCTGCCCT GCAGGGTGGGGTGATTTCAGGTGGCAGGTGCCCTAGGGTGTGCTCCATGCCCGTAGGGGAGGGAGCAACC TTGGGTGGACCCACTGCAGGTTCGTCCTGGGAGTTGGTGAAGACCTGGCTACCCCCACGTCAGAGCCCAG CCCTCCCAAGGCCCTGTGCCTGCAGAGCCTGGTCTGAAGGCCGCTTCAGAACACACAGTTGCTGCCCAGA GCCTCCCTTCCTGCTCCAGCCTAAGCCGTTTGGCAACAGTGTCTTTTGGTTTTCCTCTTTCTTTTGTTAA AATTTCCTCCCACGGGCCATGAGCCAGGCGCTGACTGCCCCCACTCTCCCTGTCCCTGGCAGACCATGAA TGACTTCGACTATCTCAAACTCCTTGGCAAGGGAACCTTTGGCAAAGTCATCCTGGTGCGGGAGAAGGCC ACTGGCCGCTACTACGCCATGAAGATCCTGCGGAAGGAAGTCATCATTGCCAAGGTGCGTGCCCCGGGAA TTGCGCTCGCGAGCCTCTGTGGGGGCTGCGGTCTGGAGCCTGACCCTGAGGCCTGGACGCTTACCCGCGC TTTCTGCTGCTGTGGGCTTATTTCCCCCACAAATTCCCCCTAGTCAGAAAAGGGGGAGCCTGAGGCCCAG AGAGGAGCAGCAGGCCTTGCTGCTGAGTCCCCACCTCCACCCTATGTTAGGGGCTGGGGGTGCCTGTGGA GAGAGAGAGCCTCGGGGCCCCACCCAGCAGGTACTGTCAAGGGAGGCTGGGGCCTGTTGGGGAGGACGTC GCTGTTGGGGAGTCCCGGGCTTTGCTCAGGGTATCCCAGGTGGAGGCCGGGCCAGGAGTGGAATTCTACT TTTTCCCTTATTTGAATTTTTTGTAGTGGAAGATTCCAAAGACATTCAAAAATTTAAAAAGAAAATAAAT ATTACGGACCCCCATGTAGCCATTGTCCAGTTTAACCAGTTATCAGCGTTTAGCCAGCCTTGTTTCCTTA GCTCTGCCTGTCCCTCTTGTTCTGGAATACTTTAAGGCCTGTCCTAGACAACACGTCACTTCACTCATCC ATACTTGAACATGTGTCCTGACAGATGAAGACTGTAAAGAATATAATCATGTGGTGCTGCCATCAGAGCC AACCAAATTAGCTGTTCATTCCTGATGTGACGATTGGGCCTAAGGCAGCCTTCCTCAGCCTCAGCACTGT TAACGTTTTGGGACAGATGATTCTGCGCTGTCGGGGCAGCCCTGTGCATTCTAGGGTTTCAGCAGCACCC CTGGCTTCTACCCACTGAAGCCAATACTAGCTCCCCAAGTTGTGACAATCAAAAATGACTTTTGGGTTGG GCGCCACAGCTCACGCCTGTAATTCCAGCACTTTAGAAGGCTGAGGTGGGAGGATCGCTTGAGCCCAGGA GTTCGAGACCAGCCTGGGCAACAAAGCAAGACCCTGTCTCTGTAAAAATAAAAATAAATTAGCTGGGCAT AGTGGCGTGCACCTGTAGTCCCAGCTGCTCAGGAGGCTGAAGTGGGAGGATCAGTGGAGCCTCAGAGGTT GAGGCTGTAGTGACCCATGTTCACACCACTGCACTCCAGCCTGGGCGACAGAGCCAGACCCCCAGCTAAA AAAAAAAAGGGAAAAAAAAAAAAAAGACTTCAGACATTCTCAGGTGTCCCCTGGGGATAAACTTGCCCCA GAGAGAGCCTGTGTTCACGTTGCTGCAGGTGGCTCCAGATTTTTGGAACCACTCCTGGTGGTTCTGCTGT ACAGTCAGGTACCAAATTAGAACCTGAATTAGAGTCACCCAAAGGGCTTGTGAGACAGTGCTGGGCCCAC CCCGAGTTTCTGACTCAGTGGGCCTGGGGGTAGGTCCCAGGAATTTGCATTGCTGCCAGTTCCCAGGCGG TGCTGAGGTGCTGTGTGGGGACCACACCAAGAAGCACTGTTTTTCCTTCTTTGGGCAAGAATGCTTTCTA GGTGGGACTTCCCACAGCCTGTGGTGGCACCTCGGGGCTCTCGTGATGTCTGTTTGTCTCCCTTGCAGGG ACGTCACAGGTGTCTTGTCCCTAGCAGCCTGGTCCTTACATTGTGACATTCCTGCTGACTTTTCACCTGT GGCTTTGAGAGCCACTGATGATCCTCGTCTGGGTCTGCTATTTGCTGAGGGTTTGCAGGCTTTCACTTTT CACTCCTGTGATTTTCTGCATTTATGGCTGGGAATGGAATTGCATTTCACAAGGCCTTGCTCCCCTTCGT CGGGGCGGAGTGGGCAGGTGTGGTGTTGCCCACCAGCCCCTCACCCGCAGTCTGTCTGCAGGATGAAGTC GCTCACACAGTCACCGAGAGCCGGGTCCTCCAGAACACCAGGCACCCGTTCCTCACTGTGAGTTGCCCTC CCCTTCCCAGACAGTGTGAGGCCAGCCTTTGGACAGAGCTCAGAGAGAGAGCCCTAATCTTCTGGTACAA AGCACAGTCTTGGGGTAGGCCAGGCGGGCAGGGCAAGGTGTTGCTGCGCCCTGCCAAGTCATCCGAACCA AGACATGTGGTGGGGGTGAGCAGGCTCGGGGAGTGGGAGGGTGACAGCTTCTTCATAGATGGTGGCTTCA TGTAAGCATTTGAACTAACTGAAGATATCACATTATTTGCTGGCTGCTGTCTCTATGAGTTAGGAGCACT TAGCCCAGCTGGTTGAAGTGGAAACATTATTTTTTTTGTTTTTGTTTTCAGATATGCTCATAGAAGCAGA TGTGTTAGCATTGTGTTGTCTGTCAGCCTGGACTGAGTAGATGCCTGTTTGGGCTGCAGTCTCCATCAAG GCCAGTGGCCACCAGTTAAATGGACTAGATTGAGGATGGCTTATGTATCATTTCTTTATCTCAGTTGCTG TCCAGGTATCCTATTAAGCCACAGTACTTTTTCAAATAAAATCTTATGAGGTACCTCAGTGCAGAAAACA GAATAGTTGAGTTGTCATGAGCTGAAGGACCCCCTGGTGGGAGTCTCTGAGGAACTCTCTGTAGATCTCC TTAGTGCAGTGGAGAACTACTGTTTGTTGACTGACAGCCTGTCCATCCTGTCATTGAAGTTGGCTCCCAA GCCTTTGCCACTCCCAGCCACAGCAGACATCACTTGTGTGTGTAAGTTGAACACATTTTACTGTAAAAAC AAGAGCCATGGTTGCTCAGAACAGCTCTAGTTCTCCCTTGGCTGTGCCTGATGGAGGCAGAGGACAAGAT GGTTCAGCATGTAACCCTTTCCTACCGCAGAGCCATGCCTTCACTTAATGCCCCAAAAGGTGCAGCCGGT ATGTGAACCCCATATGGCTGACTCCTGGGGGCCCCAGCCAGGGCAGGGTGTGTGTGTGCAGAATAAGCAG GGCCAGGGCCCTGCCCTGGCATGGCTCAGCAGAGCCCTCCTCCCTCCCACCTCCCACCCTGCTGCCTTCA TCCCCCAGGCGCTGAAGTATGCCTTCCAGACCCACGACCGCCTGTGCTTTGTGATGGAGTATGCCAACGG GGGTGAGGTGAGCCGCGGCTGCCTTGACTTTGCCCTCTGGGGCCTCCTTCTTTAGGGTGGGGCGGGATGG AGAGGAGCTGTGGGTGAGATGGAAGGGTGGAGGGAAATTTCAGTGTCATCTAGTGCCCCTCTCCCTTGAG GCAGGCGGCTTCGTCTCCATTTTGGGGGGGCAGTCACTGAGGCTCAGAGAGGTTAAGTGGCTTGCCCAAG TTTACACAGCTAGTGAGTGGGTGGGTCAGGTCCAAACCAGTCCAGAGAGGTGTGGAGAGGGCTGTGGGGC GATAGCACTGGGAAGGATGGTCTTAAAGGCCCCAGAGAAAGCCCCCAAGGGTTAAAACCTAGCAGCCCTC CGTTCCCGTGTCCTCTCGAAGTGAATTCCCGCAGCCGCTCAGCTTCCCCTTACAGAGTCGCCTCACTTTT GTCACCCACTCCTTGCCTCGCGCCTTCTCTGTGCAGTGGTTGGCACACCTGCTTTGGGATGCGTGGTTTG CTCATCTGTCTGATCTGGGCTTGCCCATGGCCTATTGTTACTTGGTCATGACGTGTGCTTCTTTTTGCCT CCATGCCATCCTCCCTCCTGTCTCGGATGTCTCTCCCATACCCTCTCATGGGTGCCTCCTGGCAGACCCT CGCCCTTCCCCCCAGCTCTGTGTCACTTATGAGCTTCTGCGCTCTGCCTTGATTGGTCCCTCTAGCTGTC ACTTGCTGGTTCATGATACAGGTGTCACCACATCACTGCGCTGGGGCAGGGGGCTGGGAAGGTGAGGGCA GGTGGGTGGGCTGGGGCCTGACCTCCTCTCCCCACCCCTTCCTCCTGCAGCTGTTCTTCCACCTGTCCCG GGAGCGTGTCTTCACAGAGGAGCGGGCCCGGTTTTATGGTGCAGAGATTGTCTCGGCTCTTGAGTACTTG CACTCGCGGGACGTGGTATACCGCGACATCAAGGTTAGTGGCAGGGTGTGCGCCAGGCTGACCTGTGGCA TGCACACCACATGGGACTCACACTGGGGAAGTTGGGCTGAGCTTCTGCCCTCATTCGCCAGGCTCCCCAC CAAGGTCCAGGGTGGTGGCTGCCCTCATTCGCCAGGCTCCCCACCAAGGTCCAGGGTGGTGGCTGCCCTC ATTCACCAGGCTCCCCACCAAGGTCCAGGGTGGTGGCTCTGTGGCAAGTTGCCCCAAGTAGGGACCTTCC CAAGCCTCCCATGAGCGCTCCTAGGCCACTAGCGGAGTGTCAACTGCCACAATACCTACTTTATTTGTAT TTATTTATTTATTTATTTTTGAGGAGTCTTACTCTGTTGAGTGCAGTGGTGTGATCTCGGCTCGCTGCAA CCTCTGCCTCCCGGGTTCAAGCGATTGTCCTGCCTCAGCCTCCCGAATAGGTGGGATTACAGGTGCCCGC CACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCATCATATTGGCCAGGCTGGTCTCA AACTCCTGACCTTGTGATCCACCCACCTCAGCCTCCCAAAGTGCTTGGATTACAGGCATGAGCCCCCGCG CCCGGCCAATTTTAGAAGATAGTTTGGCAGTGTCCACCAAAGCTGAGCACCAGTCATCTGCCCTAGCTGT GTGCACAGGAGAAGTGGGGACACACACTCACCTTAGAAAGTGTCCCCCTCACTCAGCAGCAGGACTTACT CTAGCCCCAACTGGAACAACCCAAGTATCCACTGTGAGAGGAACAGTCAGATCCACTGTGGAGTGTTCTC ACAGTGGGACGCCACACAGCAGTTAGGAATGAGCTACAGCTACACACGACAGTGTGGACGCGTCTCATAG GCTAATGTCGAGGGAAAGCCGCACAGAGGAGGTGAGTCCACAGTTCACAGGTGTGTCTGTGTGCAGTGGT ACAGATGGGAAGTAGAGGTTAATTCTTGTGGGGGATGGTCAGTAACCGGGAGGGGCACACAGGGCCTTCC AGGGGGAGATGCCACCTCAGCCTCGCAAGTAGCTGGGACTATAGGTGTGTGCCACCATGCCTGGCTAATT TTTTTTTTCATATTAAGAAATATGGAGATGGGGTCTCGCTGTGTTGCCCAGGCTGGTCTCAAACTCATGG GTTCAAGCAATCCTGCCACCTAAGTCCCCCAAATTGCTGGGATTACAGGTGTGAGCCACTTTGCCTGGCT GCATATTTCATAATTAAAGGACAGAAAGTCTAGAAAAAAAGAATAGAAGAAAGCTAGTGCCCCCACGTTC GAAATAAGAACCACAGTTCACAATGGGGACGGTGGGTGGACAGGGCCTGGCTCTCGGCTCTCCCTGCCCA GCTGTTCCCAGGTACCATGGGGGTGGGCCAGAGGGTGAGGAGGGTTGGATCTGGCCTCTCTCTGAGCCTC AGAGGGTGAGGCTGTGTGTGCTGGGCCCAGCCTGGCATGGGAGGGTTGATGTCCAGGAGCCCCGGGCATC TTTCCCTGGAAGGAAAGGCTGGGGTGGCAGGAAGCCTTGGGAGCATGCACCTGAGATCCGTTGACTTTTC CAACAGCTGGAAAACCTCATGCTGGACAAAGATGGCCACATCAAGATCACTGACTTTGGCCTCTGCAAAG AGGGCATCAGTGACGGGGCCACCATGAAAACCTTCTGTGGGACCCCGGAGTACCTGGCGCCTGAGGTGTC TGGGGTTGGTGGGGGTAGGAACGTGTGAGGCCAAGGGTAGGGGGATCCCCCAGACCTGTGTGTTTCCAGC CCAGATGCCCTGAGGGCAGGACTGTGATGCCAGCCTCAGGGCCACGGGCCCAGCCCTCATTTCTCCTCCA TCCTCAGGTGCTGGAGGACAATGACTATGGCCGGGCCGTGGACTGGTGGGGGCTGGGTGTGGTCATGTAC GAGATGATGTGCGGCCGCCTGCCCTTCTACAACCAGGACCACGAGCGCCTCTTCGAGCTCATCCTCATGG AAGAGATCCGCTTCCCGCGCACGCTCAGCCCCGAGGCCAAGTCCCTGCTTGCTGGGCTGCTTAAGAAGGA CCCCAAGCAGAGGTGAGGGCTGGCGTCGGCCCCACCCAGCCCAGCGCCAGCTGCTGCCACTGTCCCTGCG GCCTGGAGGGGGCAGCGTCCACAAGGGTGCTCGCTTGTAGGGTCGCAGTGTGTCGTCCCCACACAGCCCC TGAAAACGTCCACAGTGGCACTTAGGGAGTGCTTCCCCCAGGGCAGGCCCATCCTTGACACTGCCTTATT TTATGGGGACACTGAGGAACAGGGCATCCCCTGGGCCTGGCTGGGGCCACCAAACCATATGTGGCAGAGC CAGGATAGGAACGGAGCCTGCCCTACTAACTCCCTTTCTGGACTCAGGGTAAGGCCAGGCAGTGAGGACA CGTGGGTCCGGGTTGCTGACTCCCTGGCTCTGACCCTGGGCACGTGAGCTCCCTCCCTGAGCCTCGGTTT CCTCCTCTGTGAAGTGGTTTGTGGTCAAGACAGAATCATTAAGGGCCATACAGGGCCTGCCTGCTCCGAA AGCCCGTCTGCCCGAACCCAGCTGCTCCGGGAGGCAGGTGCTGACGGCCGTCTCTGCACAGGCTTGGTGG GGGGCCCAGCGATGCCAAGGAGGTCATGGAGCACAGGTTCTTCCTCAGCATCAACTGGCAGGACGTGGTC CAGAAGAAGGTGAGCCCCACTGCTTGCCCCAGCAGGACCCTCAGGGACCTGGCCCACTCGTGGTGACCTT GGTTGAGGCCTCCTGGCCTCAGGGTCCCTGAGCCTGAGCTCCTCTCCTCCGTAGCTCCTGCCACCCTTCA AACCTCAGGTCACGTCCGAGGTCGACACAAGGTACTTCGATGATGAATTTACCGCCCAGTCCATCACAAT CACACCCCCTGACCGCTGTGAGTGCCTGGGGCCCCCGCGCTGGTGTGCCTGCCCCAGGGGTGGAGGGATG GGATCTGCTCTTAACTCACTTCTCAAGGAGGGCCCTCGAAGGCCCCCGCTTCATGTCTGGGAGATTTCCC CAAGTCTGCTCTCAGGCCCTTTTGCTGTTGGTCCTCTTTGGACCTGGTGAGGCCACCAGGAGCCATTGAC TGCAGCACGTTCTGGAGCTCAGTCGGGGGGCTCAGGGCAGGAGGCAGCCCGGTCCCTGAGCCTGGCTGGG TTCACTGCTTTACAGCTGTTTGGGTTCTTACTCTGAACTCAGCCCAGGGCTGGGCTATGCTGGGGACACA GCACTGATTGAGCCAGCCCTGGGCCCTGCCCTGGAAAGCTCCCAGCCCAGGTAGGGTGGGCGGCCTGGAG TGGTCAGGGCTAGGGCGTGGGAGGCCAGGGACTGGGGAATCCCAGAGGAAATATCCGACCTGGCCTGCAG TTAGGGAGGGCTTTCTAGAGGAGGAAGCAAACGTGTCAGCTGGCCGGAGGAATGACGTGTGGGATGCCAG CAATGGGAGAAGCATGGCATAGCTAAGGACCGGCAGCAGCCAGGGAGATGGTGGTGAGAAGAGAGGGCAT GGGGCTGGAGTGCAAGGGTCTGGGGGCCACTGGGAGGGGTGGGGACTGCTTGCATGGCGGGAGCCAGCCA TGGAAGGGTTTCATACAGAGAGGGACAGGGTTAAAGCAGGCCTTTAGAAAGCCCCCCTGGCTGCCCGTGG AGAATGGATGGGAGGGTGCGAGAGGCAGGCCAGGACAGGGCTCTGGGCTGGACTCTGGCATGGTGGTGTG TGGGGCAGAGAGAAGGTGGGAGGCTCAGAAGGCCCTGCCAGCTGTGGGGCGCATGGGCAAGGGCACAGGA AACTCCCAGAGGAGGCCGCCCGGGGCTCAGGTTTGGGGAGTGGGTCCGTGGCTGAGGGCCTCCATTGCGG AGGGATGGGCCTTTCCTGTCCTGTCCTGTGGGCAGCCCCCGCCAGCTGGGGCCGTTTCCCCAGGGAGTCT GGGCAGGTGTCCCAGGCCCTCTCCTGACTGGTCCTCCCCATCCACCTCTGCCGCCCACAGATGACAGCCT GGGCTTACTGGAGCTGGACCAGCGGACCCACTTCCCCCAGTTCTCCTACTCGGCCAGCATCCGCGAGTGA GCAGTCTGCCCACGCAGAGGACGCACGCTCGCTGCCATCACCGCTGGGTGGTTTTTTCCCCCTAACTTTT TACTTAGCCTTTTTGGTTTGTGTCCCCACCCCCACCTCCTCACCCCCTTTCCAGTTCTTCTTCAGGCCCC TCCCAGACGCACCCCAGCGGCCCCTGCAGCCCCTGCCTCCAGCCTCCAGCCTCACCTTTGTGCCCAGACT CGCATTTGGAAGACTCCACCTCCCGCCCAGGCCTGGGCTGTTGGGCGGTTGGAGATTCAGGTTTTAATCC ACACAAGCCCCAGTGAGGGGTGAAGCATGGCGCCTGGGGCCTGCCTGAGTTTCTGGCCTGGGTGTCGTGC TGGTGTCTGCCTCCGCGCTGCTGCATCTGGACGAAGGCTGCCTTCTGGTGGGACGCGACACCCGGCAGAC AGTGGTGCTGCCTTCCAGGCCCCGTGGCCTAGGCTCGGAGTGGCCAGGCACGGGGCGGTCCAATCCCCCA CCCGCTGTCCCCCTATGGGGGCAGAAAAGCAATAATGTCCAGGGGCAGGCAGGGGCCCTTGGGAGCTGCA GGGCTGGGGGTTAGGGCTGCTCCCTGGTGAATGGAGTCAGATCCTAGGATCTGTACCATGGGGAACCAGG AGTGGCCGGGCTGGGTGCCGCCTCCTGGTCCGGCCTCCTCCCCACCAAACTGTCCTCACCCTATGGATGA GGCAGGAGGAACATTTGGGGCCAAACCTGCCTGCCTCCCAGCCCCGTGCCTTACTAGGGCTTCCTTCCAG CTGGCCTTACCTCCCGCTGGACCCTGGGCCTGGCCTGGCCCCACTGGGGGCTATGGGCTGGGCTCACCCT CTCCTCTGCGGGGGTGGAGGGCCACCAGCCTTGGCTGTTACAATCTTACACCGGACAGTATTGGGCCCCA TGGACTTGGTCAGGGAGGGGTGGGGGTGGGCATCTCTGGTACCTATTGGGGTGGGGGGCCTCTGAAAAGG GAGGCTCCTAGGCCCCCCTCACCCCTCCCTCTCCCCAGGGCCCCACGTTCTGCAGCCTTAAGGTTGAACA TGAGTGCACGTCCATGTCAGTGCTGTGGGACTCCTGTGCGTGCCTCGGACTGCGTGTGTCGGCGGGACGC AGGCACACGTGGGTGTGTGTGCATGTGTGTTTGTGTGAGGGCAGCGTGTCCTCCAGTGTGCATGGTGTGT GGGCTTGGGCCCCATCCCTGGCCCGAGCATTTCATCCTGTGGGGGAGGGGTGCTGACCTAGTGGGAGGAG CCCCACTGTGATCCATGAGCTGCCCTGCCCACGCCTCCCCTCCCTGTAGCAACACCTCTGGGTGTTTGGA GTTTAGCTTTTGTGGGTTTGCTCTCCCTATCCCATCTCCTGTACTACACAGTTCATGGCAGGGTGGGGAG GGGTGGGGTTGGTTCGGGTGGGTGAGGGTCTTTTTCCTCTGTGTGCGATGTTGTTATCTGACAGTTCTCC GTCCCTACTGGCCTTTCTCCTCGTCTTCATATTTGTACGGTACAAGCAATAAAGACACTCATTTCAGACC AGGGCCCAGCCTGCACTCACGCCAGCCCAACCACTCTGGGCTTTGCCTTGGTGATGGAGTCAGACCCCTG GGCCCCAGCTCCTCCTGTACTAGCCGTTCCCTTCAGCAAGGAGGGCACTGAGCTCAGGGTGAGGGCAGCT GGGGTGTGTGCAGGAGCTCAGGCTGGAGAGGGTGGGTGGAGCTGGTGCTGTGGGGCTGAGGGGTATGGGA AGGCTCCCCGCATGTGGGGGTGGGGTGGACAGAGACCACTCCAGGCCCTCAGTGCTGCTTAGGCTAAGAG AGGTGGGGTGGAGGGACAGGGCTGGAAGATCTGGGTAGCCCAGAATGAGGAGGGTGCCTGTGCTGTCACT GAATGAGAGGGAGTGGTTCATTCCACCCGGCTGCCGAGCCTCAGAGGGGGGCATTCCTATCCTGCCCCAC CTCCCTGTTTATGCTGCCACCTGGAAGCCTTGAGGCCCCCAAATTCCAGTACAGACCCAGTGGTGTGTTC ATGGTGGCGTGGTTGCTGTCACCTGGGAGCTCCTGAGCGTTTGGTTAGAACCCTGTTCAGCTTGGGGTCA GCCCTCCCCTAGTCACTGCCCTTTAGCCTGGATGTGTCTGGGCCCCTGCACTTCCCGTGCTTGAGTCACG TGGCTGCATGGCCGGGCGCTGGCCGGATGGAACACCTCCCCCAGCAAGGGACCAGGGACCAGAGCCCTGG CCTGCCCTGCTGAGCCCTGCTGTGCAGAGGGCCTGGCACAGATGAATTTGAGATTTTGCCGCAAGGTGTT AGCACTTCACACCCATTGAGTCTTTGAGATTTTAAGTGAATGTAAGCAGAAAAAGTCAGATCCAATTTAC AGAAATCAGAGTTAGCTACAGCTAGGACTCGTTTGGTTGGGGTTTTTTAGTTTGTCTTTCTAAAGTCATG TGGACCTTAATTTAATTACAAAAGTCTACCCTGGTGGTCATAAAATAGGCAGGCCTATGAAGAAAGGCCT TTTACTCTTCCATCTCGTCCCAGCCCCGAGTTGACCCACGTTGCTGCTCCTCACACCATGGTGATGCAGG TCTCGTAGTGTGGGCACAGGCCTGGCTACCTCATCTTTTTAGTGCCTCTCTCCTCTTCCACAGGATGGGG TCCCACAGCTGCAGCAGCTGGCCCCGTAGTTGAGCATGTGTGGTTATCCTGTAGAGCTTTTCCCAAGAAG GGTGTTTGAACTTAGAGTCTTAATAAAATCTTACCAAATAAATTTTGAGTAGAATAATCGTCTTTTGCAA TGTACATTTTAAAAATTTCACACATTCTTTTTTGTATATAAAGAACAGTGACTGGGCACAGTGGCTCATG CCTGTAATCCCAGCAATTTGGGAGGCCGAGGCGGGCGGGTCTCTTGAGGCCAGGGGTTCGAGACCAGCCT GGGCATCATAGGGAGACCTTCATCTCTACAAAAAATACAAAAATTAGCTGGGCATGGTGGTGCATGCCTG CAATCCCAGCTAACTTGGAAGGCTGAGGTGAGGTGGGAAGATCACTTGAGCCCAGGAGTTTGAGGCTGCA GTGAGCTATGATTGCGGCACTGCACTGCAGCCTGGGACAATGAGACTGTGTCTCTAAAAATAAAAAAAAA AAAAACATGATACATGCTATTAAAAAAGACAGCAAAGCAGGAGTATAAGAAAGGAAATTCACCCGAGGTC GCAGGGCCTTGAGTACTCATTTTGGTGCTGATTACCTCTCTGCAAATGGACACGGCATCATAAATTGGTA GTTTCCTGCTCTTTTTGTGTAATCTTTTCCAGTTAATGTGAAGCCTCTGGGGGCTGCCCTCGTGCACTGA TGGTTGTGTGGAGTCGGGGGCGGCAGTGCGATTCCCTTTTAGCTGCTGCATGGGGGGAACTCAGGCTTTC CAGCTGCTTCCTGGGGTTCCATGGGGTAGACCCCTCAACCGCTTCAGCTGCCCCGTTAACAGGAATTGAC TTGGTTTCGTTTGGTGCTACCAGCAGTCCTGTAATAAACTAGCTATCCATCTGTA    Download   Select all
Length	55215
OMIM ID	164731
HGNC ID	HGNC:392
Unigene ID	Hs.631535
Ensembl ID	ENSG00000105221
PharmGKB ID	-

mRNA Information

mRNA ID	NM_001243028.2
Exon	join(137..351,28478..28606,30263..30374,42845..42998, 43463..43594,45422..45487,46559..46627,47441..47563, 49147..49275,49428..49642,50182..50269,50385..50487, 51581..55215)
mRNA Sequence	>208 TGGGAGGGGGCGGTAAGCGGGGGCTGGGGGGAGGGGGCGGGGGGGGCCGCGCCGTGCTAGCCGT TGGGCCTGCCTCGGAGGAGGCGTCGCCGCCGCCGCTGCCGCTGCCGGCGCCGTTGCCGCTGCCG GGAAACACAAGGAAAGGGAACCAGCGCAGCGTGGCGATGGGCGGGGGTAGAGCCCCGCCGGAGA GGCTGGGCGGCTGCCGGTGACAGGTGAATACATCAAGACCTGGAGGCCACGGTACTTCCTGCTG AAGAGCGACGGCTCCTTCATTGGGTACAAGGAGAGGCCCGAGGCCCCTGATCAGACTCTACCCC CCTTAAACAACTTCTCCGTAGCAGAATGCCAGCTGATGAAGACCGAGAGGCCGCGACCCAACAC CTTTGTCATACGCTGCCTGCAGTGGACCACAGTCATCGAGAGGACCTTCCACGTGGATTCTCCA GACGAGAGGGAGGAGTGGATGCGGGCCATCCAGATGGTCGCCAACAGCCTCAAGCAGCGGGCCC CAGGCGAGGACCCCATGGACTACAAGTGTGGCTCCCCCAGTGACTCCTCCACGACTGAGGAGAT GGAAGTGGCGGTCAGCAAGGCACGGGCTAAAGTGACCATGAATGACTTCGACTATCTCAAACTC CTTGGCAAGGGAACCTTTGGCAAAGTCATCCTGGTGCGGGAGAAGGCCACTGGCCGCTACTACG CCATGAAGATCCTGCGGAAGGAAGTCATCATTGCCAAGGATGAAGTCGCTCACACAGTCACCGA GAGCCGGGTCCTCCAGAACACCAGGCACCCGTTCCTCACTGCGCTGAAGTATGCCTTCCAGACC CACGACCGCCTGTGCTTTGTGATGGAGTATGCCAACGGGGGTGAGCTGTTCTTCCACCTGTCCC GGGAGCGTGTCTTCACAGAGGAGCGGGCCCGGTTTTATGGTGCAGAGATTGTCTCGGCTCTTGA GTACTTGCACTCGCGGGACGTGGTATACCGCGACATCAAGCTGGAAAACCTCATGCTGGACAAA GATGGCCACATCAAGATCACTGACTTTGGCCTCTGCAAAGAGGGCATCAGTGACGGGGCCACCA TGAAAACCTTCTGTGGGACCCCGGAGTACCTGGCGCCTGAGGTGCTGGAGGACAATGACTATGG CCGGGCCGTGGACTGGTGGGGGCTGGGTGTGGTCATGTACGAGATGATGTGCGGCCGCCTGCCC TTCTACAACCAGGACCACGAGCGCCTCTTCGAGCTCATCCTCATGGAAGAGATCCGCTTCCCGC GCACGCTCAGCCCCGAGGCCAAGTCCCTGCTTGCTGGGCTGCTTAAGAAGGACCCCAAGCAGAG GCTTGGTGGGGGGCCCAGCGATGCCAAGGAGGTCATGGAGCACAGGTTCTTCCTCAGCATCAAC TGGCAGGACGTGGTCCAGAAGAAGCTCCTGCCACCCTTCAAACCTCAGGTCACGTCCGAGGTCG ACACAAGGTACTTCGATGATGAATTTACCGCCCAGTCCATCACAATCACACCCCCTGACCGCTA TGACAGCCTGGGCTTACTGGAGCTGGACCAGCGGACCCACTTCCCCCAGTTCTCCTACTCGGCC AGCATCCGCGAGTGAGCAGTCTGCCCACGCAGAGGACGCACGCTCGCTGCCATCACCGCTGGGT GGTTTTTTCCCCCTAACTTTTTACTTAGCCTTTTTGGTTTGTGTCCCCACCCCCACCTCCTCAC CCCCTTTCCAGTTCTTCTTCAGGCCCCTCCCAGACGCACCCCAGCGGCCCCTGCAGCCCCTGCC TCCAGCCTCCAGCCTCACCTTTGTGCCCAGACTCGCATTTGGAAGACTCCACCTCCCGCCCAGG CCTGGGCTGTTGGGCGGTTGGAGATTCAGGTTTTAATCCACACAAGCCCCAGTGAGGGGTGAAG CATGGCGCCTGGGGCCTGCCTGAGTTTCTGGCCTGGGTGTCGTGCTGGTGTCTGCCTCCGCGCT GCTGCATCTGGACGAAGGCTGCCTTCTGGTGGGACGCGACACCCGGCAGACAGTGGTGCTGCCT TCCAGGCCCCGTGGCCTAGGCTCGGAGTGGCCAGGCACGGGGCGGTCCAATCCCCCACCCGCTG TCCCCCTATGGGGGCAGAAAAGCAATAATGTCCAGGGGCAGGCAGGGGCCCTTGGGAGCTGCAG GGCTGGGGGTTAGGGCTGCTCCCTGGTGAATGGAGTCAGATCCTAGGATCTGTACCATGGGGAA CCAGGAGTGGCCGGGCTGGGTGCCGCCTCCTGGTCCGGCCTCCTCCCCACCAAACTGTCCTCAC CCTATGGATGAGGCAGGAGGAACATTTGGGGCCAAACCTGCCTGCCTCCCAGCCCCGTGCCTTA CTAGGGCTTCCTTCCAGCTGGCCTTACCTCCCGCTGGACCCTGGGCCTGGCCTGGCCCCACTGG GGGCTATGGGCTGGGCTCACCCTCTCCTCTGCGGGGGTGGAGGGCCACCAGCCTTGGCTGTTAC AATCTTACACCGGACAGTATTGGGCCCCATGGACTTGGTCAGGGAGGGGTGGGGGTGGGCATCT CTGGTACCTATTGGGGTGGGGGGCCTCTGAAAAGGGAGGCTCCTAGGCCCCCCTCACCCCTCCC TCTCCCCAGGGCCCCACGTTCTGCAGCCTTAAGGTTGAACATGAGTGCACGTCCATGTCAGTGC TGTGGGACTCCTGTGCGTGCCTCGGACTGCGTGTGTCGGCGGGACGCAGGCACACGTGGGTGTG TGTGCATGTGTGTTTGTGTGAGGGCAGCGTGTCCTCCAGTGTGCATGGTGTGTGGGCTTGGGCC CCATCCCTGGCCCGAGCATTTCATCCTGTGGGGGAGGGGTGCTGACCTAGTGGGAGGAGCCCCA CTGTGATCCATGAGCTGCCCTGCCCACGCCTCCCCTCCCTGTAGCAACACCTCTGGGTGTTTGG AGTTTAGCTTTTGTGGGTTTGCTCTCCCTATCCCATCTCCTGTACTACACAGTTCATGGCAGGG TGGGGAGGGGTGGGGTTGGTTCGGGTGGGTGAGGGTCTTTTTCCTCTGTGTGCGATGTTGTTAT CTGACAGTTCTCCGTCCCTACTGGCCTTTCTCCTCGTCTTCATATTTGTACGGTACAAGCAATA AAGACACTCATTTCAGACCAGGGCCCAGCCTGCACTCACGCCAGCCCAACCACTCTGGGCTTTG CCTTGGTGATGGAGTCAGACCCCTGGGCCCCAGCTCCTCCTGTACTAGCCGTTCCCTTCAGCAA GGAGGGCACTGAGCTCAGGGTGAGGGCAGCTGGGGTGTGTGCAGGAGCTCAGGCTGGAGAGGGT GGGTGGAGCTGGTGCTGTGGGGCTGAGGGGTATGGGAAGGCTCCCCGCATGTGGGGGTGGGGTG GACAGAGACCACTCCAGGCCCTCAGTGCTGCTTAGGCTAAGAGAGGTGGGGTGGAGGGACAGGG CTGGAAGATCTGGGTAGCCCAGAATGAGGAGGGTGCCTGTGCTGTCACTGAATGAGAGGGAGTG GTTCATTCCACCCGGCTGCCGAGCCTCAGAGGGGGGCATTCCTATCCTGCCCCACCTCCCTGTT TATGCTGCCACCTGGAAGCCTTGAGGCCCCCAAATTCCAGTACAGACCCAGTGGTGTGTTCATG GTGGCGTGGTTGCTGTCACCTGGGAGCTCCTGAGCGTTTGGTTAGAACCCTGTTCAGCTTGGGG TCAGCCCTCCCCTAGTCACTGCCCTTTAGCCTGGATGTGTCTGGGCCCCTGCACTTCCCGTGCT TGAGTCACGTGGCTGCATGGCCGGGCGCTGGCCGGATGGAACACCTCCCCCAGCAAGGGACCAG GGACCAGAGCCCTGGCCTGCCCTGCTGAGCCCTGCTGTGCAGAGGGCCTGGCACAGATGAATTT GAGATTTTGCCGCAAGGTGTTAGCACTTCACACCCATTGAGTCTTTGAGATTTTAAGTGAATGT AAGCAGAAAAAGTCAGATCCAATTTACAGAAATCAGAGTTAGCTACAGCTAGGACTCGTTTGGT TGGGGTTTTTTAGTTTGTCTTTCTAAAGTCATGTGGACCTTAATTTAATTACAAAAGTCTACCC TGGTGGTCATAAAATAGGCAGGCCTATGAAGAAAGGCCTTTTACTCTTCCATCTCATCCCAGCC CCGAGTTGACCCACGTTGCTGCTCCTCACACCATGGTGATGCAGGTCTCGTAGTGTGGGCACAG GCCTGGCTACCTCATCTTTTTAGTGCCTCTCTCCTCTTCCACAGGATGGGGTCCCACAGCTGCA GCAGCTGGCCCCGTAGTTGAGCATGTGTGGTTATCCTGTAGAGCTTTTCCCAAGAAGGGTGTTT GAACTTAGAGTCTTAATAAAATCTTACCAAATAAATTTTGAGTAGAATAATCGTCTTTTGCAAT GTACATTTTAAAAATTTCACACATTCTTTTTTGTATATAAAGAACAGTGACTGGGCACAGTGGC TCATGCCTGTAATCCCAGCAATTTGGGAGGCCGAGGCGGGCGGGTCTCTTGAGGCCAGGGGTTC GAGACCAGCCTGGGCATCATAGGGAGACCTTCATCTCTACAAAAAATACAAAAATTAGCTGGGC ATGGTGGTGCATGCCTGCAATCCCAGCTAACTTGGAAGGCTGAGGTGAGGTGGGAAGATCACTT GAGCCCAGGAGTTTGAGGCTGCAGTGAGCTATGATTGCGGCACTGCACTGCAGCCTGGGACAAT GAGACTGTGTCTCTAAAAATAAAAAAAAAAAAAACATGATACATGCTATTAAAAAAGACAGCAA AGCAGGAGTATAAGAAAGGAAATTCACCCGAGGTCGCAGGGCCTTGAGTACTCATTTTGGTGCT GATTACCTCTCTGCAAATGGACACGGCATCATAAATTGGTAGTTTCCTGCTCTTTTTGTGTAAT CTTTTCCAGTTAATGTGAAGCCTCTGGGGGCTGCCCTCGTGCACTGATGGTTGTGTGGAGTCGG GGGCGGCAGTGCGATTCCCTTTTAGCTGCTGCATGGGGGGAACTCAGGCTTTCCAGCTGCTTCC TGGGGTTCCATGGGGTAGACCCCTCAACCGCTTCAGCTGCCCCGTTAACAGGAATTGACTTGGT TTCGTTTGGTGCTACCAGCAGTCCTGTAATAAACTAGCTATCCATCTGTAAAAAAAAAAAAAAA AAA    Download   Select all
Length	5187

CDS Information

   

Location	join(20265..20310,28478..28606,30263..30374,42845..42998, 43463..43594,45422..45487,46559..46627,47441..47563, 49147..49275,49428..49642,50182..50269,50385..50487, 51581..51660)
CDS Sequence	>gi|339895854:356-1615 Homo sapiens v-akt murine thymoma viral oncogene homolog 2 (AKT2), transcript variant 3, mRNA ATGAAGACCGAGAGGCCGCGACCCAACACCTTTGTCATACGCTGCCTGCAGTGGACCACAGTCATCGAGA GGACCTTCCACGTGGATTCTCCAGACGAGAGGGAGGAGTGGATGCGGGCCATCCAGATGGTCGCCAACAG CCTCAAGCAGCGGGCCCCAGGCGAGGACCCCATGGACTACAAGTGTGGCTCCCCCAGTGACTCCTCCACG ACTGAGGAGATGGAAGTGGCGGTCAGCAAGGCACGGGCTAAAGTGACCATGAATGACTTCGACTATCTCA AACTCCTTGGCAAGGGAACCTTTGGCAAAGTCATCCTGGTGCGGGAGAAGGCCACTGGCCGCTACTACGC CATGAAGATCCTGCGGAAGGAAGTCATCATTGCCAAGGATGAAGTCGCTCACACAGTCACCGAGAGCCGG GTCCTCCAGAACACCAGGCACCCGTTCCTCACTGCGCTGAAGTATGCCTTCCAGACCCACGACCGCCTGT GCTTTGTGATGGAGTATGCCAACGGGGGTGAGCTGTTCTTCCACCTGTCCCGGGAGCGTGTCTTCACAGA GGAGCGGGCCCGGTTTTATGGTGCAGAGATTGTCTCGGCTCTTGAGTACTTGCACTCGCGGGACGTGGTA TACCGCGACATCAAGCTGGAAAACCTCATGCTGGACAAAGATGGCCACATCAAGATCACTGACTTTGGCC TCTGCAAAGAGGGCATCAGTGACGGGGCCACCATGAAAACCTTCTGTGGGACCCCGGAGTACCTGGCGCC TGAGGTGCTGGAGGACAATGACTATGGCCGGGCCGTGGACTGGTGGGGGCTGGGTGTGGTCATGTACGAG ATGATGTGCGGCCGCCTGCCCTTCTACAACCAGGACCACGAGCGCCTCTTCGAGCTCATCCTCATGGAAG AGATCCGCTTCCCGCGCACGCTCAGCCCCGAGGCCAAGTCCCTGCTTGCTGGGCTGCTTAAGAAGGACCC CAAGCAGAGGCTTGGTGGGGGGCCCAGCGATGCCAAGGAGGTCATGGAGCACAGGTTCTTCCTCAGCATC AACTGGCAGGACGTGGTCCAGAAGAAGCTCCTGCCACCCTTCAAACCTCAGGTCACGTCCGAGGTCGACA CAAGGTACTTCGATGATGAATTTACCGCCCAGTCCATCACAATCACACCCCCTGACCGCTATGACAGCCT GGGCTTACTGGAGCTGGACCAGCGGACCCACTTCCCCCAGTTCTCCTACTCGGCCAGCATCCGCGAGTGA    Download   Select all
CCDS ID	CCDS12552.1

Protein Information

      

Protein ID	NP_001617.1
Protein Name	V-akt murine thymoma viral oncogene homolog 2
Molecular Wt. (Da)	55638
Protein Sequence	>208 MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMK TERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPS DSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKD EVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYG AEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPE VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGL LKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSI TITPPDRYDSLGLLELDQRTHFPQFSYSASIRE    Download   Select all
Length	481
Uniprot ID	P63261
Ensembl Protein ID	ENSP00000331514

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	126
T	Phosphorylation	451
S	Phosphorylation	476
S	Phosphorylation	126
T	Phosphorylation	451
S	Phosphorylation	476
T	Phosphorylation	309
S	Phosphorylation	474
T	Phosphorylation	309
S	Phosphorylation	474
S	Phosphorylation	478
S	Phosphorylation	474
S	Phosphorylation	474

Enzyme Information

   

EC	2.7.11.1
Name	non-specific serine/threonine protein kinase A-kinase AP50 kinase ATP-protein transphosphorylase calcium-dependent protein kinase C calcium/phospholipid-dependent protein kinase cAMP-dependent protein kinase cAMP-dependent protein kinase A casein kinase casein kinase (phosphorylating) casein kinase 2 casein kinase I casein kinase II cGMP-dependent protein kinase CK-2 CKI CKII cyclic AMP-dependent protein kinase cyclic AMP-dependent protein kinase A cyclic monophosphate-dependent protein kinase cyclic nucleotide-dependent protein kinase cyclin-dependent kinase cytidine 3',5'-cyclic monophosphate-responsive protein kinase dsk1 glycogen synthase a kinase glycogen synthase kinase HIPK2 Hpr kinase hydroxyalkyl-protein kinase hydroxyalkyl-protein kinase M phase-specific cdc2 kinase mitogen-activated S6 kinase p82 kinase phosphorylase b kinase kinase PKA protein glutamyl kinase protein kinase (phosphorylating) protein kinase A protein kinase CK2 protein kinase p58 protein phosphokinase protein serine kinase protein serine-threonine kinase protein-aspartyl kinase protein-cysteine kinase protein-serine kinase Prp4 protein kinase Raf kinase Raf-1 ribosomal protein S6 kinase II ribosomal S6 protein kinase serine kinase serine protein kinase serine-specific protein kinase serine(threonine) protein kinase serine/threonine protein kinase STK32 T-antigen kinase threonine-specific protein kinase twitchin kinase type-2 casein kinase betaIIPKC epsilon PKC Wee 1-like kinase Wee-kinase WEE1Hu
Class	Transferases; Transferring phosphorus-containing groups; Protein-serine/threonine kinases
Sysname	ATP:protein phosphotransferase (non-specific)
Substrate	ATP [CPD:C00002]; protein
Product	ADP [CPD:C00008]; phosphoprotein
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                                                                     

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
207	AKT1	1261	NP_005154.2	in vitro;in vivo	1   217   633   712   149   240   000   000   000   000   000   000   000   000   000   000   000   000   000
331	XIAP	2094	NP_001158.2	in vitro;in vivo	14645242
1147	CHUK	2811	NP_001269.3	in vitro;in vivo	12048203
2099	ESR1	589	NP_000116.2	in vitro;in vivo	1   150   703   911   139   580   000   000   000   000   000
2492	FSHR	639	NP_000136.2	in vivo	15070827
3320	HSP90AA1	777	NP_001017963.2	in vitro;in vivo;yeast 2-hybrid	11988487
4303	FOXO4	2070	NP_005929.2	in vivo	11313479
6517	SLC2A4	688	NP_001033.1	in vitro	11500317
7249	TSC2	1850	NP_000539.2	in vivo	12167664
9545	RAB3D	5070	NP_004274.1	in vitro	11903042
84335	AKT1S1	12441	NP_115751.2	in vitro;in vivo	1   252   443   914   973   220

Pathway Information

                                                                                                                                                                                                                                                                                                                                                                                                                                    

Pathway Name	Pathway ID
Acute myeloid leukemia	hsa05221
Adipocytokine signaling pathway	hsa04920
Adrenergic signaling in cardiomyocytes	hsa04261
AGE-RAGE signaling pathway in diabetic complications	hsa04933
AMPK signaling pathway	hsa04152
Apoptosis	hsa04210
B cell receptor signaling pathway	hsa04662
cAMP signaling pathway	hsa04024
Carbohydrate digestion and absorption	hsa04973
Central carbon metabolism in cancer	hsa05230
cGMP-PKG signaling pathway	hsa04022
Chagas disease (American trypanosomiasis)	hsa05142
Chemokine signaling pathway	hsa04062
Choline metabolism in cancer	hsa05231
Cholinergic synapse	hsa04725
Chronic myeloid leukemia	hsa05220
Colorectal cancer	hsa05210
Dopaminergic synapse	hsa04728
Endometrial cancer	hsa05213
Epstein-Barr virus infection	hsa05169
ErbB signaling pathway	hsa04012
Estrogen signaling pathway	hsa04915
Fc epsilon RI signaling pathway	hsa04664
Fc gamma R-mediated phagocytosis	hsa04666
Focal adhesion	hsa04510
FoxO signaling pathway	hsa04068
Glioma	hsa05214
Glucagon signaling pathway	hsa04922
Hepatitis B	hsa05161
Hepatitis C	hsa05160
HIF-1 signaling pathway	hsa04066
HTLV-I infection	hsa05166
Influenza A	hsa05164
Insulin resistance	hsa04931
Insulin signaling pathway	hsa04910
Jak-STAT signaling pathway	hsa04630
Longevity regulating pathway - mammal	hsa04211
Longevity regulating pathway - multiple species	hsa04213
MAPK signaling pathway	hsa04010
Measles	hsa05162
Melanoma	hsa05218
mTOR signaling pathway	hsa04150
Neurotrophin signaling pathway	hsa04722
Non-alcoholic fatty liver disease (NAFLD)	hsa04932
Non-small cell lung cancer	hsa05223
Osteoclast differentiation	hsa04380
Pancreatic cancer	hsa05212
Pathways in cancer	hsa05200
Phospholipase D signaling pathway	hsa04072
PI3K-Akt signaling pathway	hsa04151
Platelet activation	hsa04611
Progesterone-mediated oocyte maturation	hsa04914
Prolactin signaling pathway	hsa04917
Prostate cancer	hsa05215
Proteoglycans in cancer	hsa05205
Rap1 signaling pathway	hsa04015
Ras signaling pathway	hsa04014
Regulation of lipolysis in adipocytes	hsa04923
Renal cell carcinoma	hsa05211
Signaling pathways regulating pluripotency of stem cells	hsa04550
Small cell lung cancer	hsa05222
Sphingolipid signaling pathway	hsa04071
T cell receptor signaling pathway	hsa04660
Thyroid hormone signaling pathway	hsa04919
Tight junction	hsa04530
TNF signaling pathway	hsa04668
Toll-like receptor signaling pathway	hsa04620
Toxoplasmosis	hsa05145
Tuberculosis	hsa05152
VEGF signaling pathway	hsa04370

Structure Information

PDB ID	1GZK
Resolution	2.3
Method	X-RAY DIFFRACTION
Chains	A
Molecule	RAC-BETA SERINE/THREONINE PROTEIN KINASE
Model	View

Domain Information

ID	Location	Description
cd05595	156-478	STKc_PKB_beta
cl21453	156-478	PKc_like superfamily
cd01241	4-111	PH_PKB
cl17171	4-111	PH-like superfamily
cd05571	156-478	STKc_PKB
cd05594	126-478	STKc_PKB_alpha
cd05593	135-481	STKc_PKB_gamma
cd05570	156-475	STKc_PKC
cd05575	156-475	STKc_SGK
cd05123	158-409	STKc_AGC
cd05589	152-477	STKc_PKN
cd05592	156-475	STKc_nPKC_theta_like
cd05587	155-475	STKc_cPKC
cd05584	155-454	STKc_p70S6K
cd05604	155-448	STKc_SGK3
cd05603	156-452	STKc_SGK2
cd05591	156-455	STKc_nPKC_epsilon
cd05580	150-441	STKc_PKA_like
cd05590	156-477	STKc_nPKC_eta
cd05616	151-475	STKc_cPKC_beta
cd05602	150-448	STKc_SGK1
cd05588	156-475	STKc_aPKC
cd05586	158-471	STKc_Sck1_like
cd05585	157-475	STKc_YPK1_like
cd05615	146-475	STKc_cPKC_alpha
cd05582	156-454	STKc_RSK_N
cd05617	149-454	STKc_aPKC_zeta
cd14209	151-441	STKc_PKA
cd05619	146-455	STKc_nPKC_theta
cd05618	142-454	STKc_aPKC_iota
cd05614	151-453	STKc_MSK2_N
cd05583	158-412	STKc_MSK_N
cd05612	151-441	STKc_PRKX_like
cd05573	150-441	STKc_ROCK_NDR_like
cd05620	156-475	STKc_nPKC_delta
cd05613	151-428	STKc_MSK1_N
cd05574	151-435	STKc_phototropin_like
cd14003	155-408	STKc_AMPK-like
cd05579	160-414	STKc_MAST_like
cd05117	151-408	STKc_CAMK
cd14007	151-410	STKc_Aurora
cd05599	150-455	STKc_NDR_like
cd05572	158-416	STKc_cGK
cd05578	152-409	STKc_Yank1
cd05577	158-428	STKc_GRK
cd05581	150-409	STKc_PDK1
cd05601	150-441	STKc_CRIK
cd05598	150-475	STKc_LATS
cd05605	152-428	STKc_GRK4_like
cd05609	151-414	STKc_MAST
cd05596	140-441	STKc_ROCK
cd05600	142-441	STKc_Sid2p_like
cd05597	151-453	STKc_DMPK_like
cd08215	151-409	STKc_Nek
cd05611	155-414	STKc_Rim15_like
cd05630	152-428	STKc_GRK6
cd05606	157-428	STKc_beta_ARK
cd05629	150-453	STKc_NDR_like_fungal
cd05631	152-428	STKc_GRK4
cd05608	152-428	STKc_GRK1
cd14663	151-408	STKc_SnRK3
cd05624	150-476	STKc_MRCK_beta
cd05632	150-428	STKc_GRK5
cd05633	147-444	STKc_GRK3
cd00180	158-406	PKc
cd14073	152-392	STKc_NUAK
cd06606	156-409	STKc_MAPKKK
cd14083	152-392	STKc_CaMKI
cd14008	158-409	STKc_LKB1_CaMKK
cd05610	148-446	STKc_MASTL
cd14095	152-407	STKc_DCKL
cd05607	152-428	STKc_GRK7
cd14099	156-409	STKc_PLK
cd05623	151-453	STKc_MRCK_alpha
cd14223	151-444	STKc_GRK2
cd14014	155-405	STKc_PknB_like
cd05622	140-441	STKc_ROCK1
cd14081	156-409	STKc_BRSK1_2
cd14002	150-408	STKc_STK36
cd05621	151-441	STKc_ROCK2
cd14079	156-409	STKc_AMPK_alpha
cd14078	158-407	STKc_MELK
cd14167	152-392	STKc_CaMKI_alpha
cd14166	152-392	STKc_CaMKI_gamma
cd05122	151-409	PKc_STE
cd14080	155-409	STKc_TSSK-like
cd05626	152-440	STKc_LATS2
cd14084	156-406	STKc_Chk2
cd06623	150-408	PKc_MAPKK_plant_like
cd14161	152-392	STKc_NUAK2
cd14116	148-406	STKc_Aurora-A
cd05627	149-441	STKc_NDR2
cd05625	152-440	STKc_LATS1
cd14072	152-392	STKc_MARK
cd14098	151-406	STKc_Rad53_Cds1
cd14097	158-406	STKc_STK33
cd14009	158-394	STKc_ATG1_ULK_like
cd14093	157-409	STKc_PhKG
cd14071	152-409	STKc_SIK
cd14169	158-393	STKc_CaMKI_beta
cd14077	151-408	STKc_Kin1_2
cd14006	158-407	STKc_MLCK-like
cd14087	152-393	STKc_PSKH1
cd14117	146-425	STKc_Aurora-B_like
cd14076	158-406	STKc_Kin4
cd14075	158-408	STKc_NIM1
cd05628	151-441	STKc_NDR1
cd14168	152-392	STKc_CaMKI_delta
cd06614	152-409	STKc_PAK
cd14162	156-390	STKc_TSSK4-like
cd08530	151-394	STKc_CNK2-like
cd14096	150-406	STKc_RCK1-like
cd13999	158-392	STKc_MAP3K-like
cd14089	156-407	STKc_MAPKAPK
cd14185	156-406	STKc_DCKL3
cd08529	151-392	STKc_FA2-like
cd06632	156-408	STKc_MEKK1_plant
cd14103	158-407	STKc_MLCK
cd14086	158-406	STKc_CaMKII
cd14074	152-392	STKc_SNRK
cd14085	152-393	STKc_CaMKIV
cd14118	158-393	STKc_CAMKK
cd06627	156-409	STKc_Cdc7_like
cd13994	158-409	STKc_HAL4_like
cd14189	156-409	STKc_PLK3
cd14091	151-427	STKc_RSK_C
cd14010	158-394	STKc_ULK4
cd14004	151-409	STKc_PASK
cd06626	156-408	STKc_MEKK4
cd14106	156-409	STKc_DRAK
cd08217	151-409	STKc_Nek2
cd14183	156-406	STKc_DCKL1
cd14186	151-408	STKc_PLK4
cd14184	156-406	STKc_DCKL2
cd06625	156-409	STKc_MEKK3_like
cd14092	156-393	STKc_MSK_C
cd14119	158-409	STKc_LKB1
cd14165	158-409	STKc_TSSK1_2-like
cd14665	152-393	STKc_SnRK2-3
cd14070	156-392	STKc_HUNK
cd14662	152-393	STKc_SnRK2
cd06609	150-408	STKc_MST3_like
cd14188	156-409	STKc_PLK2
cd14105	152-406	STKc_DAPK
cd14187	156-411	STKc_PLK1
cd06612	150-409	STKc_MST1_2
cd05118	155-409	STKc_CMGC
cd08222	158-408	STKc_Nek11
cd08218	155-392	STKc_Nek1
cd06605	150-409	PKc_MAPKK
cd08219	151-392	STKc_Nek3
cd14179	156-393	STKc_MSK1_C
cd06611	158-409	STKc_SLK_like
cd14181	143-409	STKc_PhKG2
cd06648	151-410	STKc_PAK_II
cd14069	150-409	STKc_Chk1
cd14196	152-393	STKc_DAPK2
cd14194	158-393	STKc_DAPK1
cd14172	156-393	STKc_MAPKAPK3
cd06613	151-409	STKc_MAP4K3_like
cd14171	151-406	STKc_MAPKAPK5
cd14182	152-409	STKc_PhKG1
cd14121	158-393	STKc_ULK3
cd14082	156-392	STKc_PKD
cd14090	157-406	STKc_Mnk
cd07833	150-409	STKc_CDKL
cd06647	158-409	STKc_PAK_I
cd14088	152-408	STKc_CaMK_like
cd14005	156-409	STKc_PIM
cd07829	154-409	STKc_CDK_like
cd08225	152-392	STKc_Nek5
cd06659	153-410	STKc_PAK6
cd14200	158-394	STKc_CaMKK1
cd06917	152-408	STKc_NAK1_like
cd14199	149-393	STKc_CaMKK2
cd06654	128-409	STKc_PAK1
cd14170	156-393	STKc_MAPKAPK2
cd14175	158-424	STKc_RSK1_C
cd08223	151-408	STKc_Nek4
cd14180	158-393	STKc_MSK2_C
cd06644	158-413	STKc_STK10
cd06656	137-409	STKc_PAK3
cd06655	137-409	STKc_PAK2
cd13987	158-407	STKc_SBK1
cd14195	158-393	STKc_DAPK3
cd14120	158-393	STKc_ULK1_2-like
cd14113	158-405	STKc_Trio_C
cd13990	155-392	STKc_TLK
cd14191	152-393	STKc_MLCK1
cd14197	158-406	STKc_DRAK1
cd13993	158-392	STKc_Pat1_like
cd14094	155-406	STKc_CASK
cd14114	152-406	STKc_Twitchin_like
cd14111	159-387	STKc_SPEG_rpt2
cd06608	150-408	STKc_myosinIII_N_like
cd08528	151-392	STKc_Nek10
cd14202	151-409	STKc_ULK1
cd14201	148-393	STKc_ULK2
cd13974	168-406	STKc_SHIK
cd14178	158-413	STKc_RSK3_C
cd13996	150-392	STKc_EIF2AK
cd14176	158-427	STKc_RSK2_C
cd14190	156-396	STKc_MLCK2
cd14173	156-406	STKc_Mnk2
cd00192	156-392	PTKc
cd07830	155-409	STKc_MAK_like
cd14198	149-406	STKc_DRAK2
cd06610	150-409	STKc_OSR1_SPAK
cd13997	151-392	PKc_Wee1_like
cd14174	156-406	STKc_Mnk1
cd06643	149-413	STKc_SLK
cd14192	156-409	STKc_MLCK3
cd07841	152-411	STKc_CDK7
cd07840	152-409	STKc_CDK9_like
cd08224	151-392	STKc_Nek6_7
cd14046	150-406	STKc_EIF2AK4_GCN2_rpt2
cd08220	151-406	STKc_Nek8
cd14107	152-409	STKc_obscurin_rpt1
cd07832	158-409	STKc_CCRK
cd13989	158-400	STKc_IKK
cd06657	152-409	STKc_PAK4
cd14193	156-406	STKc_MLCK4
cd06640	152-410	STKc_MST4
cd06629	156-408	STKc_Bck1_like
cd06628	157-408	STKc_Byr2_like
cd06658	158-409	STKc_PAK5
cd07834	152-409	STKc_MAPK
cd14059	158-354	STKc_MAP3K12_13
cd14164	152-392	STKc_TSSK6-like
cd14039	158-402	STKc_IKK_alpha
cd14050	152-392	PKc_Myt1
cd14177	158-429	STKc_RSK4_C
cd06652	156-350	STKc_MEKK2
cd06630	156-409	STKc_MEKK1
cd06642	152-410	STKc_STK25
cd08221	155-409	STKc_Nek9
cd14137	155-409	STKc_GSK3
cd06653	156-350	STKc_MEKK3_like_u1
cd07835	154-409	STKc_CDK1_CdkB_like
cd05576	161-409	STKc_RPK118_like
cd14163	156-388	STKc_TSSK3-like
cd07838	152-409	STKc_CDK4_6_like
cd08228	149-392	STKc_Nek6
cd14104	152-406	STKc_Titin
cd14115	158-392	STKc_Kalirin_C
cd06631	157-408	STKc_YSK4
cd06651	156-408	STKc_MEKK3
cd07851	155-409	STKc_p38
cd07831	156-409	STKc_MOK
cd06641	152-410	STKc_MST3
cd06646	150-408	STKc_MAP4K5
cd14061	157-350	STKc_MLK
cd06645	151-408	STKc_MAP4K3
cd06624	158-408	STKc_ASK
cd06621	150-411	PKc_Pek1_like
cd07846	150-409	STKc_CDKL2_3
cd14038	158-392	STKc_IKK_beta
cd06615	151-409	PKc_MEK
cd07866	148-409	STKc_BUR1
cd14058	158-406	STKc_TAK1
cd06620	151-392	PKc_Byr1_like
cd14041	148-393	STKc_TLK2
cd07860	152-409	STKc_CDK2_3
cd14012	204-408	PK_eIF2AK_GCN2_rpt1
cd14147	151-392	STKc_MLK3
cd08229	148-392	STKc_Nek7
cd14110	148-392	STKc_obscurin_rpt2
cd13979	158-356	STKc_Mos
cd14022	249-409	PK_TRB2
cd14049	149-392	STKc_EIF2AK1_HRI
cd14066	158-405	STKc_IRAK
cd06636	152-379	STKc_MAP4K4_6_N
cd14101	157-392	STKc_PIM2
cd13978	158-355	STKc_RIP
cd14102	157-392	STKc_PIM3
cd06619	151-413	PKc_MKK5
cd07845	148-409	STKc_CDK10
cd14019	150-409	STKc_Cdc7
cd14000	157-392	STKc_LRRK
cd06637	152-408	STKc_TNIK
cd07848	150-381	STKc_CDKL5
cd07855	158-409	STKc_ERK5
cd07865	150-409	STKc_CDK9
cd06650	150-457	PKc_MEK1
cd14133	155-409	PKc_DYRK_like
cd14100	157-392	STKc_PIM1
cd14146	157-354	STKc_MLK4
cd14210	155-409	PKc_DYRK
cd07847	154-409	STKc_CDKL1_4
cd13983	154-409	STKc_WNK
cd05081	154-343	PTKc_Jak3_rpt2
cd14040	148-393	STKc_TLK1
cd14048	149-406	STKc_EIF2AK3_PERK
cd14148	157-392	STKc_MLK2
cd06622	150-417	PKc_PBS2_like
cd14145	151-392	STKc_MLK1
cd14023	242-409	PK_TRB1
cd07871	154-409	STKc_PCTAIRE3
cd14109	156-409	PK_Unc-89_rpt1
cd14222	158-344	STKc_LIMK2
cd07877	152-450	STKc_p38alpha
cd07836	152-409	STKc_Pho85
cd06649	150-457	PKc_MEK2
cd07873	154-412	STKc_PCTAIRE1
cd07861	153-409	STKc_CDK1_euk
cd14131	155-408	PKc_Mps1
cd14047	151-344	STKc_EIF2AK2_PKR
cd13985	155-392	STKc_GAK_like
cd06638	152-408	STKc_myosinIIIA_N
cd05039	147-350	PTKc_Csk_like
cd14052	151-342	PTKc_Wee1_fungi
cd06607	152-411	STKc_TAO
cd14108	152-409	STKc_SPEG_rpt1
cd13976	242-409	PK_TRB
cd07880	155-426	STKc_p38gamma
cd07844	154-409	STKc_PCTAIRE_like
cd05074	156-392	PTKc_Tyro3
cd14024	232-396	PK_TRB3
cd14150	155-352	STKc_A-Raf
cd05038	154-343	PTKc_Jak_rpt2
cd06633	155-408	STKc_TAO3
cd06635	152-410	STKc_TAO1
cd07872	154-412	STKc_PCTAIRE2
cd14151	158-392	STKc_B-Raf
cd14065	158-349	PKc_LIMK_like
cd13986	152-406	STKc_16
cd06639	150-352	STKc_myosinIIIB_N
cd14062	158-352	STKc_Raf
cd05059	151-392	PTKc_Tec_like
cd07856	148-393	STKc_Sty1_Hog1
cd05082	147-350	PTKc_Csk
cd14033	200-409	STKc_WNK4
cd14031	189-409	STKc_WNK3
cd06634	152-410	STKc_TAO2
cd07852	262-409	STKc_MAPK15-like
cd13988	158-350	STKc_TBK1
cd14063	151-404	PK_KSR
cd14154	158-348	STKc_LIMK
cd06618	144-411	PKc_MKK7
cd07879	155-409	STKc_p38delta
cd13991	158-392	STKc_NIK
cd14134	155-409	PKc_CLK
cd14068	157-392	STKc_LRRK2
cd07857	152-416	STKc_MPK1
cd07870	155-409	STKc_PFTAIRE2
cd07858	156-412	STKc_TEY_MAPK
cd13982	258-409	STKc_IRE1
cd14221	158-348	STKc_LIMK1
cd14056	156-345	STKc_TGFbR_I
cd06617	259-409	PKc_MKK3_6
cd05045	156-392	PTKc_RET
cd14112	152-408	STKc_Unc-89_rpt2
cd14205	154-343	PTKc_Jak2_rpt2
cd07869	150-359	STKc_PFTAIRE1
cd13975	258-355	PKc_Dusty
cd05080	154-344	PTKc_Tyk2_rpt2
cd14132	148-409	STKc_CK2_alpha
smart00233	6-108	PH
cd05079	158-344	PTKc_Jak1_rpt2
cd14156	158-349	PKc_LIMK_like_unk
cd14016	155-384	STKc_CK1
cd05113	151-350	PTKc_Btk_Bmx
cd14149	158-350	STKc_C-Raf
cd07839	152-409	STKc_CDK5
cd06616	148-418	PKc_MKK4
pfam00169	6-106	PH
cd14064	158-350	PKc_TNNI3K
cd07843	151-409	STKc_CDC2L1
cd14032	200-409	STKc_WNK2_like
cd14060	159-350	STKc_MLTK
smart00133	411-477	S_TK_X
cl11395	411-477	Pkinase_C superfamily
cd05084	158-392	PTKc_Fes
cd07864	146-408	STKc_CDK12
cd07878	155-394	STKc_p38beta
cd14030	189-409	STKc_WNK1
cd05041	158-362	PTKc_Fes_like
cd13998	157-393	STKc_TGFbR-like
cd07837	152-409	STKc_CdkB_plant
cd07863	158-409	STKc_CDK4
cd05112	158-362	PTKc_Itk
cd13995	160-406	STKc_MAP3K8
cd07862	158-409	STKc_CDK6
cd05035	156-392	PTKc_TAM
cd05083	156-392	PTKc_Chk
cd14224	152-346	PKc_DYRK2_3
cd07854	155-409	STKc_MAPK4_6
cd07849	258-408	STKc_ERK1_2_like
cd05085	156-342	PTKc_Fer
cd05148	151-392	PTKc_Srm_Brk
cd14026	155-350	STKc_RIP2
cd08216	155-425	PK_STRAD
cd07859	155-409	STKc_TDY_MAPK
cd14158	157-367	STKc_IRAK4
cd14067	200-349	STKc_LRRK1
cd05116	158-394	PTKc_Syk
cd05092	158-393	PTKc_TrkA
cd05056	143-350	PTKc_FAK
cd07853	258-408	STKc_NLK
cd05114	154-362	PTKc_Tec_Rlk
cd07842	152-409	STKc_CDK8_like
cd13255	1-115	PH_TAAP2-like
cd05043	157-358	PTK_Ryk
cd14212	155-356	PKc_YAK1
cd13968	158-295	PKc_like
cd14027	158-392	STKc_RIP1
cd14664	158-405	STK_BAK1_like
cd14229	152-351	STKc_HIPK3
cd07850	155-355	STKc_JNK
cd07876	250-425	STKc_JNK2
cd07874	250-469	STKc_JNK3
cd05060	158-350	PTKc_Syk_like
cd05032	147-363	PTKc_InsR_like
cd14214	158-370	PKc_CLK3
cd14025	156-436	STKc_RIP4_like
cd05095	158-360	PTKc_DDR2
cd14155	158-349	PKc_TESK
cd05097	158-360	PTKc_DDR_like
cd14226	149-357	PKc_DYRK1
cd07875	250-355	STKc_JNK1
cd05101	143-362	PTKc_FGFR2
cd05057	147-350	PTKc_EGFR_like
cd05100	143-362	PTKc_FGFR3
cd05075	156-362	PTKc_Axl
cd05099	156-362	PTKc_FGFR4
cd14159	158-366	STKc_IRAK1
cd13276	8-109	PH_AtPH1
cd05047	157-392	PTKc_Tie
cd14227	150-351	STKc_HIPK2
cd14228	150-351	STKc_HIPK1
cd14055	156-344	STKc_TGFbR2_like
cd05090	200-392	PTKc_Ror1
cd14204	156-392	PTKc_Mer
cd14011	162-411	PK_SCY1_like
cd05040	156-343	PTKc_Ack_like
cd05053	155-392	PTKc_FGFR
cd14037	156-392	STKc_NAK_like
cd05048	147-354	PTKc_Ror
cd05093	158-393	PTKc_TrkB
cd05098	156-392	PTKc_FGFR1
cd14211	152-351	STKc_HIPK
cd05115	158-350	PTKc_Zap-70
cd05072	155-392	PTKc_Lyn
cd13977	225-393	STKc_PDIK1L
cd14152	156-358	STKc_KSR1
cd14206	154-366	PTKc_Aatyk3
cd14207	219-392	PTKc_VEGFR1
cd05103	244-392	PTKc_VEGFR2
cd00821	8-103	PH
cd05058	156-351	PTKc_Met_Ron
cd13271	5-115	PH2_TAPP1_2
cd14153	156-356	PK_KSR2
cd05067	146-350	PTKc_Lck_Blk
cd05094	158-393	PTKc_TrkC
cd05049	158-393	PTKc_Trk
cd05050	150-356	PTKc_Musk
cd05102	255-392	PTKc_VEGFR3
cd05088	150-392	PTKc_Tie2
cd01252	6-104	PH_GRP1-like
cd14225	152-356	PKc_DYRK4
cd05055	150-343	PTKc_PDGFR
cd05096	158-360	PTKc_DDR1
cd05063	156-370	PTKc_EphR_A2
cd05089	151-392	PTKc_Tie1
cd13282	8-106	PH1_PLEKHH1_PLEKHH2
cd13288	8-105	PH_Ses
cd05065	156-354	PTKc_EphR_B
cd05061	143-392	PTKc_InsR
cd05054	156-392	PTKc_VEGFR
cd05066	156-354	PTKc_EphR_A
cd05087	154-375	PTKc_Aatyk1
cd14036	156-350	STKc_GAK
cd05033	156-354	PTKc_EphR
cd05108	151-350	PTKc_EGFR
cd05052	158-343	PTKc_Abl
cd13992	257-371	PK_GC
cd05073	156-392	PTKc_Hck
cd14138	151-406	PTKc_Wee1a
cd14143	157-352	STKc_TGFbR1_ACVR1b_ACVR1c
cd13263	6-109	PH_RhoGap25-like
cd13215	5-104	PH-GRAM1_AGT26
cd13389	7-113	PH1_FGD5_FGD6
smart00220	152-409	S_TKc
pfam00069	152-409	Pkinase
PTZ00263	149-440	PTZ00263
PTZ00426	129-440	PTZ00426
COG0515	151-481	SPS1
pfam07714	155-392	Pkinase_Tyr
smart00221	155-392	STYKc
PHA03390	161-411	pk1
PTZ00267	179-392	PTZ00267
smart00219	155-392	TyrKc
PLN00034	125-425	PLN00034
PTZ00283	139-401	PTZ00283
PHA03212	128-381	PHA03212
PTZ00024	156-411	PTZ00024
PTZ00266	149-392	PTZ00266
PHA03209	124-344	PHA03209
PRK13184	149-392	pknD
PLN00009	149-409	PLN00009
PHA03207	121-351	PHA03207
PTZ00036	107-393	PTZ00036
PTZ00284	147-391	PTZ00284
TIGR03903	174-408	TOMM_kin_cyc
PHA03211	187-342	PHA03211
PHA03210	258-344	PHA03210

Ontology Information

   

HPRD ID	17
Molecular Class	Serine/threonine kinase
Molecular Function	Structural constituent of cytoskeleton (GO:0005200)
Biological Process	Cell growth and/or maintenance (GO:0008151)

SNP Information

View SNP Geneview Report   

Drug Information

No matching records could be found.

External Links

                                 

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO