Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MECOM | 2122 | MDS1 and EVI1 complex locus | 3 | MDS1-EVI1, PRDM3 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22161860 | 2013 | Cell line : Caco 2, DLD1, HCT 116, HT 29, Lovo. Source : University of Texas Medical Branch (Galveston, TX). Sample Type : CRC Tumor and adjecent normal tissue No. of Sample : - Stage : - | Immunoblotting,Immunohistochemistry, RT-PCR, Real Time RT-PCR, Promoter Cloning and Promoter Activity Assay | Up-regulation | >2-fold | Evi-1 transcript, Evi-1e, as the major Evi-1 transcript expressed in human CRCs. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Zinc fingers, C2H2-type |
| Description | The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] |
| Chromosome | 3 |
| Location | 3q26.2 |
| Start | 168801287 |
| End | 169381563 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 580277 |
| OMIM ID | 165215 |
| HGNC ID | HGNC:3498 |
| Unigene ID | Hs.744090 |
| Ensembl ID | ENSG00000085276 |
| PharmGKB ID | PA27912 |
mRNA Information
| mRNA ID | NM_001205194.1 |
|---|---|
| Exon | join(12..451,519955..520089,532256..532358,535727..535943, 541060..541207,542578..542731,547048..548404, 550913..551000,555835..555861,561561..561727, 562825..562902,568542..568711,570685..570829, 573551..573787,574604..574787,578744..580288) | mRNA Sequence | Download Select all |
| Length | 5195 |
Protein Information
| Protein ID | NP_001192123.1 |
|---|---|
| Protein Name | MDS1 and EVI1 complex locus |
| Molecular Wt. (Da) | 118146 |
| Protein Sequence | Download Select all |
| Length | 1051 |
| Uniprot ID | O43240 |
| Ensembl Protein ID | ENSP00000311746 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 858;- |
| S | Phosphorylation | 860;- |
| S | Phosphorylation | 858;- |
| S | Phosphorylation | 860;- |
| S | Phosphorylation | 854;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chronic myeloid leukemia | hsa05220 |
| MAPK signaling pathway | hsa04010 |
| Pathways in cancer | hsa05200 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam13465 | 747-771 | zf-H2C2_2 |
| cl22375 | 747-771 | zf-H2C2_2 superfamily |
| pfam13465 | 89-113 | zf-H2C2_2 |
| cl22375 | 89-113 | zf-H2C2_2 superfamily |
| pfam00096 | 733-755 | zf-C2H2 |
| cl23491 | 733-755 | zf-C2H2 superfamily |
| pfam13465 | 775-799 | zf-H2C2_2 |
| cl22375 | 775-799 | zf-H2C2_2 superfamily |
| pfam00096 | 103-125 | zf-C2H2 |
| cl23491 | 103-125 | zf-C2H2 superfamily |
| pfam02892 | 725-754 | zf-BED |
| cl02703 | 725-754 | zf-BED superfamily |
| PHA00733 | 689-785 | PHA00733 |
| pfam15263 | 296-358 | DUF4593 |
| COG5189 | 114-207 | SFP1 |
| COG5236 | 80-167 | COG5236 |
| smart00317 | 80-116 | SET |
| cl02566 | 80-116 | SET superfamily |
Ontology Information
| HPRD ID | 3200 |
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.