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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ALDH1A1 216 Aldehyde dehydrogenase 1 family, member A1  9ALDC; ALDH1; PUMB1; ALDH11; RALDH1; ALDH-E1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22670157   2012Cell line : -

Source : Tissue Micro Array (TMA) with corresponding survival and clinicopathological data (catalog number C0951, US Biomax, Rockville,MD, USA)

Sample Type : CRC tumor and Normal tissue

No. of Sample : 30

Stage : TNM Stage I-IV

ImmunohistochemistryUp-regulation-ALDH1A1 showed an association between increasing expression level and increasing stage.

22878609   2012Cell line : -

Source : -

Sample Type : CRC tumor and Normal tissue

No. of Sample : 659 primary colon cancer, 2338 rectal cancer samples and 44 palliatively resected colorectal liver metastases tissue

Stage : TNM Stage I-IV

Tissue microarray and immunohistochemistryUp-regulation-Immunohistochemical expression analysis of ALDH1A1 in colon cancer is useful for the detection of nuclear expression in a small subpopulation of patients and is associated with shorter survival.


Gene Details



Chromosome: 9; NC_000009.11 (75515578..75568233, complement)

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Gene Type protein coding
Gene Family Aldehyde dehydrogenases
Description The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]  
Chromosome 9
Location 9q21.13
Start 72900662  
End 72953317  
Strand -  
Gene Sequence

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Length 52656  
OMIM ID 100640   
HGNC ID HGNC:402   
Unigene ID Hs.76392    
Ensembl ID ENSG00000165092   
PharmGKB ID -   

mRNA Information


mRNA ID NM_000689.4
Exon join(1..383,13066..13170,22299..22439,24297..24426, 26141..26202,27706..27834,29186..29299,34496..34598, 36214..36398,41196..41360,43559..43716,47286..47360, 52038..52656)  
mRNA Sequence

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Length 2378  



CDS Information


   
Locationjoin(318..383,13066..13170,22299..22439,24297..24426, 26141..26202,27706..27834,29186..29299,34496..34598, 36214..36398,41196..41360,43559..43716,47286..47360, 52038..52110)
CDS Sequence

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CCDS ID CCDS6644.1



Protein Information


      
Protein IDNP_000680.2
Protein NameAldehyde dehydrogenase 1 family, member A1
Molecular Wt. (Da)54731
Protein Sequence

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Length 501  
Uniprot IDP63267
Ensembl Protein ID ENSP00000295137  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SAcetylation2
KAcetylation128
KAcetylation91
KAcetylation353
KAcetylation419
KAcetylation495
KAcetylation252
KAcetylation367
KAcetylation410
KAcetylation435
TPhosphorylation267
SPhosphorylation2
SPhosphorylation360

Enzyme Information


   
EC1.2.1.3
Namealdehyde dehydrogenase (NAD+)
CoA-independent aldehyde dehydrogenase
m-methylbenzaldehyde dehydrogenase
NAD-aldehyde dehydrogenase
NAD-dependent 4-hydroxynonenal dehydrogenase
NAD-dependent aldehyde dehydrogenase
NAD-linked aldehyde dehydrogenase
propionaldehyde dehydrogenase
aldehyde dehydrogenase (NAD)
ClassOxidoreductases; Acting on the aldehyde or oxo group of donors; With NAD+ or NADP+ as acceptor
Sysnamealdehyde:NAD+ oxidoreductase  
Substratealdehyde [CPD:C00071]; NAD+ [CPD:C00003]; H2O  
Productcarboxylate [CPD:C00060]; NADH [CPD:C00004]; H+  
Reaction (IUBMB)



PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


            
Pathway Name Pathway ID
Metabolic pathways hsa01100
Retinol metabolism hsa00830


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0714115-495  ALDH_F1AB_F2_RALDH1
cl1196115-495  ALDH-SF superfamily
cd0709119-494  ALDH_F1-2_Ald2-like
cd0714218-492  ALDH_F2BC
pfam0017129-492  Aldedh
cd0714318-496  ALDH_AldA_AN0554
cd0714419-494  ALDH_ALD2-YMR170C
PLN0276617-496  PLN02766
cd0707861-494  ALDH
cd0711924-492  ALDH_BADH-GbsA
cd0711235-492  ALDH_GABALDH-PuuC
cd0711542-496  ALDH_HMSADH_HapE
COG101221-497  AdhE
cd0711440-494  ALDH_DhaS
cd0714015-495  ALDH_F1L_FTFDH
cd0709340-494  ALDH_F8_HMSADH
cd0710340-494  ALDH_F5_SSADH_GabD
cd0713823-493  ALDH_CddD_SSP0762
cd0755922-494  ALDH_ACDHII_AcoD-like
cd0710940-494  ALDH_AAS00426
PRK1325224-494  PRK13252
cd0711843-494  ALDH_SNDH
cd0709040-494  ALDH_F9_TMBADH
TIGR0180424-490  BADH
cd0653465-494  ALDH-SF
cd0710640-494  ALDH_AldA-AAD23400
cd0711040-493  ALDH_F10_BADH
cd0708940-492  ALDH_CddD-AldA-like
cd0711722-494  ALDH_StaphAldA1
PLN0246722-499  PLN02467
cd0709240-494  ALDH_ABALDH-YdcW
cd0708824-492  ALDH_LactADH-AldA
cd0711124-486  ALDH_F16
cd0713923-494  ALDH_AldA-Rv0768
cd0709724-492  ALDH_KGSADH-YcbD
cd0713124-497  ALDH_AldH-CAJ73105
PRK1347321-497  PRK13473
cd0710459-494  ALDH_BenzADH-like
cd0715038-494  ALDH_VaniDH_like
cd0710840-494  ALDH_MGR_2402
TIGR0229924-496  HpaE
cd0710740-496  ALDH_PhdK-like
cd0714938-494  ALDH_y4uC
cd0711324-495  ALDH_PADH_NahF
PRK0984716-492  PRK09847
PLN022782-492  PLN02278
cd0712423-496  ALDH_PutA-P5CDH-RocA
cd0714538-494  ALDH_LactADH_F420-Bios
cd0711624-494  ALDH_ACDHII-AcoD
cd0708624-494  ALDH_F7_AASADH-like
cd0715127-495  ALDH_HBenzADH
TIGR0321624-496  OH_muco_semi_DH
cd0712041-494  ALDH_PsfA-ACA09737
TIGR0178040-490  SSADH
cd0710060-494  ALDH_SSADH1_GabD1
cd0709440-494  ALDH_F21_LactADH-like
cd0708521-495  ALDH_F6_MMSDH
cd0708222-477  ALDH_F11_NP-GAPDH
cd0709942-494  ALDH_DDALDH
PRK0313725-493  PRK03137
cd0710559-494  ALDH_SaliADH
cd0715247-494  ALDH_BenzADH
PRK0940731-494  gabD2
cd0714738-490  ALDH_F21_RNP123
cd0710143-494  ALDH_SSADH2_GabD2
TIGR0337422-495  ABALDH
cd0714640-494  ALDH_PhpJ
cd0710242-492  ALDH_EDX86601
PRK1124113-496  gabD
TIGR0428434-492  aldehy_Rv0768
TIGR0123723-493  D1pyr5carbox2
cd0709841-494  ALDH_F15-22
PRK1009089-492  PRK10090
PRK0940642-492  gabD1
cd0708323-493  ALDH_P5CDH
cd071251-499  ALDH_PutA-P5CDH
cd0713026-494  ALDH_F7_AASADH
TIGR0325033-494  PhnAcAld_DH
TIGR0172222-495  MMSDH
cd0714840-490  ALDH_RL0313
cd0709559-487  ALDH_SGSD_AstD
cd07134156-492  ALDH_AlkH-like
PLN0041222-475  PLN00412
PRK1396842-492  PRK13968
TIGR0324024-476  arg_catab_astD
TIGR0123839-479  D1pyr5carbox3
PRK0945724-476  astD
cd07087153-492  ALDH_F3-13-14_CALDH-like
cd0713368-492  ALDH_CALDH_CalB
cd0713662-492  ALDH_YwdH-P39616
cd0713558-492  ALDH_F14-YMR110C
cd0712349-473  ALDH_F4-17_P5CDH
TIGR0123634-473  D1pyr5carbox1
PLN0231524-494  PLN02315
PTZ00381153-495  PTZ00381
cd0713262-495  ALDH_F3AB
PRK1190324-479  PRK11903
cd0713764-492  ALDH_F3FHI
PLN0220353-493  PLN02203
cd0712824-479  ALDH_MaoC-N
PLN02174158-492  PLN02174
cd0708460-479  ALDH_KGSADH-like
cd0707758-322  ALDH-like
cd0712960-455  ALDH_KGSADH
cd07126159-437  ALDH_F12_P5CDH
cd07081148-476  ALDH_F20_ACDH_EutE-like
cd0712158-439  ALDH_EutE
PRK1539858-357  PRK15398
cd07122158-456  ALDH_F20_ACDH
pfam05893154-330  LuxC
TIGR02288163-335  PaaN_2
cd07127183-311  ALDH_PAD-PaaZ
cd07080154-422  ALDH_Acyl-CoA-Red_LuxC
TIGR0251867-346  EutH_ACDH
pfam07368273-400  DUF1487
PLN0246616-492  PLN02466
COG423035-479  PutA2
PLN024194-493  PLN02419
PRK1190424-496  PRK11904
PRK1190524-475  PRK11905
PRK1180939-475  putA
TIGR0227824-436  PaaN-DH
PRK1156324-440  PRK11563


Ontology Information


   
HPRD ID16
Molecular ClassEnzyme: Dehydrogenase
Molecular FunctionStructural molecule activity (GO:0005198)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P00352DB00162Vitamin ASmallMoleculeDrug
P00352DB00755TretinoinSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
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Cancer3DGO
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NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
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Osteosarcoma DatabaseGO
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