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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
FASN 2194 fatty acid synthase  17FAS, SDR27X1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25155760   2014Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Up-regulation-FASN is altered in the premalignant colonic mucosa and may serve as a marker for colonic neoplasia present elsewhere.

19491830   2009Cell line : -

Source : -

Sample Type : CRC tumor and Normal tissue

No. of Sample : 448

Stage : TNM Stage I-IV

Immunohistochemistry, tissue microarray, Western blottingUp-regulation-Identify FASN as a potential biomarker and a novel therapeutic target in distinct molecular subtypes of CRC.

FASN expression was observed in 27.1% (109/403) of Middle Eastern CRC.


Gene Details



Chromosome 17 - NC_000017.11 (82078338..82098289, complement)

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Gene Type protein coding
Gene Family Short chain dehydrogenase/reductase superfamily / Atypical members
Description The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.  
Chromosome 17
Location 17q25
Start 82078338  
End 82098289  
Strand -  
Gene Sequence

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Length 19952  
OMIM ID 600212   
HGNC ID HGNC:3594   
Unigene ID Hs.83190   
Ensembl ID ENSG00000169710   
PharmGKB ID -   

mRNA Information


mRNA ID XM_011523538.1
Exon join(1..169,1843..1971,2818..2970,4519..4692,4871..5071, 5271..5393,5478..5593,5701..5835,6606..7068,7221..7408, 7726..7915,8564..8658,8906..9040,9118..9321,9414..9529, 9728..9900,9983..10174,10256..10336,10429..10605, 10786..10965,11037..11240,11732..12036,12419..12808, 12888..13052,13134..13255,13337..13491,13574..13777, 13906..14056,14137..14315,14399..14518,14651..14773, 14865..15088,15175..15376,15612..15763,15876..15967, 16130..16281,16447..16689,16938..17126,17368..17598, 17700..17920,18052..18150,18682..18933,19010..19952)  
mRNA Sequence

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Length 8481  



CDS Information


   
Locationjoin(1845..1971,2818..2970,4519..4692,4871..5071, 5271..5393,5478..5593,5701..5835,6606..7068,7221..7408, 7726..7915,8564..8658,8906..9040,9118..9321,9414..9529, 9728..9900,9983..10174,10256..10336,10429..10605, 10786..10965,11037..11240,11732..12036,12419..12808, 12888..13052,13134..13255,13337..13491,13574..13777, 13906..14056,14137..14315,14399..14518,14651..14773,
CDS Sequence

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CCDS ID CCDS11801.1



Protein Information


      
Protein IDNP_004095.4
Protein Namefatty acid synthase
Molecular Wt. (Da)273297
Protein Sequence

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Length 2511  
Uniprot IDP13984
Ensembl Protein ID ENSP00000340823  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation2204
TPhosphorylation2204;-
SPhosphorylation2123;-
SPhosphorylation974;-
SPhosphorylation207;-
TPhosphorylation976
SPhosphorylation1411
SPhosphorylation2198
SPhosphorylation2236
KAcetylation436
KAcetylation1704
KAcetylation298
KAcetylation1771
KAcetylation673
KAcetylation1847
KAcetylation1995
KAcetylation528
KAcetylation70
KAcetylation1752
TPhosphorylation245
TPhosphorylation251
TPhosphorylation253
CS-Nitrosylation1471
YPhosphorylation222
TPhosphorylation1593
SPhosphorylation1594
TPhosphorylation217
SPhosphorylation724
SPhosphorylation725
TPhosphorylation2483
SPhosphorylation2488
SPhosphorylation2499

Enzyme Information


   
EC2.3.1.85
Namefatty-acid synthase
FASN
ClassTransferases; Acyltransferases; Transferring groups other than aminoacyl groups
Sysnameacyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)  
Substrateacetyl-CoA [CPD:C00024]; malonyl-CoA [CPD:C00083]; NADPH [CPD:C00005]; H+  
Productlong-chain fatty acid [CPD:C00638]; CoA [CPD:C00010]; CO2 [CPD:C00011]; NADP+  
Reaction (IUBMB)



PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                              
Pathway Name Pathway ID
AMPK signaling pathway hsa04152
Fatty acid biosynthesis hsa00061
Fatty acid metabolism hsa01212
Insulin signaling pathway hsa04910
Metabolic pathways hsa01100


Structure Information


PDB ID1XKT
Resolution2.6
MethodX-RAY DIFFRACTION
Chains A,B  
Molecule fatty acid synthase  
Model View



Domain Information




ID Location Description
cd008332-404  PKS
cl099382-404  cond_enzymes superfamily
cd051951566-1854  enoyl_red
cl169121566-1854  MDR superfamily
cd089541876-2112  KR_1_FAS_SDR_x
cl214541876-2112  NADB_Rossmann superfamily
cd089541316-1522  KR_1_FAS_SDR_x
cl214541316-1522  NADB_Rossmann superfamily
pfam00698493-810  Acyl_transf_1
cl08282493-810  Acyl_transf_1 superfamily
pfam001092-239  ketoacyl-synt
cd082411555-1855  QOR1
smart00827497-788  PKS_AT
cd008343-404  KAS_I_II
cd052741901-2106  KR_FAS_SDR_x
cd052761566-1854  p53_inducible_oxidoreductase
smart008221897-2065  PKS_KR
cd082511554-1854  polyketide_synthase
pfam02801243-360  Ketoacyl-synt_C
cl21486243-360  Ketoacyl-synt_C superfamily
cd082721554-1856  MDR6
cd0082580-404  decarbox_cond_enzymes
pfam086591886-2066  KR
cd082751566-1856  MDR3
cd008282-404  elong_cond_enzymes
cd082661604-1856  Zn_ADH_like1
cd051881566-1814  MDR
pfam009752242-2487  Thioesterase
cl214942242-2487  Esterase_lipase superfamily
cd089551901-2071  KR_2_FAS_SDR_x
cd082681553-1856  MDR2
cd082531626-1856  zeta_crystallin
cd082761569-1856  MDR7
cd052891566-1854  MDR_like_2
cd082671566-1854  MDR1
cd089531901-2077  KR_2_SDR_x
cd082731563-1855  MDR8
cd089521901-2067  KR_1_SDR_x
cd082711635-1856  MDR5
cd0032780-404  cond_enzymes
cd089561901-2089  KR_3_FAS_SDR_x
cd052861568-1856  QOR2
cd082741635-1854  MDR9
cd052881654-1854  PGDH
COG33192242-2324  EntF
cd082491590-1856  enoyl_reductase_like
pfam001071679-1816  ADH_zinc_N
cd052821610-1853  ETR_like
cd082591636-1854  Zn_ADH5
pfam14765874-1106  PS-DH
cl00509874-1106  hot_dog superfamily
COG0331494-776  FabD
cd082481555-1854  RTN4I1
cd082501654-1854  Mgc45594_like
smart00826874-1008  PKS_DH
cd082601636-1817  Zn_ADH6
cd082431604-1854  quinone_oxidoreductase_like_1
cd052781636-1855  FDH_like
TIGR00128494-773  fabD
smart008232111-2179  PKS_PP
cl099362111-2179  PP-binding superfamily
cd082471566-1856  AST1_like
cd082441610-1853  MDR_enoyl_red
cd082701555-1710  MDR4
cd082541621-1854  hydroxyacyl_CoA_DH
cd082351616-1855  iditol_2_DH_like
cd082631617-1770  Zn_ADH10
cd0083237-399  CLF
pfam082421243-1342  Methyltransf_12
cl171731243-1342  AdoMet_MTases superfamily
cd082551610-1839  2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_
cd082461623-1856  crotonyl_coA_red
cd082901623-1854  ETR
cd082521637-1855  AL_MDR
pfam005502125-2187  PP-binding
cd082611612-1854  Zn_ADH7
cd082971626-1854  CAD3
cd082641613-1776  Zn_ADH_like2
cd052851622-1856  sorbitol_DH
cd052801514-1854  MDR_yhdh_yhfp
cd082841633-1853  FDH_like_2
cd082581621-1817  Zn_ADH4
cd082331621-1817  butanediol_DH_like
cd082941610-1709  leukotriene_B4_DH_like
cd082401610-1855  6_hydroxyhexanoate_dh_like
cd0082965-189  SCP-x_thiolase
cd022661968-2063  SDR
cd082951654-1746  double_bond_reductase_like
cd082361633-1854  sugar_DH
cd082311636-1770  MDR_TM0436_like
cd082391621-1854  THR_DH_like
cd082851636-1856  NADP_ADH
cd053331933-2040  BKR_SDR_c
cd082861633-1745  FDH_like_ADH2
smart010021663-1746  AlaDh_PNT_C
cl214541663-1746  NADB_Rossmann superfamily
cd052811667-1856  TDH
pfam082411269-1344  Methyltransf_11
COG32082244-2341  GrsT
pfam136021808-1854  ADH_zinc_N_2
cl228521808-1854  ADH_zinc_N_2 superfamily
cd082451621-1854  CAD
pfam134891240-1389  Methyltransf_23
cd00751153-188  thiolase
cd082791635-1786  Zn_ADH_class_III
cd052791635-1760  Zn_ADH1
cd089391901-2054  KDSR-like_SDR_c
cd053051665-1744  L-AlaDH
cd082891514-1708  MDR_yhfp_like
cd082651644-1743  Zn_ADH3
cd082881514-1710  MDR_yhdh
pfam136591240-1344  Methyltransf_26
cd082781664-1770  benzyl_alcohol_DH
pfam128471241-1346  Methyltransf_18
cd082831636-1745  FDH_like_1
COG33211-1022  PksD
smart008291564-1854  PKS_ER
pfam138471239-1383  Methyltransf_31
smart008254-404  PKS_KS
COG03041-405  FabB
TIGR028134-835  omega_3_PfaA
TIGR028241556-1856  quinone_pig3
COG06041566-1856  Qor
pfam001061901-2053  adh_short
TIGR031504-405  fabF
PRK063331-406  PRK06333
PRK073141-405  PRK07314
PTZ0005018-405  PTZ00050
PTZ003541563-1856  PTZ00354
PRK06501141-404  PRK06501
PRK091161-405  PRK09116
PRK087224-405  PRK08722
PRK0796788-405  PRK07967
PRK0595281-405  PRK05952
PRK09185106-404  PRK09185
PRK07103148-405  PRK07103
PRK07910151-402  PRK07910
PRK0843954-405  PRK08439
PLN027874-406  PLN02787
PRK14691121-405  PRK14691
PLN028364-404  PLN02836
COG10641621-1854  AdhP
COG21301654-1856  CurA
PRK137711636-1854  PRK13771
PRK107541571-1770  PRK10754
PRK102522126-2409  entF
COG10631621-1854  Tdh
TIGR017511637-1861  crot-CoA-red
PRK055571901-2042  fabG
TIGR018291935-2041  AcAcCoA_reduct
PRK128251929-2042  fabG
TIGR028251654-1855  B4_12hDH
PRK124672143-2324  PRK12467
TIGR018301901-2034  3oxo_ACP_reduc
PRK056531929-2035  fabG
TIGR020721241-1382  BioC
COG10621654-1854  FrmA
TIGR028131936-2043  omega_3_PfaA
COG0183153-187  PaaJ
TIGR006921668-1853  tdh
PRK077911935-2037  PRK07791
TIGR01930153-188  AcCoA-C-Actrans
pfam00108153-187  Thiolase_N
PRK077921933-2041  fabG


Ontology Information


   
HPRD ID2018
Molecular ClassEnzyme: Synthase
Molecular FunctionHydrolase activity (GO:0016787)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P49327DB01034CeruleninSmallMoleculeDrug
P49327DB01083OrlistatSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO