Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| EXTL3 | 2137 | exostosin-like glycosyltransferase 3 | 8 | botv, REGR |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18543267 | 2008 | Cell line : Colo201, Colo205 Source : - Sample Type : CRC Tumor and adjacent normal tissue No. of Sample : - Stage : - | Methylation-specific PCR | Methylation | - | EXTL3 promoter methylation and its related loss of EXTL3 expression are involved in the loss of HS expression in mucinous CRCs. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Exostosin glycosyltransferase family |
| Description | This gene encodes a single-pass membrane protein which functions as a glycosyltransferase. The encoded protein catalyzes the transfer of N-acetylglucosamine to glycosaminoglycan chains. This reaction is important in heparin and heparan sulfate synthesis. Alternative splicing results in the multiple transcript variants. [provided by RefSeq, Nov 2012] |
| Chromosome | 8 |
| Location | 8p22-p12 |
| Start | 28558990 |
| End | 28611207 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 52218 |
| OMIM ID | 605744 |
| HGNC ID | HGNC:3518 |
| Unigene ID | Hs.491354 |
| Ensembl ID | ENSG00000012232 |
| PharmGKB ID | PA27930 |
mRNA Information
| mRNA ID | NM_001440.3 |
|---|---|
| Exon | join(1..187,11985..12078,14113..16735,29751..29878, 36047..36191,41614..41742,49185..52218) | mRNA Sequence | Download Select all |
| Length | 6351 |
Protein Information
| Protein ID | NP_001431.1 |
|---|---|
| Protein Name | exostosin-like glycosyltransferase 3 |
| Molecular Wt. (Da) | 104619 |
| Protein Sequence | Download Select all |
| Length | 919 |
| Uniprot ID | P34995 |
| Ensembl Protein ID | ENSP00000292513 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Glycosaminoglycan biosynthesis - heparan sulfate / heparin | hsa00534 |
| Metabolic pathways | hsa01100 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam09258 | 663-904 | Glyco_transf_64 |
| cl20374 | 663-904 | Glyco_transf_64 superfamily |
| pfam03016 | 190-499 | Exostosin |
| cl20239 | 190-499 | Exostosin superfamily |
| COG1196 | 86-145 | Smc |
| COG1196 | 71-150 | Smc |
| pfam11559 | 86-150 | ADIP |
| COG1196 | 82-148 | Smc |
| pfam07926 | 89-150 | TPR_MLP1_2 |
| TIGR02169 | 68-150 | SMC_prok_A |
| COG1196 | 87-148 | Smc |
| TIGR02169 | 56-148 | SMC_prok_A |
| COG0419 | 91-150 | SbcC |
| PRK12705 | 27-153 | PRK12705 |
| PRK03918 | 69-145 | PRK03918 |
| smart00787 | 81-132 | Spc7 |
| COG1196 | 86-139 | Smc |
Ontology Information
| HPRD ID | 8906 |
|---|---|
| Molecular Class | Enzyme: Glucosaminyltransferase |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.