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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| FABP5 | 2171 | Fatty acid binding protein 5 (psoriasis-associated) | 8 | EFABP; KFABP; E-FABP; PAFABP; PA-FABP |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22991145 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Fluorogenic derivatization-liquid chromatography-tandem mass spectrometry. | Unknown | - | Our results suggest that cooperative expression of FABP5 and cyclophilin A might be linked to Her2 signaling and Her2 regulates colorectal tumor progression. Include six cancer cell lines and a normal cell line differential Proteomics study. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Fatty acid binding protein family |
| Description | This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011] |
| Chromosome | 8 |
| Location | 8q21.13 |
| Start | 81280483 |
| End | 81284777 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 4295 |
| OMIM ID | 605168 |
| HGNC ID | HGNC:3560 |
| Unigene ID | Hs.408061 |
| Ensembl ID | ENSG00000164687 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001444.2 |
|---|---|
| Exon | join(1..192,2884..3056,3391..3492,4032..4295) | mRNA Sequence | Download Select all |
| Length | 751 |
CDS Information
| Location | join(114..192,2884..3056,3391..3492,4032..4085) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS6228.1 |
Protein Information
| Protein ID | NP_001435.1 |
|---|---|
| Protein Name | Fatty acid binding protein 5 (psoriasis-associated) |
| Molecular Wt. (Da) | 15033 |
| Protein Sequence | Download Select all |
| Length | 135 |
| Uniprot ID | P12644 |
| Ensembl Protein ID | ENSP00000245451 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 131;- |
| K | Acetylation | 55 |
| K | Acetylation | 17 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 6278 | S100A7 | 2645 | NP_002954.2 | in vivo | 1 033 166 612 839 570 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| PPAR signaling pathway | hsa03320 |
Structure Information
| PDB ID | 1B56 |
|---|---|
| Resolution | 2.05 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | FATTY ACID BINDING PROTEIN |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00061 | 9-134 | Lipocalin |
| cl21528 | 9-134 | Lipocalin superfamily |
| pfam14651 | 9-134 | Lipocalin_7 |
Ontology Information
| HPRD ID | 207 |
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | Receptor binding (GO:0005102) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.