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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
F11 2160 coagulation factor XI  4FXI 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20049862   2010Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

SDS-PAGE, Western blotting, confocal microscopy, flow cytometry, ImmunohistochemistryUp-regulation1.5 fold Increase in JUP, occludin and F11 receptor expression together with cadherin 17 expression could suggest a reversion to a more epithelial phenotype in highly metastatic cells.


Gene Details



NC_000004.11 (187187099..187210835)

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Gene Type protein coding
Gene Family -
Description This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]  
Chromosome 4
Location 4q35
Start 187187099  
End 187210835  
Strand +  
Gene Sequence

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Length 23737  
OMIM ID 264900   
HGNC ID HGNC:3529   
Unigene ID Hs.1430   
Ensembl ID ENSG00000088926   
PharmGKB ID PA27941   

mRNA Information


mRNA ID XM_005262821.2
Exon join(1..351,1192..1247,5665..5827,7127..7233,8172..8331, 9843..9952,10287..10446,14068..14177,14279..14441, 14527..14636,18148..18316,19694..19869,20471..20566, 21740..21879,22509..23606)  
mRNA Sequence

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Length 3169  



CDS Information


   
Location353..2233
CDS Sequence

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CCDS ID CCDS3847.1



Protein Information


      
Protein IDXP_005262878.1
Protein Namecoagulation factor XI
Molecular Wt. (Da)70120
Protein Sequence

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Length 626  
Uniprot IDP43116
Ensembl Protein ID ENSP00000245457  



Post-translational Modification Information (Source : HPRD)


Residue Type site
CDisulfide Bridge136;165
CDisulfide Bridge140;146
CDisulfide Bridge380;500
CDisulfide Bridge416;432
CDisulfide Bridge514;581
CDisulfide Bridge545;560
CDisulfide Bridge571;599
CDisulfide Bridge326;446
CDisulfide Bridge362;378
CDisulfide Bridge460;527
CDisulfide Bridge491;506
CDisulfide Bridge517;545
YPhosphorylation115
YPhosphorylation125
SPhosphorylation128
NGlycosylation126

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                          
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2147F21488NP_000497.1in vitro1652157   
2811GP1BA1976NP_000164.4in vitro11696542   
3082HGF799NP_000592.3in vitro1   237   281   910   962   000   
3827KNG11970NP_001095886.1in vitro16   521   573   936   495   
5104SERPINA53503NP_000615.3in vitro2551064   
5345SERPINF22029NP_000925.2in vivo8703832   


Pathway Information


      
Pathway Name Pathway ID
Complement and coagulation cascades hsa04610


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00190388-618  Tryp_SPc
cl21584388-618  Tryp_SPc superfamily
cd0110016-100  APPLE_Factor_XI_like
cl0011216-100  PAN_APPLE superfamily
cd01100288-371  APPLE_Factor_XI_like
cl00112288-371  PAN_APPLE superfamily
cd01100106-190  APPLE_Factor_XI_like
cl00112106-190  PAN_APPLE superfamily
cd01100196-280  APPLE_Factor_XI_like
cl00112196-280  PAN_APPLE superfamily
smart00223200-283  APPLE
smart0022320-103  APPLE
smart00223110-193  APPLE
smart00223291-374  APPLE
pfam00024291-372  PAN_1
pfam00024200-272  PAN_1
pfam00024110-193  PAN_1
pfam0002420-103  PAN_1
COG3591399-618  eMpr
pfam13365418-592  Trypsin_2
cd00129130-187  PAN_APPLE
pfam14295299-349  PAN_4
smart00020387-618  Tryp_SPc
pfam00089388-618  Trypsin
COG5640384-622  COG5640


Ontology Information


   
HPRD ID3350
Molecular ClassCoagulation factor
Molecular FunctionG-protein coupled receptor activity (GO:0004930)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


Uniprot ID DrugBank ID Name Type
P03951DB00100Coagulation Factor IXBiotechDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO